(Q47287461)

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In vitro to in vivo extrapolation and species response comparisons for drug-induced liver injury (DILI) using DILIsym™: a mechanistic, mathematical model of DILI.

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scholarly article

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Europe PubMed Central

PubMed publication ID

13 January 2018

http://europepmc.org/abstract/MED/22875368

In vitro to in vivo extrapolation and species response comparisons for drug-induced liver injury (DILI) using DILIsym™: a mechanistic, mathematical model of DILI. (English)

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Europe PubMed Central

PubMed publication ID

13 January 2018

http://europepmc.org/abstract/MED/22875368

mathematical model

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based on heuristic

inferred from title

Alison H Harrill

object named as

Alison H Harrill

5

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Melvin E. Andersen

object named as

Melvin E Andersen

7

0 references

Harvey J Clewell

6

object named as

Harvey J Clewell

1 reference

Europe PubMed Central

PubMed publication ID

13 January 2018

http://europepmc.org/abstract/MED/22875368

author name string

Brett A Howell

1

1 reference

Europe PubMed Central

PubMed publication ID

13 January 2018

http://europepmc.org/abstract/MED/22875368

Yuching Yang

2

1 reference

Europe PubMed Central

PubMed publication ID

13 January 2018

http://europepmc.org/abstract/MED/22875368

Rukmini Kumar

3

1 reference

Europe PubMed Central

PubMed publication ID

13 January 2018

http://europepmc.org/abstract/MED/22875368

Jeffrey L Woodhead

4

1 reference

Europe PubMed Central

PubMed publication ID

13 January 2018

http://europepmc.org/abstract/MED/22875368

Scott Q Siler

8

1 reference

Europe PubMed Central

PubMed publication ID

13 January 2018

http://europepmc.org/abstract/MED/22875368

Paul B Watkins

9

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Europe PubMed Central

PubMed publication ID

13 January 2018

http://europepmc.org/abstract/MED/22875368

publication date

9 August 2012

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Europe PubMed Central

PubMed publication ID

13 January 2018

http://europepmc.org/abstract/MED/22875368

Journal of Pharmacokinetics and Pharmacodynamics

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Europe PubMed Central

PubMed publication ID

13 January 2018

http://europepmc.org/abstract/MED/22875368

39

1 reference

Europe PubMed Central

PubMed publication ID

13 January 2018

http://europepmc.org/abstract/MED/22875368

5

1 reference

Europe PubMed Central

PubMed publication ID

13 January 2018

http://europepmc.org/abstract/MED/22875368

527-541

1 reference

Europe PubMed Central

PubMed publication ID

13 January 2018

http://europepmc.org/abstract/MED/22875368

https://scigraph.springernature.com/pub.10.1007/s10928-012-9266-0

0 references

Identification of genes implicated in methapyrilene-induced hepatotoxicity by comparing differential gene expression in target and nontarget tissue

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The effects of methapyrilene hydrochloride on hepatocarcinogenicity and pentobarbital-induced sleeping time in rats and mice.

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Genotoxicity, toxicity, and carcinogenicity of the antihistamine methapyrilene

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Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-acetylcysteine

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Glutamate cysteine ligase modifier subunit deficiency and gender as determinants of acetaminophen-induced hepatotoxicity in mice

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Postabsorption antidotal effects of N-acetylcysteine on acetaminophen-induced hepatotoxicity in the mouse.

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Sensitivity of liver injury in heterozygous Sod2 knockout mice treated with troglitazone or acetaminophen

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c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity

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Clinical relevance of predictive physiologically based pharmacokinetic methods

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Systems Toxicology: Integrated Genomic, Proteomic and Metabonomic Analysis of Methapyrilene Induced Hepatotoxicity in the Rat

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1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Histopathological changes in the liver following a paracetamol overdose: Correlation with clinical and biochemical parameters

1 reference

https://pubmed.ncbi.nlm.nih.gov/22875368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acarbose alone or in combination with ethanol potentiates the hepatotoxicity of carbon tetrachloride and acetaminophen in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/22875368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

VEGF isoforms and receptors expression throughout acute acetaminophen-induced liver injury and regeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/22875368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metallothionein-I/II knockout mice are sensitive to acetaminophen-induced hepatotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/22875368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of oxidative status in acetaminophen treated rat hepatocytes in culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/22875368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of acetaminophen administration on hepatic glutathione compartmentation and mitochondrial energy metabolism in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/22875368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of methapyrilene on rat hepatic xenobiotic metabolizing enzymes and liver morphology

1 reference

https://pubmed.ncbi.nlm.nih.gov/22875368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Experimental Aspects of Hepatic Regeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/22875368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stimulated hepatic tissue repair underlies heteroprotection by thioacetamide against acetaminophen-induced lethality

1 reference

https://pubmed.ncbi.nlm.nih.gov/22875368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of induction and inhibition of cytochromes P450 on the hepatotoxicity of methapyrilene

1 reference

https://pubmed.ncbi.nlm.nih.gov/22875368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Challenges and opportunities with modelling and simulation in drug discovery and drug development

1 reference

https://pubmed.ncbi.nlm.nih.gov/22875368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mild hypothermia attenuates liver injury and improves survival in mice with acetaminophen toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/22875368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of orally administered reduced- and oxidized-glutathione against acetaminophen-induced liver injury in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/22875368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of taurine in preventing acetaminophen-induced hepatic injury in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22875368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acetaminophen liver injury: sequential changes in two biochemical indices of regeneration and their relationship to histologic alterations.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22875368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Failure of methapyrilene to induce tumors in hamsters or guinea pigs

1 reference

https://pubmed.ncbi.nlm.nih.gov/22875368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methapyrilene toxicity: anchorage of pathologic observations to gene expression alterations.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22875368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolism of methapyrilene by Fischer-344 rat and B6C3F1 mouse hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22875368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of Soil Sorption Coefficient of a Diverse Set of Organic Chemicals From Molecular Structure

1 reference

https://pubmed.ncbi.nlm.nih.gov/22875368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Homeostasis of sulfate and 3'-phosphoadenosine 5'-phosphosulfate in rats after acetaminophen administration

1 reference

https://pubmed.ncbi.nlm.nih.gov/22875368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methapyrilene hepatotoxicity is associated with increased hepatic glutathione, the formation of glucuronide conjugates, and enterohepatic recirculation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22875368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiological model for tissue glutathione depletion and increased resynthesis after ethylene dichloride exposure

1 reference

https://pubmed.ncbi.nlm.nih.gov/22875368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S10928-012-9266-0

1 reference

Europe PubMed Central

PubMed publication ID

13 January 2018

http://europepmc.org/abstract/MED/22875368

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

13 January 2018

http://europepmc.org/abstract/MED/22875368

ResearchGate publication ID

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