(Q38169040)

30 August 2017

Key roles of adjuvants in modern vaccines (English)

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30 August 2017

3

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30 August 2017

Mark T Orr

2

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Steven G Reed

series ordinal

1

object named as

Steven G Reed

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PubMed ID

24309663

30 August 2017

language of work or name

English

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publication date

5 December 2013

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30 August 2017

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30 August 2017

19

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30 August 2017

12

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30 August 2017

1597-1608

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https://scigraph.springernature.com/pub.10.1038/nm.3409

30 August 2017

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Adjuvant formulation structure and composition are critical for the development of an effective vaccine against tuberculosis

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Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity

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Adjuvanticity of the oil-in-water emulsion MF59 is independent of Nlrp3 inflammasome but requires the adaptor protein MyD88

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MyD88 and TRIF synergistic interaction is required for TH1-cell polarization with a synthetic TLR4 agonist adjuvant

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Evaluation of RTS,S/AS02A and RTS,S/AS01B in adults in a high malaria transmission area.

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Vaccine adjuvants alum and MF59 induce rapid recruitment of neutrophils and monocytes that participate in antigen transport to draining lymph nodes

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12 December 2020

Enhanced humoral and memory B cellular immunity using HPV16/18 L1 VLP vaccine formulated with the MPL/aluminium salt combination (AS04) compared to aluminium salt only

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Immunopotentiation of the humoral response by liposomes: encapsulation versus covalent linkage

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Human Toll-like receptor 4 recognizes host-specific LPS modifications.

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12 December 2020

Incidence of narcolepsy in Norwegian children and adolescents after vaccination against H1N1 influenza A.

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AS03 adjuvanted AH1N1 vaccine associated with an abrupt increase in the incidence of childhood narcolepsy in Finland

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12 December 2020

Randomized, double-blind, phase 2a trial of falciparum malaria vaccines RTS,S/AS01B and RTS,S/AS02A in malaria-naive adults: safety, efficacy, and immunologic associates of protection

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Alum adjuvant: some of the tricks of the oldest adjuvant

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First results of phase 3 trial of RTS,S/AS01 malaria vaccine in African children

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Type II NKT cells facilitate Alum-sensing and humoral immunity

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12 December 2020

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12 December 2020

Cutting edge: Mincle is essential for recognition and adjuvanticity of the mycobacterial cord factor and its synthetic analog trehalose-dibehenate

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12 December 2020

Adjuvant System AS03 containing α-tocopherol modulates innate immune response and leads to improved adaptive immunity.

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12 December 2020

MR1 presents microbial vitamin B metabolites to MAIT cells

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12 December 2020

Eliciting mucosal immunity

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12 December 2020

Liposomal cationic charge and antigen adsorption are important properties for the efficient deposition of antigen at the injection site and ability of the vaccine to induce a CMI response

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12 December 2020

MF59 emulsion is an effective delivery system for a synthetic TLR4 agonist (E6020).

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12 December 2020

AS04, an aluminum salt- and TLR4 agonist-based adjuvant system, induces a transient localized innate immune response leading to enhanced adaptive immunity

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12 December 2020

The potential of 1018 ISS adjuvant in hepatitis B vaccines: HEPLISAV™ review

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12 December 2020

Toxicity and cellular uptake of gold nanoparticles: what we have learned so far?

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12 December 2020

Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

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12 December 2020

The adjuvants aluminum hydroxide and MF59 induce monocyte and granulocyte chemoattractants and enhance monocyte differentiation toward dendritic cells

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12 December 2020

Gout-associated uric acid crystals activate the NALP3 inflammasome

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Pre-clinical evaluation of new adjuvant formulations to improve the immunogenicity of the malaria vaccine RTS,S/AS02A.

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Molecular and cellular signatures of human vaccine adjuvants.

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12 December 2020

Inflammasome-independent role of the apoptosis-associated speck-like protein containing CARD (ASC) in the adjuvant effect of MF59.

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12 December 2020

Fast rise of broadly cross-reactive antibodies after boosting long-lived human memory B cells primed by an MF59 adjuvanted prepandemic vaccine.

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12 December 2020

Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway

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12 December 2020

Antibody response to polyhistidine-tagged peptide and protein antigens attached to liposomes via lipid-linked nitrilotriacetic acid in mice

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12 December 2020

Alum adjuvanticity: unraveling a century old mystery

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12 December 2020

Selection of an adjuvant for seasonal influenza vaccine in elderly people: modelling immunogenicity from a randomized trial

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12 December 2020

Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns

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12 December 2020

A preliminary evaluation of a recombinant circumsporozoite protein vaccine against Plasmodium falciparum malaria. RTS,S Malaria Vaccine Evaluation Group

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12 December 2020

Negatively charged liposomes show potent adjuvant activity when simply admixed with protein antigens

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12 December 2020

Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+ cells as homologues of mouse CD8+ dendritic cells

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12 December 2020

MF59 oil-in-water emulsion in combination with a synthetic TLR4 agonist (E6020) is a potent adjuvant for a combination Meningococcus vaccine

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12 December 2020

Alum's adjuvant action: grease is the word.

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12 December 2020

Influenza virosomes as a vaccine adjuvant and carrier system

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12 December 2020

Targeting TLRs expands the antibody repertoire in response to a malaria vaccine.

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12 December 2020

Randomized controlled trial of RTS,S/AS02D and RTS,S/AS01E malaria candidate vaccines given according to different schedules in Ghanaian children

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12 December 2020

The mycobacterial cord factor adjuvant analogue trehalose-6,6'-dibehenate (TDB) activates the Nlrp3 inflammasome.

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12 December 2020

Narcolepsy onset is seasonal and increased following the 2009 H1N1 pandemic in China

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12 December 2020

Quantitative proteomics analysis of adsorbed plasma proteins classifies nanoparticles with different surface properties and size

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12 December 2020

Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848

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12 December 2020

MF59 adjuvant enhances diversity and affinity of antibody-mediated immune response to pandemic influenza vaccines

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12 December 2020

Human CD141+ (BDCA-3)+ dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens.

1 reference

12 December 2020

DNA released from dying host cells mediates aluminum adjuvant activity

1 reference

12 December 2020

The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1beta secretion but dispensable for adjuvant activity

1 reference

12 December 2020

Risk of narcolepsy in children and young people receiving AS03 adjuvanted pandemic A/H1N1 2009 influenza vaccine: retrospective analysis

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12 December 2020

Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity

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12 December 2020

Pre-existing immunity against vaccine vectors--friend or foe?

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12 December 2020

Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans

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12 December 2020

Administration routes affect the quality of immune responses: A cross-sectional evaluation of particulate antigen-delivery systems

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12 December 2020

Improved T cell responses to Plasmodium falciparum circumsporozoite protein in mice and monkeys induced by a novel formulation of RTS,S vaccine antigen

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12 December 2020

The effect of micro and nanotopography on endocytosis in drug and gene delivery systems.

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12 December 2020

Expression of genes associated with immunoproteasome processing of major histocompatibility complex peptides is indicative of protection with adjuvanted RTS,S malaria vaccine.

1 reference

12 December 2020

The importance of adjuvant formulation in the development of a tuberculosis vaccine

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12 December 2020

Programming the magnitude and persistence of antibody responses with innate immunity

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12 December 2020

Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

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12 December 2020

Modification of the structure and activity of lipid A in Yersinia pestis lipopolysaccharide by growth temperature

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12 December 2020

Materials engineering for immunomodulation

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12 December 2020

Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity

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12 December 2020

A comparative study of stress-mediated immunological functions with the adjuvanticity of alum

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12 December 2020

Mechanism of action of licensed vaccine adjuvants

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12 December 2020

Demonstration of safety and enhanced seroprotection against hepatitis B with investigational HBsAg-1018 ISS vaccine compared to a licensed hepatitis B vaccine

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12 December 2020

Liposomal formulations of synthetic MUC1 peptides: effects of encapsulation versus surface display of peptides on immune responses.

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12 December 2020

Alum increases antigen uptake, reduces antigen degradation and sustains antigen presentation by DCs in vitro

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12 December 2020

Implications of narcolepsy link with swine-influenza vaccine

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12 December 2020

Explorations of clinical trials and pharmacovigilance databases of MF59®-adjuvanted influenza vaccines for associated cases of narcolepsy

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12 December 2020

Pivotal advance: eosinophils mediate early alum adjuvant-elicited B cell priming and IgM production

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12 December 2020

Relationship between the size of nanoparticles and their adjuvant activity: data from a study with an improved experimental design

1 reference

12 December 2020

Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells

1 reference

12 December 2020

A randomized, observer-blinded immunogenicity trial of Cervarix(®) and Gardasil(®) Human Papillomavirus vaccines in 12-15 year old girls

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12 December 2020

Polymer particle shape independently influences binding and internalization by macrophages

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12 December 2020

Cross-priming CD8+ T cells by targeting antigens to human dendritic cells through DCIR

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12 December 2020

Vaccine adjuvant activity of 3M-052: an imidazoquinoline designed for local activity without systemic cytokine induction

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12 December 2020

Synthetic and natural TLR4 agonists as safe and effective vaccine adjuvants

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12 December 2020

Enhancing immunogenicity of a 3'aminomethylnicotine-DT-conjugate anti-nicotine vaccine with CpG adjuvant in mice and non-human primates

1 reference

12 December 2020

Activation of influenza virus-specific CD4+ and CD8+ T cells: a new role for plasmacytoid dendritic cells in adaptive immunity

1 reference

12 December 2020

Increased childhood incidence of narcolepsy in western Sweden after H1N1 influenza vaccination

1 reference

12 December 2020

Use of CpG oligodeoxynucleotides as immune adjuvants

1 reference

12 December 2020

Increased potency of an inactivated trivalent polio vaccine with oil-in-water emulsions

1 reference

12 December 2020

Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens

1 reference

12 December 2020

Nano-microparticles as immune adjuvants: correlating particle sizes and the resultant immune responses

1 reference

12 December 2020

Adjuvant effect of cationic liposomes and CpG depends on administration route.

1 reference

12 December 2020

Differential activation of human and mouse Toll-like receptor 4 by the adjuvant candidate LpxL1 of Neisseria meningitidis

1 reference

12 December 2020

Towards an understanding of the adjuvant action of aluminium

1 reference

12 December 2020

How do adjuvants work? Important considerations for new generation adjuvants

1 reference

12 December 2020

Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6

1 reference

12 December 2020

Accessing the therapeutic potential of immunostimulatory nucleic acids

1 reference

12 December 2020

Optimized subunit vaccine protects against experimental leishmaniasis

1 reference

12 December 2020

MF59 formulated with CpG ODN as a potent adjuvant of recombinant HSP65-MUC1 for inducing anti-MUC1+ tumor immunity in mice.

1 reference

12 December 2020

The vesicle size of DDA:TDB liposomal adjuvants plays a role in the cell-mediated immune response but has no significant effect on antibody production.

1 reference

12 December 2020

Increased incidence and clinical picture of childhood narcolepsy following the 2009 H1N1 pandemic vaccination campaign in Finland

1 reference

12 December 2020

Immunogenicity and safety of an adjuvanted hepatitis B vaccine in pre-hemodialysis and hemodialysis patients

1 reference

12 December 2020

In vivo studies on the effect of co-encapsulation of CpG DNA and antigen in acid-degradable microparticle vaccines

1 reference

12 December 2020

MF59 and Pam3CSK4 Boost Adaptive Responses to Influenza Subunit Vaccine through an IFN Type I-Independent Mechanism of Action

1 reference

12 December 2020

A 2-dose regimen of a recombinant hepatitis B vaccine with the immune stimulant AS04 compared with the standard 3-dose regimen of Engerix-B in healthy young adults

1 reference

12 December 2020

Improved CD4⁺ T cell responses to Mycobacterium tuberculosis in PPD-negative adults by M72/AS01 as compared to the M72/AS02 and Mtb72F/AS02 tuberculosis candidate vaccine formulations: a randomized trial.

1 reference

12 December 2020

Distinct TLR adjuvants differentially stimulate systemic and local innate immune responses in nonhuman primates

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12 December 2020

The role of the lymphatic system in vaccine trafficking and immune response

1 reference

12 December 2020

Chitosan Microparticles and Nanoparticles as Biocompatible Delivery Vehicles for Peptide and Protein-Based Immunocontraceptive Vaccines

1 reference

12 December 2020

Innovations in emulsion technology

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNM.3409

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NM.3409

1 reference

30 August 2017

1 reference

PubMed ID

24309663