(Q38169790)

30 August 2017

title

Chimeric rodents with humanized liver: bridging the preclinical/clinical trial gap in ADME/toxicity studies (English)

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30 August 2017

John R Foster

1

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30 August 2017

Garry Lund

2

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30 August 2017

Svetlana Sapelnikova

3

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30 August 2017

D Lorne Tyrrell

4

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30 August 2017

Norman M Kneteman

5

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30 August 2017

language of work or name

English

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publication date

10 December 2013

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30 August 2017

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30 August 2017

volume

44

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30 August 2017

issue

2

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30 August 2017

page(s)

109-122

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30 August 2017

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Absence of viral interference and different susceptibility to interferon between hepatitis B virus and hepatitis C virus in human hepatocyte chimeric mice.

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CYP2C9-catalyzed metabolism of S-warfarin to 7-hydroxywarfarin in vivo and in vitro in chimeric mice with humanized liver

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Humanization of excretory pathway in chimeric mice with humanized liver.

21 January 2018

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21 January 2018

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Fat apoptosis through targeted activation of caspase 8: a new mouse model of inducible and reversible lipoatrophy

21 January 2018

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Can 'humanized' mice improve drug development in the 21st century?

21 January 2018

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Prediction of adipose tissue: plasma partition coefficients for structurally unrelated drugs

21 January 2018

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Prediction of pharmacokinetics prior to in vivo studies. 1. Mechanism-based prediction of volume of distribution.

21 January 2018

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Detection and structural investigation of metabolites of stanozolol in human urine by liquid chromatography tandem mass spectrometry

21 January 2018

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Detection and characterization of a new metabolite of 17alpha-methyltestosterone

21 January 2018

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The metabolism of primaquine to its active metabolite is dependent on CYP 2D6

21 January 2018

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Complete reconstitution of mouse liver with xenogeneic hepatocytes

21 January 2018

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21 January 2018

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Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases.

21 January 2018

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21 January 2018

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21 January 2018

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Complete hepatic regeneration after somatic deletion of an albumin-plasminogen activator transgene

21 January 2018

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Prediction of in vivo hepatic clearance and half-life of drug candidates in human using chimeric mice with humanized liver

21 January 2018

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Predictability of metabolism of ibuprofen and naproxen using chimeric mice with human hepatocytes

21 January 2018

1 reference

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Human hepatocytes can repopulate mouse liver: histopathology of the liver in human hepatocyte-transplanted chimeric mice and toxicologic responses to acetaminophen

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2013.867553

Evaluation of the pharmacokinetics, biotransformation and hepatic transporter effects of troglitazone in mice with humanized livers

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2013.867553

Are animal models predictive for humans?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2013.867553

Lipoprotein profiles in SCID/uPA mice transplanted with human hepatocytes become human-like and correlate with HCV infection success

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2013.867553

Chimeric mice with humanized liver: tools for the study of drug metabolism, excretion, and toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2013.867553

Repopulation of the immunosuppressed retrorsine-treated infant rat liver with human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2013.867553

Host sphingolipid biosynthesis is a promising therapeutic target for the inhibition of hepatitis B virus replication

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2013.867553

Morphological and microarray analyses of human hepatocytes from xenogeneic host livers

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2013.867553

Near completely humanized liver in mice shows human-type metabolic responses to drugs

21 January 2018

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Utility of physiologically based pharmacokinetic models to drug development and rational drug discovery candidate selection.

21 January 2018

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Plasma concentrations of melengestrol acetate in humans extrapolated from the pharmacokinetics established in in vivo experiments with rats and chimeric mice with humanized liver and physiologically based pharmacokinetic modeling.

21 January 2018

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Preerythrocytic, live-attenuated Plasmodium falciparum vaccine candidates by design

21 January 2018

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In vivo treatment with monoclonal antibody 3.2.3 selectively eliminates natural killer cells in rats

21 January 2018

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Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications

21 January 2018

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Complete Plasmodium falciparum liver-stage development in liver-chimeric mice

21 January 2018

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https://api.crossref.org/works/10.3109%2F00498254.2013.867553

The entry inhibitor Myrcludex-B efficiently blocks intrahepatic virus spreading in humanized mice previously infected with hepatitis B virus.

21 January 2018

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https://api.crossref.org/works/10.3109%2F00498254.2013.867553

Production of infectious hepatitis C virus in tissue culture from a cloned viral genome

21 January 2018

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Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo.

21 January 2018

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A humanized mouse model to study hepatitis C virus infection, immune response, and liver disease.

21 January 2018

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A physiological model for the estimation of the fraction dose absorbed in humans.

21 January 2018

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The chimpanzee (Pan troglodytes) as a pharmacokinetic model for selection of drug candidates: model characterization and application

21 January 2018

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Human hepatocytes transplanted into genetically immunocompetent rats are susceptible to infection by hepatitis B virus in situ

21 January 2018

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A novel immunocompetent rat model of HCV infection and hepatitis

21 January 2018

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In vivo drug interactions of the teratogen thalidomide with midazolam: heterotropic cooperativity of human cytochrome P450 in humanized TK-NOG mice.

21 January 2018

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https://api.crossref.org/works/10.3109%2F00498254.2013.867553

In vivo formation of a glutathione conjugate derived from thalidomide in humanized uPA-NOG mice

21 January 2018

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https://api.crossref.org/works/10.3109%2F00498254.2013.867553

Prediction of hepatic clearance from microsomes, hepatocytes, and liver slices

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2013.867553

10.3109/00498254.2013.867553

21 January 2018

Identifiers

DOI

1 reference

30 August 2017

1 reference