(Q38111622)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23732569%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

title

Gene-function studies in systemic lupus erythematosus (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23732569%20AND%20SRC:MED&resulttype=core&format=json

systemic lupus erythematosus

2 March 2020

main subject

0 references

author

Christian M Hedrich

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23732569%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

author name string

José C Crispín

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23732569%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

George C Tsokos

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23732569%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

language of work or name

English

0 references

publication date

4 June 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23732569%20AND%20SRC:MED&resulttype=core&format=json

Nature Reviews Rheumatology

2 March 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23732569%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

volume

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23732569%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

issue

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23732569%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

page(s)

476-484

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23732569%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/nrrheum.2013.78

2 March 2020

exact match

0 references

cites work

Unraveling the genetics of systemic lupus erythematosus

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

A revised estimate of twin concordance in systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Recent insights into the genetic basis of systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

The genetics of systemic lupus erythematosus and implications for targeted therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Genetic susceptibility to SLE: new insights from fine mapping and genome-wide association studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Copy number variants in genetic susceptibility and severity of systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Gene copy-number variation and associated polymorphisms of complement component C4 in human systemic lupus erythematosus (SLE): low copy number is a risk factor for and high copy number is a protective factor against SLE susceptibility in European A

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Phenotypes, genotypes and disease susceptibility associated with gene copy number variations: complement C4 CNVs in European American healthy subjects and those with systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

The role of complement in the development of systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Complement deficiencies and systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Immune complex processing in patients with systemic lupus erythematosus. In vivo imaging and clearance studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Autoimmune manifestations in primary immune deficiencies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

A protective role for innate immunity in systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Infectious diseases associated with complement deficiencies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

New roles for the major human 3'-5' exonuclease TREX1 in human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Chilblain lupus erythematosus--a review of literature.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Familial chilblain lupus--a monogenic form of cutaneous lupus erythematosus due to a heterozygous mutation in TREX1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Epigenetic mechanisms in systemic lupus erythematosus and other autoimmune diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Trex1 prevents cell-intrinsic initiation of autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Evaluation of the TREX1 gene in a large multi-ancestral lupus cohort

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

A quarter century of granzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Granzyme A activates another way to die

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Expanding the phenotypic spectrum of lupus erythematosus in Aicardi-Goutières syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

C-terminal truncations in human 3'-5' DNA exonuclease TREX1 cause autosomal dominant retinal vasculopathy with cerebral leukodystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Hyperresponsive B cells in CD22-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Deficiency in CD22, a B cell-specific inhibitory receptor, is sufficient to predispose to development of high affinity autoantibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Natural ligands of the B cell adhesion molecule CD22 beta can be masked by 9-O-acetylation of sialic acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Molecular cloning and characterization of lysosomal sialic acid O-acetylesterase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

B cell antigen receptor signal strength and peripheral B cell development are regulated by a 9-O-acetyl sialic acid esterase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Functionally defective germline variants of sialic acid acetylesterase in autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

M89V Sialic acid Acetyl Esterase (SIAE) and all other non-synonymous common variants of this gene are catalytically normal

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Intraluminal crawling of neutrophils to emigration sites: a molecularly distinct process from adhesion in the recruitment cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

The rs1143679 (R77H) lupus associated variant of ITGAM (CD11b) impairs complement receptor 3 mediated functions in human monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

A systemic lupus erythematosus-associated R77H substitution in the CD11b chain of the Mac-1 integrin compromises leukocyte adhesion and phagocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Human lupus serum induces neutrophil-mediated organ damage in mice that is enabled by Mac-1 deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Taming lupus-a new understanding of pathogenesis is leading to clinical advances

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Time to renal disease and end-stage renal disease in PROFILE: a multiethnic lupus cohort

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Fc receptor genes and the systemic lupus erythematosus diathesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Fc-receptors as regulators of immunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Endocytosis of soluble immune complexes leads to their clearance by FcγRIIIB but induces neutrophil extracellular traps via FcγRIIA in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Genomic pathology of SLE-associated copy-number variation at the FCGR2C/FCGR3B/FCGR2B locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

IgG receptor polymorphisms: risk factors for disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Protein phosphatase 2A is a negative regulator of IL-2 production in patients with systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

PP2A holoenzyme assembly: in cauda venenum (the sting is in the tail).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

PP2A dephosphorylates Elf-1 and determines the expression of CD3zeta and FcRgamma in human systemic lupus erythematosus T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Transcriptional activation of the cAMP-responsive modulator promoter in human T cells is regulated by protein phosphatase 2A-mediated dephosphorylation of SP-1 and reflects disease activity in patients with systemic lupus erythematosus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Association of PPP2CA polymorphisms with systemic lupus erythematosus susceptibility in multiple ethnic groups

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Methylation status of CpG islands flanking a cAMP response element motif on the protein phosphatase 2Ac alpha promoter determines CREB binding and activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Promoter hypomethylation results in increased expression of protein phosphatase 2A in T cells from patients with systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Cutting edge: protein phosphatase 2A confers susceptibility to autoimmune disease through an IL-17-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

SLAM family receptors and the SLAM-associated protein (SAP) modulate T cell functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Confirmation of genetic linkage between human systemic lupus erythematosus and chromosome 1q41.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Genome-wide screen for systemic lupus erythematosus susceptibility genes in multiplex families

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Linkage and interaction of loci on 1q23 and 16q12 may contribute to susceptibility to systemic lupus erythematosus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Effect of genetic background on the contribution of New Zealand black loci to autoimmune lupus nephritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Lupus susceptibility loci in New Zealand mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Increased expression of SLAM receptors SLAMF3 and SLAMF6 in systemic lupus erythematosus T lymphocytes promotes Th17 differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

CD3-T cell receptor co-stimulation through SLAMF3 and SLAMF6 receptors enhances RORγt recruitment to the IL17A promoter in human T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Overexpression of CD70 and overstimulation of IgG synthesis by lupus T cells and T cells treated with DNA methylation inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Epigenetic control of T-helper-cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

The epigenetic face of systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Epigenetics and SLE: RFX1 downregulation causes CD11a and CD70 overexpression by altering epigenetic modifications in lupus CD4+ T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Impaired DNA methylation and its mechanisms in CD4(+)T cells of systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Mechanisms of drug-induced lupus. II. T cells overexpressing lymphocyte function-associated antigen 1 become autoreactive and cause a lupuslike disease in syngeneic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

A methylation rendezvous: reader meets writers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Epigenetics and autoimmunity, with special emphasis on methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Epigenetic alterations in autoimmune rheumatic diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

cAMP-responsive element modulator (CREM)α protein signaling mediates epigenetic remodeling of the human interleukin-2 gene: implications in systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

cAMP response element modulator α controls IL2 and IL17A expression during CD4 lineage commitment and subset distribution in lupus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Decreased DNA methyltransferase levels contribute to abnormal gene expression in "senescent" CD4(+)CD28(-) T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

cAMP-responsive element modulator (CREM)α protein induces interleukin 17A expression and mediates epigenetic alterations at the interleukin-17A gene locus in patients with systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Demethylation of ITGAL (CD11a) regulatory sequences in systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Demethylation of the same promoter sequence increases CD70 expression in lupus T cells and T cells treated with lupus-inducing drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Demethylation of CD40LG on the inactive X in T cells from women with lupus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Demethylation of promoter regulatory elements contributes to perforin overexpression in CD4+ lupus T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Stimulatory and inhibitory killer Ig-like receptor molecules are expressed and functional on lupus T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Decreased ERK and JNK signaling contribute to gene overexpression in "senescent" CD4+CD28- T cells through epigenetic mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

DNA methylation inhibition increases T cell KIR expression through effects on both promoter methylation and transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

miRNA in systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Identification of microRNA-31 as a novel regulator contributing to impaired interleukin-2 production in T cells from patients with systemic lupus erythematosus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Mechanisms of Disease: the complement system and the pathogenesis of systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Familial aggregation of systemic lupus erythematosus, rheumatoid arthritis, and other autoimmune diseases in 1,177 lupus patients from the GLADEL cohort

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

A nonsynonymous functional variant in integrin-αM (encoded by ITGAM) is associated with systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Nucleic acid driven sterile inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

MicroRNA-146A contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteins

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.78

Mapping autoimmune disease genes in humans: lessons from IBD and SLE

31 March 2020

1 reference

12 December 2020

Hypomethylation of IL10 and IL13 promoters in CD4+ T cells of patients with systemic lupus erythematosus

1 reference

12 December 2020

Procainamide inhibits DNA methyltransferase in a human T cell line

1 reference

12 December 2020

Multiple lupus susceptibility loci map to chromosome 1 in BXSB mice

1 reference

12 December 2020

DNA methyltransferases: facts, clues, mysteries.

1 reference

12 December 2020

C1q binds directly and specifically to surface blebs of apoptotic human keratinocytes: complement deficiency and systemic lupus erythematosus revisited

1 reference

12 December 2020

Role of the CD6 glycoprotein in antigen-specific and autoreactive responses of cloned human T lymphocytes.

1 reference

12 December 2020

Complement deficiency: predisposing factor to autoimmune syndromes

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRRHEUM.2013.78

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23732569%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

2 March 2020

1008861047

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23732569%20AND%20SRC:MED&resulttype=core&format=json