(Q38170338)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24327420%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

title

Alternative approaches for PET radiotracer development in Alzheimer's disease: imaging beyond plaque (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24327420%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

0 references

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24327420%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

Benjamin H. Rotstein

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24327420%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

Steven H. Liang

2

0 references

Thomas Lee Collier

4

object named as

Thomas L Collier

0 references

Neil Vasdev

7

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Nickeisha A Stephenson

5

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author name string

Ivan Greguric

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24327420%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

publication date

11 December 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24327420%20AND%20SRC:MED&resulttype=core&format=json

Journal of Labelled Compounds and Radiopharmaceuticals

2 March 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24327420%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

volume

57

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24327420%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24327420%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

page(s)

323-331

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24327420%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

1 reference

The Mini-Mental State Examination: A Comprehensive Review

21 January 2018

1 reference

Amyloid deposition as the central event in the aetiology of Alzheimer's disease

21 January 2018

1 reference

Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B

21 January 2018

1 reference

Positron emission tomography radiopharmaceuticals for imaging brain Beta-amyloid

21 January 2018

1 reference

Aβ Imaging: feasible, pertinent, and vital to progress in Alzheimer's disease

21 January 2018

1 reference

PET imaging of amyloid in Alzheimer's disease.

21 January 2018

1 reference

Positron emission tomography radioligands for in vivo imaging of Aβ plaques

21 January 2018

1 reference

Therapeutics for Alzheimer's disease based on the metal hypothesis

21 January 2018

1 reference

Metals in Alzheimer's disease: a systemic perspective

21 January 2018

1 reference

The curious case of clioquinol

21 January 2018

1 reference

A rapid and efficient preparation of [123I]radiopharmaceuticals using a small HPLC (Rocket) column

21 January 2018

1 reference

Evaluation of [(11)C]N-Methyl Lansoprazole as a Radiopharmaceutical for PET Imaging of Tau Neurofibrillary Tangles.

21 January 2018

1 reference

Cyclohexanehexol inhibitors of Abeta aggregation prevent and reverse Alzheimer phenotype in a mouse model.

21 January 2018

1 reference

Predicting the energetics of osmolyte-induced protein folding/unfolding.

21 January 2018

1 reference

Amyloid-β-dependent compromise of microvascular structure and function in a model of Alzheimer's disease.

21 January 2018

1 reference

Synthesis of scyllo-inositol derivatives and their effects on amyloid beta peptide aggregation.

21 January 2018

1 reference

Synthesis and preliminary biological evaluations of [18F]-1-deoxy-1-fluoro-scyllo-inositol

21 January 2018

1 reference

Comparisons of [18F]-1-deoxy-1-fluoro-scyllo-inositol with [18F]-FDG for PET imaging of inflammation, breast and brain cancer xenografts in athymic mice.

21 January 2018

1 reference

Determination of lipophilicity and its use as a predictor of blood-brain barrier penetration of molecular imaging agents

21 January 2018

1 reference

Radiosynthesis and in vivo tumor uptake of 2-deoxy-2-[(18)F]fluoro-myo-inositol

21 January 2018

1 reference

The cholinergic hypothesis of geriatric memory dysfunction

21 January 2018

1 reference

The cholinergic hypothesis of Alzheimer's disease: a review of progress

21 January 2018

1 reference

The cholinergic hypothesis of age and Alzheimer's disease-related cognitive deficits: recent challenges and their implications for novel drug development

21 January 2018

1 reference

The history of the cholinergic hypothesis

21 January 2018

1 reference

Revisiting the cholinergic hypothesis in the development of Alzheimer's disease

21 January 2018

1 reference

On neurodegenerative diseases, models, and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesis

21 January 2018

1 reference

PET probes for imaging brain acetylcholinesterase

21 January 2018

1 reference

Pharmacological evaluation of [11C]donepezil as a tracer for visualization of acetylcholinesterase by PET.

21 January 2018

1 reference

Synthesis of 1-[11C]methylpiperidin-4-yl propionate ([11C]PMP) for in vivo measurements of acetylcholinesterase activity.

21 January 2018

1 reference

In vivo studies of acetylcholinesterase activity using a labeled substrate, N-[11C]methylpiperdin-4-yl propionate ([11C]PMP).

21 January 2018

1 reference

In vivo mapping of cerebral acetylcholinesterase activity in aging and Alzheimer's disease

21 January 2018

1 reference

Measurement of acetylcholinesterase by positron emission tomography in the brains of healthy controls and patients with Alzheimer's disease.

21 January 2018

1 reference

The GSK3 hypothesis of Alzheimer's disease

21 January 2018

1 reference

GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides

21 January 2018

1 reference

GSK3beta signalling: casting a wide net in Alzheimer's disease

21 January 2018

1 reference

Selectively silencing GSK-3 isoforms reduces plaques and tangles in mouse models of Alzheimer's disease

21 January 2018

1 reference

Synthesis and ex vivo evaluation of carbon-11 labelled N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea ([11C]AR-A014418): a radiolabelled glycogen synthase kinase-3beta specific inhibitor for PET studies.

21 January 2018

1 reference

Towards the preparation of radiolabeled 1-aryl-3-benzyl ureas: Radiosynthesis of [(11)C-carbonyl] AR-A014418 by [(11)C]CO(2) fixation.

21 January 2018

1 reference

Radiolabeled small molecule protein kinase inhibitors for imaging with PET or SPECT.

21 January 2018

1 reference

Epigenetic regulation of fatty acid amide hydrolase in Alzheimer disease

21 January 2018

1 reference

PET imaging of fatty acid amide hydrolase in the brain: synthesis and biological evaluation of an 11C-labelled URB597 analogue

21 January 2018

1 reference

[11C]CURB: Evaluation of a novel radiotracer for imaging fatty acid amide hydrolase by positron emission tomography.

21 January 2018

1 reference

Radiosynthesis and evaluation of [¹¹C-carbonyl]-labeled carbamates as fatty acid amide hydrolase radiotracers for positron emission tomography.

21 January 2018

1 reference

Development and characterization of a promising fluorine-18 labelled radiopharmaceutical for in vivo imaging of fatty acid amide hydrolase

21 January 2018

1 reference

Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor

21 January 2018

1 reference

The synthesis and in vivo evaluation of [18F]PF-9811: a novel PET ligand for imaging brain fatty acid amide hydrolase (FAAH).

21 January 2018

1 reference

The cannabinoid CB2 receptor as a target for inflammation-dependent neurodegeneration

21 January 2018

1 reference

Fluorinated cannabinoid CB2 receptor ligands: synthesis and in vitro binding characteristics of 2-oxoquinoline derivatives

21 January 2018

1 reference

Synthesis and preliminary evaluation of [18F]-labeled 2-oxoquinoline derivatives for PET imaging of cannabinoid CB2 receptor

21 January 2018

1 reference

In vivo tumor grading of prostate cancer using quantitative 111In-capromab pendetide SPECT/CT.

21 January 2018

1 reference

Synthesis and biodistribution of [11C]A-836339, a new potential radioligand for PET imaging of cannabinoid type 2 receptors (CB2).

21 January 2018

1 reference

Activated MAO-B in the brain of Alzheimer patients, demonstrated by [11C]-L-deprenyl using whole hemisphere autoradiography.

21 January 2018

1 reference

Monoamine oxidase-B inhibitors in the treatment of Alzheimer's disease

21 January 2018

1 reference

Monoamine oxidase: radiotracer development and human studies

21 January 2018

1 reference

Translational neuroimaging: positron emission tomography studies of monoamine oxidase.

21 January 2018

1 reference

Radiochemistry devoted to the production of monoamine oxidase (MAO-A and MAO-B) ligands for brain imaging with positron emission tomography

21 January 2018

1 reference

Development of new radiopharmaceuticals for imaging monoamine oxidase B.

21 January 2018

1 reference

Synthesis of (R)-(-)- and (S)-(+)-4-fluorodeprenyl and (R)-(-)- and (S)-(+)-[N-11C-methyl]-4-fluorodeprenyl and positron emission tomography studies in baboon brain.

21 January 2018

1 reference

The synthesis of no-carrier-added DL-4-[18F]fluorodeprenyl via the nucleophilic aromatic substitution reaction.

21 January 2018

1 reference

Synthesis and evaluation of [¹⁸F]fluororasagiline, a novel positron emission tomography (PET) radioligand for monoamine oxidase B (MAO-B).

21 January 2018

1 reference

Synthesis and in vivo studies of a specific monoamine oxidase B inhibitor: 5-[4-(benzyloxy)phenyl]-3-(2-cyanoethyl)- 1,3,4-oxadiazol-[11C]-2(3H)-one.

21 January 2018

1 reference

[(11)C]SL25.1188, a new reversible radioligand to study the monoamine oxidase type B with PET: preclinical characterisation in nonhuman primate

21 January 2018

1 reference

Neuroinflammation in Alzheimer's disease wanes with age

21 January 2018

1 reference

In vivo positron emission tomographic imaging of glial responses to amyloid-beta and tau pathologies in mouse models of Alzheimer's disease and related disorders

21 January 2018

1 reference

In-vivo measurement of activated microglia in dementia

21 January 2018

1 reference

21 January 2018

The translocator protein

1 reference

Radiolabelled molecules for imaging the translocator protein (18 kDa) using positron emission tomography

21 January 2018

1 reference

The potential of carbon-11 and fluorine-18 chemistry: illustration through the development of positron emission tomography radioligands targeting the translocator protein 18 kDa

21 January 2018

1 reference

Synthesis and biological evaluation of substituted [18F]imidazo[1,2-a]pyridines and [18F]pyrazolo[1,5-a]pyrimidines for the study of the peripheral benzodiazepine receptor using positron emission tomography

21 January 2018

1 reference

In vivo imaging of neuroinflammation: a comparative study between [(18)F]PBR111, [ (11)C]CLINME and [ (11)C]PK11195 in an acute rodent model

21 January 2018

1 reference

Synthesis of [¹¹C]PBR06 and [¹⁸F]PBR06 as agents for positron emission tomographic (PET) imaging of the translocator protein (TSPO).

21 January 2018

1 reference

Synthesis of 6-[¹⁸F]fluoro-PBR28, a novel radiotracer for imaging the TSPO 18 kDa with PET.

21 January 2018

1 reference

Radiosynthesis and initial evaluation of [18F]-FEPPA for PET imaging of peripheral benzodiazepine receptors

21 January 2018

1 reference

FMRP mediates mGluR5-dependent translation of amyloid precursor protein

21 January 2018

1 reference

Group II metabotropic glutamate receptor stimulation triggers production and release of Alzheimer's amyloid(beta)42 from isolated intact nerve terminals

21 January 2018

1 reference

Group 1 mGluR-dependent synaptic long-term depression: mechanisms and implications for circuitry and disease

21 January 2018

1 reference

Synthesis, characterization, and first successful monkey imaging studies of metabotropic glutamate receptor subtype 5 (mGluR5) PET radiotracers

21 January 2018

1 reference

Biodistribution and radiation dosimetry of [18F]F-PEB in nonhuman primates

21 January 2018

1 reference

ABP688, a novel selective and high affinity ligand for the labeling of mGlu5 receptors: identification, in vitro pharmacology, pharmacokinetic and biodistribution studies

21 January 2018

1 reference

18F-FPEB, a PET radiopharmaceutical for quantifying metabotropic glutamate 5 receptors: a first-in-human study of radiochemical safety, biokinetics, and radiation dosimetry

21 January 2018

1 reference

Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors

21 January 2018

1 reference

Imaging of muscarinic receptors in the central nervous system

21 January 2018

1 reference

Persistent binding and functional antagonism by xanomeline at the muscarinic M5 receptor

21 January 2018

1 reference

Loss of M2 muscarine receptors in the cerebral cortex in Alzheimer's disease and experimental cholinergic denervation.

21 January 2018

1 reference

Down-regulation of muscarinic acetylcholine receptor M2 adversely affects the expression of Alzheimer's disease-relevant genes and proteins

21 January 2018

1 reference

Muscarinic cholinergic receptor measurements with [18F]FP-TZTP: control and competition studies.

21 January 2018

1 reference

An improved radiosynthesis of the muscarinic M2 radiopharmaceutical, [18F]FP-TZTP.

21 January 2018

1 reference

Regional brain uptake of the muscarinic ligand, [18F]FP-TZTP, is greatly decreased in M2 receptor knockout mice but not in M1, M3 and M4 receptor knockout mice

21 January 2018

1 reference

Radiosynthesis of carbon-11 and fluorine-18 labelled radiotracers to image the ionotropic and metabotropic glutamate receptors.

21 January 2018

1 reference

Emerging structure of the nicotinic acetylcholine receptors

21 January 2018

1 reference

Immunohistochemical localisation of nicotinic acetylcholine receptor subunits in human cerebellum

21 January 2018

1 reference

Nicotinic acetylcholine receptor distribution in Alzheimer's disease, dementia with Lewy bodies, Parkinson's disease, and vascular dementia: in vitro binding study using 5-[(125)i]-a-85380.

21 January 2018

1 reference

The role of nicotinic acetylcholine receptors in Alzheimer's disease

21 January 2018

1 reference

Nicotinic acetylcholine receptor signalling: roles in Alzheimer's disease and amyloid neuroprotection.

21 January 2018

1 reference

Recent PET radioligands with optimal brain kinetics for imaging nicotinic acetylcholine receptors

21 January 2018

1 reference

Development of radioligands with optimized imaging properties for quantification of nicotinic acetylcholine receptors by positron emission tomography

21 January 2018

1 reference

Biodistribution and radiation dosimetry of the α7 nicotinic acetylcholine receptor ligand [11C]CHIBA-1001 in humans.

21 January 2018

1 reference

Preclinical and the first clinical studies on [11C]CHIBA-1001 for mapping alpha7 nicotinic receptors by positron emission tomography.

21 January 2018

1 reference

11C-NS14492 as a novel PET radioligand for imaging cerebral alpha7 nicotinic acetylcholine receptors: in vivo evaluation and drug occupancy measurements.

21 January 2018

1 reference

Molecular imaging of alpha7 nicotinic acetylcholine receptors: design and evaluation of the potent radioligand [18F]NS10743.

21 January 2018

1 reference

Evaluation of 18F-nifene binding to α4β2 nicotinic receptors in the rat brain using microPET imaging

21 January 2018

1 reference

PET imaging of α4β2* nicotinic acetylcholine receptors: quantitative analysis of 18F-nifene kinetics in the nonhuman primate.

21 January 2018

1 reference

Evaluation of [18F]Nifene biodistribution and dosimetry based on whole-body PET imaging of mice.

21 January 2018

1 reference

PET Imaging of nicotinic acetylcholine receptors in baboons with 18F-AZAN, a radioligand with improved brain kinetics

21 January 2018

1 reference

Imaging of central nAChReceptors with 2-[18F]F-A85380: optimized synthesis and in vitro evaluation in Alzheimer's disease.

21 January 2018

1 reference

Feasibility of [18F]-2-Fluoro-A85380-PET imaging of human vascular nicotinic acetylcholine receptors in vivo

21 January 2018

1 reference

Loss of functional GABA(A) receptors in the Alzheimer diseased brain

21 January 2018

1 reference

γ-Aminobutyric acid type A (GABAA) receptor activation modulates tau phosphorylation.

21 January 2018

1 reference

Development of new carbon-11 labelled radiotracers for imaging GABAA- and GABAB-benzodiazepine receptors.

21 January 2018

1 reference

The development of potential new fluorine-18 labelled radiotracers for imaging the GABA(A) receptor.

21 January 2018

1 reference

In-vivo imaging characteristics of two fluorinated flumazenil radiotracers in the rat.

21 January 2018

1 reference

Development of radioligands for in vivo imaging of GABA(A)-benzodiazepine receptors

21 January 2018

1 reference

PET radioligands targeting the brain GABAA /benzodiazepine receptor complex

21 January 2018

1 reference

Decreased carbon-11-flumazenil binding in early Alzheimer's disease.

21 January 2018

1 reference

Biological evaluation of 2'-[18F]fluoroflumazenil ([18F]FFMZ), a potential GABA receptor ligand for PET.

21 January 2018

1 reference

18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease

21 January 2018

1 reference