(Q38124801)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23893608%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

title

Cyclotides as grafting frameworks for protein engineering and drug design applications (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23893608%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

0 references

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23893608%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

Aaron G. Poth

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23893608%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

Lai Yue Chan

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23893608%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

author name string

Aaron G Poth

1

1 reference

29 August 2017

Lai Y Chan

2

1 reference

29 August 2017

1 September 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23893608%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23893608%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

volume

100

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23893608%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

issue

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23893608%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

page(s)

480-491

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23893608%20AND%20SRC:MED&resulttype=core&format=json

Elucidation of the primary and three-dimensional structure of the uterotonic polypeptide kalata B1

6 March 2020

cites work

1 reference

Discovery of cyclotides in the fabaceae plant family provides new insights into the cyclization, evolution, and distribution of circular proteins.

21 January 2018

1 reference

Cyclotides associate with leaf vasculature and are the products of a novel precursor in petunia (Solanaceae)

21 January 2018

1 reference

Discovery of linear cyclotides in monocot plant Panicum laxum of Poaceae family provides new insights into evolution and distribution of cyclotides in plants

21 January 2018

1 reference

Thermal, chemical, and enzymatic stability of the cyclotide kalata B1: the importance of the cyclic cystine knot.

21 January 2018

1 reference

Cyclic peptides from Oldenlandia affinis DC. Molecular and biological properties

21 January 2018

1 reference

Novel cyclotides and uncyclotides with highly shortened precursors from Chassalia chartacea and effects of methionine oxidation on bioactivities

21 January 2018

1 reference

Discovery and characterization of novel cyclotides originated from chimeric precursors consisting of albumin-1 chain a and cyclotide domains in the Fabaceae family

21 January 2018

1 reference

Biomedicine in the environment: cyclotides constitute potent natural toxins in plants and soil bacteria

21 January 2018

1 reference

The cyclotide cycloviolacin O2 from Viola odorata has potent bactericidal activity against Gram-negative bacteria

21 January 2018

1 reference

An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides

21 January 2018

1 reference

Cycloviolins A-D, anti-HIV macrocyclic peptides from Leonia cymosa

21 January 2018

1 reference

21 January 2018

1 reference

New circulin macrocyclic polypeptides from Chassalia parvifolia

21 January 2018

1 reference

Cyclopsychotride A, a biologically active, 31-residue cyclic peptide isolated from Psychotria longipes

21 January 2018

1 reference

Anti-HIV cyclotides from the Chinese medicinal herb Viola yedoensis.

21 January 2018

1 reference

Reversible antifouling effect of the cyclotide cycloviolacin O2 against barnacles

21 January 2018

1 reference

Biosynthesis and insecticidal properties of plant cyclotides: the cyclic knotted proteins from Oldenlandia affinis

21 January 2018

1 reference

Isolation, solution structure, and insecticidal activity of kalata B2, a circular protein with a twist: do Möbius strips exist in nature?

21 January 2018

1 reference

Discovery of an unusual biosynthetic origin for circular proteins in legumes

21 January 2018

1 reference

Plant cyclotides disrupt epithelial cells in the midgut of lepidopteran larvae

21 January 2018

1 reference

Cyclotides: natural, circular plant peptides that possess significant activity against gastrointestinal nematode parasites of sheep.

21 January 2018

1 reference

The anthelmintic activity of the cyclotides: natural variants with enhanced activity

21 January 2018

1 reference

Anthelmintic activity of cyclotides: In vitro studies with canine and human hookworms.

21 January 2018

1 reference

Lysine-scanning mutagenesis reveals an amendable face of the cyclotide kalata B1 for the optimization of nematocidal activity

21 January 2018

1 reference

Backbone cyclised peptides from plants show molluscicidal activity against the rice pest Pomacea canaliculata (golden apple snail).

21 January 2018

1 reference

The cyclotide family of circular miniproteins: nature's combinatorial peptide template.

21 January 2018

1 reference

Cyclotides as a basis for drug design

21 January 2018

1 reference

Cyclotides, a novel ultrastable polypeptide scaffold for drug discovery

21 January 2018

1 reference

Cyclotides as templates in drug design

21 January 2018

1 reference

Cyclotides, a promising molecular scaffold for peptide-based therapeutics

21 January 2018

1 reference

The cystine knot motif in toxins and implications for drug design.

21 January 2018

1 reference

A structural superfamily of growth factors containing a cystine knot motif

21 January 2018

1 reference

A common structural motif incorporating a cystine knot and a triple-stranded beta-sheet in toxic and inhibitory polypeptides

21 January 2018

1 reference

21 January 2018

1 reference

Chemical synthesis and folding pathways of large cyclic polypeptides: studies of the cystine knot polypeptide kalata B1.

21 January 2018

1 reference

PA1b, an Insecticidal Protein Extracted from Pea Seeds (Pisum sativum): 1H-2-D NMR Study and Molecular Modeling,

21 January 2018

1 reference

Solution structure of the major alpha-amylase inhibitor of the crop plant amaranth

21 January 2018

1 reference

Solution structure of the main alpha-amylase inhibitor from amaranth seeds

21 January 2018

1 reference

High-resolution solution structure of gurmarin, a sweet-taste-suppressing plant polypeptide

21 January 2018

1 reference

Structure of potato carboxypeptidase inhibitor: disulfide pairing and exposure of aromatic residues

21 January 2018

1 reference

Refined crystal structure of the potato inhibitor complex of carboxypeptidase A at 2.5 A resolution

21 January 2018

1 reference

Determination of the complete three-dimensional structure of the trypsin inhibitor from squash seeds in aqueous solution by nuclear magnetic resonance and a combination of distance geometry and dynamical simulated annealing

21 January 2018

1 reference

An 1H NMR determination of the three-dimensional structures of mirror-image forms of a Leu-5 variant of the trypsin inhibitor from Ecballium elaterium (EETI-II).

21 January 2018

1 reference

Structure of potato inhibitor complex of carboxypeptidase A at 5.5-A resolution

21 January 2018

1 reference

Molecular recognition between serine proteases and new bioactive microproteins with a knotted structure

21 January 2018

1 reference

Plant cyclotides: A unique family of cyclic and knotted proteins that defines the cyclic cystine knot structural motif

21 January 2018

1 reference

Synthesis of large cyclic cystine-knot peptide by orthogonal coupling strategy using unprotected peptide precursor

21 January 2018

1 reference

Design and chemical synthesis of a 32 residues chimeric microprotein inhibiting both trypsin and carboxypeptidase A.

21 January 2018

1 reference

Scorpion toxins as natural scaffolds for protein engineering

21 January 2018

1 reference

Acyclic permutants of naturally occurring cyclic proteins. Characterization of cystine knot and beta-sheet formation in the macrocyclic polypeptide kalata B1.

21 January 2018

1 reference

Engineering stabilized vascular endothelial growth factor-A antagonists: synthesis, structural characterization, and bioactivity of grafted analogues of cyclotides

21 January 2018

1 reference

Design of a novel cyclotide-based CXCR4 antagonist with anti-human immunodeficiency virus (HIV)-1 activity

21 January 2018

1 reference

Peptide quantification by matrix-assisted laser desorption ionisation time-of-flight mass spectrometry: investigations of the cyclotide kalata B1 in biological fluids.

21 January 2018

1 reference

Bendamustine HCL for the treatment of relapsed indolent non-Hodgkin's lymphoma

21 January 2018

1 reference

Evaluation and improvement of the properties of the novel cystine-knot microprotein McoEeTI for oral administration.

21 January 2018

1 reference

Biosynthesis of the cyclotide Kalata B1 by using protein splicing

21 January 2018

1 reference

Formation of cyclotides and variations in cyclotide expression in Oldenlandia affinis suspension cultures

21 January 2018

1 reference

Cyclotide synthesis and supply: from plant to bioprocess

21 January 2018

1 reference

Biosynthesis of a fully functional cyclotide inside living bacterial cells.

21 January 2018

1 reference

Biosynthesis and biological screening of a genetically encoded library based on the cyclotide MCoTI-I.

21 January 2018

1 reference

Structural plasticity of the cyclic-cystine-knot framework: implications for biological activity and drug design.

21 January 2018

1 reference

Alanine scanning mutagenesis of the prototypic cyclotide reveals a cluster of residues essential for bioactivity.

21 January 2018

1 reference

Design, Synthesis, Structural and Functional Characterization of Novel Melanocortin Agonists Based on the Cyclotide Kalata B1

21 January 2018

1 reference

Pharmacological, pharmacokinetic, and primate analgesic efficacy profile of the novel bradykinin B1 Receptor antagonist ELN441958.

21 January 2018

1 reference

Orally active peptidic bradykinin B1 receptor antagonists engineered from a cyclotide scaffold for inflammatory pain treatment

21 January 2018

1 reference

Combined X-ray and NMR Analysis of the Stability of the Cyclotide Cystine Knot Fold That Underpins Its Insecticidal Activity and Potential Use as a Drug Scaffold

21 January 2018

1 reference

The cystine knot of a squash-type protease inhibitor as a structural scaffold for Escherichia coli cell surface display of conformationally constrained peptides

21 January 2018

1 reference

Ecallantide (DX-88), a plasma kallikrein inhibitor for the treatment of hereditary angioedema and the prevention of blood loss in on-pump cardiothoracic surgery

21 January 2018

1 reference

Engineered cystine-knot peptides that bind alpha(v)beta(3) integrin with antibody-like affinities

21 January 2018

1 reference

Selection of potent chymotrypsin and elastase inhibitors from M13 phage library of basic pancreatic trypsin inhibitor (BPTI).

21 January 2018

1 reference

Iterative optimization of high-affinity protease inhibitors using phage display. 2. Plasma kallikrein and thrombin

21 January 2018

1 reference

Iterative optimization of high-affinity proteases inhibitors using phage display. 1. Plasmin

21 January 2018

1 reference

The potential of cystine-knot microproteins as novel pharmacophoric scaffolds in oral peptide drug delivery

21 January 2018

1 reference

Protease-resistant peptide ligands from a knottin scaffold library

21 January 2018

1 reference

Chemical and biomimetic total syntheses of natural and engineered MCoTI cyclotides.

21 January 2018

1 reference

Potent inhibitors of beta-tryptase and human leukocyte elastase based on the MCoTI-II scaffold

21 January 2018

1 reference

Engineered cystine knot miniproteins as potent inhibitors of human mast cell tryptase beta

21 January 2018

1 reference

The three-dimensional structure of recombinant leech-derived tryptase inhibitor in complex with trypsin. Implications for the structure of human mast cell tryptase and its inhibition

21 January 2018

1 reference

Circular proteins in plants: solution structure of a novel macrocyclic trypsin inhibitor from Momordica cochinchinensis

21 January 2018

1 reference

Pharmacokinetically stabilized cystine knot peptides that bind alpha-v-beta-6 integrin with single-digit nanomolar affinities for detection of pancreatic cancer

21 January 2018

1 reference

The CXCR4-CXCL12 axis in Ewing sarcoma: promotion of tumor growth rather than metastatic disease

21 January 2018

1 reference

HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor

21 January 2018

1 reference

Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists

21 January 2018

1 reference

CyBase: a database of cyclic protein sequences and structures, with applications in protein discovery and engineering

21 January 2018

1 reference

Identification and characterization of a new family of cell-penetrating peptides: cyclic cell-penetrating peptides

21 January 2018

1 reference

Cellular uptake of cyclotide MCoTI-I follows multiple endocytic pathways.

21 January 2018

1 reference

The cyclic cystine knot miniprotein MCoTI-II is internalized into cells by macropinocytosis.

21 January 2018

1 reference

Direct peptide interaction with surface glycosaminoglycans contributes to the cell penetration of maurocalcine

21 January 2018

1 reference

"Splicing up" drug discovery. Cell-based expression and screening of genetically-encoded libraries of backbone-cyclized polypeptides

21 January 2018

1 reference

Diverse backbone-cyclized peptides via codon reprogramming

21 January 2018

1 reference

Solution structure of .gamma.1-H and .gamma.1-P thionins from barley and wheat endosperm determined by proton NMR: a structural motif common to toxic arthropod proteins

21 January 2018

1 reference

Distribution and evolution of circular miniproteins in flowering plants

21 January 2018

1 reference