(Q38175498)

30 August 2017

title

Nuclease-mediated genome editing: At the front-line of functional genomics technology (English)

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30 August 2017

0 references

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1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24387662%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Knut Woltjen

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24387662%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

author name string

Tetsushi Sakuma

series ordinal

1

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30 August 2017

Knut Woltjen

series ordinal

2

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30 August 2017

language of work or name

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5 January 2014

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Development, Growth and Differentiation

30 August 2017

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24387662%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

volume

56

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24387662%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

issue

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24387662%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

page(s)

2-13

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24387662%20AND%20SRC:MED&resulttype=core&format=json

ENU mutagenesis, a way forward to understand gene function

13 June 2020

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Heritable and precise zebrafish genome editing using a CRISPR-Cas system

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Efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system

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A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

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Modeling human epilepsy by TALEN targeting of mouse sodium channel Scn8a

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TALENs: a widely applicable technology for targeted genome editing

21 January 2018

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Efficient targeted mutagenesis of the chordate Ciona intestinalis genome with zinc-finger nucleases.

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Surrogate reporters for enrichment of cells with nuclease-induced mutations

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Hybrid restriction enzymes: zinc finger fusions to Fok I cleavage domain

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Monomeric site-specific nucleases for genome editing

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Cerebral organoids model human brain development and microcephaly

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Targeted chromosomal duplications and inversions in the human genome using zinc finger nucleases

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Simultaneous generation and germline transmission of multiple gene mutations in rat using CRISPR-Cas systems.

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piggyBac transposase tools for genome engineering

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Efficient and specific modifications of the Drosophila genome by means of an easy TALEN strategy.

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Precise and heritable genome editing in evolutionarily diverse nematodes using TALENs and CRISPR/Cas9 to engineer insertions and deletions

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Highly efficient and specific genome editing in silkworm using custom TALENs

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Robust, synergistic regulation of human gene expression using TALE activators

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RNA-guided human genome engineering via Cas9

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Generation of knockout rats with X-linked severe combined immunodeficiency (X-SCID) using zinc-finger nucleases

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Efficient gene targeting by TAL effector nucleases coinjected with exonucleases in zygotes

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Targeted gene inactivation in zebrafish using engineered zinc-finger nucleases

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Generation of Rag1-knockout immunodeficient rats and mice using engineered meganucleases

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Efficient targeted mutagenesis in the monarch butterfly using zinc-finger nucleases

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Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases

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TALE nucleases: tailored genome engineering made easy

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Screening methods to identify TALEN-mediated knockout mice

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Zinc-finger nuclease-mediated targeted insertion of reporter genes for quantitative imaging of gene expression in sea urchin embryos.

21 January 2018

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Reading frame correction by targeted genome editing restores dystrophin expression in cells from Duchenne muscular dystrophy patients.

21 January 2018

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Efficient identification of TALEN-mediated genome modifications using heteroduplex mobility assays.

21 January 2018

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High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity

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21 January 2018

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Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases

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21 January 2018

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Cancer translocations in human cells induced by zinc finger and TALE nucleases

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21 January 2018

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Engineered zinc finger nickases induce homology-directed repair with reduced mutagenic effects

21 January 2018

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Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity

21 January 2018

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Genome engineering using the CRISPR-Cas9 system

21 January 2018

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A protocol describing the genetic correction of somatic human cells and subsequent generation of iPS cells.

21 January 2018

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21 January 2018

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Targeted mutagenesis of multiple and paralogous genes in Xenopus laevis using two pairs of transcription activator-like effector nucleases.

21 January 2018

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Efficient TALEN construction and evaluation methods for human cell and animal applications.

21 January 2018

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Repeating pattern of non-RVD variations in DNA-binding modules enhances TALEN activity.

21 January 2018

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Regulation of gene expression in Arabidopsis thaliana by artificial zinc finger chimeras

21 January 2018

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ZiFiT (Zinc Finger Targeter): an updated zinc finger engineering tool

21 January 2018

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Targeted mutagenesis in the malaria mosquito using TALE nucleases

21 January 2018

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Gene-trap mutagenesis: past, present and beyond

21 January 2018

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Versatile strategy for isolating transcription activator-like effector nuclease-mediated knockout mutants in Caenorhabditis elegans

21 January 2018

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High efficiency TALENs enable F0 functional analysis by targeted gene disruption in Xenopus laevis embryos

21 January 2018

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Efficient nonmeiotic allele introgression in livestock using custom endonucleases

21 January 2018

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Knockout rats generated by embryo microinjection of TALENs.

21 January 2018

1 reference

Diseases in a dish: modeling human genetic disorders using induced pluripotent cells

21 January 2018

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Use of zinc-finger nucleases to knock out the WAS gene in K562 cells: a human cellular model for Wiskott-Aldrich syndrome

21 January 2018

1 reference

Transcription activator-like effector proteins induce the expression of the frataxin gene

21 January 2018

1 reference

Genome editing with engineered zinc finger nucleases

21 January 2018

1 reference

Highly efficient endogenous human gene correction using designed zinc-finger nucleases

21 January 2018

1 reference

Plant genome engineering with sequence-specific nucleases

21 January 2018

1 reference

One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering

21 January 2018

1 reference

Targeted gene addition to a predetermined site in the human genome using a ZFN-based nicking enzyme

21 January 2018

1 reference

Non-transgenic genome modifications in a hemimetabolous insect using zinc-finger and TAL effector nucleases

21 January 2018

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Direct production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides

21 January 2018

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Targeted genome editing across species using ZFNs and TALENs

21 January 2018

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Standardized reagents and protocols for engineering zinc finger nucleases by modular assembly.

21 January 2018

1 reference

EENdb: a database and knowledge base of ZFNs and TALENs for endonuclease engineering

21 January 2018

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Chromosomal deletions and inversions mediated by TALENs and CRISPR/Cas in zebrafish.

21 January 2018

1 reference

Optimized regulation of gene expression using artificial transcription factors

21 January 2018

1 reference

One-step generation of mice carrying reporter and conditional alleles by CRISPR/Cas-mediated genome engineering

21 January 2018

1 reference

Efficient targeted gene disruption in the soma and germ line of the frog Xenopus tropicalis using engineered zinc-finger nucleases.

21 January 2018

1 reference

Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon

21 January 2018

1 reference

TALEN-mediated precise genome modification by homologous recombination in zebrafish.

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1111/DGD.12111

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24387662%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

1 reference