(Q38166961)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24285312%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

title

Radioligands targeting P-glycoprotein and other drug efflux proteins at the blood-brain barrier (English)

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1 March 2020

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3

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1 March 2020

Severin Mairinger

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24285312%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

author name string

Thomas Wanek

series ordinal

1

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1 March 2020

language of work or name

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1 March 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24285312%20AND%20SRC:MED&resulttype=core&format=json

Journal of Labelled Compounds and Radiopharmaceuticals

1 March 2020

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24285312%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

volume

56

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1 March 2020

issue

3-4

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1 March 2020

page(s)

68-77

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PET radiotracers: crossing the blood-brain barrier and surviving metabolism

1 March 2020

cites work

1 reference

Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases

21 January 2018

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A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

21 January 2018

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ABCG2: a perspective.

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A family of drug transporters: the multidrug resistance-associated proteins.

21 January 2018

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Do ATP-binding cassette transporters cause pharmacoresistance in epilepsy? Problems and approaches in determining which antiepileptic drugs are affected

21 January 2018

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ABCB1: the role in Parkinson's disease and pharmacokinetics of antiparkinsonian drugs

21 January 2018

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P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model

21 January 2018

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Tariquidar (XR9576): a P-glycoprotein drug efflux pump inhibitor

21 January 2018

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Targeting multidrug resistance in cancer

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Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

21 January 2018

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Imaging the function of P-glycoprotein with radiotracers: pharmacokinetics and in vivo applications

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Carbon-11 labeled tracers for in vivo imaging P-glycoprotein function: kinetics, advantages and disadvantages.

21 January 2018

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PET and SPECT radiotracers to assess function and expression of ABC transporters in vivo

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Evaluation of tracer kinetic models for quantification of P-glycoprotein function using (R)-[11C]verapamil and PET.

21 January 2018

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Pgp-mediated interaction between (R)-[11C]verapamil and tariquidar at the human blood-brain barrier: a comparison with rat data

21 January 2018

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A pilot study to assess the efficacy of tariquidar to inhibit P-glycoprotein at the human blood-brain barrier with (R)-11C-verapamil and PET

21 January 2018

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P-glycoprotein function at the blood-brain barrier in humans can be quantified with the substrate radiotracer 11C-N-desmethyl-loperamide

21 January 2018

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The "specific" P-glycoprotein inhibitor Tariquidar is also a substrate and an inhibitor for breast cancer resistance protein (BCRP/ABCG2).

21 January 2018

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Identification of novel specific and general inhibitors of the three major human ATP-binding cassette transporters P-gp, BCRP and MRP2 among registered drugs.

21 January 2018

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Complete in vivo reversal of P-glycoprotein pump function in the blood-brain barrier visualized with positron emission tomography

21 January 2018

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Quantitative assessment of P-glycoprotein function in the rat blood-brain barrier by distribution volume of [11C]verapamil measured with PET.

21 January 2018

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An improved method for the preparation of [11C]verapamil

21 January 2018

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Imaging P-glycoprotein transport activity at the human blood-brain barrier with positron emission tomography

21 January 2018

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Fully automated high yield synthesis of (R)- and (S)-[11C]verapamil for measuring P-glycoprotein function with positron emission tomography

21 January 2018

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(R)- and (S)-[11C]verapamil as PET-tracers for measuring P-glycoprotein function: in vitro and in vivo evaluation.

21 January 2018

1 reference

Synthesis and preclinical evaluation of [11C]D617, a metabolite of (R)-[11C]verapamil

21 January 2018

1 reference

Evaluation of (R)-[11C]verapamil as PET tracer of P-glycoprotein function in the blood-brain barrier: kinetics and metabolism in the rat.

21 January 2018

1 reference

A novel positron emission tomography imaging protocol identifies seizure-induced regional overactivity of P-glycoprotein at the blood-brain barrier

21 January 2018

1 reference

Dose-response assessment of tariquidar and elacridar and regional quantification of P-glycoprotein inhibition at the rat blood-brain barrier using (R)-[(11)C]verapamil PET.

21 January 2018

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Blood-brain barrier P-glycoprotein function in Alzheimer's disease.

21 January 2018

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Pharmacoresistance in epilepsy: a pilot PET study with the P-glycoprotein substrate R-[(11)C]verapamil

21 January 2018

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Effect of age on functional P-glycoprotein in the blood-brain barrier measured by use of (R)-[(11)C]verapamil and positron emission tomography

21 January 2018

1 reference

11C-loperamide and its N-desmethyl radiometabolite are avid substrates for brain permeability-glycoprotein efflux

21 January 2018

1 reference

Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function

21 January 2018

1 reference

P-glycoprotein function at the blood-brain barrier imaged using 11C-N-desmethyl-loperamide in monkeys

21 January 2018

1 reference

Lysosomal trapping of a radiolabeled substrate of P-glycoprotein as a mechanism for signal amplification in PET

21 January 2018

1 reference

Effects of ketoconazole on the biodistribution and metabolism of [11C]loperamide and [11C]N-desmethyl-loperamide in wild-type and P-gp knockout mice

21 January 2018

1 reference

High-yield radiosynthesis and preliminary in vivo evaluation of p-[18F]MPPF, a fluoro analog of WAY-100635.

21 January 2018

1 reference

Highlighting the Versatility of the Tracerlab Synthesis Modules. Part 1: Fully Automated Production of [F]Labelled Radiopharmaceuticals using a Tracerlab FX(FN).

21 January 2018

1 reference

Uptake and binding of the serotonin 5-HT1A antagonist [18F]-MPPF in brain of rats: effects of the novel P-glycoprotein inhibitor tariquidar

21 January 2018

1 reference

Transport of selected PET radiotracers by human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2): an in vitro screening.

21 January 2018

1 reference

Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives

21 January 2018

1 reference

Synthesis and preclinical evaluation of novel PET probes for P-glycoprotein function and expression.

21 January 2018

1 reference

The molecular interaction of the high affinity reversal agent XR9576 with P-glycoprotein

21 January 2018

1 reference

Potent and selective inhibitors of breast cancer resistance protein (ABCG2) derived from the p-glycoprotein (ABCB1) modulator tariquidar

21 January 2018

1 reference

Synthesis and evaluation of [11C]XR9576 to assess the function of drug efflux transporters using PET.

21 January 2018

1 reference

Synthesis and in vivo evaluation of [11C]tariquidar, a positron emission tomography radiotracer based on a third-generation P-glycoprotein inhibitor

21 January 2018

1 reference

Breast cancer resistance protein and P-glycoprotein in brain cancer: two gatekeepers team up

21 January 2018

1 reference

A novel PET protocol for visualization of breast cancer resistance protein function at the blood-brain barrier

21 January 2018

1 reference

A comparative small-animal PET evaluation of [11C]tariquidar, [11C]elacridar and (R)-[11C]verapamil for detection of P-glycoprotein-expressing murine breast cancer

21 January 2018

1 reference

Synthesis and in vivo evaluation of ¹⁸F-fluoroethyl GF120918 and XR9576 as positron emission tomography probes for assessing the function of drug efflux transporters

21 January 2018

1 reference

Reversal of resistance by GF120918 in cell lines expressing the ABC half-transporter, MXR.

21 January 2018

1 reference

Synthesis and small-animal positron emission tomography evaluation of [11C]-elacridar as a radiotracer to assess the distribution of P-glycoprotein at the blood-brain barrier

21 January 2018

1 reference

Evaluation of limiting brain penetration related to P-glycoprotein and breast cancer resistance protein using [(11)C]GF120918 by PET in mice

21 January 2018

1 reference

Radiosynthesis and in vivo evaluation of 1-[18F]fluoroelacridar as a positron emission tomography tracer for P-glycoprotein and breast cancer resistance protein

21 January 2018

1 reference

Evaluation of [11C]laniquidar as a tracer of P-glycoprotein: radiosynthesis and biodistribution in rats

21 January 2018

1 reference

The influence of mass of [11C]-laniquidar and [11C]-N-desmethyl-loperamide on P-glycoprotein blockage at the blood-brain barrier

21 January 2018

1 reference

Kinetic analysis of the cooperation of P-glycoprotein (P-gp/Abcb1) and breast cancer resistance protein (Bcrp/Abcg2) in limiting the brain and testis penetration of erlotinib, flavopiridol, and mitoxantrone

21 January 2018

1 reference

Radiosynthesis of [2-(11)C-carbonyl]dantrolene using [(11)C]phosgene for PET.

21 January 2018

1 reference

Radiosynthesis of [13N]dantrolene, a positron emission tomography probe for breast cancer resistant protein, using no-carrier-added [13N]ammonia.

21 January 2018

1 reference

DNA topoisomerase poisons as antitumor drugs

21 January 2018

1 reference

P-glycoprotein and breast cancer resistance protein: two dominant transporters working together in limiting the brain penetration of topotecan

21 January 2018

1 reference

Evaluation of the P-glycoprotein- and breast cancer resistance protein-mediated brain penetration of 11C-labeled topotecan using small-animal positron emission tomography

21 January 2018

1 reference

High-affinity interaction of tyrosine kinase inhibitors with the ABCG2 multidrug transporter

21 January 2018

1 reference

In vivo evaluation of P-glycoprotein and breast cancer resistance protein modulation in the brain using [(11)C]gefitinib

21 January 2018

1 reference

Insight into the cooperation of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) at the blood-brain barrier: a case study examining sorafenib efflux clearance

21 January 2018

1 reference

Noninvasive and quantitative assessment of the function of multidrug resistance-associated protein 1 in the living brain

21 January 2018

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21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JLCR.2993

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24285312%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

1 reference