(Q38174793)

30 August 2017

Therapeutic targeting of EPH receptors and their ligands (English)

1 reference

30 August 2017

Andrew W Boyd

1

1 reference

PubMed ID

24378802

30 August 2017

Perry F Bartlett

series ordinal

2

1 reference

PubMed ID

24378802

30 August 2017

Martin Lackmann

series ordinal

3

1 reference

30 August 2017

1 January 2014

1 reference

Nature Reviews Drug Discovery

30 August 2017

1 reference

30 August 2017

13

1 reference

30 August 2017

1

1 reference

30 August 2017

39-62

1 reference

https://scigraph.springernature.com/pub.10.1038/nrd4175

30 August 2017

0 references

cites work

Eph receptors and ephrins in cancer: bidirectional signalling and beyond

1 reference

Eph, a protein family coming of age: more confusion, insight, or complexity?

21 January 2018

1 reference

Eph/ephrin signalling and function in oncogenesis: lessons from embryonic development.

21 January 2018

1 reference

Non-SH2/PDZ reverse signaling by ephrins

21 January 2018

1 reference

Ephrin signaling in vivo: look both ways

21 January 2018

1 reference

Concepts and consequences of Eph receptor clustering

21 January 2018

1 reference

Eph/ephrin signaling: networks.

21 January 2018

1 reference

Eph/ephrin molecules--a hub for signaling and endocytosis

21 January 2018

1 reference

Eph-dependent cell-cell adhesion and segregation in development and cancer.

21 January 2018

1 reference

Molecular mechanisms of cell segregation and boundary formation in development and tumorigenesis

21 January 2018

1 reference

Diverse roles of eph receptors and ephrins in the regulation of cell migration and tissue assembly

21 January 2018

1 reference

Ephrins and Eph receptors in stem cells and cancer

21 January 2018

1 reference

Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4

21 January 2018

1 reference

Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development

21 January 2018

1 reference

Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis

21 January 2018

1 reference

Control of skeletal patterning by ephrinB1-EphB interactions

21 January 2018

1 reference

Ephrin-B1 forward and reverse signaling are required during mouse development

21 January 2018

1 reference

EphA4 (Sek1) receptor tyrosine kinase is required for the development of the corticospinal tract

21 January 2018

1 reference

Role of EphA4 and EphrinB3 in local neuronal circuits that control walking

21 January 2018

1 reference

Segregation of axial motor and sensory pathways via heterotypic trans-axonal signaling

21 January 2018

1 reference

Eph/ephrin signaling as a potential therapeutic target after central nervous system injury

21 January 2018

1 reference

Bidirectional modulation of synaptic functions by Eph/ephrin signaling.

21 January 2018

1 reference

Eph and ephrin interactions in bone.

21 January 2018

1 reference

Essential roles of EphB receptors and EphrinB ligands in endothelial cell function and angiogenesis

21 January 2018

1 reference

Eph-ephrin signalling in adult tissues and cancer

21 January 2018

1 reference

The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling

21 January 2018

1 reference

Paradoxes of the EphB4 receptor in cancer

21 January 2018

1 reference

Eph-ephrin bidirectional signaling in physiology and disease

21 January 2018

1 reference

Competition amongst Eph receptors regulates contact inhibition of locomotion and invasiveness in prostate cancer cells

21 January 2018

1 reference

Silencing of EphA3 through a cis interaction with ephrinA5.

21 January 2018

1 reference

Ephrin-mediated cis-attenuation of Eph receptor signaling is essential for spinal motor axon guidance.

21 January 2018

1 reference

Coexpressed EphA receptors and ephrin-A ligands mediate opposing actions on growth cone navigation from distinct membrane domains

21 January 2018

1 reference

Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation

21 January 2018

1 reference

Activation of EphA receptor tyrosine kinase inhibits the Ras/MAPK pathway

21 January 2018

1 reference

Preferential induction of EphB4 over EphB2 and its implication in colorectal cancer progression

21 January 2018

1 reference

The EphB4 receptor suppresses breast cancer cell tumorigenicity through an Abl-Crk pathway

21 January 2018

1 reference

EphB2 receptor controls proliferation/migration dichotomy of glioblastoma by interacting with focal adhesion kinase

21 January 2018

1 reference

EphB receptor activity suppresses colorectal cancer progression

21 January 2018

1 reference

The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse

21 January 2018

1 reference

Dissociation of EphB2 signaling pathways mediating progenitor cell proliferation and tumor suppression.

21 January 2018

1 reference

EphB receptors regulate stem/progenitor cell proliferation, migration, and polarity during hippocampal neurogenesis

21 January 2018

1 reference

Ephrin-B1 forward signaling regulates craniofacial morphogenesis by controlling cell proliferation across Eph-ephrin boundaries.

21 January 2018

1 reference

Ephrin signalling controls brain size by regulating apoptosis of neural progenitors

21 January 2018

1 reference

Ephrin-A2 reverse signaling negatively regulates neural progenitor proliferation and neurogenesis

21 January 2018

1 reference

Ephrins as negative regulators of adult neurogenesis in diverse regions of the central nervous system

21 January 2018

1 reference

EphA3 maintains tumorigenicity and is a therapeutic target in glioblastoma multiforme.

21 January 2018

1 reference

Dancing with the dead: Eph receptors and their kinase-null partners

21 January 2018

1 reference

Kinase-dependent and kinase-independent functions of EphA4 receptors in major axon tract formation in vivo.

21 January 2018

1 reference

Kinase-independent requirement of EphB2 receptors in hippocampal synaptic plasticity

21 January 2018

1 reference

The EphA8 receptor regulates integrin activity through p110gamma phosphatidylinositol-3 kinase in a tyrosine kinase activity-independent manner

21 January 2018

1 reference

Biphasic functions of the kinase-defective Ephb6 receptor in cell adhesion and migration

21 January 2018

1 reference

Elevated protein tyrosine phosphatase activity provokes Eph/ephrin-facilitated adhesion of pre-B leukemia cells.

21 January 2018

1 reference

Cleavage of E-cadherin by ADAM10 mediates epithelial cell sorting downstream of EphB signalling

21 January 2018

1 reference

Compartmentalized signaling by GPI-anchored ephrin-A5 requires the Fyn tyrosine kinase to regulate cellular adhesion

21 January 2018

1 reference

Ephrin signaling: One raft to rule them all? One raft to sort them? One raft to spread their call and in signaling bind them?

21 January 2018

1 reference

Regulation of repulsion versus adhesion by different splice forms of an Eph receptor

21 January 2018

1 reference

Mutations of ephrin-B1 (EFNB1), a marker of tissue boundary formation, cause craniofrontonasal syndrome

21 January 2018

1 reference

Inhibition of gap junction communication at ectopic Eph/ephrin boundaries underlies craniofrontonasal syndrome

21 January 2018

1 reference

Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis

21 January 2018

1 reference

Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis

21 January 2018

1 reference

AL-1-induced growth cone collapse of rat cortical neurons is correlated with REK7 expression and rearrangement of the actin cytoskeleton.

21 January 2018

1 reference

Restriction of receptor movement alters cellular response: physical force sensing by EphA2.

21 January 2018

1 reference

Eph receptors and ephrins restrict cell intermingling and communication.

21 January 2018

1 reference

Retinal axon response to ephrin-as shows a graded, concentration-dependent transition from growth promotion to inhibition

21 January 2018

1 reference

EphB-ephrin-B interactions suppress colorectal cancer progression by compartmentalizing tumor cells.

21 January 2018

1 reference

Ephrin-independent regulation of cell substrate adhesion by the EphB4 receptor

21 January 2018

1 reference

Tissue morphogenesis coupled with cell shape changes

21 January 2018

1 reference

Neural map specification by gradients

21 January 2018

1 reference

Axon guidance molecules in vascular patterning

21 January 2018

1 reference

Bone cell interactions through Eph/ephrin: bone modeling, remodeling and associated diseases

21 January 2018

1 reference

Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport

21 January 2018

1 reference

EphB4 controls blood vascular morphogenesis during postnatal angiogenesis

21 January 2018

1 reference

EphrinB reverse signaling contributes to endothelial and mural cell assembly into vascular structures.

21 January 2018

1 reference

Ephrin-A3 suppresses Wnt signaling to control retinal stem cell potency

21 January 2018

1 reference

EphB signaling controls lineage plasticity of adult neural stem cell niche cells

21 January 2018

1 reference

Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB

21 January 2018

1 reference

Isolation and in vitro expansion of human colonic stem cells.

21 January 2018

1 reference

The EphA2 receptor and ephrinA1 ligand in solid tumors: function and therapeutic targeting

21 January 2018

1 reference

EPHA3 as a novel therapeutic target in the hematological malignancies

21 January 2018

1 reference

Molecular features of the transition from prostatic intraepithelial neoplasia (PIN) to prostate cancer: genome-wide gene-expression profiles of prostate cancers and PINs

21 January 2018

1 reference

Overexpression of the receptor tyrosine kinase EphA4 in human gastric cancers.

21 January 2018

1 reference

Mining the cancer genome uncovers therapeutic activity of EphA7 against lymphoma.

21 January 2018

1 reference

EphB6 receptor significantly alters invasiveness and other phenotypic characteristics of human breast carcinoma cells

21 January 2018

1 reference

Eph/ephrin profiling in human breast cancer reveals significant associations between expression level and clinical outcome.

21 January 2018

1 reference

EphA2 receptor tyrosine kinase as a promising target for cancer therapeutics.

21 January 2018

1 reference

EphA2 receptor tyrosine kinase regulates endothelial cell migration and vascular assembly through phosphoinositide 3-kinase-mediated Rac1 GTPase activation.

21 January 2018

1 reference

A kinase-dependent role for EphA2 receptor in promoting tumor growth and metastasis.

21 January 2018

1 reference

The ephrin-A1 ligand and its receptor, EphA2, are expressed during tumor neovascularization

21 January 2018

1 reference

Expression of Ephb2 and Ephb4 in breast carcinoma

21 January 2018

1 reference

Receptor tyrosine kinase EphB4 is a survival factor in breast cancer

21 January 2018

1 reference

Tyrosine phosphorylation profiling reveals the signaling network characteristics of Basal breast cancer cells.

21 January 2018

1 reference

EphA2 reexpression prompts invasion of melanoma cells shifting from mesenchymal to amoeboid-like motility style

21 January 2018

1 reference

EphA2 is a critical oncogene in melanoma

21 January 2018

1 reference

Interplay between EphB4 on tumor cells and vascular ephrin-B2 regulates tumor growth

21 January 2018

1 reference

EphB4 promotes or suppresses Ras/MEK/ERK pathway in a context-dependent manner: Implications for EphB4 as a cancer target

21 January 2018

1 reference

The receptor tyrosine kinase EPHB4 has tumor suppressor activities in intestinal tumorigenesis.

21 January 2018

1 reference

EphB2 is a prognostic factor in colorectal cancer

21 January 2018

1 reference

Complex expression patterns of Eph receptor tyrosine kinases and their ephrin ligands in colorectal carcinogenesis.

21 January 2018

1 reference

Effects of cancer-associated EPHA3 mutations on lung cancer.

21 January 2018

1 reference

The EphA2 receptor drives self-renewal and tumorigenicity in stem-like tumor-propagating cells from human glioblastomas.

21 January 2018

1 reference

Gene sets identified with oncogene cooperativity analysis regulate in vivo growth and survival of leukemia stem cells.

21 January 2018

1 reference

EphB4 expression and biological significance in prostate cancer

21 January 2018

1 reference

Activation of the receptor protein tyrosine kinase EphB4 in endometrial hyperplasia and endometrial carcinoma

21 January 2018

1 reference

Class I and III HDACs and loss of active chromatin features contribute to epigenetic silencing of CDX1 and EPHB tumor suppressor genes in colorectal cancer.

21 January 2018

1 reference

Disruption of EphA2 receptor tyrosine kinase leads to increased susceptibility to carcinogenesis in mouse skin

21 January 2018

1 reference

The Eph-receptor A7 is a soluble tumor suppressor for follicular lymphoma

21 January 2018

1 reference

EphA2 mediates ligand-dependent inhibition and ligand-independent promotion of cell migration and invasion via a reciprocal regulatory loop with Akt

21 January 2018

1 reference

A conditional feedback loop regulates Ras activity through EphA2.

21 January 2018

1 reference

Global DNA methylation profiling reveals silencing of a secreted form of Epha7 in mouse and human germinal center B-cell lymphomas.

21 January 2018

1 reference

Downregulation of EphA7 by hypermethylation in colorectal cancer

21 January 2018

1 reference

Differential expression of EphA7 receptor tyrosine kinase in gastric carcinoma

21 January 2018

1 reference

Aberrant methylation of EphA7 in human prostate cancer and its relation to clinicopathologic features

21 January 2018

1 reference

Mechanisms of inactivation of the receptor tyrosine kinase EPHB2 in colorectal tumors.

21 January 2018

1 reference

Aberrant DNA methylation and epigenetic inactivation of Eph receptor tyrosine kinases and ephrin ligands in acute lymphoblastic leukemia

21 January 2018

1 reference

The consensus coding sequences of human breast and colorectal cancers

21 January 2018

1 reference

Somatic mutations affect key pathways in lung adenocarcinoma

21 January 2018

1 reference

Novel somatic and germline mutations in cancer candidate genes in glioblastoma, melanoma, and pancreatic carcinoma

21 January 2018

1 reference

Exploring the link between germline and somatic genetic alterations in breast carcinogenesis

21 January 2018

1 reference

Cancer somatic mutations disrupt functions of the EphA3 receptor tyrosine kinase through multiple mechanisms

21 January 2018

1 reference

Targeting of EPH receptor tyrosine kinases for anticancer therapy

21 January 2018

1 reference

Essential role of Vav family guanine nucleotide exchange factors in EphA receptor-mediated angiogenesis

21 January 2018

1 reference

Efficacy and antivascular effects of EphA2 reduction with an agonistic antibody in ovarian cancer

21 January 2018

1 reference

Dual targeting of EphA2 and ER restores tamoxifen sensitivity in ER/EphA2-positive breast cancer

21 January 2018

1 reference

Elevation of receptor tyrosine kinase EphA2 mediates resistance to trastuzumab therapy.

21 January 2018

1 reference

A human antibody-drug conjugate targeting EphA2 inhibits tumor growth in vivo

21 January 2018

1 reference

EphA2 immunoconjugate as molecularly targeted chemotherapy for ovarian carcinoma

21 January 2018

1 reference

EphA2 targeted chemotherapy using an antibody drug conjugate in endometrial carcinoma

21 January 2018

1 reference

Phase 1, open-label study of MEDI-547 in patients with relapsed or refractory solid tumors

21 January 2018

1 reference

EphB2 as a therapeutic antibody drug target for the treatment of colorectal cancer

21 January 2018

1 reference

EphB2 and EphB4 receptors forward signaling promotes SDF-1-induced endothelial cell chemotaxis and branching remodeling

21 January 2018

1 reference

The soluble extracellular domain of EphB4 (sEphB4) antagonizes EphB4-EphrinB2 interaction, modulates angiogenesis, and inhibits tumor growth

21 January 2018

1 reference

Inhibition of tumor growth and angiogenesis by soluble EphB4.

21 January 2018

1 reference

Novel EphB4 monoclonal antibodies modulate angiogenesis and inhibit tumor growth

21 January 2018

1 reference

Blocking ephrinB2 with highly specific antibodies inhibits angiogenesis, lymphangiogenesis, and tumor growth

21 January 2018

1 reference

Concurrent binding of anti-EphA3 antibody and ephrin-A5 amplifies EphA3 signaling and downstream responses: potential as EphA3-specific tumor-targeting reagents

21 January 2018

1 reference

EphB4 promotes site-specific metastatic tumor cell dissemination by interacting with endothelial cell-expressed ephrinB2.

21 January 2018

1 reference

The role of Ephs, Ephrins, and growth factors in Kaposi sarcoma and implications of EphrinB2 blockade

21 January 2018

1 reference

Combination of Dll4/Notch and Ephrin-B2/EphB4 targeted therapy is highly effective in disrupting tumor angiogenesis

21 January 2018

1 reference

Antiangiogenic and antitumor efficacy of EphA2 receptor antagonist

21 January 2018

1 reference

Soluble monomeric EphrinA1 is released from tumor cells and is a functional ligand for the EphA2 receptor

21 January 2018

1 reference

Immunocompetent mouse model of breast cancer for preclinical testing of EphA2-targeted therapy

21 January 2018

1 reference

A novel, potent, and specific ephrinA1-based cytotoxin against EphA2 receptor expressing tumor cells

21 January 2018

1 reference

Molecular targeting of malignant glioma cells with an EphA2-specific immunotoxin delivered by human bone marrow-derived mesenchymal stem cells

21 January 2018

1 reference

A disalicylic acid-furanyl derivative inhibits ephrin binding to a subset of Eph receptors

21 January 2018

1 reference

Small molecules can selectively inhibit ephrin binding to the EphA4 and EphA2 receptors

21 January 2018

1 reference

Lithocholic acid is an Eph-ephrin ligand interfering with Eph-kinase activation

21 January 2018

1 reference

Cupredoxin-cancer interrelationship: azurin binding with EphB2, interference in EphB2 tyrosine phosphorylation, and inhibition of cancer growth.

21 January 2018

1 reference

Inhibition of the T790M gatekeeper mutant of the epidermal growth factor receptor by EXEL-7647.

21 January 2018

1 reference

XL647--a multitargeted tyrosine kinase inhibitor: results of a phase II study in subjects with non-small cell lung cancer who have progressed after responding to treatment with either gefitinib or erlotinib.

21 January 2018

1 reference

Phase II study of the multitargeted tyrosine kinase inhibitor XL647 in patients with non-small-cell lung cancer.

21 January 2018

1 reference

Dasatinib: an anti-tumour agent via Src inhibition

21 January 2018

1 reference

Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors

21 January 2018

1 reference

An efficient rapid system for profiling the cellular activities of molecular libraries.

21 January 2018

1 reference

Identification of candidate molecular markers predicting sensitivity in solid tumors to dasatinib: rationale for patient selection

21 January 2018

1 reference

Effects of dasatinib on EphA2 receptor tyrosine kinase activity and downstream signalling in pancreatic cancer.

21 January 2018

1 reference

Crystal structure of the EphA4 protein tyrosine kinase domain in the apo- and dasatinib-bound state

21 January 2018

1 reference

A phase 2 trial of dasatinib in advanced melanoma

21 January 2018

1 reference

A comprehensive target selectivity survey of the BCR-ABL kinase inhibitor INNO-406 by kinase profiling and chemical proteomics in chronic myeloid leukemia cells

21 January 2018

1 reference

Inhibitors of the tyrosine kinase EphB4. Part 1: Structure-based design and optimization of a series of 2,4-bis-anilinopyrimidines

21 January 2018

1 reference

Discovery and structural analysis of Eph receptor tyrosine kinase inhibitors

21 January 2018

1 reference

The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesis

21 January 2018

1 reference

EphA2 expression is associated with aggressive features in ovarian carcinoma

21 January 2018

1 reference

Intraperitoneal delivery of liposomal siRNA for therapy of advanced ovarian cancer

21 January 2018

1 reference

Erythropoietin-producing hepatocyte B6 variant-derived peptides with the ability to induce glioma-reactive cytotoxic T lymphocytes in human leukocyte antigen-A2+ glioma patients

21 January 2018

1 reference

Induction of CD8+ T-cell responses against novel glioma-associated antigen peptides and clinical activity by vaccinations with {alpha}-type 1 polarized dendritic cells and polyinosinic-polycytidylic acid stabilized by lysine and carboxymethylcellulo

21 January 2018

1 reference

Dual-function probe for PET and near-infrared fluorescence imaging of tumor vasculature

21 January 2018

1 reference

Peptide-conjugated polymeric micellar nanoparticles for Dual SPECT and optical imaging of EphB4 receptors in prostate cancer xenografts

21 January 2018

1 reference

Kinase inhibitors as potential therapeutics for acute and chronic neurodegenerative conditions

21 January 2018

1 reference

Roles of Eph receptors and ephrins in the normal and damaged adult CNS.

21 January 2018

1 reference

Eph receptors and ephrins in neuron-astrocyte communication at synapses

21 January 2018

1 reference

Eph receptors at synapses: implications in neurodegenerative diseases.

21 January 2018

1 reference

Neuropsin cleaves EphB2 in the amygdala to control anxiety

21 January 2018

1 reference

Reversing EphB2 depletion rescues cognitive functions in Alzheimer model

21 January 2018

1 reference

Semiquantitative expression analysis of ephrine-receptor tyrosine kinase mRNA's in a rat model of traumatic brain injury.

21 January 2018

1 reference

Upregulation of EphA4 on astrocytes potentially mediates astrocytic gliosis after cortical lesion in the marmoset monkey

21 January 2018

1 reference

Expression and activation of EphA4 in the human brain after traumatic injury.

21 January 2018

1 reference

Functional and histological outcome after focal traumatic brain injury is not improved in conditional EphA4 knockout mice.

21 January 2018

1 reference

Axonal regeneration and lack of astrocytic gliosis in EphA4-deficient mice

21 January 2018

1 reference

Upregulation of EphA3 receptor after spinal cord injury.

21 January 2018

1 reference

Transection of the adult rat spinal cord upregulates EphB3 receptor and ligand expression.

21 January 2018

1 reference

Accumulation of the inhibitory receptor EphA4 may prevent regeneration of corticospinal tract axons following lesion.

21 January 2018

1 reference

Partial change in EphA4 knockout mouse phenotype: loss of diminished GFAP upregulation following spinal cord injury.

21 January 2018

1 reference

EphA4 deficient mice maintain astroglial-fibrotic scar formation after spinal cord injury

21 January 2018

1 reference

Myelin-derived ephrinB3 restricts axonal regeneration and recovery after adult CNS injury.

21 January 2018

1 reference

Improved axonal regeneration after spinal cord injury in mice with conditional deletion of ephrin B2 under the GFAP promoter.

21 January 2018

1 reference

EphA4 blockers promote axonal regeneration and functional recovery following spinal cord injury in mice

21 January 2018

1 reference

Acute delivery of EphA4-Fc improves functional recovery after contusive spinal cord injury in rats

21 January 2018

1 reference

Regeneration-enhancing effects of EphA4 blocking peptide following corticospinal tract injury in adult rat spinal cord

21 January 2018

1 reference

PEGylation potentiates the effectiveness of an antagonistic peptide that targets the EphB4 receptor with nanomolar affinity

21 January 2018

1 reference

Inhibition of EphA7 up-regulation after spinal cord injury reduces apoptosis and promotes locomotor recovery

21 January 2018

1 reference

Expression profile and role of EphrinA1 ligand after spinal cord injury

21 January 2018

1 reference

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

21 January 2018

1 reference

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

21 January 2018

1 reference

Embryonic stem cells express multiple Eph-subfamily receptor tyrosine kinases.

21 January 2018

1 reference

EphBs: an integral link between synaptic function and synaptopathies

21 January 2018

1 reference

Ligand binding and calcium influx induce distinct ectodomain/gamma-secretase-processing pathways of EphB2 receptor

21 January 2018

1 reference

Synaptic activity prompts gamma-secretase-mediated cleavage of EphA4 and dendritic spine formation

21 January 2018

1 reference

Involvement of the γ-secretase-mediated EphA4 signaling pathway in synaptic pathogenesis of Alzheimer's disease.

21 January 2018

1 reference

Ephrin A receptors and ligands in lesions and normal-appearing white matter in multiple sclerosis

21 January 2018

1 reference

EphA4 receptor tyrosine kinase is a modulator of onset and disease severity of experimental autoimmune encephalomyelitis (EAE)

21 January 2018

1 reference

Axon guidance and synaptic maintenance: preclinical markers for neurodegenerative disease and therapeutics

21 January 2018

1 reference

Ephrin-A1-mediated dopaminergic neurogenesis and angiogenesis in a rat model of Parkinson's disease

21 January 2018

1 reference

The amyotrophic lateral sclerosis 8 protein VAPB is cleaved, secreted, and acts as a ligand for Eph receptors

21 January 2018

1 reference

Structural, stability, dynamic and binding properties of the ALS-causing T46I mutant of the hVAPB MSP domain as revealed by NMR and MD simulations

21 January 2018

1 reference

EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans

21 January 2018

1 reference

Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

21 January 2018

1 reference

Eph/Ephrin signaling in injury and inflammation

21 January 2018

1 reference

Putative dual role of ephrin-Eph receptor interactions in inflammation

21 January 2018

1 reference

Eph kinases and ephrins support thrombus growth and stability by regulating integrin outside-in signaling in platelets.

21 January 2018

1 reference

EphB6-null mutation results in compromised T cell function

21 January 2018

1 reference

Regulation of angiogenesis by Eph-ephrin interactions

21 January 2018

1 reference

A novel immediate-early response gene of endothelium is induced by cytokines and encodes a secreted protein

21 January 2018

1 reference

Role of B61, the ligand for the Eck receptor tyrosine kinase, in TNF-alpha-induced angiogenesis

21 January 2018

1 reference

Receptor tyrosine kinase EphA2 mediates thrombin-induced upregulation of ICAM-1 in endothelial cells in vitro

21 January 2018

1 reference

EphA2 activation promotes the endothelial cell inflammatory response: a potential role in atherosclerosis

21 January 2018

1 reference

Overexpression of EPHA2 receptor destabilizes adherens junctions via a RhoA-dependent mechanism.

21 January 2018

1 reference

Inactivation of EphA2 promotes tight junction formation and impairs angiogenesis in brain endothelial cells

21 January 2018

1 reference

Evidence that the EphA2 receptor exacerbates ischemic brain injury

21 January 2018

1 reference

Upregulation of EphA2 during in vivo and in vitro renal ischemia-reperfusion injury: role of Src kinases.

21 January 2018

1 reference

EphA2 receptor mediates increased vascular permeability in lung injury due to viral infection and hypoxia

21 January 2018

1 reference

Eph receptors and ephrin ligands. essential mediators of vascular development.

21 January 2018

1 reference

Ephrin-B2 regulates endothelial cell morphology and motility independently of Eph-receptor binding.

21 January 2018

1 reference

Involvement of endothelial ephrin-B2 in adhesion and transmigration of EphB-receptor-expressing monocytes

21 January 2018

1 reference

Ephrin-B2 ligand is a functional receptor for Hendra virus and Nipah virus

21 January 2018

1 reference

The platelet P2Y12 receptor contributes to granule secretion through Ephrin A4 receptor

21 January 2018

1 reference

Enhancement of lymphocyte migration and cytokine production by ephrinB1 system in rheumatoid arthritis

21 January 2018

1 reference

Expression of Eph receptors and their ligands, ephrins, during lipopolysaccharide fever in rats

21 January 2018

1 reference

Expression profiling of the ephrin (EFN) and Eph receptor (EPH) family of genes in atherosclerosis-related human cells.

21 January 2018

1 reference

Eph/ephrin signaling in epidermal differentiation and disease

21 January 2018

1 reference

EphrinB2 regulation by PTH and PTHrP revealed by molecular profiling in differentiating osteoblasts

21 January 2018

1 reference

Activation of the receptor EphB4 by its specific ligand ephrin B2 in human osteoarthritic subchondral bone osteoblasts.

21 January 2018

1 reference

Critical role of the axonal guidance cue EphrinB2 in lung growth, angiogenesis, and repair.

21 January 2018

1 reference

A relative signalling model for the formation of a topographic neural map.

21 January 2018

1 reference

Bidirectional Eph-ephrin signaling during axon guidance

21 January 2018

1 reference

Cell-specific information processing in segregating populations of Eph receptor ephrin-expressing cells

21 January 2018

1 reference

Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans

21 January 2018

1 reference

Cytoplasmic relaxation of active Eph controls ephrin shedding by ADAM10

21 January 2018

1 reference

Eph receptor function is modulated by heterooligomerization of A and B type Eph receptors

21 January 2018

1 reference

PTP1B regulates Eph receptor function and trafficking

21 January 2018

1 reference

Regulation of EphB2 activation and cell repulsion by feedback control of the MAPK pathway

21 January 2018

1 reference

Eph receptors are negatively controlled by protein tyrosine phosphatase receptor type O.

21 January 2018

1 reference

Regulated cleavage of a contact-mediated axon repellent

21 January 2018

1 reference

Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signaling

21 January 2018

1 reference

Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligands

21 January 2018

1 reference

EphB3 is overexpressed in non-small-cell lung cancer and promotes tumor metastasis by enhancing cell survival and migration

21 January 2018

1 reference

PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature

21 January 2018

1 reference

Ephrin-B1 regulates axon guidance by reverse signaling through a PDZ-dependent mechanism

21 January 2018

1 reference

EphrinA5 acts as a tumor suppressor in glioma by negative regulation of epidermal growth factor receptor

21 January 2018

1 reference

EphrinA5 suppresses colon cancer development by negatively regulating epidermal growth factor receptor stability

21 January 2018

1 reference

The SH2/SH3 adaptor Grb4 transduces B-ephrin reverse signals

21 January 2018

1 reference

Ephrin-B3 reverse signaling through Grb4 and cytoskeletal regulators mediates axon pruning

21 January 2018

1 reference

ephrinB1 signals from the cell surface to the nucleus by recruitment of STAT3.

21 January 2018

1 reference

Ephrin-B reverse signaling is mediated by a novel PDZ-RGS protein and selectively inhibits G protein-coupled chemoattraction

21 January 2018

1 reference

p75(NTR) mediates ephrin-A reverse signaling required for axon repulsion and mapping

21 January 2018

1 reference

Manipulation of EphB2 regulatory motifs and SH2 binding sites switches MAPK signaling and biological activity

21 January 2018

1 reference

Cell adhesion and EGFR activation regulate EphA2 expression in cancer

21 January 2018

1 reference

Eph and NMDA receptors control Ca2+/calmodulin-dependent protein kinase II activation during C. elegans oocyte meiotic maturation.

21 January 2018

1 reference

Ephrin-B2 controls cell motility and adhesion during blood-vessel-wall assembly

21 January 2018

1 reference

PSGL-1-mediated activation of EphB4 increases the proangiogenic potential of endothelial progenitor cells

21 January 2018

1 reference

The Notch1-Dll4 signaling pathway regulates mouse postnatal lymphatic development

21 January 2018

1 reference

A critical role for the EphA3 receptor tyrosine kinase in heart development

21 January 2018

1 reference

Regulation of heart valve morphogenesis by Eph receptor ligand, ephrin-A1

21 January 2018

1 reference

Capillary defects and exaggerated inflammatory response in the airways of EphA2-deficient mice

21 January 2018

1 reference

Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity

21 January 2018

1 reference

Disruption of Eph/ephrin signaling affects migration and proliferation in the adult subventricular zone.

21 January 2018

1 reference

Crystal structure of an Eph receptor-ephrin complex

21 January 2018

1 reference

An extracellular steric seeding mechanism for Eph-ephrin signaling platform assembly

21 January 2018

1 reference

Architecture of Eph receptor clusters

21 January 2018

1 reference

Structural and functional characterization of an agonistic anti-human EphA2 monoclonal antibody

21 January 2018

1 reference

Vaccines targeting tumor blood vessel antigens promote CD8(+) T cell-dependent tumor eradication or dormancy in HLA-A2 transgenic mice

21 January 2018

1 reference

Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis

21 January 2018

1 reference

EphrinA1-induced cytoskeletal re-organization requires FAK and p130(cas).

21 January 2018

1 reference

EphB receptors coordinate migration and proliferation in the intestinal stem cell niche

31 March 2020

1 reference

Impaired tumor microenvironment in EphA2-deficient mice inhibits tumor angiogenesis and metastatic progression

31 March 2020

1 reference

Clinicopathological significance and prognostic value of EphA3 and CD133 expression in colorectal carcinoma

31 March 2020

1 reference

Dendritic cell-based vaccines suppress metastatic liver tumor via activation of local innate and acquired immunity

31 March 2020

1 reference

In vivo small-animal PET/CT of EphB4 receptors using 64Cu-labeled peptide

31 March 2020

1 reference

Early changes in hippocampal Eph receptors precede the onset of memory decline in mouse models of Alzheimer's disease.

31 March 2020

1 reference

Ephrin-B2 and EphB2 regulation of astrocyte-meningeal fibroblast interactions in response to spinal cord lesions in adult rats.

31 March 2020

1 reference

Replication study of 10 genes showing evidence for association with multiple sclerosis: validation of TMEM39A, IL12B and CLBL genes

31 March 2020

1 reference

The Eph/ephrinB signal balance determines the pattern of T-cell maturation in the thymus

31 March 2020

1 reference

Intramyocardial administration of chimeric ephrinA1-Fc promotes tissue salvage following myocardial infarction in mice

31 March 2020

1 reference

EphrinB2 is the entry receptor for Nipah virus, an emergent deadly paramyxovirus

31 March 2020

1 reference

Hypoxia up-regulates expression of Eph receptors and ephrins in mouse skin

31 March 2020

1 reference

How attraction turns to repulsion

31 March 2020

1 reference

EphA2 promotes epithelial-mesenchymal transition through the Wnt/β-catenin pathway in gastric cancer cells

31 March 2020

1 reference

Functional ephrin-B2 expression for promotive interaction between arterial and venous vessels in postnatal neovascularization

31 March 2020

1 reference

Modulation of ephrinB2 leads to increased angiogenesis in ischemic myocardium and endothelial cell proliferation

31 March 2020

1 reference

Ephrin-B1 is a novel specific component of the lateral membrane of the cardiomyocyte and is essential for the stability of cardiac tissue architecture cohesion

31 March 2020

1 reference

EphrinA1 inactivates integrin-mediated vascular smooth muscle cell spreading via the Rac/PAK pathway

31 March 2020

1 reference

12 December 2020

Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3-expressing 293T and melanoma cells by CrkII and Rho-mediated signalling

1 reference

12 December 2020

Isolation and characterization of a novel receptor-type protein tyrosine kinase (hek) from a human pre-B cell line

1 reference

12 December 2020

Kinase independent function of EphB receptors in retinal axon pathfinding to the optic disc from dorsal but not ventral retina.

1 reference

12 December 2020

Identification of a tumor-specific shared antigen derived from an Eph receptor and presented to CD4 T cells on HLA class II molecules

1 reference

12 December 2020

Growth factor receptors in hematopoietic stem cells: EPH family expression in CD34+ and CD133+ cell populations from mobilized peripheral blood.

1 reference

12 December 2020

Ephrins negatively regulate cell proliferation in the epidermis and hair follicle

1 reference

12 December 2020

Antibody targeting of the EphA2 tyrosine kinase inhibits malignant cell behavior

1 reference

12 December 2020

EphB3 limits the expansion of neural progenitor cells in the subventricular zone by regulating p53 during homeostasis and following traumatic brain injury

1 reference

12 December 2020

Cloning and characterization of EphA3 (Hek) gene promoter: DNA methylation regulates expression in hematopoietic tumor cells.

1 reference

12 December 2020

The Eck receptor tyrosine kinase is implicated in pattern formation during gastrulation, hindbrain segmentation and limb development

1 reference

12 December 2020

EphA2 overexpression causes tumorigenesis of mammary epithelial cells.

1 reference

12 December 2020

c-Cbl-dependent EphA2 protein degradation is induced by ligand binding.

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRD4175

1 reference

30 August 2017

1 reference

PubMed ID

24378802