(Q37774037)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20642797%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

review article

1 reference

title

Targeting histone deacetylases for the treatment of Huntington's disease (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20642797%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

0 references

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20642797%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

author name string

Steven G Gray

series ordinal

1

1 reference

23 August 2017

1 December 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20642797%20AND%20SRC:MED&resulttype=core&format=json

CNS Neuroscience & Therapeutics

8 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20642797%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

volume

16

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20642797%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

issue

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20642797%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

page(s)

348-361

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20642797%20AND%20SRC:MED&resulttype=core&format=json

A site to remember: H3K36 methylation a mark for histone deacetylation

8 February 2020

cites work

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00184.X

Endoplasmic reticulum stress: signaling the unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00184.X

Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00184.X

A stress sensitive ER membrane-association domain in Huntingtin protein defines a potential role for Huntingtin in the regulation of autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00184.X

HspB8 and Bag3: a new chaperone complex targeting misfolded proteins to macroautophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00184.X

Neuroprotective effects of phenylbutyrate in the N171-82Q transgenic mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00184.X

Long-term treatment of juvenile Huntington's chorea with dipropylacetic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00184.X

Valproate Sodium in Huntington Chorea

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00184.X

Sodium valproate in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00184.X

Differential display PCR reveals novel targets for the mood-stabilizing drug valproate including the molecular chaperone GRP78

21 January 2018

1 reference

12 December 2020

Huntington's disease intranuclear inclusions contain truncated, ubiquitinated huntingtin protein

1 reference

12 December 2020

Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtin

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12 December 2020

Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells

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12 December 2020

Chemical chaperones mediate increased secretion of mutant alpha 1-antitrypsin (alpha 1-AT) Z: A potential pharmacological strategy for prevention of liver injury and emphysema in alpha 1-AT deficiency

1 reference

12 December 2020

Transcriptional repression by blimp-1 (PRDI-BF1) involves recruitment of histone deacetylase

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12 December 2020

The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription

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12 December 2020

Increased expression of endoplasmic reticulum stress proteins following chronic valproate treatment of rat C6 glioma cells.

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12 December 2020

Improvement of Huntington's disease with olanzapine and valproate

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12 December 2020

Chronic valproate treatment increases expression of endoplasmic reticulum stress proteins in the rat cerebral cortex and hippocampus

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12 December 2020

Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity

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12 December 2020

Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

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12 December 2020

Altered transcription in yeast expressing expanded polyglutamine

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12 December 2020

Huntingtin is present in the nucleus, interacts with the transcriptional corepressor C-terminal binding protein, and represses transcription

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12 December 2020

Requirement of an intact microtubule cytoskeleton for aggregation and inclusion body formation by a mutant huntingtin fragment.

1 reference

12 December 2020

Perinuclear localization of huntingtin as a consequence of its binding to microtubules through an interaction with beta-tubulin: relevance to Huntington's disease

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12 December 2020

HDAC6 is a microtubule-associated deacetylase

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12 December 2020

The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt.

1 reference

12 December 2020

Identification of a presymptomatic molecular phenotype in Hdh CAG knock-in mice

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12 December 2020

Cell death triggered by polyglutamine-expanded huntingtin in a neuronal cell line is associated with degradation of CREB-binding protein

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12 December 2020

The Set2 histone methyltransferase functions through the phosphorylated carboxyl-terminal domain of RNA polymerase II.

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12 December 2020

Valproate inhibits oxidative damage to lipid and protein in primary cultured rat cerebrocortical cells

1 reference

12 December 2020

Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease

1 reference

12 December 2020

Phosphorylation of RNA polymerase II CTD regulates H3 methylation in yeast

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12 December 2020

The histone 3 lysine 36 methyltransferase, SET2, is involved in transcriptional elongation

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12 December 2020

Methylation of histone H3 by Set2 in Saccharomyces cerevisiae is linked to transcriptional elongation by RNA polymerase II

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12 December 2020

Mutant huntingtin increases nuclear corepressor function and enhances ligand-dependent nuclear hormone receptor activation

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12 December 2020

Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes

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12 December 2020

Microtubule destabilization and nuclear entry are sequential steps leading to toxicity in Huntington's disease

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12 December 2020

Histone Deacetylase Inhibition by Sodium Butyrate Chemotherapy Ameliorates the Neurodegenerative Phenotype in Huntington's Disease Mice

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12 December 2020

The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress

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12 December 2020

The serum- and glucocorticoid-induced kinase SGK inhibits mutant huntingtin-induced toxicity by phosphorylating serine 421 of huntingtin.

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12 December 2020

A trip to the ER: coping with stress

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12 December 2020

Coupling endoplasmic reticulum stress to the cell death program

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12 December 2020

SUMO modification of Huntingtin and Huntington's disease pathology

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12 December 2020

Sodium 4-phenylbutyrate protects against cerebral ischemic injury.

1 reference

12 December 2020

Chemical chaperones protect from effects of apoptosis-inducing mutation in carbonic anhydrase IV identified in retinitis pigmentosa 17.

1 reference

12 December 2020

Activation of the IkappaB kinase complex and nuclear factor-kappaB contributes to mutant huntingtin neurotoxicity.

1 reference

12 December 2020

HspB8, a small heat shock protein mutated in human neuromuscular disorders, has in vivo chaperone activity in cultured cells.

1 reference

12 December 2020

Endoplasmic reticulum stress induction of the Grp78/BiP promoter: activating mechanisms mediated by YY1 and its interactive chromatin modifiers.

1 reference

12 December 2020

Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity

1 reference

12 December 2020

Chronic treatment with mood stabilizers lithium and valproate prevents excitotoxicity by inhibiting oxidative stress in rat cerebral cortical cells.

1 reference

12 December 2020

Genome-wide expression profiling of human blood reveals biomarkers for Huntington's disease.

1 reference

12 December 2020

Histone H3 K36 methylation is associated with transcription elongation in Schizosaccharomyces pombe

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12 December 2020

Endoplasmic reticulum stress compromises the ubiquitin-proteasome system

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12 December 2020

Identification and characterization of a novel human histone H3 lysine 36-specific methyltransferase

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12 December 2020

Sodium 4-phenylbutyrate protects against liver ischemia reperfusion injury by inhibition of endoplasmic reticulum-stress mediated apoptosis

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12 December 2020

Endoplasmic reticulum stress: cell life and death decisions.

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12 December 2020

Mood stabilizing drug lithium increases expression of endoplasmic reticulum stress proteins in primary cultured rat cerebral cortical cells

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12 December 2020

Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex

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12 December 2020

Inhibition of calcineurin by FK506 protects against polyglutamine-huntingtin toxicity through an increase of huntingtin phosphorylation at S421.

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12 December 2020

Mutant huntingtin represses CBP, but not p300, by binding and protein degradation

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12 December 2020

Reciprocal actions of REST and a microRNA promote neuronal identity

1 reference

12 December 2020

Dose-dependent improvement of myoclonic hyperkinesia due to Valproic acid in eight Huntington's Disease patients: a case series.

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12 December 2020

Differential contributions of Caenorhabditis elegans histone deacetylases to huntingtin polyglutamine toxicity.

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12 December 2020

Suppressive effects of 4-phenylbutyrate on the aggregation of Pael receptors and endoplasmic reticulum stress

1 reference

12 December 2020

Selective inhibition of endoplasmic reticulum-associated degradation rescues DeltaF508-cystic fibrosis transmembrane regulator and suppresses interleukin-8 levels: therapeutic implications.

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12 December 2020

Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function

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12 December 2020

BLIMP-1 is a target of cellular stress and downstream of the unfolded protein response.

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12 December 2020

Dynamic recruitment of transcription factors and epigenetic changes on the ER stress response gene promoters

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12 December 2020

Depletion of CBP is directly linked with cellular toxicity caused by mutant huntingtin

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12 December 2020

Huntingtin phosphorylation sites mapped by mass spectrometry. Modulation of cleavage and toxicity

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12 December 2020

Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes

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12 December 2020

Comparative sequence analysis reveals an intricate network among REST, CREB and miRNA in mediating neuronal gene expression

1 reference

12 December 2020

Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration.

1 reference

12 December 2020

Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration

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12 December 2020

ESET/SETDB1 gene expression and histone H3 (K9) trimethylation in Huntington's disease

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12 December 2020

Role of glutathione in neuroprotective effects of mood stabilizing drugs lithium and valproate.

1 reference

12 December 2020

1 reference

12 December 2020

Sodium 4-phenylbutyrate acts as a chemical chaperone on misfolded myocilin to rescue cells from endoplasmic reticulum stress and apoptosis

1 reference

12 December 2020

Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation

1 reference

12 December 2020

Modulation of nucleosome dynamics in Huntington's disease

1 reference

12 December 2020

Histones associated with downregulated genes are hypo-acetylated in Huntington's disease models

1 reference

12 December 2020

Oxidative stress induces the endoplasmic reticulum stress and facilitates inclusion formation in cultured cells

1 reference

12 December 2020

Regulation of P-TEFb elongation complex activity by CDK9 acetylation

1 reference

12 December 2020

Mallory body formation is associated with epigenetic phenotypic change in hepatocytes in vivo

1 reference

12 December 2020

Signal integration in the endoplasmic reticulum unfolded protein response

1 reference

12 December 2020

HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS

1 reference

12 December 2020

Widespread disruption of repressor element-1 silencing transcription factor/neuron-restrictive silencer factor occupancy at its target genes in Huntington's disease.

1 reference

12 December 2020

Phosphorylation of huntingtin by cyclin-dependent kinase 5 is induced by DNA damage and regulates wild-type and mutant huntingtin toxicity in neurons.

1 reference

12 December 2020

Chemical chaperones reduce endoplasmic reticulum stress and prevent mutant HFE aggregate formation

1 reference

12 December 2020

H2B Ubiquitylation Acts as a Barrier to Ctk1 Nucleosomal Recruitment Prior to Removal by Ubp8 within a SAGA-Related Complex

1 reference

12 December 2020

Global changes to the ubiquitin system in Huntington's disease.

1 reference

12 December 2020

Histone deacetylase inhibitors: molecular mechanisms of action

1 reference

12 December 2020

Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity

1 reference

12 December 2020

Cellular osmolytes reduce lens epithelial cell death and alleviate cataract formation in galactosemic rats

1 reference

12 December 2020

HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates

1 reference

12 December 2020

Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors

1 reference

12 December 2020

Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion

1 reference

12 December 2020

Histone deacetylase inhibitors selectively suppress expression of HDAC7

1 reference

12 December 2020

In and Out of the ER: Protein Folding, Quality Control, Degradation, and Related Human Diseases

1 reference

12 December 2020

Systems biology of the endoplasmic reticulum stress response.

1 reference

12 December 2020

Differentially expressed genes are marked by histone 3 lysine 9 trimethylation in human cancer cells

1 reference

12 December 2020

HspB8 chaperone activity toward poly(Q)-containing proteins depends on its association with Bag3, a stimulator of macroautophagy.

1 reference

12 December 2020

Mitogen- and stress-activated protein kinase-1 deficiency is involved in expanded-huntingtin-induced transcriptional dysregulation and striatal death.

1 reference

12 December 2020

Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes

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12 December 2020

The deacetylase HDAC6 is a novel critical component of stress granules involved in the stress response

1 reference

12 December 2020

HDAC6 a new cellular stress surveillance factor.

1 reference

12 December 2020

Inhibition of endoplasmic reticulum stress counteracts neuronal cell death and protein aggregation caused by N-terminal mutant huntingtin proteins

1 reference

12 December 2020

Monoallele deletion of CBP leads to pericentromeric heterochromatin condensation through ESET expression and histone H3 (K9) methylation

1 reference

12 December 2020

Impaired ubiquitin-proteasome system activity in the synapses of Huntington's disease mice

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12 December 2020

Role of the repressor JDP2 in the amino acid-regulated transcription of CHOP

1 reference

12 December 2020

Altered histone monoubiquitylation mediated by mutant huntingtin induces transcriptional dysregulation

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12 December 2020

Phosphoproteomic analysis of human brain by calcium phosphate precipitation and mass spectrometry

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12 December 2020

The multi-tasking P-TEFb complex

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12 December 2020

Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons

1 reference

12 December 2020

A quantitative atlas of mitotic phosphorylation

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12 December 2020

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle

1 reference

12 December 2020

Phosphorylation of mutant huntingtin at S421 restores anterograde and retrograde transport in neurons.

1 reference

12 December 2020

Pisa syndrome and parkinsonism secondary to valproic acid in Huntington's disease

1 reference

12 December 2020

The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice

1 reference

12 December 2020

Phosphorylation of huntingtin reduces the accumulation of its nuclear fragments

1 reference

12 December 2020

One step at a time: endoplasmic reticulum-associated degradation

1 reference

12 December 2020

Direct binding with histone deacetylase 6 mediates the reversible recruitment of parkin to the centrosome

1 reference

12 December 2020

HspB8 participates in protein quality control by a non-chaperone-like mechanism that requires eIF2{alpha} phosphorylation

1 reference

12 December 2020

The bifunctional microRNA miR-9/miR-9* regulates REST and CoREST and is downregulated in Huntington's disease

1 reference

12 December 2020

The gene coding for PGC-1alpha modifies age at onset in Huntington's Disease

1 reference

12 December 2020

PGC-1alpha as modifier of onset age in Huntington disease

1 reference

12 December 2020

SCAMP5 links endoplasmic reticulum stress to the accumulation of expanded polyglutamine protein aggregates via endocytosis inhibition

1 reference

12 December 2020

Acetylation targets mutant huntingtin to autophagosomes for degradation

1 reference

12 December 2020

SysPTM: a systematic resource for proteomic research on post-translational modifications

1 reference

12 December 2020

Mechanisms of transcriptional repression by histone lysine methylation

1 reference

12 December 2020

Rrs1 is involved in endoplasmic reticulum stress response in Huntington disease

1 reference

12 December 2020

Tau--an inhibitor of deacetylase HDAC6 function.

1 reference

12 December 2020

Impaired PGC-1alpha function in muscle in Huntington's disease.

1 reference

12 December 2020

Genetic knock-down of HDAC7 does not ameliorate disease pathogenesis in the R6/2 mouse model of Huntington's disease

1 reference

12 December 2020

IKKalpha and IKKbeta regulation of DNA damage-induced cleavage of huntingtin

1 reference

12 December 2020

Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity

1 reference

12 December 2020

Oxidative stress induced lung cancer and COPD: opportunities for epigenetic therapy

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12 December 2020

Phosphoproteomic analysis of human embryonic stem cells

1 reference

12 December 2020

Accumulation of ubiquitin conjugates in a polyglutamine disease model occurs without global ubiquitin/proteasome system impairment

1 reference

12 December 2020

Valproate ameliorates the survival and the motor performance in a transgenic mouse model of Huntington's disease.

1 reference

12 December 2020

Phosphorylation of threonine 3: implications for Huntingtin aggregation and neurotoxicity

1 reference

12 December 2020

Transcriptional dysregulation of coding and non-coding genes in cellular models of Huntington's disease

1 reference

12 December 2020

IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome.

1 reference

12 December 2020

Identification of phenylbutyrate-generated metabolites in Huntington disease patients using parallel liquid chromatography/electrochemical array/mass spectrometry and off-line tandem mass spectrometry

1 reference

12 December 2020

Huntingtin interacts with the cue domain of gp78 and inhibits gp78 binding to ubiquitin and p97/VCP.

1 reference

12 December 2020

Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons

1 reference

12 December 2020

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

1 reference

12 December 2020

The ER-overload response: activation of NF-kappa B.

1 reference

12 December 2020

Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice.

1 reference

12 December 2020

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

1 reference

12 December 2020

10.1111/J.1755-5949.2010.00184.X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20642797%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20642797%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

1 reference