(Q38214522)

31 August 2017

title

Genetic susceptibility to type 2 diabetes and obesity: from genome-wide association studies to rare variants and beyond (English)

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genome-wide association study

31 August 2017

main subject

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1

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31 August 2017

4

Oluf Pedersen

1 reference

31 August 2017

Camilla H Sandholt

2

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31 August 2017

Torben Hansen

series ordinal

3

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31 August 2017

publication date

24 May 2014

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31 August 2017

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31 August 2017

volume

57

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31 August 2017

issue

8

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31 August 2017

page(s)

1528-1541

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Global burden of obesity in 2005 and projections to 2030.

31 August 2017

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Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

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Identification of low-frequency and rare sequence variants associated with elevated or reduced risk of type 2 diabetes

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New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

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A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B

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Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India

21 January 2018

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Genome-wide association study for type 2 diabetes in Indians identifies a new susceptibility locus at 2q21.

21 January 2018

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Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci

21 January 2018

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A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans

21 January 2018

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Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians

21 January 2018

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Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci

21 January 2018

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Genome-wide association study identifies three novel loci for type 2 diabetes

21 January 2018

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Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

21 January 2018

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Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

21 January 2018

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TCF7L2 is reproducibly associated with type 2 diabetes in various ethnic groups: a global meta-analysis

21 January 2018

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Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

21 January 2018

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Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

21 January 2018

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A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

21 January 2018

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Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways

21 January 2018

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Genetic variants affecting incretin sensitivity and incretin secretion

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Physiologic characterization of type 2 diabetes-related loci

21 January 2018

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Reduced insulin exocytosis in human pancreatic β-cells with gene variants linked to type 2 diabetes

21 January 2018

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Variants at DGKB/TMEM195, ADRA2A, GLIS3 and C2CD4B loci are associated with reduced glucose-stimulated beta cell function in middle-aged Danish people

21 January 2018

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Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans

21 January 2018

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Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B affect different aspects of pancreatic beta-cell function

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Beta cell function and its relation to insulin action in humans: a critical appraisal

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Common variants near MC4R are associated with fat mass, weight and risk of obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Common genetic variation near MC4R is associated with waist circumference and insulin resistance

21 January 2018

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Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution

21 January 2018

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Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups

21 January 2018

1 reference

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A genome-wide association meta-analysis identifies new childhood obesity loci

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Genome wide association study identifies KCNMA1 contributing to human obesity

21 January 2018

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Genome-wide population-based association study of extremely overweight young adults--the GOYA study

21 January 2018

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Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Obesity-susceptibility loci and the tails of the pediatric BMI distribution.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

FTO genotype is associated with phenotypic variability of body mass index

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Meta-analysis identifies common variants associated with body mass index in east Asians

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Consistent association of type 2 diabetes risk variants found in europeans in diverse racial and ethnic groups

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Consistent directions of effect for established type 2 diabetes risk variants across populations: the population architecture using Genomics and Epidemiology (PAGE) Consortium

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Cellular characterisation of the GCKR P446L variant associated with type 2 diabetes risk.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Survival of pancreatic beta cells is partly controlled by a TCF7L2-p53-p53INP1-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Genotype and tissue-specific effects on alternative splicing of the transcription factor 7-like 2 gene in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

A map of open chromatin in human pancreatic islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Mutation in hepatocyte nuclear factor-1 beta gene (TCF2) associated with MODY.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3)

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Mutations in GLIS3 are responsible for a rare syndrome with neonatal diabetes mellitus and congenital hypothyroidism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Two variants on chromosome 17 confer prostate cancer risk and the one in TCF2 protects against type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

A frameshift mutation in MC4R associated with dominantly inherited human obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Brain-derived neurotrophic factor and obesity in the WAGR syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Large, rare chromosomal deletions associated with severe early-onset obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

A de novo mutation affecting human TrkB associated with severe obesity and developmental delay

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Variation in FTO contributes to childhood obesity and severe adult obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

FTO, type 2 diabetes, and weight gain throughout adult life: a meta-analysis of 41,504 subjects from the Scandinavian HUNT, MDC, and MPP studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Shared quantitative trait loci underlying the genetic correlation between continuous traits

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Shared genetic influence of BMI, physical activity and type 2 diabetes: a twin study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Evidence that BMI and type 2 diabetes share only a minor fraction of genetic variance: a follow-up study of 23,585 monozygotic and dizygotic twins from the Finnish Twin Cohort Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Biological, clinical and population relevance of 95 loci for blood lipids

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Pleiotropic effects of obesity-susceptibility loci on metabolic traits: a meta-analysis of up to 37,874 individuals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Improved glucose homeostasis and enhanced insulin signalling in Grb14-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Contribution of 24 obesity-associated genetic variants to insulin resistance, pancreatic beta-cell function and type 2 diabetes risk in the French population

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Myocardial infarction and ischemic heart disease in overweight and obesity with and without metabolic syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Are metabolically healthy overweight and obesity benign conditions?: A systematic review and meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Personal genomes: The case of the missing heritability

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

On the allelic spectrum of human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

The allelic architecture of human disease genes: common disease-common variant... or not?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Common and rare variants in multifactorial susceptibility to common diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Are rare variants responsible for susceptibility to complex diseases?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

A map of human genome variation from population-scale sequencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Evolution and functional impact of rare coding variation from deep sequencing of human exomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Evolutionary quantitative genetics: how little do we know?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Revisiting the thrifty gene hypothesis via 65 loci associated with susceptibility to type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Multiple Rare Alleles Contribute to Low Plasma Levels of HDL Cholesterol

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Heterozygous mutations causing partial prohormone convertase 1 deficiency contribute to human obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Heritability in the genomics era — concepts and misconceptions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Discovery and refinement of loci associated with lipid levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Evaluating empirical bounds on complex disease genetic architecture

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

A new highly penetrant form of obesity due to deletions on chromosome 16p11.2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Parental origin of sequence variants associated with complex diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Searching for missing heritability: designing rare variant association studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

A rare variant in MYH6 is associated with high risk of sick sinus syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Imputation of variants from the 1000 Genomes Project modestly improves known associations and can identify low-frequency variant-phenotype associations undetected by HapMap based imputation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Genetic architecture of vitamin B12 and folate levels uncovered applying deeply sequenced large datasets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Exome sequencing followed by large-scale genotyping fails to identify single rare variants of large effect in idiopathic generalized epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Exome sequencing followed by large-scale genotyping suggests a limited role for moderately rare risk factors of strong effect in schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Computational and statistical approaches to analyzing variants identified by exome sequencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

The empirical power of rare variant association methods: results from sanger sequencing in 1,998 individuals

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Whole-exome sequencing of 2,000 Danish individuals and the role of rare coding variants in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Power of family-based association designs to detect rare variants in large pedigrees using imputed genotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

The future of genetic studies of complex human diseases

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Strong association of de novo copy number mutations with autism

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Patterns and rates of exonic de novo mutations in autism spectrum disorders

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Rate of de novo mutations and the importance of father's age to disease risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Clinical spectrum associated with hepatocyte nuclear factor-1beta mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

A window into third-generation sequencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Genotype score in addition to common risk factors for prediction of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Clinical risk factors, DNA variants, and the development of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Combined analyses of 20 common obesity susceptibility variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Diagnosis and management of maturity onset diabetes of the young (MODY).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Heritability and familiality of type 2 diabetes and related quantitative traits in the Botnia Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Prevalence of Mutations and Functional Analyses of Melanocortin 4 Receptor Variants Identified among 750 Men with Juvenile-Onset Obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3270-4

Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension

21 January 2018

1 reference

12 December 2020

[Predictive value of diagnostic procedures]

1 reference

12 December 2020

Is FTO a type 2 diabetes susceptibility gene?

1 reference

12 December 2020

Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"?

1 reference

12 December 2020

Type 2 diabetes: prevalence and relevance of genetic and acquired factors for its prediction

1 reference

12 December 2020

Influences of genes and shared family environment on adult body mass index assessed in an adoption study by a comprehensive path model

1 reference

12 December 2020

Effect of genome-wide genotyping and reference panels on rare variants imputation

1 reference

12 December 2020

10.1007/S00125-014-3270-4

Identifiers

DOI

1 reference

Dimensions Publication ID

31 August 2017

1013134889

0 references

1 reference