(Q36086407)

12 August 2017

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title

New technologies and screening strategies for hepatotoxicity: use of in vitro models (English)

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12 August 2017

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Donna M Dambach

1

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12 August 2017

Barbara A Andrews

series ordinal

2

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12 August 2017

Frederic Moulin

series ordinal

3

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12 August 2017

language of work or name

English

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publication date

1 January 2005

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12 August 2017

published in

Toxicologic Pathology

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12 August 2017

volume

33

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12 August 2017

issue

1

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12 August 2017

page(s)

17-26

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Hepatotoxicity in drug development: detection, significance and solutions

12 August 2017

cites work

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Identification of in vitro protein biomarkers of idiosyncratic liver toxicity

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In vitro models to study hepatotoxicity.

21 January 2018

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Use of human hepatocyte cultures for drug metabolism studies

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Use of hepatocyte cultures for the study of hepatotoxic compounds

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Toxicogenomics: an opportunity to optimise drug development and safety evaluation

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Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation.

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Drug-induced hepatotoxicity.

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Differentiating members of the thiazolidinedione class: a focus on safety

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Preclinical evaluation of drug-drug interaction potential: present status of the application of primary human hepatocytes in the evaluation of cytochrome P450 induction.

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Aflatoxin B1-induced DNA adduct formation and p53 mutations in CYP450-expressing human liver cell lines

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Concordance of the toxicity of pharmaceuticals in humans and in animals

21 January 2018

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Simian virus 40 large tumor antigen-immortalized normal human liver epithelial cells express hepatocyte characteristics and metabolize chemical carcinogens

21 January 2018

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Pharmacogenetics and psychopharmacotherapy

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21 January 2018

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21 January 2018

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Cultured hepatocytes as investigational models for hepatic toxicity: practical applications in drug discovery and development

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Human drug metabolism and the cytochromes P450: application and relevance of in vitro models

21 January 2018

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Microarray analysis of hepatotoxins in vitro reveals a correlation between gene expression profiles and mechanisms of toxicity

21 January 2018

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Role of cytochromes P450 in drug metabolism and hepatotoxicity

21 January 2018

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In vitro methods for assessing human hepatic drug metabolism: their use in drug development

21 January 2018

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Semi-automatic quantitative RT-PCR to measure CYP induction by drugs in human hepatocytes

21 January 2018

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Cytochrome P-450 mRNA Expression in Human Liver and Its Relationship with Enzyme Activity

21 January 2018

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10.1080/01926230590522284

21 January 2018

Identifiers

DOI

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12 August 2017

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