(Q38120958)

29 August 2017

Newly described pattern recognition receptors team up against intracellular pathogens (English)

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pattern recognition receptors

29 August 2017

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1

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29 August 2017

Denise M Monack

2

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29 August 2017

12 July 2013

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Nature Reviews Immunology

29 August 2017

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29 August 2017

13

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29 August 2017

8

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29 August 2017

551-565

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https://scigraph.springernature.com/pub.10.1038/nri3479

29 August 2017

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

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STING is a direct innate immune sensor of cyclic di-GMP

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Structural Analysis of the STING Adaptor Protein Reveals a Hydrophobic Dimer Interface and Mode of Cyclic di-GMP Binding

31 March 2020

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Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP

31 March 2020

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Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system

31 March 2020

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Cyclic di-GMP sensing via the innate immune signaling protein STING

31 March 2020

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The structural basis for the sensing and binding of cyclic di-GMP by STING

31 March 2020

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c-di-AMP secreted by intracellular Listeria monocytogenes activates a host type I interferon response

31 March 2020

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Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway

31 March 2020

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Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA

31 March 2020

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Bacterial c-di-GMP is an immunostimulatory molecule

31 March 2020

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c-di-GMP as a vaccine adjuvant enhances protection against systemic methicillin-resistant Staphylococcus aureus (MRSA) infection.

31 March 2020

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The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells

31 March 2020

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The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response

31 March 2020

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IFI16 is an innate immune sensor for intracellular DNA

31 March 2020

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Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein

31 March 2020

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The intracellular DNA sensor IFI16 gene acts as restriction factor for human cytomegalovirus replication

31 March 2020

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The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway

31 March 2020

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Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3

31 March 2020

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Detection of prokaryotic mRNA signifies microbial viability and promotes immunity

31 March 2020

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Cutting edge: Ku70 is a novel cytosolic DNA sensor that induces type III rather than type I IFN.

31 March 2020

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DEAD/H BOX 3 (DDX3) helicase binds the RIG-I adaptor IPS-1 to up-regulate IFN-beta-inducing potential

31 March 2020

1 reference

DDX1, DDX21, and DHX36 helicases form a complex with the adaptor molecule TRIF to sense dsRNA in dendritic cells

31 March 2020

1 reference

DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting RIG-I-like receptor-mediated signaling

31 March 2020

1 reference

Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells

31 March 2020

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DExD/H box RNA helicases: multifunctional proteins with important roles in transcriptional regulation

31 March 2020

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IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA

31 March 2020

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Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins

31 March 2020

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Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1

31 March 2020

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TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria

31 March 2020

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Francisella Recognition by Inflammasomes: Differences between Mice and Men.

31 March 2020

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Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

31 March 2020

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31 March 2020

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Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages

31 March 2020

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Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf

31 March 2020

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Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome

31 March 2020

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Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin

31 March 2020

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31 March 2020

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The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus.

31 March 2020

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Formation and structure of a NAIP5-NLRC4 inflammasome induced by direct interactions with conserved N- and C-terminal regions of flagellin.

31 March 2020

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Phosphorylation of NLRC4 is critical for inflammasome activation

31 March 2020

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Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury

31 March 2020

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A functional role for Nlrp6 in intestinal inflammation and tumorigenesis

31 March 2020

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NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis

31 March 2020

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Control of Intestinal Homeostasis, Colitis, and Colitis-Associated Colorectal Cancer by the Inflammatory Caspases

31 March 2020

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Inflammasomes in health and disease

31 March 2020

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The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis

31 March 2020

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An NLRP7-containing inflammasome mediates recognition of microbial lipopeptides in human macrophages

31 March 2020

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Monarch-1/PYPAF7 and other CATERPILLER (CLR, NOD, NLR) proteins with negative regulatory functions

31 March 2020

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NLRP12 suppresses colon inflammation and tumorigenesis through the negative regulation of noncanonical NF-κB signaling

31 March 2020

1 reference

The NLRP12 inflammasome recognizes Yersinia pestis

31 March 2020

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A Yersinia effector protein promotes virulence by preventing inflammasome recognition of the type III secretion system

31 March 2020

1 reference

YopJ-induced caspase-1 activation in Yersinia-infected macrophages: independent of apoptosis, linked to necrosis, dispensable for innate host defense

31 March 2020

1 reference

Type I interferon signaling is required for activation of the inflammasome during Francisella infection

31 March 2020

1 reference

Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule

31 March 2020

1 reference

Viral infection and the evolution of caspase 8-regulated apoptotic and necrotic death pathways

31 March 2020

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Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase

31 March 2020

1 reference

The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways

31 March 2020

1 reference

cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms

31 March 2020

1 reference

The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs

31 March 2020

1 reference

Virus inhibition of RIP3-dependent necrosis

31 March 2020

1 reference

Type I interferon induces necroptosis in macrophages during infection with Salmonella enterica serovar Typhimurium

31 March 2020

1 reference

Non-canonical inflammasome activation targets caspase-11

31 March 2020

1 reference

Caspase-11 stimulates rapid flagellin-independent pyroptosis in response to Legionella pneumophila

31 March 2020

1 reference

Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome

31 March 2020

1 reference

Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation.

31 March 2020

1 reference

AIM2/ASC triggers caspase-8-dependent apoptosis in Francisella-infected caspase-1-deficient macrophages.

31 March 2020

1 reference

Recognition of profilin by Toll-like receptor 12 is critical for host resistance to Toxoplasma gondii

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23846113

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRI3479

1 reference

PubMed ID

23846113

Dimensions Publication ID

29 August 2017

0 references

1 reference

PubMed ID

23846113