(Q38182480)

1 July 2019

title

Manganese in health and disease. (English)

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1 July 2019

3

Michael Aschner

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1 July 2019

author name string

Daiana Silva Avila

series ordinal

1

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1 July 2019

Robson Luiz Puntel

series ordinal

2

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1 July 2019

publication date

1 January 2013

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1 July 2019

Metal ions in life sciences

published in

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1 July 2019

volume

13

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1 July 2019

page(s)

199-227

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1 July 2019

The regulation of mineral absorption in the gastrointestinal tract

cites work

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12 December 2020

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12 December 2020

Manganese uptake and distribution in the central nervous system (CNS).

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12 December 2020

Nutritional aspects of manganese from experimental studies.

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12 December 2020

Manganese neurotoxicity: a review of clinical features, imaging and pathology.

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12 December 2020

Long-term exposure to "low levels" of manganese oxides and neurofunctional changes in ferroalloy workers.

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12 December 2020

Animal models of manganese's neurotoxicity

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12 December 2020

Manganese and calcium transport in mitochondria: implications for manganese toxicity

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12 December 2020

Manganese deficiency and toxicity: are high or low dietary amounts of manganese cause for concern?

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12 December 2020

Hepatic encephalopathy: An update of pathophysiologic mechanisms

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12 December 2020

Arginase: a binuclear manganese metalloenzyme.

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12 December 2020

A novel mammalian iron-regulated protein involved in intracellular iron metabolism

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12 December 2020

Manganese: brain transport and emerging research needs

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12 December 2020

Brain manganese deposition and blood levels in patients undergoing home parenteral nutrition

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12 December 2020

The molecular defect in hypotransferrinemic mice

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12 December 2020

Identification of binding sites on protein targeting to glycogen for enzymes of glycogen metabolism.

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12 December 2020

The neurobehavioral effects of subchronic manganese exposure in the presence and absence of pre-parkinsonism

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12 December 2020

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12 December 2020

Calcium sequestering ability of mitochondria modulates influx of calcium through glutamate receptor channel.

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12 December 2020

Selective vulnerability of pallidal neurons in the early phases of manganese intoxication.

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12 December 2020

Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c.

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12 December 2020

Properties of the mammalian and yeast metal-ion transporters DCT1 and Smf1p expressed in Xenopus laevis oocytes.

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12 December 2020

Influence of dietary manganese on the pharmacokinetics of inhaled manganese sulfate in male CD rats.

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12 December 2020

Effects of an inhibitor of poly(ADP-ribose) polymerase, desmethylselegiline, trientine, and lipoic acid in transgenic ALS mice.

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12 December 2020

Dietary reference intakes: vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc

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12 December 2020

Bioaccumulation and locomotor effect of manganese dust in rats.

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12 December 2020

Calcium: the Darth Vader of ALS.

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12 December 2020

Manganese toxicity is associated with mitochondrial dysfunction and DNA fragmentation in rat primary striatal neurons

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12 December 2020

Mutation screening of manganese superoxide dismutase in amyotrophic lateral sclerosis

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12 December 2020

Modulation of oxidative events by multivalent manganese complexes in brain tissue

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12 December 2020

Inhibition of the rat blood-brain barrier choline transporter by manganese chloride

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12 December 2020

Functional expression in yeast of the human secretory pathway Ca(2+), Mn(2+)-ATPase defective in Hailey-Hailey disease

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12 December 2020

Cloning and functional expression of human short TRP7, a candidate protein for store-operated Ca2+ influx.

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12 December 2020

Oxidative stress involves in astrocytic alterations induced by manganese

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12 December 2020

Myoclonic involuntary movement associated with chronic manganese poisoning

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12 December 2020

Astrocytes and manganese neurotoxicity

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12 December 2020

Low cumulative manganese exposure affects striatal GABA but not dopamine

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12 December 2020

Overexpression of Alzheimer's disease amyloid-beta opposes the age-dependent elevations of brain copper and iron.

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12 December 2020

Molecular physiology of P2X receptors

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12 December 2020

Glutamate/aspartate transporter (GLAST), taurine transporter and metallothionein mRNA levels are differentially altered in astrocytes exposed to manganese chloride, manganese phosphate or manganese sulfate

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12 December 2020

Manganese causes differential regulation of glutamate transporter (GLAST) taurine transporter and metallothionein in cultured rat astrocytes

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12 December 2020

Manganese action in brain function

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12 December 2020

Manganese distribution across the blood-brain barrier. I. Evidence for carrier-mediated influx of managanese citrate as well as manganese and manganese transferrin

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12 December 2020

DMT1: a mammalian transporter for multiple metals

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12 December 2020

Manganese neurotoxicity: an update of pathophysiologic mechanisms

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12 December 2020

Manganese neurotoxicity and glutamate-GABA interaction

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12 December 2020

Energy metabolism in astrocytes and neurons treated with manganese: relation among cell-specific energy failure, glucose metabolism, and intercellular trafficking using multinuclear NMR-spectroscopic analysis

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12 December 2020

Oxidation of dopamine to aminochrome as a mechanism for neurodegeneration of dopaminergic systems in Parkinson's disease. Possible neuroprotective role of DT-diaphorase

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12 December 2020

Early-onset Parkinson's disease caused by a compound heterozygous DJ-1 mutation

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12 December 2020

Dietary manganese intake and type of lipid do not affect clinical or neuropsychological measures in healthy young women

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12 December 2020

EXPERIMENTAL MANGANESE ENCEPHALOPATHY IN MONKEYS. A PRELIMINARY REPORT

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12 December 2020

THE ENERGY-LINKED REACTION OF CALCIUM WITH MITOCHONDRIA

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12 December 2020

Localization of iron metabolism–related mRNAs in rat liver indicate that HFE is expressed predominantly in hepatocytes

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12 December 2020

In vitro effect of manganese chloride exposure on reactive oxygen species generation and respiratory chain complexes activities of mitochondria isolated from rat brain

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12 December 2020

The nervous system effects of occupational exposure on workers in a South African manganese smelter

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12 December 2020

Dopamine transporter binding in chronic manganese intoxication

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12 December 2020

DJ-1 has a role in antioxidative stress to prevent cell death

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12 December 2020

Expression of the iron transporter ferroportin in synaptic vesicles and the blood-brain barrier

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12 December 2020

Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset

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12 December 2020

Manganese distribution across the blood-brain barrier III. The divalent metal transporter-1 is not the major mechanism mediating brain manganese uptake.

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12 December 2020

Manganese neurotoxicity

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12 December 2020

Manganese-induced parkinsonism and Parkinson's disease

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12 December 2020

Manganese induces the mitochondrial permeability transition in cultured astrocytes

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12 December 2020

The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization

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12 December 2020

Manganese-induced cytotoxicity in dopamine-producing cells

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12 December 2020

Parkin attenuates manganese-induced dopaminergic cell death

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12 December 2020

Nasal toxicity of manganese sulfate and manganese phosphate in young male rats following subchronic (13-week) inhalation exposure

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12 December 2020

P2Y receptor-mediated Ca(2+) signaling increases human vascular endothelial cell permeability

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12 December 2020

Immunolocalization and regulation of iron handling proteins ferritin and ferroportin in the retina

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12 December 2020

Amyotrophic lateral sclerosis (ALS): a phylogenetic disease of the corticomotoneuron?

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12 December 2020

Enhanced autoxidation of dopamine as a possible basis of manganese neurotoxicity

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12 December 2020

[18F]FDOPA PET and clinical features in parkinsonism due to manganism

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12 December 2020

Manganese dosimetry: species differences and implications for neurotoxicity

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12 December 2020

Manganese oxidation state mediates toxicity in PC12 cells

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12 December 2020

Expression of P2X receptors in rat choroid plexus

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12 December 2020

Manganese distribution across the blood-brain barrier. IV. Evidence for brain influx through store-operated calcium channels.

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12 December 2020

Manganese transport by rat brain endothelial (RBE4) cell-based transwell model in the presence of astrocyte conditioned media

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12 December 2020

Prevalence and incidence of Parkinson's disease in Europe

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12 December 2020

History of genetic disease: the molecular genetics of Huntington disease - a history

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12 December 2020

LRRK2 gene in Parkinson disease: Mutation analysis and case control association study

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12 December 2020

Characteristics of manganese (Mn) transport in rat brain endothelial (RBE4) cells, an in vitro model of the blood-brain barrier

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12 December 2020

Excitotoxicity and ALS: what is unique about the AMPA receptors expressed on spinal motor neurons?

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12 December 2020

The crucial role of metal ions in neurodegeneration: the basis for a promising therapeutic strategy

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12 December 2020

Mn2+ sequestration by mitochondria and inhibition of oxidative phosphorylation

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12 December 2020

Acute manganese administration alters dopamine transporter levels in the non-human primate striatum

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12 December 2020

Manganese exposure: neuropsychological and neurological symptoms and effects in welders.

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12 December 2020

The diagnosis of Parkinson's disease

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12 December 2020

Postnatal manganese exposure attenuates cocaine-induced locomotor activity and reduces dopamine transporters in adult male rats

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12 December 2020

ZIP8, member of the solute-carrier-39 (SLC39) metal-transporter family: characterization of transporter properties

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12 December 2020

Reduction in mitochondrial superoxide dismutase modulates Alzheimer's disease-like pathology and accelerates the onset of behavioral changes in human amyloid precursor protein transgenic mice.

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12 December 2020

A manganese-enhanced diet alters brain metals and transporters in the developing rat.

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12 December 2020

Speciation of manganese in cells and mitochondria: a search for the proximal cause of manganese neurotoxicity

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12 December 2020

Effective treatment of manganese-induced occupational Parkinsonism with p-aminosalicylic acid: a case of 17-year follow-up study

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12 December 2020

Activation of superoxide dismutases: putting the metal to the pedal

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12 December 2020

Arginase 1 regulation of nitric oxide production is key to survival of trophic factor-deprived motor neurons

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12 December 2020

Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase

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12 December 2020

Manganese neurotoxicity: a focus on the neonate

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12 December 2020

Olfactory uptake of manganese requires DMT1 and is enhanced by anemia

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12 December 2020

Selective enrichment of DJ-1 protein in primate striatal neuronal processes: implications for Parkinson's disease

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12 December 2020

Manganese: pharmacokinetics and molecular mechanisms of brain uptake

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12 December 2020

Newly identified iron-binding protein in human duodenal mucosa

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12 December 2020

Manganese uptake and efflux in cultured rat astrocytes

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12 December 2020

Assessment of the permissible exposure level to manganese in workers exposed to manganese dioxide dust

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12 December 2020

Manganese inhalation by rhesus monkeys is associated with brain regional changes in biomarkers of neurotoxicity.

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12 December 2020

Inhibition of DAT function attenuates manganese accumulation in the globus pallidus

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12 December 2020

Manganese induces cell swelling in cultured astrocytes.

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12 December 2020

Manganese: recent advances in understanding its transport and neurotoxicity

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12 December 2020

Manganese induces oxidative impairment in cultured rat astrocytes.

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12 December 2020

Putative proteins involved in manganese transport across the blood-brain barrier

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12 December 2020

Iron absorption by Belgrade rat pups during lactation

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12 December 2020

High prevalence of Parkinsonian disorders associated to manganese exposure in the vicinities of ferroalloy industries

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12 December 2020

Sub-cellular localization of manganese in the basal ganglia of normal and manganese-treated rats An electron spectroscopy imaging and electron energy-loss spectroscopy study

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12 December 2020

Proposed cycles for functional glutamate trafficking in synaptic neurotransmission

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12 December 2020

Glutamate and astrocytes--key players in human mesial temporal lobe epilepsy?

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12 December 2020

Measuring brain manganese and iron accumulation in rats following 14 weeks of low-dose manganese treatment using atomic absorption spectroscopy and magnetic resonance imaging

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12 December 2020

Transgenic mice overexpressing tyrosine-to-cysteine mutant human alpha-synuclein: a progressive neurodegenerative model of diffuse Lewy body disease

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12 December 2020

Pharmacokinetic Modeling of Manganese in the Rat IV: Assessing Factors that Contribute to Brain Accumulation During Inhalation Exposure

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12 December 2020

Mitochondrial-dependent manganese neurotoxicity in rat primary astrocyte cultures

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12 December 2020

Parkinson's disease: clinical features and diagnosis

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12 December 2020

Manganese accumulates primarily in nuclei of cultured brain cells

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12 December 2020

T2* and FSE MRI distinguishes four subtypes of neurodegeneration with brain iron accumulation

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12 December 2020

Direct effects of manganese compounds on dopamine and its metabolite Dopac: an in vitro study

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12 December 2020

Postnatal manganese exposure alters dopamine transporter function in adult rats: Potential impact on nonassociative and associative processes

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12 December 2020

Saturable Transport of Manganese(II) Across the Rat Blood-Brain Barrier

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12 December 2020

Huntingtin-interacting proteins, HIP14 and HIP14L, mediate dual functions, palmitoyl acyltransferase and Mg2+ transport

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12 December 2020

Reciprocal modulation of function between the D1 and D2 dopamine receptors and the Na+,K+-ATPase

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12 December 2020

Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease

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12 December 2020

Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity

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12 December 2020

Copper complexes as anticancer agents

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12 December 2020

Manganese disrupts astrocyte glutamine transporter expression and function

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12 December 2020

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12 December 2020

Manganese-induced dopaminergic neurodegeneration: insights into mechanisms and genetics shared with Parkinson's disease

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12 December 2020

Manganese neurotoxicity: cellular effects and blood-brain barrier transport

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12 December 2020

Manganese and its role in Parkinson's disease: from transport to neuropathology

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12 December 2020

Intracellular Ca2+- and Mn2+-transport ATPases

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12 December 2020

Are there common biochemical and molecular mechanisms controlling manganism and parkisonism

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12 December 2020

Disease-toxicant screen reveals a neuroprotective interaction between Huntington's disease and manganese exposure

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12 December 2020

Ferroportin is a manganese-responsive protein that decreases manganese cytotoxicity and accumulation

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12 December 2020

Effects of MK-801, taurine and dextromethorphan on neurotoxicity caused by manganese in rats

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12 December 2020

Parkin regulates metal transport via proteasomal degradation of the 1B isoforms of divalent metal transporter 1.

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12 December 2020

Manganese and Parkinson's disease: a critical review and new findings

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12 December 2020

Altered manganese homeostasis and manganese toxicity in a Huntington's disease striatal cell model are not explained by defects in the iron transport system.

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12 December 2020

The G2019S pathogenic mutation disrupts sensitivity of leucine-rich repeat kinase 2 to manganese kinase inhibition

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12 December 2020

Induction of FPN1 transcription by MTF-1 reveals a role for ferroportin in transition metal efflux

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12 December 2020

Mitochondrial dysfunction and loss of Parkinson's disease-linked proteins contribute to neurotoxicity of manganese-containing welding fumes

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12 December 2020

Extracellular dopamine potentiates mn-induced oxidative stress, lifespan reduction, and dopaminergic neurodegeneration in a BLI-3-dependent manner in Caenorhabditis elegans

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12 December 2020

Manganese encephalopathy: an under-recognized condition in the intensive care unit

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12 December 2020

Identification of a gain-of-function mutation in a Golgi P-type ATPase that enhances Mn2+ efflux and protects against toxicity.

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12 December 2020

Analysis of manganese tracer kinetics and target tissue dosimetry in monkeys and humans with multi-route physiologically based pharmacokinetic models

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12 December 2020

Human iron transporters

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12 December 2020

Manganese-induced NF-kappaB activation and nitrosative stress is decreased by estrogen in juvenile mice

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12 December 2020

Manganese induces oxidative stress, redox state unbalance and disrupts membrane bound ATPases on murine neuroblastoma cells in vitro: protective role of silymarin.

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12 December 2020

Protective effects of antioxidants and anti-inflammatory agents against manganese-induced oxidative damage and neuronal injury

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12 December 2020

Measurement of isoprostanes as markers of oxidative stress

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12 December 2020

Mechanisms by which mitochondria transport calcium

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12 December 2020

Role of manganese in neurodegenerative diseases

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12 December 2020

Protective effect of Melissa officinalis aqueous extract against Mn-induced oxidative stress in chronically exposed mice.

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12 December 2020

Manganese enhanced MRI (MEMRI): neurophysiological applications

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12 December 2020

The inhibitory effect of manganese on acetylcholinesterase activity enhances oxidative stress and neuroinflammation in the rat brain

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12 December 2020

Gene deletion of nos2 protects against manganese-induced neurological dysfunction in juvenile mice

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12 December 2020

The iron transporter ferroportin can also function as a manganese exporter

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12 December 2020

Protective effects of ebselen (Ebs) and para-aminosalicylic acid (PAS) against manganese (Mn)-induced neurotoxicity.

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12 December 2020

Effects of superoxide radicals on transport (Na+K) adenosine triphosphatase and protection by superoxide dismutase

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12 December 2020

Changes in the striatal proteome of YAC128Q mice exhibit gene-environment interactions between mutant huntingtin and manganese

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12 December 2020

Syndrome of hepatic cirrhosis, dystonia, polycythemia, and hypermanganesemia caused by mutations in SLC30A10, a manganese transporter in man

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12 December 2020

Metal transport and homeostasis within the human body: toxicity associated with transport abnormalities

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12 December 2020

Transforming growth factor-α mediates estrogen-induced upregulation of glutamate transporter GLT-1 in rat primary astrocytes

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12 December 2020

Evaluation of manganese uptake and toxicity in mouse brain during continuous MnCl2 administration using osmotic pumps.

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12 December 2020

High levels of Mn²⁺ inhibit secretory pathway Ca²⁺/Mn²⁺-ATPase (SPCA) activity and cause Golgi fragmentation in neurons and glia

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12 December 2020

Genetic risk for Parkinson's disease correlates with alterations in neuronal manganese sensitivity between two human subjects

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12 December 2020

Manganese and calcium efflux kinetics in brain mitochondria. Relevance to manganese toxicity

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12 December 2020

Manganese efflux in Parkinsonism: insights from newly characterized SLC30A10 mutations

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12 December 2020

Manganese-exposed developing rats display motor deficits and striatal oxidative stress that are reversed by Trolox

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12 December 2020

Plasma manganese concentrations in infants and children receiving parenteral nutrition

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12 December 2020

On the mechanism of the Mn3(+)-induced neurotoxicity of dopamine:prevention of quinone-derived oxygen toxicity by DT diaphorase and superoxide dismutase

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12 December 2020

Identification of transferrin as the major plasma carrier protein for manganese introduced orally or intravenously or after in vitro addition in the rat

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12 December 2020

Magnetic resonance imaging studies of the brains of anesthetized rats treated with manganese chloride

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12 December 2020

Selective vulnerability of glutathione metabolism and cellular defense mechanisms in rat striatum to manganese.

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12 December 2020

Manganese-mediated increase in the rat brain mitochondrial cytochrome P-450 and drug metabolism activity: susceptibility of the striatum

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12 December 2020

Manganese poisoning and the attack of trivalent manganese upon catecholamines

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12 December 2020

The biochemical basis of mitochondrial diseases

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12 December 2020

Functions of trace elements in brain metabolism

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12 December 2020

Epidemiological survey among workers exposed to manganese: effects on lung, central nervous system, and some biological indices.

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12 December 2020

The clearance of manganese chloride in the primate

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12 December 2020

Chronic manganese poisoning: a neuropathological study with determination of manganese distribution in the brain

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12 December 2020

Heavy metal concentrations in blood cells in patients with amyotrophic lateral sclerosis

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12 December 2020

Chronic manganese intoxication.

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12 December 2020

Biliary excretion of manganese in rats, rabbits, and dogs

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12 December 2020

Manganous ion as a spin label in studies of mitochondrial uptake of manganese

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12 December 2020

Manganese, copper, and zinc concentrations in serum and packed blood cells during acute hepatitis, chronic hepatitis, and posthepatitic cirrhosis.

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12 December 2020

Chronic manganese poisoning Clearance of tissue manganese concentrations with persistence of the neurological picture

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12 December 2020

Pyruvate carboxylase. VII. A possible role for tightly bound manganese

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12 December 2020

The Discrimination between Magnesium and Manganese by Serum Proteins

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12 December 2020

Manganese neurotoxicity: a model for free radical mediated neurodegeneration?

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12 December 2020

Glutamine Synthetase: The Major Mn(II) Enzyme in Mammalian Brain

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12 December 2020

Manganese and extrapyramidal disorders (a critical review and tribute to Dr. George C. Cotzias).

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12 December 2020

The effect of manganese inhalation on basal ganglia dopamine concentrations in rhesus monkey

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12 December 2020

Pyruvate carboxylase activity in primary cultures of astrocytes and neurons.

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12 December 2020

Alterations in brain dopamine and GABA following inorganic or organic manganese administration.

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12 December 2020

The regional distribution of manganese in the normal human brain

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12 December 2020

Distribution of trace elements in the human body determined by neutron activation analysis

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12 December 2020

Inhibition of high-affinity glutamate transport in neuronal and glial cells by arachidonic acid and oxygen-free radicals. Molecular mechanisms and neuropathological relevance

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12 December 2020

Neurobehavioral effects of manganese in workers from a ferroalloy plant after temporary cessation of exposure.

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12 December 2020

The mitochondrial permeability transition.

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12 December 2020

Rapid brain uptake of manganese(II) across the blood-brain barrier.

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12 December 2020

Trace elements in nutrition for premature infants.

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12 December 2020

Axonal transport of manganese and its relevance to selective neurotoxicity in the rat basal ganglia

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12 December 2020

Essential and toxic element concentrations in fresh and formalin-fixed human autopsy tissues

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12 December 2020

Manganism and idiopathic parkinsonism: similarities and differences

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12 December 2020

Sex affects manganese absorption and retention by humans from a diet adequate in manganese

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12 December 2020

Brain uptake of trace metals, zinc and manganese, in rats.

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12 December 2020

Manganese (Mn) transport across the rat blood-brain barrier: saturable and transferrin-dependent transport mechanisms.

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12 December 2020

Parkinson's disease mortality and the industrial use of heavy metals in Michigan

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12 December 2020

Determination of manganese in human brain samples

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12 December 2020

Biological half-lives of zinc and manganese in rat brain

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12 December 2020

Manganese-induced reactive oxygen species: comparison between Mn+2 and Mn+3

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12 December 2020

Manganese intoxication in the rhesus monkey: a clinical, imaging, pathologic, and biochemical study

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12 December 2020

Distribution of injected iron 59 and manganese 54 in hypotransferrinemic mice.

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12 December 2020

Pallidal lesions in patients with liver cirrhosis: clinical and MRI evaluation.

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12 December 2020

Manganese toxicity, dopaminergic dysfunction and hepatic encephalopathy

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12 December 2020

Increased blood manganese in cirrhotic patients: relationship to pallidal magnetic resonance signal hyperintensity and neurological symptoms

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12 December 2020

Mitochondria and programmed cell death: back to the future.

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12 December 2020

Total diet study: estimated dietary intakes of nutritional elements, 1982-1991.

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12 December 2020

Animal models of ALS.

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12 December 2020

Occupational exposures to metals as risk factors for Parkinson's disease

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12 December 2020

Essential trace element alterations in amyotrophic lateral sclerosis

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12 December 2020

Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene

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12 December 2020

Cloning and characterization of a mammalian proton-coupled metal-ion transporter

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12 December 2020

Manganese metabolism is impaired in the Belgrade laboratory rat.

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12 December 2020

Manganese transport through human erythrocyte membranes. An EPR study

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12 December 2020

Manganese decreases glutamate uptake in cultured astrocytes

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12 December 2020

Structural chemistry and biology of manganese metalloenzymes

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12 December 2020

Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport.

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12 December 2020

Dietary standards for manganese: overlap between nutritional and toxicological studies

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12 December 2020

Diorthosubstituted polychlorinated biphenyls in caudate nucleus in Parkinson's disease.

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12 December 2020

Ammonia and manganese increase arginine uptake in cultured astrocytes.

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12 December 2020

Mitochondria and apoptosis

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12 December 2020

Reduced mitochondrial manganese-superoxide dismutase activity exacerbates glutamate toxicity in cultured mouse cortical neurons

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12 December 2020

10.1007/978-94-007-7500-8_7

Identifiers

DOI

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1 July 2019

PMC publication ID

6589086

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1 July 2019

PubMed publication ID

24470093

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1 July 2019