(Q38113122)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23748872%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

title

Cardiac glycosides in cancer therapy: from preclinical investigations towards clinical trials (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23748872%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

4

1 reference

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2 March 2020

Claudia Cerella

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23748872%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

Henk-Jan Guchelaar

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23748872%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

author name string

M Slingerland

1

1 reference

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2 March 2020

H Gelderblom

5

1 reference

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2 March 2020

publication date

10 June 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23748872%20AND%20SRC:MED&resulttype=core&format=json

Investigational New Drugs

2 March 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23748872%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

volume

31

1 reference

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2 March 2020

issue

4

1 reference

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2 March 2020

page(s)

1087-1094

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https://scigraph.springernature.com/pub.10.1007/s10637-013-9984-1

2 March 2020

exact match

0 references

cites work

Therapeutic and toxic effects of digitalis: William Withering, 1785.

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Cardiac glycosides as novel cancer therapeutic agents

21 January 2018

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The sodium pump. Its molecular properties and mechanics of ion transport

21 January 2018

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Regulation and critical role of potassium homeostasis in apoptosis

21 January 2018

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The role of apoptotic volume decrease and ionic homeostasis in the activation and repression of apoptosis

21 January 2018

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Na+, K+-ATPase: the new face of an old player in pathogenesis and apoptotic/hybrid cell death

21 January 2018

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Apoptotic volume decrease and the incredible shrinking cell

21 January 2018

1 reference

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Uncoupling cell shrinkage from apoptosis reveals that Na+ influx is required for volume loss during programmed cell death

21 January 2018

1 reference

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On the mechanism of ionic regulation of apoptosis: would the Na+/K+-ATPase please stand up?

21 January 2018

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Regulation of cell death: the calcium-apoptosis link

21 January 2018

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Assembling the puzzle of anti-cancer mechanisms triggered by cardiac glycosides

21 January 2018

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The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis.

21 January 2018

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Hydrogen ion-dependent oncogenesis and parallel new avenues to cancer prevention and treatment using a H(+)-mediated unifying approach: pH-related and pH-unrelated mechanisms

21 January 2018

1 reference

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Intracellular pH is increased after transformation of Chinese hamster embryo fibroblasts

21 January 2018

1 reference

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Increased pH and tumorigenicity of fibroblasts expressing a yeast proton pump.

21 January 2018

1 reference

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Na+/H+ exchanger-dependent intracellular alkalinization is an early event in malignant transformation and plays an essential role in the development of subsequent transformation-associated phenotypes.

21 January 2018

1 reference

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Intracellular acidification triggered by mitochondrial-derived hydrogen peroxide is an effector mechanism for drug-induced apoptosis in tumor cells

21 January 2018

1 reference

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Amiloride potentiates TRAIL-induced tumor cell apoptosis by intracellular acidification-dependent Akt inactivation.

21 January 2018

1 reference

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Alterations of intracellular pH homeostasis in apoptosis: origins and roles

21 January 2018

1 reference

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Apoptosis induced in Jurkat cells by several agents is preceded by intracellular acidification

21 January 2018

1 reference

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Mitochondria-dependent apoptosis and cellular pH regulation

21 January 2018

1 reference

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Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis

21 January 2018

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Interleukin-8 and human cancer biology

21 January 2018

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The role of interleukin-8 in cancer cells and microenvironment interaction

21 January 2018

1 reference

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UNBS1450, a steroid cardiac glycoside inducing apoptotic cell death in human leukemia cells

21 January 2018

1 reference

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Digitoxin mimics gene therapy with CFTR and suppresses hypersecretion of IL-8 from cystic fibrosis lung epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-013-9984-1

Cardiac glycosides inhibit TNF-alpha/NF-kappaB signaling by blocking recruitment of TNF receptor-associated death domain to the TNF receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-013-9984-1

Digitoxin inhibits the growth of cancer cell lines at concentrations commonly found in cardiac patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-013-9984-1

Digitoxin, at concentrations commonly found in the plasma of cardiac patients, antagonizes etoposide and idarubicin activity in K562 leukemia cells.

21 January 2018

1 reference

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Inhibition of DNA topoisomerases I and II, and growth inhibition of breast cancer MCF-7 cells by ouabain, digoxin and proscillaridin A.

21 January 2018

1 reference

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Identification of a pool of non-pumping Na/K-ATPase

21 January 2018

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Functional characterization of Src-interacting Na/K-ATPase using RNA interference assay

21 January 2018

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Digitalis-induced signaling by Na+/K+-ATPase in human breast cancer cells.

21 January 2018

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Endogenous cardiotonic steroids: physiology, pharmacology, and novel therapeutic targets

21 January 2018

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Digoxin-associated decrease in parathyroid hormone (PTH) concentrations in patients with atrial fibrillation

21 January 2018

1 reference

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Preoperative endogenous ouabain predicts acute kidney injury in cardiac surgery patients

21 January 2018

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Interaction of atrial natriuretic peptide and ouabain in the myocardium.

21 January 2018

1 reference

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Endogenous concentrations of ouabain act as a cofactor to stimulate fluid secretion and cyst growth of in vitro ADPKD models via cAMP and EGFR-Src-MEK pathways

21 January 2018

1 reference

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The Na+-K+-ATPase as self-adhesion molecule and hormone receptor

21 January 2018

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UNBS1450 from Calotropis procera as a regulator of signaling pathways involved in proliferation and cell death

21 January 2018

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Cardiotonic steroids attenuate ERK phosphorylation and generate cell cycle arrest to block human hepatoma cell growth

21 January 2018

1 reference

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2'-epi-2'-O-Acetylthevetin B extracted from seeds of Cerbera manghas L. induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells

21 January 2018

1 reference

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Bufalin induces autophagy-mediated cell death in human colon cancer cells through reactive oxygen species generation and JNK activation.

21 January 2018

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Cardiac glycosides exert anticancer effects by inducing immunogenic cell death

21 January 2018

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Autophagy-dependent anticancer immune responses induced by chemotherapeutic agents in mice

21 January 2018

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Digitoxin medication and cancer; case control and internal dose-response studies

21 January 2018

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Digitalis and breast cancer

21 January 2018

1 reference

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Digoxin treatment is associated with an increased incidence of breast cancer: a population-based case-control study

21 January 2018

1 reference

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Inhibition of export of fibroblast growth factor-2 (FGF-2) from the prostate cancer cell lines PC3 and DU145 by Anvirzel and its cardiac glycoside component, oleandrin

21 January 2018

1 reference

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Identification of a novel cardenolide (2''-oxovoruscharin) from Calotropis procera and the hemisynthesis of novel derivatives displaying potent in vitro antitumor activities and high in vivo tolerance: structure-activity relationship analyses.

21 January 2018

1 reference

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Cardenolide-induced lysosomal membrane permeabilization demonstrates therapeutic benefits in experimental human non-small cell lung cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-013-9984-1

The cardenolide UNBS1450 is able to deactivate nuclear factor kappaB-mediated cytoprotective effects in human non-small cell lung cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-013-9984-1

Nucleolus and c-Myc: potential targets of cardenolide-mediated antitumor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-013-9984-1

Targeting the alpha 1 subunit of the sodium pump to combat glioblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-013-9984-1

The sodium pump alpha1 subunit as a potential target to combat apoptosis-resistant glioblastomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-013-9984-1

Possible future issues in the treatment of glioblastomas: special emphasis on cell migration and the resistance of migrating glioblastoma cells to apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-013-9984-1

Digitoxin as an anticancer agent with selectivity for cancer cells: possible mechanisms involved

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-013-9984-1

21 January 2018

1 reference

12 December 2020

Oleandrin suppresses activation of nuclear transcription factor-kappaB, activator protein-1, and c-Jun NH2-terminal kinase

1 reference

12 December 2020

The role of pH dynamics and the Na+/H+ antiporter in the etiopathogenesis and treatment of cancer. Two faces of the same coin--one single nature

1 reference

12 December 2020

Evidence of a modifying influence of heart glucosides on the development of breast cancer.

1 reference

12 December 2020

Neriifolin from seeds of Cerbera manghas L. induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells

1 reference

12 December 2020

Bufalin induces growth inhibition, cell cycle arrest and apoptosis in human endometrial and ovarian cancer cells

1 reference

12 December 2020

Apoptosis of leukemic cells accompanies reduction in intracellular pH after targeted inhibition of the Na(+)/H(+) exchanger

1 reference

12 December 2020

Phase 1 trial of Anvirzel in patients with refractory solid tumors

1 reference

12 December 2020

Cardiac glycosides stimulate Ca2+ increases and apoptosis in androgen-independent, metastatic human prostate adenocarcinoma cells

1 reference

12 December 2020

Bufalin reduces the level of topoisomerase II in human leukemia cells and affects the cytotoxicity of anticancer drugs

1 reference

12 December 2020

HIF-1: hypoxia-inducible factor or dysoxia-inducible factor?

1 reference

12 December 2020

Identification of interleukin 8 as an inhibitor of tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in the ovarian carcinoma cell line OVCAR3.

1 reference

12 December 2020

Growth inhibitory effect of cardiac glycosides and aglycones on neoplastic cells: in vitro and in vivo studies

1 reference

12 December 2020

Cell cycle arrest and protein kinase modulating effect of bufalin on human leukemia ML1 cells

1 reference

12 December 2020

Cardiotonic steroids on the road to anti-cancer therapy

1 reference

12 December 2020

Cardiac glycosides and breast cancer, revisited

1 reference

12 December 2020

Cardiac glycosides and breast cancer

1 reference

12 December 2020

Death of tumor cells after intracellular acidification is dependent on stress-activated protein kinases (SAPK/JNK) pathway activation and cannot be inhibited by Bcl-2 expression or interleukin 1beta-converting enzyme inhibition

1 reference

12 December 2020

10.1007/S10637-013-9984-1

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23748872%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

2 March 2020

1021284862

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23748872%20AND%20SRC:MED&resulttype=core&format=json