(Q38129508)

29 August 2017

title

Phosphoinositide 3-kinases as accelerators and brakes of autophagy (English)

1 reference

29 August 2017

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3

Harald Stenmark

1 reference

29 August 2017

Tor E Rusten

2

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author name string

Fergal O Farrell

series ordinal

1

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29 August 2017

language of work or name

English

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publication date

5 September 2013

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29 August 2017

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29 August 2017

volume

280

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29 August 2017

issue

24

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29 August 2017

page(s)

6322-6337

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Autophagy fights disease through cellular self-digestion

29 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Ubiquitination and selective autophagy

21 January 2018

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The Role of Atg Proteins in Autophagosome Formation

21 January 2018

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Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes

21 January 2018

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The role of lipids in the control of autophagy

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Inhibition of PI3K signaling spurs new therapeutic opportunities in inflammatory/autoimmune diseases and hematological malignancies.

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The emerging mechanisms of isoform-specific PI3K signalling

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Regulation and cellular functions of class II phosphoinositide 3-kinases.

21 January 2018

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Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate

21 January 2018

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Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae

21 January 2018

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The Beclin 1-VPS34 complex--at the crossroads of autophagy and beyond

21 January 2018

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Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.12486

Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L.

21 January 2018

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Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase

21 January 2018

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A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Beclin-1-interacting autophagy protein Atg14L targets the SNARE-associated protein Snapin to coordinate endocytic trafficking

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.12486

Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.12486

UVRAG mutations associated with microsatellite unstable colon cancer do not affect autophagy

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.12486

Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

21 January 2018

The Beclin 1 interactome

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https://api.crossref.org/works/10.1111%2FFEBS.12486

Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Nedd4-dependent lysine-11-linked polyubiquitination of the tumour suppressor Beclin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Rubicon and PLEKHM1 negatively regulate the endocytic/autophagic pathway via a novel Rab7-binding domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Induction of autophagy and inhibition of tumorigenesis by beclin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Ambra1 at the crossroad between autophagy and cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Autophagy suppresses tumor progression by limiting chromosomal instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Autophagy suppresses tumorigenesis through elimination of p62

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

A dual role for UVRAG in maintaining chromosomal stability independent of autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Genetic analysis of the myotubularin family of phosphatases in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Regulation of Fab1 phosphatidylinositol 3-phosphate 5-kinase pathway by Vac7 protein and Fig4, a polyphosphoinositide phosphatase family member.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Atg6 is required for multiple vesicle trafficking pathways and hematopoiesis in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Defects of Vps15 in skeletal muscles lead to autophagic vacuolar myopathy and lysosomal disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

The Class III Kinase Vps34 Promotes T Lymphocyte Survival through Regulating IL-7Rα Surface Expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

The class II phosphoinositide 3-kinase C2beta is not essential for epidermal differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Endothelial PI3K-C2α, a class II PI3K, has an essential role in angiogenesis and vascular barrier function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Class II phosphoinositide 3-kinase regulates exocytosis of insulin granules in pancreatic beta cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

UVRAG is required for organ rotation by regulating Notch endocytosis in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Phosphatidylinositol-3-phosphate clearance plays a key role in autophagosome completion

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Characterization of a novel phosphatidylinositol 3-phosphate-binding protein containing two FYVE fingers in tandem that is targeted to the Golgi

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

The Atg18-Atg2 complex is recruited to autophagic membranes via phosphatidylinositol 3-phosphate and exerts an essential function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Roles of the lipid-binding motifs of Atg18 and Atg21 in the cytoplasm to vacuole targeting pathway and autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Two-Site Recognition of Phosphatidylinositol 3-Phosphate by PROPPINs in Autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

How Atg18 and the WIPIs sense phosphatidylinositol 3-phosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Structural and functional characterization of the two phosphoinositide binding sites of PROPPINs, a β-propeller protein family

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Autophagosome formation can be achieved in the absence of Atg18 by expressing engineered PAS-targeted Atg2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Fine mapping of autophagy-related proteins during autophagosome formation in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Freeze-fracture replica immunolabelling reveals human WIPI-1 and WIPI-2 as membrane proteins of autophagosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

The WD40 repeat PtdIns(3)P-binding protein EPG-6 regulates progression of omegasomes to autophagosomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

De novo mutations in the autophagy gene WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Rab10 in insulin-stimulated GLUT4 translocation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

mTOR generates an auto-amplification loop by triggering the βTrCP- and CK1α-dependent degradation of DEPTOR

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

DEPTOR, an mTOR Inhibitor, Is a Physiological Substrate of SCFβTrCP E3 Ubiquitin Ligase and Regulates Survival and Autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Differential membrane localization of ERas and Rheb, two Ras-related proteins involved in the phosphatidylinositol 3-kinase/mTOR pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Novel role of the small GTPase Rheb: its implication in endocytic pathway independent of the activation of mammalian target of rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Localization of Rheb to the endomembrane is critical for its signaling function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Regulation of TORC1 by Rag GTPases in nutrient response

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Molecular mechanisms of mTOR-mediated translational control

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

21 January 2018

mTOR and cancer therapy

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Two-tiered control of epithelial growth and autophagy by the insulin receptor and the ret-like receptor, stitcher

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

The autophagic tumor stroma model of cancer or "battery-operated tumor growth": A simple solution to the autophagy paradox

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Coordinate autophagy and mTOR pathway inhibition enhances cell death in melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Akt and autophagy cooperate to promote survival of drug-resistant glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

AMP-activated protein kinase: nature's energy sensor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

AMPK phosphorylation of raptor mediates a metabolic checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

TOR complex 2: a signaling pathway of its own.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

FOXO3A directs a protective autophagy program in haematopoietic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Bcl-2 family members: dual regulators of apoptosis and autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Bcl-xL and UVRAG cause a monomer-dimer switch in Beclin1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

The class IA phosphatidylinositol 3-kinase p110-β subunit is a positive regulator of autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Phosphatidylinositol-3-OH kinases are Rab5 effectors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Class IA PI3K p110β subunit promotes autophagy through Rab5 small GTPase in response to growth factor limitation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

The late endosome is essential for mTORC1 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Rubicon controls endosome maturation as a Rab7 effector

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Role of Drosophila Rab5 during endosomal trafficking at the synapse and evoked neurotransmitter release

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Class III PI-3-kinase activates phospholipase D in an amino acid–sensing mTORC1 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Autophagy modulation as a potential therapeutic target for diverse diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Autophagy in tumour suppression and promotion

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Can autophagy protect against neurodegeneration caused by aggregate-prone proteins?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

The Role of Phosphoinositide 3-Kinase C2α in Insulin Signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

Transport of phosphatidylinositol 3-phosphate into the vacuole via autophagic membranes in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12486

21 January 2018

Identifiers

DOI

10.1111/FEBS.12486

1 reference

29 August 2017

1 reference