(Q37962584)

26 August 2017

title

Epigenetic treatment of neurological disease (English)

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26 August 2017

Steven G Gray

1

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publication date

1 August 2011

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26 August 2017

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26 August 2017

volume

3

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26 August 2017

issue

4

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26 August 2017

page(s)

431-450

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26 August 2017

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Targeting histone deacetylases for the treatment of Huntington's disease.

21 January 2018

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Amyloid-β and tau--a toxic pas de deux in Alzheimer's disease

21 January 2018

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New nomenclature for chromatin-modifying enzymes

21 January 2018

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Histone methyltransferases in cancer

21 January 2018

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Is there a code embedded in proteins that is based on post-translational modifications?

21 January 2018

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A pervasive role of histone acetyltransferases and deacetylases in an NF-kappaB-signaling code

21 January 2018

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Targeting Huntington's disease through histone deacetylases

21 January 2018

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Sumoylation of amyloid precursor protein negatively regulates Abeta aggregate levels

21 January 2018

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HDAC2 negatively regulates memory formation and synaptic plasticity.

21 January 2018

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Selective toxicity by HDAC3 in neurons: regulation by Akt and GSK3beta

21 January 2018

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Mutant huntingtin increases nuclear corepressor function and enhances ligand-dependent nuclear hormone receptor activation

21 January 2018

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Mice knock out for the histone acetyltransferase p300/CREB binding protein-associated factor develop a resistance to amyloid toxicity

21 January 2018

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Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration

21 January 2018

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Differential contributions of Caenorhabditis elegans histone deacetylases to huntingtin polyglutamine toxicity.

21 January 2018

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A comparative study of histone acetylation in neuronal and glial nuclei enriched rat brain fractions

21 January 2018

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Developmental expression of histone deacetylase 11 in the murine brain

21 January 2018

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CoREST-like complexes regulate chromatin modification and neuronal gene expression

21 January 2018

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Upregulation of class II histone deacetylases mRNA during neural differentiation of cultured rat hippocampal progenitor cells

21 January 2018

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Histone deacetylase activity is retained in primary neurons expressing mutant huntingtin protein

21 January 2018

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Differential regulation of the Sir2 histone deacetylase gene family by inhibitors of class I and II histone deacetylases

21 January 2018

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Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

21 January 2018

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Epigenetic programming by maternal behavior

21 January 2018

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Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli

21 January 2018

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Genome-wide expression profiling of human blood reveals biomarkers for Huntington's disease.

21 January 2018

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Histones associated with downregulated genes are hypo-acetylated in Huntington's disease models

21 January 2018

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Modulation of nucleosome dynamics in Huntington's disease

21 January 2018

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Epigenetic modification is linked to Alzheimer's disease: is it a maker or a marker?

21 January 2018

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Epigenetic regulation in the pathophysiology of Alzheimer's disease

21 January 2018

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Activation of GSK-3 and phosphorylation of CRMP2 in transgenic mice expressing APP intracellular domain

21 January 2018

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Alzheimer's disease-like pathological features in transgenic mice expressing the APP intracellular domain.

21 January 2018

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The amyloid precursor protein intracellular domain alters gene expression and induces neuron-specific apoptosis

21 January 2018

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APP Intracellular Domain Impairs Adult Neurogenesis in Transgenic Mice by Inducing Neuroinflammation

21 January 2018

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Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation

21 January 2018

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Mediator is a transducer of amyloid-precursor-protein-dependent nuclear signalling

21 January 2018

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REST and CoREST modulate neuronal subtype specification, maturation and maintenance

21 January 2018

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REST and CoREST are transcriptional and epigenetic regulators of seminal neural fate decisions

21 January 2018

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Neuronal target genes of the neuron-restrictive silencer factor in neurospheres derived from fetuses with Down's syndrome: a gene expression study

21 January 2018

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A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death

21 January 2018

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REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis.

21 January 2018

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REST repression of neuronal genes requires components of the hSWI.SNF complex

21 January 2018

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Opposing LSD1 complexes function in developmental gene activation and repression programmes

21 January 2018

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The bifunctional microRNA miR-9/miR-9* regulates REST and CoREST and is downregulated in Huntington's disease

21 January 2018

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Transcriptional dysregulation of coding and non-coding genes in cellular models of Huntington's disease

21 January 2018

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Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes

21 January 2018

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Reciprocal actions of REST and a microRNA promote neuronal identity

21 January 2018

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Comparative sequence analysis reveals an intricate network among REST, CREB and miRNA in mediating neuronal gene expression

21 January 2018

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The role of REST in transcriptional and epigenetic dysregulation in Huntington's disease

21 January 2018

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Altered microRNA regulation in Huntington's disease models

21 January 2018

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microRNA-22, downregulated in hepatocellular carcinoma and correlated with prognosis, suppresses cell proliferation and tumourigenicity

21 January 2018

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Evaluation of histone deacetylases as drug targets in Huntington's disease models. Study of HDACs in brain tissues from R6/2 and CAG140 knock-in HD mouse models and human patients and in a neuronal HD cell model

21 January 2018

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Targeting the correct HDAC(s) to treat cognitive disorders

21 January 2018

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Constitutive repression of E2F1 transcriptional activity through HDAC proteins is essential for neuronal survival

21 January 2018

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Cell cycle activation in striatal neurons from Huntington's disease patients and rats treated with 3-nitropropionic acid

21 January 2018

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Altered distribution of cell cycle transcriptional regulators during Alzheimer disease.

21 January 2018

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Transcriptional therapy with the histone deacetylase inhibitor trichostatin A ameliorates experimental autoimmune encephalomyelitis.

21 January 2018

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Increased cell proliferation and neurogenesis in the adult human Huntington's disease brain

21 January 2018

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Expanded CAG repeats in the murine Huntington's disease gene increases neuronal differentiation of embryonic and neural stem cells

21 January 2018

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When neurogenesis encounters aging and disease

21 January 2018

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Increased hippocampal neurogenesis in the progressive stage of Alzheimer's disease phenotype in an APP/PS1 double transgenic mouse model

21 January 2018

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Histone deacetylases 1 and 2 are expressed at distinct stages of neuro-glial development

21 January 2018

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Complementary roles for histone deacetylases 1, 2, and 3 in differentiation of pluripotent stem cells

21 January 2018

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Histone deacetylases 1 and 2 control the progression of neural precursors to neurons during brain development

21 January 2018

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Sirt1 contributes critically to the redox-dependent fate of neural progenitors.

21 January 2018

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Orphan nuclear receptor TLX recruits histone deacetylases to repress transcription and regulate neural stem cell proliferation

21 January 2018

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Valproic acid promotes neuronal differentiation by induction of proneural factors in association with H4 acetylation

21 January 2018

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Inhibition of histone deacetylase activity induces developmental plasticity in oligodendrocyte precursor cells

21 January 2018

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The glial or neuronal fate choice of oligodendrocyte progenitors is modulated by their ability to acquire an epigenetic memory

21 January 2018

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The transcription factor Yin Yang 1 is essential for oligodendrocyte progenitor differentiation.

21 January 2018

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Activation of REST/NRSF target genes in neural stem cells is sufficient to cause neuronal differentiation

21 January 2018

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RE1 Silencing transcription factor maintains a repressive chromatin environment in embryonic hippocampal neural stem cells.

21 January 2018

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Distinct profiles of REST interactions with its target genes at different stages of neuronal development

21 January 2018

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HDAC inhibition promotes neuronal outgrowth and counteracts growth cone collapse through CBP/p300 and P/CAF-dependent p53 acetylation

21 January 2018

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Recovery of learning and memory is associated with chromatin remodelling

21 January 2018

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Altered transcription in yeast expressing expanded polyglutamine

21 January 2018

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Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

21 January 2018

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Huntingtin is present in the nucleus, interacts with the transcriptional corepressor C-terminal binding protein, and represses transcription

21 January 2018

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Sodium butyrate induces aberrant tau phosphorylation and programmed cell death in human neuroblastoma cells

21 January 2018

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Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease

21 January 2018

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Neuroprotective effects of phenylbutyrate in the N171-82Q transgenic mouse model of Huntington's disease

21 January 2018

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Identification of phenylbutyrate-generated metabolites in Huntington disease patients using parallel liquid chromatography/electrochemical array/mass spectrometry and off-line tandem mass spectrometry

21 January 2018

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Phenylbutyrate ameliorates cognitive deficit and reduces tau pathology in an Alzheimer's disease mouse model

21 January 2018

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Neurons derived from transplanted neural stem cells restore disrupted neuronal circuitry in a mouse model of spinal cord injury.

21 January 2018

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Valproate ameliorates the survival and the motor performance in a transgenic mouse model of Huntington's disease.

21 January 2018

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Valproic acid inhibits Abeta production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse models

21 January 2018

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Pisa syndrome and parkinsonism secondary to valproic acid in Huntington's disease

21 January 2018

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Histone deacetylase inhibitor valproic acid inhibits cancer cell proliferation via down-regulation of the alzheimer amyloid precursor protein

21 January 2018

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Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease

21 January 2018

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Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors

21 January 2018

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Genetic knock-down of HDAC7 does not ameliorate disease pathogenesis in the R6/2 mouse model of Huntington's disease

21 January 2018

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Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation

21 January 2018

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Tau--an inhibitor of deacetylase HDAC6 function

21 January 2018

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Direct binding with histone deacetylase 6 mediates the reversible recruitment of parkin to the centrosome

21 January 2018

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The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations

21 January 2018

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Neuroprotective properties of resveratrol and derivatives

21 January 2018

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The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice

21 January 2018

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Searching for disease modifiers-PKC activation and HDAC inhibition - a dual drug approach to Alzheimer's disease that decreases Abeta production while blocking oxidative stress

21 January 2018

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SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis

21 January 2018

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A brain-permeable small molecule reduces neuronal cholesterol by inhibiting activity of sirtuin 2 deacetylase

21 January 2018

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Protein lysine acetylation in cellular function and its role in cancer manifestation

21 January 2018

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HDAC6 is a microtubule-associated deacetylase

21 January 2018

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Acetylation targets mutant huntingtin to autophagosomes for degradation

21 January 2018

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NF-kappaB regulation: the nuclear response

21 January 2018

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IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome.

21 January 2018

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The acetylation of tau inhibits its function and promotes pathological tau aggregation

21 January 2018

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Acetylation of tau inhibits its degradation and contributes to tauopathy

21 January 2018

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Aggregation of detergent-insoluble tau is involved in neuronal loss but not in synaptic loss

21 January 2018

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The proteins BACE1 and BACE2 and beta-secretase activity in normal and Alzheimer's disease brain.

21 January 2018

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The role of amyloid precursor protein processing by BACE1, the beta-secretase, in Alzheimer disease pathophysiology

21 January 2018

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Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase

21 January 2018

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A reversible form of lysine acetylation in the ER and Golgi lumen controls the molecular stabilization of BACE1.

21 January 2018

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Two endoplasmic reticulum (ER)/ER Golgi intermediate compartment-based lysine acetyltransferases post-translationally regulate BACE1 levels

21 January 2018

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SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10.

21 January 2018

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Modulation of SIRT1 expression in different neurodegenerative models and human pathologies

21 January 2018

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Immunity, Inflammation, and Cancer

21 January 2018

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Targeting histone deacetylases for the treatment of immune, endocrine & metabolic disorders

21 January 2018

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Inflammation in neurodegenerative diseases

21 January 2018

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Inflammation in transgenic mouse models of neurodegenerative disorders

21 January 2018

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Targeting histone deacetylases for the treatment of disease

21 January 2018

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Activation of the IkappaB kinase complex and nuclear factor-kappaB contributes to mutant huntingtin neurotoxicity.

21 January 2018

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IKKalpha and IKKbeta regulation of DNA damage-induced cleavage of huntingtin

21 January 2018

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NFkappaB-dependent control of BACE1 promoter transactivation by Abeta42.

21 January 2018

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The Toll-->NFkappaB signaling pathway mediates the neuropathological effects of the human Alzheimer's Abeta42 polypeptide in Drosophila

21 January 2018

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SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling

21 January 2018

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A trip to the ER: coping with stress

21 January 2018

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In and Out of the ER: Protein Folding, Quality Control, Degradation, and Related Human Diseases

21 January 2018

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Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes

21 January 2018

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Mallory body formation is associated with epigenetic phenotypic change in hepatocytes in vivo

21 January 2018

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Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion

21 January 2018

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Dynamic recruitment of transcription factors and epigenetic changes on the ER stress response gene promoters

21 January 2018

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Endoplasmic reticulum stress induction of the Grp78/BiP promoter: activating mechanisms mediated by YY1 and its interactive chromatin modifiers.

21 January 2018

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Role of the repressor JDP2 in the amino acid-regulated transcription of CHOP

21 January 2018

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Converging pathways in the occurrence of endoplasmic reticulum (ER) stress in Huntington's disease

21 January 2018

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Inhibition of endoplasmic reticulum stress counteracts neuronal cell death and protein aggregation caused by N-terminal mutant huntingtin proteins

21 January 2018

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A stress sensitive ER membrane-association domain in Huntingtin protein defines a potential role for Huntingtin in the regulation of autophagy

21 January 2018

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Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity

21 January 2018

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Huntingtin interacts with the cue domain of gp78 and inhibits gp78 binding to ubiquitin and p97/VCP.

21 January 2018

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SCAMP5 links endoplasmic reticulum stress to the accumulation of expanded polyglutamine protein aggregates via endocytosis inhibition

21 January 2018

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Rrs1 is involved in endoplasmic reticulum stress response in Huntington disease

21 January 2018

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Identification of a presymptomatic molecular phenotype in Hdh CAG knock-in mice

21 January 2018

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Global changes to the ubiquitin system in Huntington's disease.

21 January 2018

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Impaired ubiquitin-proteasome system activity in the synapses of Huntington's disease mice

21 January 2018

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The ubiquitin-proteasome system in Alzheimer's disease

21 January 2018

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Endoplasmic reticulum stress compromises the ubiquitin-proteasome system

21 January 2018

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HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS

21 January 2018

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HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy

21 January 2018

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The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress

21 January 2018

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HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates

21 January 2018

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The deacetylase HDAC6 is a novel critical component of stress granules involved in the stress response

21 January 2018

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HDAC6 a new cellular stress surveillance factor.

21 January 2018

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The role of the ubiquitin proteasome system in Alzheimer's disease

21 January 2018

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Ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memory

21 January 2018

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The unfolded protein response is activated in Alzheimer's disease.

21 January 2018

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The unfolded protein response is activated in pretangle neurons in Alzheimer's disease hippocampus

21 January 2018

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The unfolded protein response affects neuronal cell cycle protein expression: implications for Alzheimer's disease pathogenesis.

21 January 2018

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Amyloid precursor protein promotes endoplasmic reticulum stress-induced cell death via C/EBP homologous protein-mediated pathway

21 January 2018

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Increased BACE1 mRNA and noncoding BACE1-antisense transcript in sporadic inclusion-body myositis muscle fibers--possibly caused by endoplasmic reticulum stress

21 January 2018

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Chemical chaperones mediate increased secretion of mutant alpha 1-antitrypsin (alpha 1-AT) Z: A potential pharmacological strategy for prevention of liver injury and emphysema in alpha 1-AT deficiency

21 January 2018

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Sodium 4-phenylbutyrate protects against cerebral ischemic injury.

21 January 2018

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Sodium 4-phenylbutyrate protects against liver ischemia reperfusion injury by inhibition of endoplasmic reticulum-stress mediated apoptosis

21 January 2018

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Chemical chaperones protect from effects of apoptosis-inducing mutation in carbonic anhydrase IV identified in retinitis pigmentosa 17.

21 January 2018

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Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes

21 January 2018

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Chemical chaperones reduce endoplasmic reticulum stress and prevent mutant HFE aggregate formation

21 January 2018

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Suppressive effects of 4-phenylbutyrate on the aggregation of Pael receptors and endoplasmic reticulum stress

21 January 2018

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Mood stabilizing drug lithium increases expression of endoplasmic reticulum stress proteins in primary cultured rat cerebral cortical cells

21 January 2018

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Role of glutathione in neuroprotective effects of mood stabilizing drugs lithium and valproate.

21 January 2018

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HDAC6-p97/VCP controlled polyubiquitin chain turnover

21 January 2018

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Histone deacetylase 6 regulates growth factor-induced actin remodeling and endocytosis

21 January 2018

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HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor

21 January 2018

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Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: a novel basis for antileukemia activity of histone deacetylase inhibitors.

21 January 2018

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Hydroxamic acid analogue histone deacetylase inhibitors attenuate estrogen receptor-alpha levels and transcriptional activity: a result of hyperacetylation and inhibition of chaperone function of heat shock protein 90.

21 January 2018

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Histone deacetylase inhibitors induce VHL and ubiquitin-independent proteasomal degradation of hypoxia-inducible factor 1alpha

21 January 2018

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An acetylation site in the middle domain of Hsp90 regulates chaperone function

21 January 2018

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Human class I histone deacetylase complexes show enhanced catalytic activity in the presence of ATP and co-immunoprecipitate with the ATP-dependent chaperone protein Hsp70

21 January 2018

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Sodium 4-phenylbutyrate acts as a chemical chaperone on misfolded myocilin to rescue cells from endoplasmic reticulum stress and apoptosis

21 January 2018

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Defective trafficking of nephrin missense mutants rescued by a chemical chaperone

21 January 2018

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4-Phenylbutyrate rescues trafficking incompetent mutant alpha-galactosidase A without restoring its functionality.

21 January 2018

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Signal sequence mutation in autosomal dominant form of hypoparathyroidism induces apoptosis that is corrected by a chemical chaperone

21 January 2018

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Functional and trafficking defects in ATP binding cassette A3 mutants associated with respiratory distress syndrome

21 January 2018

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Valproate Sodium in Huntington Chorea

21 January 2018

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Sodium valproate in Huntington's disease

21 January 2018

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Dose-dependent improvement of myoclonic hyperkinesia due to Valproic acid in eight Huntington's Disease patients: a case series.

21 January 2018

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Improvement of Huntington's disease with olanzapine and valproate

21 January 2018

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FDA approval summary: vorinostat for treatment of advanced primary cutaneous T-cell lymphoma

21 January 2018

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Sodium phenylbutyrate in Huntington's disease: a dose-finding study.

21 January 2018

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Histone deacetylase inhibitor activity in royal jelly might facilitate caste switching in bees.

21 January 2018

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Cancer chemoprevention by dietary polyphenols: promising role for epigenetics

21 January 2018

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Epigenetic targets of bioactive dietary components for cancer prevention and therapy

21 January 2018

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Distinct biological network properties between the targets of natural products and disease genes

21 January 2018

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Stem cells for the treatment of neurological disorders

21 January 2018

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Inhibition of Sirt1 promotes neural progenitors toward motoneuron differentiation from human embryonic stem cells

21 January 2018

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Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation.

21 January 2018

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Direct conversion of C. elegans germ cells into specific neuron types.

21 January 2018

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RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model

21 January 2018

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Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits

21 January 2018

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Sustained effects of nonallele-specific Huntingtin silencing

21 January 2018

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Nonallele-specific silencing of mutant and wild-type huntingtin demonstrates therapeutic efficacy in Huntington's disease mice.

21 January 2018

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Identification and allele-specific silencing of the mutant huntingtin allele in Huntington's disease patient-derived fibroblasts.

21 January 2018

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Tailor-made RNAi knockdown against triplet repeat disease-causing alleles

21 January 2018

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Five siRNAs targeting three SNPs may provide therapy for three-quarters of Huntington's disease patients

21 January 2018

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A majority of Huntington's disease patients may be treatable by individualized allele-specific RNA interference.

21 January 2018

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Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model

21 January 2018

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Allele-specific RNAi mitigates phenotypic progression in a transgenic model of Alzheimer's disease

21 January 2018

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Neuronal microRNA deregulation in response to Alzheimer's disease amyloid-beta

21 January 2018

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miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues

21 January 2018

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MicroRNA-9 coordinates proliferation and migration of human embryonic stem cell-derived neural progenitors

21 January 2018

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Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer

21 January 2018

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MicroRNA-101 regulates amyloid precursor protein expression in hippocampal neurons

21 January 2018

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MicroRNA-101 downregulates Alzheimer's amyloid-β precursor protein levels in human cell cultures and is differentially expressed.

21 January 2018

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miR-449a targets HDAC-1 and induces growth arrest in prostate cancer

21 January 2018

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E2F1-inducible microRNA 449a/b suppresses cell proliferation and promotes apoptosis

21 January 2018

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A novel pathway regulates memory and plasticity via SIRT1 and miR-134

21 January 2018

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Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes

21 January 2018

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MicroRNA-regulated, systemically delivered rAAV9: a step closer to CNS-restricted transgene expression

21 January 2018

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Global gene transfer into the CNS across the BBB after neonatal systemic delivery of single-stranded AAV vectors

21 January 2018

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Transvascular delivery of small interfering RNA to the central nervous system.

21 January 2018

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Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

21 January 2018

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Liposome-siRNA-peptide complexes cross the blood-brain barrier and significantly decrease PrP on neuronal cells and PrP in infected cell cultures

21 January 2018

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Post-translational modifications of tau protein: implications for Alzheimer's disease.

21 January 2018

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SCFFbx2-E3-ligase-mediated degradation of BACE1 attenuates Alzheimer's disease amyloidosis and improves synaptic function

21 January 2018

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Neuronal Sirt3 protects against excitotoxic injury in mouse cortical neuron culture

21 January 2018

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Genomic instability and aging-like phenotype in the absence of mammalian SIRT6

21 January 2018

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Reduction of acetylated alpha-tubulin immunoreactivity in neurofibrillary tangle-bearing neurons in Alzheimer's disease.

21 January 2018

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21 January 2018

Identifiers

DOI

10.2217/EPI.11.67

1 reference

26 August 2017

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