(Q39855572)

English

Identification of novel specific and general inhibitors of the three major human ATP-binding cassette transporters P-gp, BCRP and MRP2 among registered drugs.

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1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19421845%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

Identification of novel specific and general inhibitors of the three major human ATP-binding cassette transporters P-gp, BCRP and MRP2 among registered drugs (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19421845%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19421845%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19421845%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

Christel A. S. Bergström

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19421845%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

author name string

Jenny M Pedersen

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19421845%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

Per Artursson

5

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19421845%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

language of work or name

1 reference

based on heuristic

inferred from title

publication date

7 May 2009

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19421845%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

Pharmaceutical Research

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19421845%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

26

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19421845%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

8

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19421845%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

1816-1831

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19421845%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

Role reversal for anticancer agents

1 reference

https://api.crossref.org/works/10.1007%2FS11095-009-9896-0

21 January 2018

Unexpected mexiletine responses of a mutant cardiac Na+ channel implicate the selectivity filter as a structural determinant of antiarrhythmic drug access

1 reference

https://api.crossref.org/works/10.1007%2FS11095-009-9896-0

21 January 2018

New light on multidrug binding by an ATP-binding-cassette transporter

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure-activity relationship of P-glycoprotein substrates and modifiers.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug metabolite profiling and elucidation of drug-induced hepatotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of ABCG2/BCRP in biology and medicine

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding site of activators of the cystic fibrosis transmembrane conductance regulator in the nucleotide binding domains.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Computational models for identifying potential P-glycoprotein substrates and inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Carboxylesterase-mediated sensitization of human tumor cells to CPT-11 cannot override ABCG2-mediated drug resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P-glycoprotein models of the apo and ATP-bound states based on homology with Sav1866 and MalK

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutational analysis of a highly conserved proline residue in MRP1, MRP2, and MRP3 reveals a partially conserved function

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Localization of P-gp (Abcb1) and Mrp2 (Abcc2) in freshly isolated rat hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ABCG2 transports sulfated conjugates of steroids and xenobiotics

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Perfusion studies of glyburide transfer across the human placenta: implications for fetal safety

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for two interacting ligand binding sites in human multidrug resistance protein 2 (ATP binding cassette C2).

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wild-type breast cancer resistance protein (BCRP/ABCG2) is a methotrexate polyglutamate transporter

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conformational transitions induced by the binding of MgATP to the vitamin B12 ATP-binding cassette (ABC) transporter BtuCD.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple molecular mechanisms for multidrug resistance transporters

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantification and characterization of P-glycoprotein-substrate interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reversal of resistance by GF120918 in cell lines expressing the ABC half-transporter, MXR.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A computational ensemble pharmacophore model for identifying substrates of P-glycoprotein

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemistry of multidrug resistance mediated by the multidrug transporter

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure-function relationships of multidrug resistance P-glycoprotein

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stoichiometry and physical chemistry of promiscuous aggregate-based inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ambient occlusion and edge cueing to enhance real time molecular visualization.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ABC of oral bioavailability: transporters as gatekeepers in the gut.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Flavonoids: a class of modulators with bifunctional interactions at vicinal ATP- and steroid-binding sites on mouse P-glycoprotein

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation and culture of primary human hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative structure--activity relationship analysis and molecular dynamics simulation to functionally validate nonsynonymous polymorphisms of human ABC transporter ABCB1 (P-glycoprotein/MDR1).

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MRP2 and 3 in health and disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure of the human multidrug resistance protein 1 nucleotide binding domain 1 bound to Mg2+/ATP reveals a non-productive catalytic site

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association between the number of coadministered P-glycoprotein inhibitors and serum digoxin levels in patients on therapeutic drug monitoring

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rational use of in vitro P-glycoprotein assays in drug discovery

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of half-transporters in multidrug resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug absorption limited by P-glycoprotein-mediated secretory drug transport in human intestinal epithelial Caco-2 cell layers

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The power of the pump: mechanisms of action of P-glycoprotein (ABCB1).

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of the apical membrane-targeting signal of the multidrug resistance-associated protein 2 (MRP2/MOAT).

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P-glycoprotein substrate binding domains are located at the transmembrane domain/transmembrane domain interfaces: a combined photoaffinity labeling-protein homology modeling approach

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vanadate inhibits the ATPase activity and DNA binding capability of bacterial MutS. A structural model for the vanadate-MutS interaction at the Walker A motif

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacophore model of drugs involved in P-glycoprotein multidrug resistance: explanation of structural variety (hypothesis).

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of the intracellular accumulation of saquinavir in peripheral blood mononuclear cells by inhibitors of MRP1, MRP2, P-gp and BCRP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HIV protease inhibitors are inhibitors but not substrates of the human breast cancer resistance protein (BCRP/ABCG2).

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Application of three-dimensional quantitative structure-activity relationships of P-glycoprotein inhibitors and substrates

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P-glycoprotein: from genomics to mechanism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of Bcrp1 (Abcg2) on the in vivo pharmacokinetics and brain penetration of imatinib mesylate (Gleevec): implications for the use of breast cancer resistance protein and P-glycoprotein inhibitors to enable the brain penetration of imatinib

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A general pattern for substrate recognition by P-glycoprotein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Portrait of multifaceted transporter, the multidrug resistance-associated protein 1 (MRP1/ABCC1).

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification and 3D structural analysis of oligomeric human multidrug transporter ABCG2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Three-dimensional structure of P-glycoprotein: the transmembrane regions adopt an asymmetric configuration in the nucleotide-bound state.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Global and Local Computational Models for Aqueous Solubility Prediction of Drug-Like Molecules

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of in vivo biliary clearance from the in vitro transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II monolayer expressing both rat organic anion transporting polypeptide 4 and multidrug resista

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transporter database, TP-Search: a web-accessible comprehensive database for research in pharmacokinetics of drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sequence requirements of the ATP-binding site within the C-terminal nucleotide-binding domain of mouse P-glycoprotein: structure-activity relationships for flavonoid binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exploring the quantitative relationship between the level of MDR1 transcript, protein and function using digoxin as a marker of MDR1-dependent drug efflux activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The leukotriene LTD4 receptor antagonist MK571 specifically modulates MRP associated multidrug resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exploring the role of different drug transport routes in permeability screening.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mammalian ABC transporters in health and disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of efflux transporter ABCG2/BCRP does not restore mitoxantrone sensitivity in irinotecan-selected human leukemia CPT-K5 cells: evidence for multifactorial multidrug resistance.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of Multidrug Resistance Protein 2 (MRP2, ABCC2) in Alkylating Agent Detoxification: MRP2 Potentiates GlutathioneS-Transferase A1-1-Mediated Resistance to Chlorambucil Cytotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemical basis of polyvalency as a strategy for enhancing the efficacy of P-glycoprotein (ABCB1) modulators: stipiamide homodimers separated with defined-length spacers reverse drug efflux with greater efficacy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Roles of P-glycoprotein, Bcrp, and Mrp2 in biliary excretion of spiramycin in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Positively cooperative sites for drug transport by P-glycoprotein with distinct drug specificities

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of transported drugs with the lipid bilayer and P-glycoprotein through a solvation exchange mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of P-glycoprotein on the transplacental passage of cyclosporine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A global drug inhibition pattern for the human ATP-binding cassette transporter breast cancer resistance protein (ABCG2).

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polar molecular surface properties predict the intestinal absorption of drugs in humans.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oseltamivir (Tamiflu) efflux transport at the blood-brain barrier via P-glycoprotein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of ABC transporters in drug resistance, metabolism and toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reversal of a novel multidrug resistance mechanism in human colon carcinoma cells by fumitremorgin C.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ATP-dependent transport of rosuvastatin in membrane vesicles expressing breast cancer resistance protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/19421845

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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