(Q38182833)

30 August 2017

title

Exploration of liver cancer genomes (English)

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30 August 2017

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2

Hiroyuki Aburatani

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30 August 2017

1

Tatsuhiro Shibata

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30 August 2017

language of work or name

English

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publication date

28 January 2014

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Nature Reviews Gastroenterology & Hepatology

30 August 2017

published in

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30 August 2017

volume

11

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30 August 2017

issue

6

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30 August 2017

page(s)

340-349

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https://scigraph.springernature.com/pub.10.1038/nrgastro.2014.6

30 August 2017

exact match

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An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer

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Identification of a therapeutic strategy targeting amplified FGF19 in liver cancer by Oncogenomic screening

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High-resolution characterization of a hepatocellular carcinoma genome

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Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators

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Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma

21 January 2018

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Mechanisms of HBV-related hepatocarcinogenesis

21 January 2018

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The effects of hepatitis B virus integration into the genomes of hepatocellular carcinoma patients.

21 January 2018

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Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma

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Endogenous retrotransposition activates oncogenic pathways in hepatocellular carcinoma

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Modeling pathogenesis of primary liver cancer in lineage-specific mouse cell types.

21 January 2018

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Epigenetic mechanisms in hepatocellular carcinoma: how environmental factors influence the epigenome

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2014.6

CpG island methylator phenotype in colorectal cancer

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2014.6

DNA methylation in endometrial cancer

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2014.6

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2014.6

Integrated molecular analysis of clear-cell renal cell carcinoma

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2014.6

Review of genetic and epigenetic alterations in hepatocarcinogenesis

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2014.6

CpG island methylator phenotype association with elevated serum alpha-fetoprotein level in hepatocellular carcinoma

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2014.6

TETonic shift: biological roles of TET proteins in DNA demethylation and transcription

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2014.6

Loss of 5-hydroxymethylcytosine is accompanied with malignant cellular transformation

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2014.6

Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas

21 January 2018

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Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma

21 January 2018

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Identification of genes preferentially methylated in hepatitis C virus-related hepatocellular carcinoma

21 January 2018

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Genome-wide DNA methylation profiling using Infinium® assay

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A comparison of the whole genome approach of MeDIP-seq to the targeted approach of the Infinium HumanMethylation450 BeadChip(®) for methylome profiling

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p16 promoter hypermethylation in human hepatocellular carcinoma with or without hepatitis virus infection

21 January 2018

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High frequency of promoter hypermethylation of RASSF1A and p16 and its relationship to aflatoxin B1-DNA adduct levels in human hepatocellular carcinoma

21 January 2018

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Aberrant Promoter Methylation Profiles of Tumor Suppressor Genes in Hepatocellular Carcinoma

21 January 2018

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Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation and its relationship to aflatoxin B1-DNA adducts and p53 mutation in hepatocellular carcinoma

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2014.6

Allelic imbalances and homozygous deletion on 8p23.2 for stepwise progression of hepatocarcinogenesis.

21 January 2018

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Enhanced hepatocarcinogenesis in mouse models and human hepatocellular carcinoma by coordinate KLF6 depletion and increased messenger RNA splicing

21 January 2018

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Impairment of pre-mRNA splicing in liver disease: mechanisms and consequences.

21 January 2018

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Aberrant splicing of Hugl-1 is associated with hepatocellular carcinoma progression

21 January 2018

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Identification of T-cell factor-4 isoforms that contribute to the malignant phenotype of hepatocellular carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2014.6

Amphiregulin induces the alternative splicing of p73 into its oncogenic isoform DeltaEx2p73 in human hepatocellular tumors.

21 January 2018

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Hepatocellular carcinoma: transcriptome diversity regulated by RNA editing

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2014.6

Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2014.6

TP53 mutations and hepatocellular carcinoma: insights into the etiology and pathogenesis of liver cancer

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2014.6

The ATM protein kinase: regulating the cellular response to genotoxic stress, and more

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2014.6

WAF1, a potential mediator of p53 tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2014.6

CpG island methylator phenotype association with upregulated telomerase activity in hepatocellular carcinoma

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2014.6

RB loss abrogates cell cycle control and genome integrity to promote liver tumorigenesis.

21 January 2018

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Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

21 January 2018

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Highly recurrent TERT promoter mutations in human melanoma

21 January 2018

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TERT promoter mutations in familial and sporadic melanoma

21 January 2018

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TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal

21 January 2018

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High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2014.6

Somatic mutations of the beta-catenin gene are frequent in mouse and human hepatocellular carcinomas

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2014.6

AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1

21 January 2018

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Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas

21 January 2018

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Frequent epigenetic inactivation of SFRP genes in hepatocellular carcinoma

21 January 2018

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SOX1 functions as a tumor suppressor by antagonizing the WNT/β-catenin signaling pathway in hepatocellular carcinoma

21 January 2018

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Identification of c-MYC as a target of the APC pathway

21 January 2018

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Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells

21 January 2018

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SWI/SNF chromatin-remodeling factors: multiscale analyses and diverse functions

21 January 2018

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SWI/SNF nucleosome remodellers and cancer.

21 January 2018

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The spectrum of SWI/SNF mutations, ubiquitous in human cancers

21 January 2018

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Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2014.6

MLL targets SET domain methyltransferase activity to Hox gene promoters

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2014.6

Recognition of a mononucleosomal histone modification pattern by BPTF via multivalent interactions

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2014.6

Genomic and genetic characterization of cholangiocarcinoma identifies therapeutic targets for tyrosine kinase inhibitors

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2014.6

Hepatic transforming growth factor beta gives rise to tumor-initiating cells and promotes liver cancer development.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2014.6

Autocrine insulin-like growth factor-II stimulation of tumor cell migration is a progression step in human hepatocarcinogenesis

21 January 2018

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Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution

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21 January 2018

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Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2014.6

Yes-associated protein up-regulates Jagged-1 and activates the Notch pathway in human hepatocellular carcinoma

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2014.6

Notch signaling is activated in human hepatocellular carcinoma and induces tumor formation in mice

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2014.6

Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2014.6

The role of Notch in tumorigenesis: oncogene or tumour suppressor?

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2014.6

Molecular diagnostic algorithms in hepatocellular carcinoma: dead-end street or light at the end of the tunnel?

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2014.6

Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2014.6

Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2014.6

Focal gains of VEGFA and molecular classification of hepatocellular carcinoma

21 January 2018

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Risk factors contributing to early and late phase intrahepatic recurrence of hepatocellular carcinoma after hepatectomy.

21 January 2018

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Gene expression in fixed tissues and outcome in hepatocellular carcinoma.

21 January 2018

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Signatures of mutational processes in human cancer

21 January 2018

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A Hepatocellular Carcinoma 5-Gene Score Associated With Survival of Patients After Liver Resection

21 January 2018

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Isolation and characterization of a novel oncogene, amplified in liver cancer 1, within a commonly amplified region at 1q21 in hepatocellular carcinoma.

21 January 2018

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Identification of driver genes in hepatocellular carcinoma by exome sequencing

31 March 2020

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Exome sequencing of liver fluke-associated cholangiocarcinoma

31 March 2020

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Repetitive DNA and next-generation sequencing: computational challenges and solutions

31 March 2020

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Chromosomal Instability and Tumors Promoted by DNA Hypomethylation

31 March 2020

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Tissue-specific demethylation in CpG-poor promoters during cellular differentiation

31 March 2020

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High frequency of p16INK4A gene alterations in hepatocellular carcinoma

31 March 2020

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Genetic alterations and oncogenic pathways in hepatocellular carcinoma.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2014.6

Infrequent point mutations in codons 12 and 61 of ras oncogenes in human hepatocellular carcinomas

31 March 2020

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Absence of PIK3CA hotspot mutations in hepatocellular carcinoma in Japanese patients

31 March 2020

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Vascular endothelial growth factor tightly regulates in vivo development of murine hepatocellular carcinoma cells

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRGASTRO.2014.6

1 reference

Dimensions Publication ID

30 August 2017

1001466523

0 references

1 reference