(Q38210478)

31 August 2017

Epigenetic-based immune intervention for rheumatic diseases (English)

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31 August 2017

Steven G Gray

1

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publication date

1 April 2014

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31 August 2017

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31 August 2017

6

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31 August 2017

2

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31 August 2017

253-271

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Hypermethylation of EBF3 and IRX1 genes in synovial fibroblasts of patients with rheumatoid arthritis

31 August 2017

1 reference

Cancer epigenomics: beyond genomics

21 January 2018

1 reference

Role of histone and transcription factor acetylation in diabetes pathogenesis

21 January 2018

1 reference

Epigenetic treatment of neurological disease

21 January 2018

1 reference

Twin concordance rates for rheumatoid arthritis: results from a nationwide study.

21 January 2018

1 reference

Characterizing the quantitative genetic contribution to rheumatoid arthritis using data from twins

21 January 2018

1 reference

On the origin of rheumatoid arthritis: the impact of environment and genes--a population based twin study

21 January 2018

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Hypomethylation distinguishes genes of some human cancers from their normal counterparts

21 January 2018

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Genome-scale case-control analysis of CD4+ T-cell DNA methylation in juvenile idiopathic arthritis reveals potential targets involved in disease.

21 January 2018

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Dissecting complex epigenetic alterations in human lupus

21 January 2018

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Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus

21 January 2018

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Genome-wide DNA methylation patterns in CD4+ T cells from patients with systemic lupus erythematosus

21 January 2018

1 reference

Genome-wide DNA methylation analysis of systemic lupus erythematosus reveals persistent hypomethylation of interferon genes and compositional changes to CD4+ T-cell populations

21 January 2018

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Genome-wide DNA methylation study suggests epigenetic accessibility and transcriptional poising of interferon-regulated genes in naïve CD4+ T cells from lupus patients

21 January 2018

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Analysis of associations between the patterns of global DNA hypomethylation and expression of DNA methyltransferase in patients with systemic lupus erythematosus.

21 January 2018

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Abnormal DNA methylation in CD4+ T cells from patients with systemic lupus erythematosus, systemic sclerosis, and dermatomyositis

21 January 2018

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Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis

21 January 2018

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DNA methylome signature in rheumatoid arthritis

21 January 2018

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Regulation of DNA methylation in rheumatoid arthritis synoviocytes

21 January 2018

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Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors

21 January 2018

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An imprinted rheumatoid arthritis methylome signature reflects pathogenic phenotype

21 January 2018

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Functional characterization of the MECP2/IRAK1 lupus risk haplotype in human T cells and a human MECP2 transgenic mouse

21 January 2018

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Association of an activity-enhancing variant of IRAK1 and an MECP2-IRAK1 haplotype with increased susceptibility to rheumatoid arthritis

21 January 2018

1 reference

MeCP2 modulates the canonical Wnt pathway activation by targeting SFRP4 in rheumatoid arthritis fibroblast-like synoviocytes in rats

21 January 2018

1 reference

TET enzymes, TDG and the dynamics of DNA demethylation.

21 January 2018

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TETonic shift: biological roles of TET proteins in DNA demethylation and transcription

21 January 2018

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Impaired DNA methylation and its mechanisms in CD4(+)T cells of systemic lupus erythematosus

21 January 2018

1 reference

PTMcode: a database of known and predicted functional associations between post-translational modifications in proteins

21 January 2018

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Deciphering a global network of functionally associated post-translational modifications

21 January 2018

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The emerging role of epigenetics in rheumatic diseases

21 January 2018

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Expression and function of histone deacetylases in rheumatoid arthritis synovial fibroblasts.

21 January 2018

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Histone deacetylases are dysregulated in rheumatoid arthritis and a novel histone deacetylase 3-selective inhibitor reduces interleukin-6 production by peripheral blood mononuclear cells from rheumatoid arthritis patients

21 January 2018

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Increased activity and expression of histone deacetylase 1 in relation to tumor necrosis factor-alpha in synovial tissue of rheumatoid arthritis

21 January 2018

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Histone deacetylase/acetylase activity in total synovial tissue derived from rheumatoid arthritis and osteoarthritis patients

21 January 2018

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The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase

21 January 2018

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Sumoylation of LAP1 is involved in the HDAC4-mediated repression of COX-2 transcription.

21 January 2018

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Inhibition of androgen receptor activity by histone deacetylase 4 through receptor SUMOylation

21 January 2018

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HDAC4 contributes to IL-1-induced mPGES-1 expression in human synovial fibroblasts through up-regulation of Egr-1 transcriptional activity

21 January 2018

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Epigenetics and rheumatoid arthritis: the role of SENP1 in the regulation of MMP-1 expression

21 January 2018

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Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling

21 January 2018

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Histone deacetylase 9 deficiency protects against effector T cell-mediated systemic autoimmunity

21 January 2018

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Inhibited expression of hematopoietic progenitor kinase 1 associated with loss of jumonji domain containing 3 promoter binding contributes to autoimmunity in systemic lupus erythematosus.

21 January 2018

1 reference

Epigenetics and SLE: RFX1 downregulation causes CD11a and CD70 overexpression by altering epigenetic modifications in lupus CD4+ T cells.

21 January 2018

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RFX1 regulates CD70 and CD11a expression in lupus T cells by recruiting the histone methyltransferase SUV39H1

21 January 2018

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Differentially expressed epigenome modifiers, including aurora kinases A and B, in immune cells in rheumatoid arthritis in humans and mouse models.

21 January 2018

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Apoptosis-induced histone H3 methylation is targeted by autoantibodies in systemic lupus erythematosus

21 January 2018

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21 January 2018

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Systemic lupus erythematosus patients contain significantly less igm against mono-methylated lysine than healthy subjects

21 January 2018

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Autoantibody epitope spreading in the pre-clinical phase predicts progression to rheumatoid arthritis

21 January 2018

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Peptidylarginine deiminase 2, 3 and 4 have distinct specificities against cellular substrates: novel insights into autoantigen selection in rheumatoid arthritis

21 January 2018

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Autoantibodies to PAD4 and BRAF in rheumatoid arthritis.

21 January 2018

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Anti-PAD4 autoantibodies in rheumatoid arthritis: levels in serum over time and impact on PAD4 activity as measured with a small synthetic substrate

21 January 2018

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Association of autoimmunity to peptidyl arginine deiminase type 4 with genotype and disease severity in rheumatoid arthritis.

21 January 2018

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Autoimmunity to peptidyl arginine deiminase type 4 precedes clinical onset of rheumatoid arthritis.

21 January 2018

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Erosive rheumatoid arthritis is associated with antibodies that activate PAD4 by increasing calcium sensitivity

21 January 2018

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Specific post-translational histone modifications of neutrophil extracellular traps as immunogens and potential targets of lupus autoantibodies

21 January 2018

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Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation.

21 January 2018

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PAD4 mediated histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular trap-like structures

21 January 2018

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Activation of PAD4 in NET formation

21 January 2018

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Histone variants in pluripotency and disease

21 January 2018

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Current progress on structural studies of nucleosomes containing histone H3 variants

21 January 2018

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Clinical correlates of CENP-A and CENP-B antibodies in a large cohort of patients with systemic sclerosis

21 January 2018

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ceRNA cross-talk in cancer: when ce-bling rivalries go awry.

21 January 2018

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The long and short of microRNA.

21 January 2018

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The role of miRNAs in regulating gene expression networks

21 January 2018

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MicroRNAs in systemic rheumatic diseases

21 January 2018

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MicroRNA control in the development of systemic autoimmunity

21 January 2018

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MicroRNA, a new paradigm for understanding immunoregulation, inflammation, and autoimmune diseases

21 January 2018

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Epigenomic and microRNA-mediated regulation in cartilage development, homeostasis, and osteoarthritis

21 January 2018

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Disrupted microRNA expression caused by Mecp2 loss in a mouse model of Rett syndrome

21 January 2018

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New advances of microRNAs in the pathogenesis of rheumatoid arthritis, with a focus on the crosstalk between DNA methylation and the microRNA machinery

21 January 2018

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Altered miR-146a expression in Sjögren's syndrome and its functional role in innate immunity

21 January 2018

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Circulating microRNAs as candidate biomarkers in patients with systemic lupus erythematosus.

21 January 2018

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MicroRNA-126 regulates DNA methylation in CD4+ T cells and contributes to systemic lupus erythematosus by targeting DNA methyltransferase 1.

21 January 2018

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MicroRNA-21 and microRNA-148a contribute to DNA hypomethylation in lupus CD4+ T cells by directly and indirectly targeting DNA methyltransferase 1.

21 January 2018

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MicroRNA-29b contributes to DNA hypomethylation of CD4+ T cells in systemic lupus erythematosus by indirectly targeting DNA methyltransferase 1.

21 January 2018

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Circulating microRNA expression profiles associated with systemic lupus erythematosus.

21 January 2018

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MiR-138 inhibits tumor growth through repression of EZH2 in non-small cell lung cancer

21 January 2018

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Suppression of tumorigenicity by microRNA-138 through inhibition of EZH2-CDK4/6-pRb-E2F1 signal loop in glioblastoma multiforme

21 January 2018

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MiR-365: a mechanosensitive microRNA stimulates chondrocyte differentiation through targeting histone deacetylase 4.

21 January 2018

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The cartilage specific microRNA-140 targets histone deacetylase 4 in mouse cells

21 January 2018

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Biological functions of miR-29b contribute to positive regulation of osteoblast differentiation

21 January 2018

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miR-200a regulates SIRT1 expression and epithelial to mesenchymal transition (EMT)-like transformation in mammary epithelial cells

21 January 2018

1 reference

Resveratrol mediated modulation of Sirt-1/Runx2 promotes osteogenic differentiation of mesenchymal stem cells: potential role of Runx2 deacetylation

21 January 2018

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Serum and urinary free microRNA level in patients with systemic lupus erythematosus.

21 January 2018

1 reference

Aberrant expression pattern of histone acetylation modifiers and mitigation of lupus by SIRT1-siRNA in MRL/lpr mice.

21 January 2018

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Miravirsen (SPC3649) can inhibit the biogenesis of miR-122.

21 January 2018

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Treatment of HCV infection by targeting microRNA

21 January 2018

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Modulation of renal disease in MRL/lpr mice by suberoylanilide hydroxamic acid

21 January 2018

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Histone deacetylase inhibitors modulate renal disease in the MRL-lpr/lpr mouse.

21 January 2018

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Resetting the epigenetic histone code in the MRL-lpr/lpr mouse model of lupus by histone deacetylase inhibition

21 January 2018

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Function of histone deacetylase inhibitors in inflammation.

21 January 2018

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Deacetylase inhibition increases regulatory T cell function and decreases incidence and severity of collagen-induced arthritis

21 January 2018

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Studies of H3K4me3 demethylation by KDM5B/Jarid1B/PLU1 reveals strong substrate recognition in vitro and identifies 2,4-pyridine-dicarboxylic acid as an in vitro and in cell inhibitor

21 January 2018

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Pharmacological modulation of histone demethylase activity by a small molecule isolated from subcritical water extracts of Sasa senanensis leaves prolongs the lifespan of Drosophila melanogaster

21 January 2018

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A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

21 January 2018

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Synthesis and Screening of a Haloacetamidine Containing Library To Identify PAD4 Selective Inhibitors

21 January 2018

1 reference

Protein arginine deiminase 4: a target for an epigenetic cancer therapy

21 January 2018

1 reference

Anticancer peptidylarginine deiminase (PAD) inhibitors regulate the autophagy flux and the mammalian target of rapamycin complex 1 activity.

21 January 2018

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Substrate specificity and kinetic studies of PADs 1, 3, and 4 identify potent and selective inhibitors of protein arginine deiminase 3.

21 January 2018

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Novel small molecule protein arginine deiminase 4 (PAD4) inhibitors

21 January 2018

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Autophagy regulates TNFα-mediated joint destruction in experimental arthritis.

21 January 2018

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Peptidylarginine deiminase inhibition is immunomodulatory and vasculoprotective in murine lupus

21 January 2018

1 reference

Genome-wide epigenetic regulation of miRNAs in cancer

21 January 2018

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DNA methylation-associated silencing of tumor-suppressor microRNAs in cancer

21 January 2018

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Dysregulated expression of miR-146a contributes to age-related dysfunction of macrophages

21 January 2018

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Targeting human microRNA genes using engineered Tal-effector nucleases (TALENs)

21 January 2018

1 reference

Epigenetics underpinning the regulation of the CXC (ELR+) chemokines in non-small cell lung cancer

21 January 2018

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IL-20 is epigenetically regulated in NSCLC and down regulates the expression of VEGF.

21 January 2018

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Biological properties and regulation of IL-10 related cytokines and their contribution to autoimmune disease and tissue injury.

21 January 2018

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cAMP-responsive element modulator (CREM)α protein induces interleukin 17A expression and mediates epigenetic alterations at the interleukin-17A gene locus in patients with systemic lupus erythematosus

21 January 2018

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IL-23: one cytokine in control of autoimmunity

21 January 2018

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Up-regulation of IL-23p19 expression in rheumatoid arthritis synovial fibroblasts by IL-17 through PI3-kinase-, NF-kappaB- and p38 MAPK-dependent signalling pathways.

21 January 2018

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Elevated levels of T helper 17 cells are associated with disease activity in patients with rheumatoid arthritis

21 January 2018

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IL-23 is pro-proliferative, epigenetically regulated and modulated by chemotherapy in non-small cell lung cancer.

21 January 2018

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Prostacyclin synthase expression and epigenetic regulation in nonsmall cell lung cancer.

21 January 2018

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Histone deacetylase inhibitors suppress rheumatoid arthritis fibroblast-like synoviocyte and macrophage IL-6 production by accelerating mRNA decay

21 January 2018

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Treating activated CD4+ T cells with either of two distinct DNA methyltransferase inhibitors, 5-azacytidine or procainamide, is sufficient to cause a lupus-like disease in syngeneic mice

21 January 2018

1 reference

Dose-dependent LDL-cholesterol lowering effect by plant stanol ester consumption: clinical evidence.

21 January 2018

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Cancer chemoprevention by dietary polyphenols: promising role for epigenetics

21 January 2018

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Modulation of immune function by polyphenols: possible contribution of epigenetic factors

21 January 2018

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Oxidative stress induced lung cancer and COPD: opportunities for epigenetic therapy

21 January 2018

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A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis

21 January 2018

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Curcumin attenuates lupus nephritis upon interaction with regulatory T cells in New Zealand Black/White mice.

21 January 2018

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Curcumin analogue CDF inhibits pancreatic tumor growth by switching on suppressor microRNAs and attenuating EZH2 expression

21 January 2018

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Curcumin aggravates CNS pathology in experimental systemic lupus erythematosus

21 January 2018

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Do anthocyanins and anthocyanidins, cancer chemopreventive pigments in the diet, merit development as potential drugs?

21 January 2018

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Delphinidin, a specific inhibitor of histone acetyltransferase, suppresses inflammatory signaling via prevention of NF-κB acetylation in fibroblast-like synoviocyte MH7A cells.

21 January 2018

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A dietary anthocyanidin delphinidin induces apoptosis of human prostate cancer PC3 cells in vitro and in vivo: involvement of nuclear factor-kappaB signaling

21 January 2018

1 reference

Resveratrol is not a direct activator of SIRT1 enzyme activity

21 January 2018

1 reference

Evidence for a common mechanism of SIRT1 regulation by allosteric activators

21 January 2018

1 reference

Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases

21 January 2018

1 reference

Resveratrol as a pan-HDAC inhibitor alters the acetylation status of histone [corrected] proteins in human-derived hepatoblastoma cells

21 January 2018

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Caspase-8 has an essential role in resveratrol-induced apoptosis of rheumatoid fibroblast-like synoviocytes.

21 January 2018

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Effects of resveratrol in inflammatory arthritis

21 January 2018

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Influence of resveratrol on rheumatoid fibroblast-like synoviocytes analysed with gene chip transcription.

21 January 2018

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Resveratrol induces apoptosis MH7A human rheumatoid arthritis synovial cells in a sirtuin 1-dependent manner

21 January 2018

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Resveratrol inhibits TNF-α-induced IL-1β, MMP-3 production in human rheumatoid arthritis fibroblast-like synoviocytes via modulation of PI3kinase/Akt pathway

21 January 2018

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Epigenetic impact of dietary isothiocyanates in cancer chemoprevention

21 January 2018

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Comparison of isothiocyanate metabolite levels and histone deacetylase activity in human subjects consuming broccoli sprouts or broccoli supplement

21 January 2018

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Sulforaphane inhibits the Th2 immune response in ovalbumin-induced asthma.

21 January 2018

1 reference

Inhibition of synovial hyperplasia, rheumatoid T cell activation, and experimental arthritis in mice by sulforaphane, a naturally occurring isothiocyanate.

21 January 2018

1 reference

Novel concepts of broccoli sulforaphanes and disease: induction of phase II antioxidant and detoxification enzymes by enhanced-glucoraphanin broccoli

21 January 2018

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Ingestion of broccoli sprouts does not improve endothelial function in humans with hypertension

21 January 2018

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A diet rich in high-glucoraphanin broccoli interacts with genotype to reduce discordance in plasma metabolite profiles by modulating mitochondrial function

21 January 2018

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Lupus autoimmunity altered by cellular methylation metabolism

21 January 2018

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Diet influences expression of autoimmune-associated genes and disease severity by epigenetic mechanisms in a transgenic mouse model of lupus.

21 January 2018

1 reference

Intratumor heterogeneity: seeing the wood for the trees.

21 January 2018

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Intratumor heterogeneity: evolution through space and time

21 January 2018

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A systems approach to rheumatoid arthritis

21 January 2018

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Sulforaphane represses matrix-degrading proteases and protects cartilage from destruction in vitro and in vivo

21 January 2018

1 reference

A whole genome methylation analysis of systemic lupus erythematosus: hypomethylation of the IL10 and IL1R2 promoters is associated with disease activity

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.2217/EPI.13.87

1 reference

31 August 2017

1 reference

PubMed ID

24811793