(Q38207946)

31 August 2017

title

Drug safety testing paradigm, current progress and future challenges: an overview (English)

1 reference

31 August 2017

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24777877%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

author name string

Sharad Sharma

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24777877%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

language of work or name

English

0 references

publication date

29 October 2013

1 reference

Journal of Applied Toxicology

31 August 2017

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24777877%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

volume

34

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24777877%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

issue

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24777877%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

page(s)

576-594

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24777877%20AND%20SRC:MED&resulttype=core&format=json

Application of a high-content multiparameter cytotoxicity assay to prioritize compounds based on toxicity potential in humans

1 June 2020

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Metabolomics and its potential in drug development.

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Use of toxicogenomics to understand mechanisms of drug-induced hepatotoxicity during drug discovery and development

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The use of embryonic stem cells for regulatory developmental toxicity testing in vitro--the current status of test development

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Biomarkers of drug-induced vascular injury.

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A strategy for primary high throughput cytotoxicity screening in pharmaceutical toxicology

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RNA expression in the early characterization of hepatotoxicants in Wistar rats by high-density DNA microarrays

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Commentary: Discovery Toxicology--a nascent science.

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Exploratory safety pharmacology: a new safety paradigm to de-risk drug candidates prior to selection for regulatory science investigations

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Pharmaceutical toxicology: designing studies to reduce animal use, while maximizing human translation

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Optimization of the adult zebrafish ECG method for assessment of drug-induced QTc prolongation.

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Using the zebrafish lateral line to screen for ototoxicity

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Metabolic profiling as a tool for understanding mechanisms of toxicity

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Use of human stem cell derived cardiomyocytes to examine sunitinib mediated cardiotoxicity and electrophysiological alterations

21 January 2018

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Imaging in the cardiovascular and metabolic disease area

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Neuropharmacological properties of neurons derived from human stem cells

21 January 2018

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The role of genetic toxicology in drug discovery and optimization

21 January 2018

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Progress and future challenges in stem cell-derived liver technologies

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Potential candidate genomic biomarkers of drug induced vascular injury in the rat.

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New technologies and screening strategies for hepatotoxicity: use of in vitro models

21 January 2018

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The contribution of endoplasmic reticulum stress to liver diseases

21 January 2018

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The price of innovation: new estimates of drug development costs

21 January 2018

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Developmental nephrotoxicity of aristolochic acid in a zebrafish model

21 January 2018

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A transgenic Lef1/beta-catenin-dependent reporter is expressed in spatially restricted domains throughout zebrafish development.

21 January 2018

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Strategies to reduce late-stage drug attrition due to mitochondrial toxicity

21 January 2018

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The significance of mitochondrial toxicity testing in drug development

21 January 2018

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Metabolic response to low-level toxicant exposure in a novel renal tubule epithelial cell system

21 January 2018

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Development of a high throughput in vitro toxicity screen predictive of high acute in vivo toxic potential

21 January 2018

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Application of toxicogenomic tools in the drug research and development process

21 January 2018

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Multiparameter measurement of caspase 3 activation and apoptotic cell death in NT2 neuronal precursor cells using high-content analysis

21 January 2018

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Metabolomics – the link between genotypes and phenotypes

21 January 2018

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Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicity

21 January 2018

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Identification of in vitro protein biomarkers of idiosyncratic liver toxicity

21 January 2018

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Biomarker discovery in biological fluids

21 January 2018

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Quantification of the proliferation index of human dermal fibroblast cultures with the ArrayScan high-content screening reader

21 January 2018

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Selection of cytotoxicity markers for the screening of new chemical entities in a pharmaceutical context: a preliminary study using a multiplexing approach

21 January 2018

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An evaluation of hERG current assay performance: Translating preclinical safety studies to clinical QT prolongation

21 January 2018

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In vitro evaluation of potential hepatotoxicity induced by drugs.

21 January 2018

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Biomarker qualification pilot process at the US Food and Drug Administration

21 January 2018

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Identification and measurement of genomic biomarkers of nephrotoxicity

21 January 2018

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Fishing for genes controlling development

21 January 2018

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Pluripotent stem cell derived hepatocyte like cells and their potential in toxicity screening

21 January 2018

1 reference

Stem cell-derived hepatocytes and their use in toxicology

21 January 2018

1 reference

Analysis of two matrix metalloproteinase inhibitors and their metabolites for induction of phospholipidosis in rat and human hepatocytes(1).

21 January 2018

1 reference

Inter-laboratory assessment of a harmonized zebrafish developmental toxicology assay - progress report on phase I.

21 January 2018

1 reference

Developing a strategy for the nonclinical assessment of proarrhythmic risk of pharmaceuticals due to prolonged ventricular repolarization

21 January 2018

1 reference

Cationic amphiphilic drug-induced phospholipidosis

21 January 2018

1 reference

Safety pharmacology--current and emerging concepts.

21 January 2018

1 reference

Metabolic activation capacity by primary hepatocytes expands the applicability of the embryonic stem cell test as alternative to experimental animal testing

21 January 2018

1 reference

Progressing preclinical drug candidates: strategies on preclinical safety studies and the quest for adequate exposure

21 January 2018

1 reference

Zebrafish as a model vertebrate for investigating chemical toxicity

21 January 2018

1 reference

Evaluation of a urinary kidney biomarker panel in rat models of acute and subchronic nephrotoxicity

21 January 2018

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Metabonomic characterization of genetic variations in toxicological and metabolic responses using probabilistic neural networks

21 January 2018

1 reference

Stem cell technology for drug discovery and development

21 January 2018

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Understanding mechanisms of toxicity: insights from drug discovery research

21 January 2018

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Development of an in vitro liver toxicity prediction model based on longer term primary rat hepatocyte culture

21 January 2018

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Pulmonary and generalized lysosomal storage induced by amphiphilic drugs

21 January 2018

1 reference

Physiochemical drug properties associated with in vivo toxicological outcomes

21 January 2018

1 reference

A high-throughput dual parameter assay for assessing drug-induced mitochondrial dysfunction provides additional predictivity over two established mitochondrial toxicity assays

21 January 2018

1 reference

Identification of a primary target of thalidomide teratogenicity

21 January 2018

1 reference

An FDA perspective on the nonclinical use of the X-Omics technologies and the safety of new drugs

21 January 2018

1 reference

Mechanisms of hepatotoxicity

21 January 2018

1 reference

Assessing the potential toxicity of new pharmaceuticals

21 January 2018

1 reference

Mechanisms of pathogenesis in drug hepatotoxicity putting the stress on mitochondria

21 January 2018

1 reference

A comprehensive listing of bioactivation pathways of organic functional groups

21 January 2018

1 reference

Minimising the potential for metabolic activation in drug discovery

21 January 2018

1 reference

Drug-induced vascular injury--a quest for biomarkers.

21 January 2018

1 reference

Thalidomide: the tragedy of birth defects and the effective treatment of disease

21 January 2018

1 reference

Stages of embryonic development of the zebrafish

21 January 2018

1 reference

BSEP inhibition: in vitro screens to assess cholestatic potential of drugs

21 January 2018

1 reference

Practical application of toxicogenomics for profiling toxicant-induced biological perturbations

21 January 2018

1 reference

Identifying developmental toxicity pathways for a subset of ToxCast chemicals using human embryonic stem cells and metabolomics.

21 January 2018

1 reference

Rapid behavior-based identification of neuroactive small molecules in the zebrafish

21 January 2018

1 reference

Target promiscuity and physicochemical properties contribute to pharmacologically induced ER-stress

21 January 2018

1 reference

A long-term three dimensional liver co-culture system for improved prediction of clinically relevant drug-induced hepatotoxicity

21 January 2018

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The application of discovery toxicology and pathology towards the design of safer pharmaceutical lead candidates

21 January 2018

1 reference

Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach

21 January 2018

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Progress in QSAR toxicity screening of pharmaceutical impurities and other FDA regulated products

21 January 2018

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Enterohepatic bile salt transporters in normal physiology and liver disease

21 January 2018

1 reference

Zebrafish embryos express an orthologue of HERG and are sensitive toward a range of QT-prolonging drugs inducing severe arrhythmia

21 January 2018

1 reference

Development of an in vitro test battery for assessing chemical effects on bovine germ cells under the ReProTect umbrella

21 January 2018

1 reference

Drug-induced hepatotoxicity.

21 January 2018

1 reference

The influence of drug-like concepts on decision-making in medicinal chemistry

21 January 2018

1 reference

Cell viability and PSA secretion assays in LNCaP cells: a tiered in vitro approach to screen chemicals with a prostate-mediated effect on male reproduction within the ReProTect project.

21 January 2018

1 reference

Biomarkers and mechanisms of drug-induced vascular injury in non-rodents

21 January 2018

1 reference

HepaRG human hepatic cell line utility as a surrogate for primary human hepatocytes in drug metabolism assessment in vitro

21 January 2018

1 reference

Transferability and inter-laboratory variability assessment of the in vitro bovine oocyte maturation (IVM) test within ReProTect

21 January 2018

1 reference

Integration of safety pharmacology endpoints into toxicology studies

21 January 2018

1 reference

Bioactivation of minocycline to reactive intermediates by myeloperoxidase, horseradish peroxidase, and hepatic microsomes: implications for minocycline-induced lupus and hepatitis.

21 January 2018

1 reference

Impact of biomarker development on drug safety assessment

21 January 2018

1 reference

Current status of conducting function tests in repeated dose toxicity studies in Japan

21 January 2018

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Non-invasive imaging in experimental medicine for drug development

21 January 2018

1 reference

Zebrafish: a predictive model for assessing drug-induced toxicity

21 January 2018

1 reference

Nile Red binding to HepG2 cells: an improved assay for in vitro studies of hepatosteatosis

21 January 2018

1 reference

Toxicity of ecstasy (MDMA) towards embryonic stem cell-derived cardiac and neural cells.

21 January 2018

1 reference

Dynamic and static small-animal SPECT in rats for monitoring renal function after 177Lu-labeled Tyr3-octreotate radionuclide therapy

21 January 2018

1 reference

Drugs that induce repolarization abnormalities cause bradycardia in zebrafish

21 January 2018

1 reference

Primary culture of rat hepatocytes in 96-well plates: effects of extracellular matrix configuration on cytochrome P450 enzyme activity and inducibility, and its application in in vitro cytotoxicity screening

21 January 2018

1 reference

Toxicogenomic multigene biomarker for predicting the future onset of proximal tubular injury in rats

21 January 2018

1 reference

Comparison of in vitro assays of cellular toxicity in the human hepatic cell line HepG2.

21 January 2018

1 reference

Evaluation of zebrafish embryos as a model for assessing inhibition of hERG.

21 January 2018

1 reference

Functional assays for neurotoxicity testing

21 January 2018

1 reference

Computational toxicology in drug development

21 January 2018

1 reference

The classification of motor neuron defects in the zebrafish embryo toxicity test (ZFET) as an animal alternative approach to assess developmental neurotoxicity.

21 January 2018

1 reference

Preliminary interlaboratory comparison of the ex vivo dual human placental perfusion system

21 January 2018

1 reference

Target identification of drug induced mitochondrial toxicity using immunocapture based OXPHOS activity assays.

21 January 2018

1 reference

Screening for phospholipidosis induced by central nervous drugs: comparing the predictivity of an in vitro assay to high throughput in silico assays

21 January 2018

1 reference

'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data

21 January 2018

1 reference

Human and animal hepatocytes in vitro with extrapolation in vivo

21 January 2018

1 reference

High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening

21 January 2018

1 reference

Concordance of the toxicity of pharmaceuticals in humans and in animals

21 January 2018

1 reference

The predictivity of the toxicity of pharmaceuticals in humans from animal data--an interim assessment

21 January 2018

1 reference

A panel of urinary biomarkers to monitor reversibility of renal injury and a serum marker with improved potential to assess renal function

21 January 2018

1 reference

Predicted drug-induced bradycardia related cardio toxicity using a zebrafish in vivo model is highly correlated with results from in vitro tests.

21 January 2018

1 reference

Hepatobiliary transporters and drug-induced cholestasis

21 January 2018

1 reference

Retinoic acid-mediated gene expression in transgenic reporter zebrafish

21 January 2018

1 reference

Mitochondrial involvement in drug-induced liver injury.

21 January 2018

1 reference

Hepatotoxicity due to mitochondrial dysfunction

21 January 2018

1 reference

Assessing the data quality in predictive toxicology using a panel of cell lines and cytotoxicity assays

21 January 2018

1 reference

High content cellular screening

21 January 2018

1 reference

Zebrafish assays as early safety pharmacology screens: paradigm shift or red herring?

21 January 2018

1 reference

Two zebrafish alcohol dehydrogenases share common ancestry with mammalian class I, II, IV, and V alcohol dehydrogenase genes but have distinct functional characteristics

21 January 2018

1 reference

Genomic and functional conservation of sedative-hypnotic targets in the zebrafish.

21 January 2018

1 reference

Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro

21 January 2018

1 reference

Toxicodynamics and long-term toxicity of the recreational drug, 3, 4-methylenedioxymethamphetamine (MDMA, 'Ecstasy').

21 January 2018

1 reference

Validation of the use of zebrafish larvae in visual safety assessment.

21 January 2018

1 reference

A morphology- and kinetics-based cascade for human neural cell high content screening

21 January 2018

1 reference

Toxicological and pathophysiological roles of reactive oxygen and nitrogen species

21 January 2018

1 reference

Metabonomics: evaluation of nuclear magnetic resonance (NMR) and pattern recognition technology for rapid in vivo screening of liver and kidney toxicants

21 January 2018

1 reference

Zebrafish assays for drug toxicity screening

21 January 2018

1 reference

Concise review: Human pluripotent stem cell-based models for cardiac and hepatic toxicity assessment

21 January 2018

1 reference

Testing paradigm for prediction of development-limiting barriers and human drug toxicity

21 January 2018

1 reference

Evaluation of the use of human Mesenchymal Stem Cells for acute toxicity tests.

21 January 2018

1 reference

The ReProTect Feasibility Study, a novel comprehensive in vitro approach to detect reproductive toxicants

21 January 2018

1 reference

Zebrafish: as an integrative model for twenty-first century toxicity testing.

21 January 2018

1 reference

An EU perspective on the use of in vitro methods in regulatory pharmaceutical toxicology

21 January 2018

1 reference

Computational prediction of genotoxicity: room for improvement

21 January 2018

1 reference

In vitro differentiation of embryonic and adult stem cells into hepatocytes: state of the art.

21 January 2018

1 reference

Proteomics: applications and opportunities in preclinical drug development

21 January 2018

1 reference

Zebrafish for drug toxicity screening: bridging the in vitro cell-based models and in vivo mammalian models.

21 January 2018

1 reference

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

21 January 2018

1 reference

Potentials and limitations of nonclinical safety assessment for predicting clinical adverse drug reactions: correlation analysis of 142 approved drugs in Japan

21 January 2018

1 reference

Embryonic stem cell lines derived from human blastocysts

21 January 2018

1 reference

Biomarker panel of cardiac and skeletal muscle troponins, fatty acid binding protein 3 and myosin light chain 3 for the accurate diagnosis of cardiotoxicity and musculoskeletal toxicity in rats

21 January 2018

1 reference

Evaluation of the usefulness of urinary biomarkers for nephrotoxicity in rats

21 January 2018

1 reference

Species-specific differences in coumarin-induced hepatotoxicity as an example toxicogenomics-based approach to assessing risk of toxicity to humans

21 January 2018

1 reference

Toxicogenomic biomarkers for renal papillary injury in rats

21 January 2018

1 reference

Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies.

21 January 2018

1 reference

Safety and secondary pharmacology: successes, threats, challenges and opportunities

21 January 2018

1 reference

A framework to assess the translation of safety pharmacology data to humans.

21 January 2018

1 reference

Predictive computational toxicology to support drug safety assessment

21 January 2018

1 reference

The use of metabolomics for the discovery of new biomarkers of effect.

21 January 2018

1 reference

Proteomics in the search for mechanisms and biomarkers of drug-induced hepatotoxicity

21 January 2018

1 reference

A novel in vitro metabolomics approach for neurotoxicity testing, proof of principle for methyl mercury chloride and caffeine

21 January 2018

1 reference

Challenges of using pluripotent stem cells for safety assessments of substances

21 January 2018

1 reference

Strategic approach to fit-for-purpose biomarkers in drug development

21 January 2018

1 reference

Validation of putative genomic biomarkers of nephrotoxicity in rats

21 January 2018

1 reference

Microarray analysis of hepatotoxins in vitro reveals a correlation between gene expression profiles and mechanisms of toxicity

21 January 2018

1 reference

The H9C2 cell line and primary neonatal cardiomyocyte cells show similar hypertrophic responses in vitro

21 January 2018

1 reference

Toxicoproteomics: proteomics applied to toxicology and pathology

21 January 2018

1 reference

A practical note on the use of cytotoxicity assays.

21 January 2018

1 reference

Keynote review: in vitro safety pharmacology profiling: an essential tool for successful drug development

21 January 2018

1 reference

The role of pharmacological profiling in safety assessment

21 January 2018

1 reference

High-throughput micro-computed tomography imaging as a method to evaluate rat and rabbit fetal skeletal abnormalities for developmental toxicity studies

21 January 2018

1 reference

The assessment of estrogenic or anti-estrogenic activity of chemicals by the human stably transfected estrogen sensitive MELN cell line: results of test performance and transferability

21 January 2018

1 reference

Differential expression of cytosolic proteins in the rat kidney cortex and medulla: preliminary proteomics

21 January 2018

1 reference

Web resources for drug toxicity

21 January 2018

1 reference

Multiplexed assay panel of cytotoxicity in HK-2 cells for detection of renal proximal tubule injury potential of compounds

21 January 2018

1 reference

Qualified kidney biomarkers and their potential significance in drug safety evaluation and prediction

21 January 2018

1 reference

Applications of cytotoxicity assays and pre-lethal mechanistic assays for assessment of human hepatotoxicity potential

21 January 2018

1 reference

Cellular imaging predictions of clinical drug-induced liver injury

21 January 2018

1 reference

Identification of a novel set of biomarkers for evaluating phospholipidosis-inducing potential of compounds using rat liver microarray data measured 24-h after single dose administration

21 January 2018

1 reference