(Q38200941)

30 August 2017

title

Transport and diffusion of Tau protein in neurons (English)

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30 August 2017

2

Eckhard Mandelkow

1 reference

30 August 2017

Tim Scholz

1

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30 August 2017

publication date

1 April 2014

1 reference

Cellular and Molecular Life Sciences

30 August 2017

published in

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30 August 2017

volume

71

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30 August 2017

issue

16

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30 August 2017

page(s)

3139-3150

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Nonsaturable binding indicates clustering of tau on the microtubule surface in a paired helical filament-like conformation.

30 August 2017

cites work

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21 January 2018

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Interaction of tau with the neural plasma membrane mediated by tau's amino-terminal projection domain

21 January 2018

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Tau protein binds to microtubules through a flexible array of distributed weak sites

21 January 2018

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Projection domains of MAP2 and tau determine spacings between microtubules in dendrites and axons

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Human microtubule-associated-protein tau regulates the number of protofilaments in microtubules: a synchrotron x-ray scattering study.

21 January 2018

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Physical and chemical properties of purified tau factor and the role of tau in microtubule assembly

21 January 2018

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The diffusive interaction of microtubule binding proteins

21 January 2018

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Phosphorylation of tau regulates its axonal transport by controlling its binding to kinesin.

21 January 2018

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Differential regulation of dynein and kinesin motor proteins by tau

21 January 2018

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Tau protein function in living cells

21 January 2018

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Kinesin-1 transport reductions enhance human tau hyperphosphorylation, aggregation and neurodegeneration in animal models of tauopathies

21 January 2018

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Axonal stress kinase activation and tau misbehavior induced by kinesin-1 transport defects.

21 January 2018

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The mitotic kinesin-14 Ncd drives directional microtubule-microtubule sliding

21 January 2018

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Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo.

21 January 2018

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Minus-end-directed motor Ncd exhibits processive movement that is enhanced by microtubule bundling in vitro

21 January 2018

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Going new places using an old MAP: tau, microtubules and human neurodegenerative disease.

21 January 2018

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Frontotemporal dementia: implications for understanding Alzheimer disease

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Mutations causing neurodegenerative tauopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Functional interactions between the proline-rich and repeat regions of tau enhance microtubule binding and assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Monastrol, a prototype anti-cancer drug that inhibits a mitotic kinesin, induces rapid bursts of axonal outgrowth from cultured postmitotic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Role of cytoplasmic dynein in the axonal transport of microtubules and neurofilaments

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Tau protein diffuses along the microtubule lattice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Selective stabilization of tau in axons and microtubule-associated protein 2C in cell bodies and dendrites contributes to polarized localization of cytoskeletal proteins in mature neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Tau proteins: the molecular structure and mode of binding on microtubules

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Structural investigations into microtubule-MAP complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Amyloid-β and tau--a toxic pas de deux in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Phosphorylated Tau interacts with c-Jun N-terminal kinase-interacting protein 1 (JIP1) in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Global hairpin folding of tau in solution

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Phosphorylation in the amino terminus of tau prevents inhibition of anterograde axonal transport.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Pathogenic forms of tau inhibit kinesin-dependent axonal transport through a mechanism involving activation of axonal phosphotransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Repeat motifs of tau bind to the insides of microtubules in the absence of taxol

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Regulators of the cytoplasmic dynein motor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Developmentally regulated expression of specific tau sequences

21 January 2018

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From the polymorphism of amyloid fibrils to their assembly mechanism and cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

The amino terminus of tau inhibits kinesin-dependent axonal transport: implications for filament toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Neurodegenerative tauopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Protein phosphatase 1 is targeted to microtubules by the microtubule-associated protein Tau.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Common and distinct tubulin binding sites for microtubule-associated proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Diffusive movement of processive kinesin-1 on microtubules

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Interaction of tau protein with the dynactin complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Evidence for two distinct binding sites for tau on microtubules

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Microtubule-dependent oligomerization of tau. Implications for physiological tau function and tauopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Biochemistry and cell biology of tau protein in neurofibrillary degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

The nucleotide-binding state of microtubules modulates kinesin processivity and the ability of Tau to inhibit kinesin-mediated transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Tau binding to microtubules does not directly affect microtubule-based vesicle motility

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

The pool of map kinase associated with microtubules is small but constitutively active

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

21 January 2018

The many faces of tau

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Structural polymorphism of 441-residue tau at single residue resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Thermal drift is enough to drive a single microtubule along its axis even in the absence of motor proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Kinetic Stabilization of Microtubule Dynamics at Steady State by Tau and Microtubule-Binding Domains of Tau

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Tau--an inhibitor of deacetylase HDAC6 function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Cytoplasmic dynein and microtubule transport in the axon: the action connection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Tau phosphorylation affects its axonal transport and degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Axonal transport of tubulin in Ti1 pioneer neurons in situ

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Tau interaction with microtubules in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Surface-decoration of microtubules by human tau

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

The axonal transport of mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Single-molecule investigation of the interference between kinesin, tau and MAP2c

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Localization of the tubulin binding site for tau protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Functions and malfunctions of the tau proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Molecular interactions among protein phosphatase 2A, tau, and microtubules. Implications for the regulation of tau phosphorylation and the development of tauopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Differential effect of three-repeat and four-repeat tau on mitochondrial axonal transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Tau phosphorylation: physiological and pathological consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Partial interruption of axonal transport due to microtubule breakage accounts for the formation of periodic varicosities after traumatic axonal injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Axonal transport, tau protein, and neurodegeneration in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Missorting of tau in neurons causes degeneration of synapses that can be rescued by the kinase MARK2/Par-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Tau/PTL-1 associates with kinesin-3 KIF1A/UNC-104 and affects the motor's motility characteristics in C. elegans neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Molecular motors implicated in the axonal transport of tau and alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Multiple-motor based transport and its regulation by Tau.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Tuning microtubule-based transport through filamentous MAPs: the problem of dynein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

The core of tau-paired helical filaments studied by scanning transmission electron microscopy and limited proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

A protein factor essential for microtubule assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Microtubule binding and trapping at the tip of neurites regulate tau motion in living neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Aβ Oligomers Cause Localized Ca2+Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Retarded axonal transport of R406W mutant tau in transgenic mice with a neurodegenerative tauopathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Tau protein binding forms a 1nm thick layer along protofilaments without affecting the radial elasticity of microtubules

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1610-7

Embryonic lethal abnormal vision-like RNA-binding proteins regulate neurite outgrowth and tau expression in PC12 cells

21 January 2018

1 reference

12 December 2020

Tau regulates the attachment/detachment but not the speed of motors in microtubule-dependent transport of single vesicles and organelles

1 reference

12 December 2020

Kinesin and tau bind to distinct sites on microtubules

1 reference

12 December 2020

Microtubule-associated proteins and microtubule-based translocators have different binding sites on tubulin molecule

1 reference

12 December 2020

Structural studies of tau protein and Alzheimer paired helical filaments show no evidence for beta-structure

1 reference

12 December 2020

Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain

1 reference

12 December 2020

Facilitated target location in biological systems

1 reference

12 December 2020

Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2.

1 reference

12 December 2020

Neurofibrillary tangles of Alzheimer's disease: an immunohistochemical study

1 reference

12 December 2020

Three distinct axonal transport rates for tau, tubulin, and other microtubule-associated proteins: evidence for dynamic interactions of tau with microtubules in vivo

1 reference

12 December 2020

Tau isoform-specific modulation of kinesin-driven microtubule gliding rates and trajectories as determined with tau-stabilized microtubules

1 reference

12 December 2020

A spatial gradient of tau protein phosphorylation in nascent axons.

1 reference

12 December 2020

Domains of tau protein and interactions with microtubules

1 reference

12 December 2020

RNA trafficking in axons.

1 reference

12 December 2020

Expression of a minus-end-directed motor protein induces Sf9 cells to form axon-like processes with uniform microtubule polarity orientation

1 reference

12 December 2020

Competition between motor molecules (kinesin and cytoplasmic dynein) and fibrous microtubule-associated proteins in binding to microtubules.

1 reference

12 December 2020

Tau binds to the distal axon early in development of polarity in a microtubule- and microfilament-dependent manner

1 reference

12 December 2020

Sorting mechanisms of tau and MAP2 in neurons: suppressed axonal transit of MAP2 and locally regulated microtubule binding

1 reference

12 December 2020

Microtubules released from the neuronal centrosome are transported into the axon

1 reference

12 December 2020

The slow axonal transport of the microtubule-associated protein tau and the transport rates of different isoforms and mutants in cultured neurons.

1 reference

12 December 2020

Role of actin filaments in the axonal transport of microtubules

1 reference

12 December 2020

Swimming against the tide: mobility of the microtubule-associated protein tau in neurons

1 reference

12 December 2020

The regulation of bidirectional mitochondrial transport is coordinated with axonal outgrowth

1 reference

12 December 2020

Tau interacts with src-family non-receptor tyrosine kinases

1 reference

12 December 2020

Axonal tau mRNA localization coincides with tau protein in living neuronal cells and depends on axonal targeting signal.

1 reference

12 December 2020

Rapid movement of microtubules in axons

1 reference

12 December 2020

The 'jaws' model of tau-microtubule interaction examined in CHO cells

1 reference

12 December 2020

Tau is enriched on dynamic microtubules in the distal region of growing axons

1 reference

12 December 2020

Light and electron microscope localization of the microtubule-associated tau protein in rat brain

1 reference

12 December 2020

MAP2 and tau segregate into dendritic and axonal domains after the elaboration of morphologically distinct neurites: an immunocytochemical study of cultured rat cerebrum

1 reference

12 December 2020

10.1007/S00018-014-1610-7

Identifiers

DOI

1 reference

release_wrysqhflrzc2podrsgcsdbmgiu

30 August 2017

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Fatcat

https://api.fatcat.wiki/v0/release/wrysqhflrzc2podrsgcsdbmgiu

24 November 2022

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