(Q38155656)

29 August 2017

The molecular landscape of diffuse glioma and prospects for biomarker development (English)

1 reference

29 August 2017

0 references

Jason T Huse

1

1 reference

PubMed ID

24161073

29 August 2017

Kenneth D Aldape

series ordinal

2

1 reference

PubMed ID

24161073

29 August 2017

language of work or name

English

0 references

publication date

28 October 2013

1 reference

Expert Opinion on Medical Diagnostics

29 August 2017

1 reference

29 August 2017

7

1 reference

29 August 2017

6

1 reference

29 August 2017

573-587

1 reference

Malignant gliomas in adults

29 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Radiotherapy for newly diagnosed malignant glioma in adults: a systematic review

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Randomized trial of radiation therapy plus procarbazine, lomustine, and vincristine chemotherapy for supratentorial adult low-grade glioma: initial results of RTOG 9802.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Long-term efficacy of early versus delayed radiotherapy for low-grade astrocytoma and oligodendroglioma in adults: the EORTC 22845 randomised trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

The 2007 WHO classification of tumours of the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Genetic modeling of gliomas in mice: new tools to tackle old problems

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Genetically engineered mouse models of brain cancer and the promise of preclinical testing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

An integrated genomic analysis of human glioblastoma multiforme

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Specific genetic predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Integrated molecular genetic profiling of pediatric high-grade gliomas reveals key differences with the adult disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Genome-wide analyses identify recurrent amplifications of receptor tyrosine kinases and cell-cycle regulatory genes in diffuse intrinsic pontine glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Structural alterations of the epidermal growth factor receptor gene in human gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Whole-genome profiling of pediatric diffuse intrinsic pontine gliomas highlights platelet-derived growth factor receptor alpha and poly (ADP-ribose) polymerase as potential therapeutic targets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Mosaic amplification of multiple receptor tyrosine kinase genes in glioblastoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Platelet-derived growth factor and its receptor expression in human oligodendrogliomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

IDH mutation and neuroglial developmental features define clinically distinct subclasses of lower grade diffuse astrocytic glioma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Platelet-derived growth factor in human glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Molecular profiling identifies prognostic subgroups of pediatric glioblastoma and shows increased YB-1 expression in tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Integrative genome analysis reveals an oncomir/oncogene cluster regulating glioblastoma survivorship

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Activation of PI3K/mTOR pathway occurs in most adult low-grade gliomas and predicts patient survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Methylation of the PTEN promoter defines low-grade gliomas and secondary glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Localization of common deletion regions on 1p and 19q in human gliomas and their association with histological subtype.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Mutations in CIC and FUBP1 contribute to human oligodendroglioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Concurrent CIC mutations, IDH mutations, and 1p/19q loss distinguish oligodendrogliomas from other cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Concurrent inactivation of RB1 and TP53 pathways in anaplastic oligodendrogliomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

MGMT gene silencing and benefit from temozolomide in glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

MGMT promoter methylation status can predict the incidence and outcome of pseudoprogression after concomitant radiochemotherapy in newly diagnosed glioblastoma patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Immediate post-radiotherapy changes in malignant glioma can mimic tumor progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

CpG island methylator phenotype in colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

IDH mutation impairs histone demethylation and results in a block to cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Polycomb group proteins: navigators of lineage pathways led astray in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Understanding the language of Lys36 methylation at histone H3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Distinct factors control histone variant H3.3 localization at specific genomic regions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Altered telomeres in tumors with ATRX and DAXX mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Loss of ATRX leads to chromosome cohesion and congression defects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

ATRX interacts with H3.3 in maintaining telomere structural integrity in pluripotent embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

TERT promoter mutations in familial and sporadic melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Highly recurrent TERT promoter mutations in human melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Whole-exome sequencing identifies ATRX mutation as a key molecular determinant in lower-grade glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Different angiogenic phenotypes in primary and secondary glioblastomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Gene expression profiling identifies molecular subtypes of gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Distinct transcription profiles of primary and secondary glioblastoma subgroups.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Molecular subclassification of diffuse gliomas: seeing order in the chaos

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

A developmental taxonomy of glioblastoma defined and maintained by MicroRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

The proneural molecular signature is enriched in oligodendrogliomas and predicts improved survival among diffuse gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Gone FISHing: clinical lessons learned in brain tumor molecular diagnostics over the last decade

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Optimization of quantitative MGMT promoter methylation analysis using pyrosequencing and combined bisulfite restriction analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Universal, robust, highly quantitative SNP allele frequency measurement in DNA pools.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Whole genome SNP arrays using DNA derived from formalin-fixed, paraffin-embedded ovarian tumor tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

DNA fragmentation simulation method (FSM) and fragment size matching improve aCGH performance of FFPE tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Quantitative gene expression profiling in formalin-fixed, paraffin-embedded tissues using universal bead arrays

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Genome-wide expression assay comparison across frozen and fixed postmortem brain tissue samples

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Gene expression profiles from formalin fixed paraffin embedded breast cancer tissue are largely comparable to fresh frozen matched tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Direct multiplexed measurement of gene expression with color-coded probe pairs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

High-throughput detection of actionable genomic alterations in clinical tumor samples by targeted, massively parallel sequencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Statistical challenges associated with detecting copy number variations with next-generation sequencing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Next-generation sequencing in the clinic: are we ready?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Patients with IDH1 wild type anaplastic astrocytomas exhibit worse prognosis than IDH1-mutated glioblastomas, and IDH1 mutation status accounts for the unfavorable prognostic effect of higher age: implications for classification of gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Molecular classification of low-grade diffuse gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Isocitrate dehydrogenase 1 codon 132 mutation is an important prognostic biomarker in gliomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

IDH1 mutations in grade II astrocytomas are associated with unfavorable progression-free survival and prolonged postrecurrence survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

IDH1 and IDH2 mutations in gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

MGMT promoter methylation is predictive of response to radiotherapy and prognostic in the absence of adjuvant alkylating chemotherapy for glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Current clinical development of PI3K pathway inhibitors in glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Signal transduction inhibitors and antiangiogenic therapies for malignant glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

EGFRvIII-targeted vaccination therapy of malignant glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Proteomic analysis of PAXgene-fixed tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Histological assessment of PAXgene tissue fixation and stabilization reagents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

A portrait of tissue phosphoprotein stability in the clinical tissue procurement process

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Identification of microRNAs in the cerebrospinal fluid as biomarker for the diagnosis of glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Proteomics of gliomas: initial biomarker discovery and evolution of technology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

GC/MS-based metabolomic analysis of cerebrospinal fluid (CSF) from glioma patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

MicroRNAs in cerebrospinal fluid identify glioblastoma and metastatic brain cancers and reflect disease activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

Tumor marker utility grading system: a framework to evaluate clinical utility of tumor markers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17530059.2013.846321

10.1517/17530059.2013.846321

21 January 2018

Identifiers

DOI

1 reference

29 August 2017

1 reference

PubMed ID

24161073