(Q38123214)

29 August 2017

title

Hepatotoxicity: a scheme for generating chemical categories for read-across, structural alerts and insights into mechanism(s) of action (English)

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29 August 2017

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M Hewitt

1

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29 August 2017

S J Enoch

2

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29 August 2017

J C Madden

3

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29 August 2017

K R Przybylak

4

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29 August 2017

M T D Cronin

5

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29 August 2017

language of work or name

English

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publication date

1 August 2013

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Critical Reviews in Toxicology

29 August 2017

published in

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29 August 2017

volume

43

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29 August 2017

issue

7

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29 August 2017

page(s)

537-558

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Mechanisms of immune-mediated liver injury

29 August 2017

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Mechanisms of the deleterious effects of tamoxifen on mitochondrial respiration rate and phosphorylation efficiency

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Extensive Ca2+ release from energized mitochondria induced by disulfiram

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Dexamethasone reduces methotrexate biliary elimination and potentiates its hepatotoxicity in rats

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Chlorpromazine induces apoptosis in activated human lymphoblasts: a mechanism supporting the induction of drug-induced lupus erythematosus?

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21 January 2018

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DNA polymerase gamma, the mitochondrial replicase

21 January 2018

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Pharmacology of nucleoside and nucleotide reverse transcriptase inhibitor-induced mitochondrial toxicity.

21 January 2018

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Prediction of drug-induced liver injury in humans by using in vitro methods: the case of ximelagatran

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Influence of tamoxifen on gluconeogenesis and glycolysis in the perfused rat liver.

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Identification of tamoxifen-DNA adducts formed by 4-hydroxytamoxifen quinone methide.

21 January 2018

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Slip and leak in mitochondrial oxidative phosphorylation

21 January 2018

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Target identification of drug induced mitochondrial toxicity using immunocapture based OXPHOS activity assays.

21 January 2018

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21 January 2018

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21 January 2018

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Can in vitro metabolism-dependent covalent binding data in liver microsomes distinguish hepatotoxic from nonhepatotoxic drugs? An analysis of 18 drugs with consideration of intrinsic clearance and daily dose

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling

21 January 2018

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Why drugs fail--a study on side effects in new chemical entities.

21 January 2018

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A large population histology study showing the lack of association between ALT elevation and significant fibrosis in chronic hepatitis B.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

57 Mitochondrial electron-transport inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Role of reactive metabolites in drug-induced hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Structural alert/reactive metabolite concept as applied in medicinal chemistry to mitigate the risk of idiosyncratic drug toxicity: a perspective based on the critical examination of trends in the top 200 drugs marketed in the United States

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Review of liver injury associated with dietary supplements

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Role of metabolism in drug-induced idiosyncratic hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Reduction of hepatic and adipose tissue glucocorticoid receptor expression with antisense oligonucleotides improves hyperglycemia and hyperlipidemia in diabetic rodents without causing systemic glucocorticoid antagonism

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408444.2013.811215

The respiratory-chain NADH dehydrogenase (complex I) of mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Estrogen receptor alpha mediates 17alpha-ethynylestradiol causing hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

Mitochondrial injury by disulfiram: two different mechanisms of the mitochondrial permeability transition.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

FDA-approved drug labeling for the study of drug-induced liver injury

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

The Mitochondrial Permeability Transition Pore is Modulated by Oxidative Agents Through Both Pyridine Nucleotides and Glutathione at Two Separate Sites

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.811215

10.3109/10408444.2013.811215

21 January 2018

Identifiers

DOI

1 reference

29 August 2017

1 reference