(Q38175079)

30 August 2017

title

New assays and approaches for discovery and design of Sirtuin modulators (English)

1 reference

30 August 2017

Mike Schutkowski

1

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Clemens Steegborn

series ordinal

4

object named as

Clemens Steegborn

1 reference

30 August 2017

Frank Fischer

2

1 reference

30 August 2017

Claudia Roessler

series ordinal

3

1 reference

30 August 2017

language of work or name

English

0 references

publication date

2 January 2014

1 reference

Expert Opinion on Drug Discovery

30 August 2017

published in

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30 August 2017

volume

9

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30 August 2017

issue

2

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30 August 2017

page(s)

183-199

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Cell biology. Rise of the rival

30 August 2017

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Lysine acetylation targets protein complexes and co-regulates major cellular functions

21 January 2018

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Unstructured conformations are a substrate requirement for the Sir2 family of NAD-dependent protein deacetylases

21 January 2018

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21 January 2018

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Silent information regulator 2 family of NAD- dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose

21 January 2018

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Structural identification of 2'- and 3'-O-acetyl-ADP-ribose as novel metabolites derived from the Sir2 family of beta -NAD+-dependent histone/protein deacetylases

21 January 2018

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Use of substrate analogs and mutagenesis to study substrate binding and catalysis in the Sir2 family of NAD-dependent protein deacetylases

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.875526

Microplate filtration assay for nicotinamide release from NAD using a boronic acid resin

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.875526

Improvement and validation of the fluorescence-based histone deacetylase assay using an internal standard

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.875526

Identification of a small molecule inhibitor of Sir2p

21 January 2018

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Negative control of p53 by Sir2alpha promotes cell survival under stress

21 January 2018

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Activation of the protein deacetylase SIRT6 by long-chain fatty acids and widespread deacylation by mammalian sirtuins

21 January 2018

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Substrate specificity and kinetic mechanism of the Sir2 family of NAD+-dependent histone/protein deacetylases

21 January 2018

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A non-isotopic assay for histone deacetylase activity

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.875526

A fluorometric assay of SIRT1 deacetylation activity through quantification of nicotinamide adenine dinucleotide

21 January 2018

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SIRT1 top 40 hits: use of one-bead, one-compound acetyl-peptide libraries and quantum dots to probe deacetylase specificity

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.875526

Biotinylation of lysine method identifies acetylated histone H3 lysine 79 in Saccharomyces cerevisiae as a substrate for Sir2

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.875526

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways

21 January 2018

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SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle

21 January 2018

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Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5

21 January 2018

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Peptide microarrays for profiling of modification state-specific antibodies

21 January 2018

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SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.875526

Structure-based development of novel sirtuin inhibitors

21 January 2018

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Measurement of the cellular deacetylase activity of SIRT1 on p53 via LanthaScreen® technology

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.875526

TR-FRET cellular assays for interrogating posttranslational modifications of histone H3.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.875526

Sirt5 deacylation activities show differential sensitivities to nicotinamide inhibition

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.875526

Advances in label-free screening approaches for studying sirtuin-mediated deacetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.875526

Sirtuin 3 (SIRT3) protein regulates long-chain acyl-CoA dehydrogenase by deacetylating conserved lysines near the active site

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.875526

A continuous microplate assay for sirtuins and nicotinamide-producing enzymes

21 January 2018

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Substrate-specific activation of sirtuins by resveratrol

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.875526

A fluorogenic assay for screening Sirt6 modulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.875526

Kinetics and comparative reactivity of human class I and class IIb histone deacetylases

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.875526

A bioluminogenic HDAC activity assay: validation and screening.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.875526

N-lysine propionylation controls the activity of propionyl-CoA synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.875526

Lysine propionylation and butyrylation are novel post-translational modifications in histones

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.875526

The 31-kDa precursor of interleukin 1 alpha is myristoylated on specific lysines within the 16-kDa N-terminal propiece

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.875526

The sirtuin SIRT6 deacetylates H3 K56Ac in vivo to promote genomic stability

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.875526

Acetyl-phosphate is a critical determinant of lysine acetylation in E. coli.

21 January 2018

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Acetylation regulates Cyclophilin A catalysis, immunosuppression and HIV isomerization

21 January 2018

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Therapeutic potential of resveratrol: the in vivo evidence

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.875526

Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.875526

Sirtuin mechanism and inhibition: explored with N(ε)-acetyl-lysine analogs

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.875526

Site-specific introduction of an acetyl-lysine mimic into peptides and proteins by cysteine alkylation.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.875526

Inhibition of human sirtuins by in situ generation of an acetylated lysine-ADP-ribose conjugate.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.875526

Mechanism-based inhibition of Sir2 deacetylases by thioacetyl-lysine peptide

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.875526

Biochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.875526

Structures of human sirtuin 3 complexes with ADP-ribose and with carba-NAD+ and SRT1720: binding details and inhibition mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.875526

Crystal structure analysis of human Sirt2 and its ADP-ribose complex

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.875526

Mechanism of human SIRT1 activation by resveratrol

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.875526

Molecular architecture of the human protein deacetylase Sirt1 and its regulation by AROS and resveratrol

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.875526

Crystal structures of Sirt3 complexes with 4'-bromo-resveratrol reveal binding sites and inhibition mechanism

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.875526

Dietary restriction: standing up for sirtuins

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.875526

Synthesis of carba-NAD and the structures of its ternary complexes with SIRT3 and SIRT5

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.875526

NMR Profiling of Histone Deacetylase and Acetyl-transferase Activities in Real Time

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.875526

Structure-activity studies on suramin analogues as inhibitors of NAD+-dependent histone deacetylases (sirtuins)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.875526

10.1517/17460441.2014.875526

21 January 2018

Identifiers

DOI

1 reference

30 August 2017

1 reference