(Q38115212)

29 August 2017

Getting intimate with trypsin, the leading protease in proteomics (English)

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29 August 2017

Lennart Martens

3

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author name string

Elien Vandermarliere

series ordinal

1

1 reference

PubMed ID

23775586

29 August 2017

Michael Mueller

series ordinal

2

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PubMed ID

23775586

29 August 2017

language of work or name

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15 June 2013

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Mass Spectrometry Reviews

29 August 2017

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29 August 2017

32

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29 August 2017

6

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29 August 2017

453-465

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Recent advances in atherosclerosis-based proteomics: new biomarkers and a future perspective.

29 August 2017

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A human proteome detection and quantitation project

21 January 2018

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High-yielding enzymatic method for isolation and culture of microvascular endothelial cells from bovine retinal blood vessels

21 January 2018

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Role of a Buried Acid Group in the Mechanism of Action of Chymotrypsin

21 January 2018

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The refined crystal structure of bovine beta-trypsin at 1.8 A resolution. II. Crystallographic refinement, calcium binding site, benzamidine binding site and active site at pH 7.0

21 January 2018

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Crystal structure of bovine trypsinogen at 1-8 A resolution. I. Data collection, application of patterson search techniques and preliminary structural interpretation

21 January 2018

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Surfome analysis of a wild-type wine Saccharomyces cerevisiae strain.

21 January 2018

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Optimization of mass spectrometry-compatible surfactants for shotgun proteomics

21 January 2018

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Changes in insulin-receptor structure associated with trypsin-induced activation of the receptor tyrosine kinase

21 January 2018

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TANDEM: matching proteins with tandem mass spectra

21 January 2018

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Preparation of stable isotope-incorporated peptide internal standards for field desorption mass spectrometry quantification of peptides in biologic tissue.

21 January 2018

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21 January 2018

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Unconventional serine proteases: variations on the catalytic Ser/His/Asp triad configuration

21 January 2018

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Probability-based pattern recognition and statistical framework for randomization: modeling tandem mass spectrum/peptide sequence false match frequencies.

21 January 2018

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Protein cleavage strategies for an improved analysis of the membrane proteome

21 January 2018

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Digestion and depletion of abundant proteins improves proteomic coverage

21 January 2018

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Probing the partly folded states of proteins by limited proteolysis

21 January 2018

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Chymotrypsinogen: 2,5-Å crystal structure, comparison with α-chymotrypsin, and implications for zymogen activation

21 January 2018

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Open mass spectrometry search algorithm

21 January 2018

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A la carte proteomics with an emphasis on gel-free techniques

21 January 2018

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Does protein structure influence trypsin miscleavage? Using structural properties to predict the behavior of related proteins.

21 January 2018

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Proteomics, human proteome project, and chromosomes.

21 January 2018

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Use of matrix clusters and trypsin autolysis fragments as mass calibrants in matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

21 January 2018

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Serine protease mechanism and specificity

21 January 2018

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Comparison of digestion protocols for microgram quantities of enriched protein samples.

21 January 2018

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The role of trypsin, trypsin inhibitor, and trypsin receptor in the onset and aggravation of pancreatitis

21 January 2018

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The use of selected reaction monitoring in quantitative proteomics

21 January 2018

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The structural aspects of limited proteolysis of native proteins

21 January 2018

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Infrastructure for the life sciences: design and implementation of the UniProt website

21 January 2018

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Digesting new information about the role of trypsin in pancreatitis

21 January 2018

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The susceptibility to tryptic hydrolysis of peptide bonds involving ϵ-N-methyllysine

21 January 2018

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Assigning significance to peptides identified by tandem mass spectrometry using decoy databases

21 January 2018

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21 January 2018

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Comparative effects of trypsin, collagenase and mechanical harvesting on cell membrane lipids studied in monolayer-cultured endothelial cells and a green monkey kidney cell line.

21 January 2018

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Effects of modified digestion schemes on the identification of proteins from complex mixtures

21 January 2018

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FORMATION OF TRYPSIN FROM CRYSTALLINE TRYPSINOGEN BY MEANS OF ENTEROKINASE

21 January 2018

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Selected reaction monitoring for quantitative proteomics: a tutorial

21 January 2018

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Sodium-deoxycholate-assisted tryptic digestion and identification of proteolytically resistant proteins

21 January 2018

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PRIDE: the proteomics identifications database

21 January 2018

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Proteolytic enzymes past and present: the second golden era. Recollections, special section in honor of Max Perutz

21 January 2018

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Molecular cloning of a potential proteinase activated receptor

21 January 2018

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Trypsin cleaves exclusively C-terminal to arginine and lysine residues

21 January 2018

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Common protein architecture and binding sites in proteases utilizing a Ser/Lys dyad mechanism

21 January 2018

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Evolution of peptidase diversity

21 January 2018

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The Chromosome-Centric Human Proteome Project for cataloging proteins encoded in the genome.

21 January 2018

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Standard guidelines for the chromosome-centric human proteome project.

21 January 2018

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Probability-based protein identification by searching sequence databases using mass spectrometry data

21 January 2018

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The catalytic triad of serine peptidases

21 January 2018

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Cell-based proteome analysis: the first stage in the pipeline for biomarker discovery

21 January 2018

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A quantitative study of the effects of chaotropic agents, surfactants, and solvents on the digestion efficiency of human plasma proteins by trypsin

21 January 2018

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Cleavage specificities of the brother and sister proteases Lys-C and Lys-N.

21 January 2018

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Families of serine peptidases.

21 January 2018

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MEROPS: the database of proteolytic enzymes, their substrates and inhibitors

21 January 2018

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Bioinformatic challenges in targeted proteomics

21 January 2018

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Stabilization of bovine trypsin by reductive methylation

21 January 2018

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Does trypsin cut before proline?

21 January 2018

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Multiple effects of N-alpha-tosyl-L-phenylalanyl chloromethyl ketone (TPCK) on apoptotic pathways in human prostatic carcinoma cell lines

21 January 2018

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Structure of the complex formed by bovine trypsin and bovine pancreatic trypsin inhibitor. Crystal structure determination and stereochemistry of the contact region

21 January 2018

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Large-scale database searching using tandem mass spectra: looking up the answer in the back of the book

21 January 2018

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On the size of the active site in proteases. I. Papain

21 January 2018

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Trypsin is the culprit of multiple organ injury with severe acute pancreatitis.

21 January 2018

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Three-dimensional Structure of Tosyl-elastase

21 January 2018

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Prediction of missed cleavage sites in tryptic peptides aids protein identification in proteomics

21 January 2018

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A protocol for isolation and culture of mesenchymal stem cells from mouse bone marrow

21 January 2018

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The three-dimensional structure of Asn102 mutant of trypsin: role of Asp102 in serine protease catalysis

21 January 2018

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Global differential non-gel proteomics by quantitative and stable labeling of tryptic peptides with oxygen-18.

21 January 2018

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Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism

21 January 2018

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Value of using multiple proteases for large-scale mass spectrometry-based proteomics

21 January 2018

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Influence of basic residue content on fragment ion peak intensities in low-energy collision-induced dissociation spectra of peptides

21 January 2018

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Analysis of missed cleavage sites, tryptophan oxidation and N-terminal pyroglutamylation after in-gel tryptic digestion

21 January 2018

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Shedding & shaving: disclosure of proteomic expressions on a bacterial face

21 January 2018

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Comparison of protein fragments identified by limited proteolysis and by computational cutting of proteins

21 January 2018

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Ongoing and future developments at the Universal Protein Resource

21 January 2018

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Current methods for global proteome identification

21 January 2018

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A guide to the Proteomics Identifications Database proteomics data repository

21 January 2018

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Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

21 January 2018

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TRYPSINOGEN AND CHYMOTRYPSINOGEN AS HOMOLOGOUS PROTEINS

21 January 2018

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Mass spectrometry-based proteomics in cell biology

21 January 2018

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Large-scale analysis of the yeast proteome by multidimensional protein identification technology

21 January 2018

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Human pancreatic digestive enzymes

21 January 2018

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Universal sample preparation method for proteome analysis

21 January 2018

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Secondary and conformational specificities of trypsin and chymotrypsin

21 January 2018

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Improving sensitivity in shotgun proteomics using a peptide-centric database with reduced complexity: protease cleavage and SCX elution rules from data mining of MS/MS spectra

21 January 2018

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Large-Scale Quantitative Assessment of Different In-Solution Protein Digestion Protocols Reveals Superior Cleavage Efficiency of Tandem Lys-C/Trypsin Proteolysis over Trypsin Digestion

21 January 2018

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Systematic and quantitative comparison of digest efficiency and specificity reveals the impact of trypsin quality on MS-based proteomics

21 January 2018

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Utility of Accurate Mass Tags for Proteome-Wide Protein Identification

21 January 2018

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DBToolkit: processing protein databases for peptide-centric proteomics

21 January 2018

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Is a gene-centric human proteome project the best way for proteomics to serve biology?

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/MAS.21376

1 reference

29 August 2017

1 reference

PubMed ID

23775586