(Q38161471)

30 August 2017

title

Linking physiology to toxicity using DILIsym®, a mechanistic mathematical model of drug-induced liver injury (English)

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30 August 2017

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Lisl K M Shoda

1

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30 August 2017

Jeffrey L Woodhead

2

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30 August 2017

Scott Q Siler

3

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30 August 2017

Paul B Watkins

4

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30 August 2017

Brett A Howell

5

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30 August 2017

publication date

25 November 2013

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Biopharmaceutics and Drug Disposition

30 August 2017

published in

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30 August 2017

volume

35

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30 August 2017

issue

1

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30 August 2017

page(s)

33-49

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Drug safety sciences and the bottleneck in drug development

30 August 2017

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In vitro to in vivo extrapolation and species response comparisons for drug-induced liver injury (DILI) using DILIsym™: a mechanistic, mathematical model of DILI.

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Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity

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Interactions of combined bile acids on hepatocyte viability: cytoprotection or synergism.

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Identification of a nuclear receptor for bile acids

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Bile acid-induced liver toxicity: relation to the hydrophobic-hydrophilic balance of bile acids.

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The role of the sodium-taurocholate cotransporting polypeptide (NTCP) and of the bile salt export pump (BSEP) in physiology and pathophysiology of bile formation

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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The pathogenic roles of tumor necrosis factor receptor p55 in acetaminophen-induced liver injury in mice

21 January 2018

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Sinusoidal endothelial cells as a target for acetaminophen toxicity. Direct action versus requirement for hepatocyte activation in different mouse strains.

21 January 2018

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High-mobility group box-1 protein and keratin-18, circulating serum proteins informative of acetaminophen-induced necrosis and apoptosis in vivo

21 January 2018

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Diet Restriction Inhibits Apoptosis and HMGB1 Oxidation and Promotes Inflammatory Cell Recruitment during Acetaminophen Hepatotoxicity

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30 December 2023

https://opencitations.net/index/api/v1/citations/10.2119/MOLMED.2010.00126

Identifiers

DOI

10.1002/BDD.1878

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30 August 2017

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