(Q37780493)

23 August 2017

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title

Genetic variants affecting incretin sensitivity and incretin secretion (English)

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23 August 2017

2

H Staiger

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23 August 2017

5

A Fritsche

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23 August 2017

3

F Machicao

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23 August 2017

4

H-U Häring

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23 August 2017

1

K Müssig

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23 August 2017

publication date

17 August 2010

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23 August 2017

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23 August 2017

volume

53

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23 August 2017

issue

11

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23 August 2017

page(s)

2289-2297

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https://scigraph.springernature.com/pub.10.1007/s00125-010-1876-8

23 August 2017

exact match

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cites work

Ion channels in secretory granules of the pancreas and their role in exocytosis and release of secretory proteins

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00125-010-1876-8

The E23K variant of KCNJ11 encoding the pancreatic beta-cell adenosine 5'-triphosphate-sensitive potassium channel subunit Kir6.2 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes.

21 January 2018

1 reference

12 December 2020

Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

1 reference

12 December 2020

Type 2 diabetes-associated missense polymorphisms KCNJ11 E23K and ABCC8 A1369S influence progression to diabetes and response to interventions in the Diabetes Prevention Program

1 reference

12 December 2020

Association studies of variants in promoter and coding regions of beta-cell ATP-sensitive K-channel genes SUR1 and Kir6.2 with Type 2 diabetes mellitus (UKPDS 53).

1 reference

12 December 2020

Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance.

1 reference

12 December 2020

Glucose intolerance caused by a defect in the entero-insular axis: a study in gastric inhibitory polypeptide receptor knockout mice

1 reference

12 December 2020

Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance

1 reference

12 December 2020

A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations: results from the EUGENE2 study

1 reference

12 December 2020

WFS1 (Wolfram syndrome 1) gene product: predominant subcellular localization to endoplasmic reticulum in cultured cells and neuronal expression in rat brain

1 reference

12 December 2020

TCF7L2 in the Go-DARTS study: evidence for a gene dose effect on both diabetes susceptibility and control of glucose levels

1 reference

12 December 2020

K121Q PC‐1 Gene Polymorphism Is Not Associated with Insulin Resistance in a Spanish Population

1 reference

12 December 2020

Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion

1 reference

12 December 2020

Association of Transcription Factor 7-Like 2 (TCF7L2) Variants With Type 2 Diabetes in a Finnish Sample

1 reference

12 December 2020

The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes

1 reference

12 December 2020

The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes

1 reference

12 December 2020

Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B affect different aspects of pancreatic beta-cell function

1 reference

12 December 2020

Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes

1 reference

12 December 2020

Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians

1 reference

12 December 2020

A common genetic variant in WFS1 determines impaired glucagon-like peptide-1-induced insulin secretion

1 reference

12 December 2020

The T allele of rs7903146 TCF7L2 is associated with impaired insulinotropic action of incretin hormones, reduced 24 h profiles of plasma insulin and glucagon, and increased hepatic glucose production in young healthy men.

1 reference

12 December 2020

Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

1 reference

12 December 2020

Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution

1 reference

12 December 2020

Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms.

1 reference

12 December 2020

Is the diminished incretin effect in type 2 diabetes just an epi-phenomenon of impaired beta-cell function?

1 reference

12 December 2020

Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function

1 reference

12 December 2020

Beta cell glucose sensitivity is decreased by 39% in non-diabetic individuals carrying multiple diabetes-risk alleles compared with those with no risk alleles.

1 reference

12 December 2020

Polymorphism in the transcription factor 7-like 2 (TCF7L2) gene is associated with reduced insulin secretion in nondiabetic women.

1 reference

12 December 2020

Molecular biology and the prolonged QT syndromes

1 reference

12 December 2020

WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic beta-cells

1 reference

12 December 2020

TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program

1 reference

12 December 2020

The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetes

1 reference

12 December 2020

Role of Wnt signaling in the development of type 2 diabetes.

1 reference

12 December 2020

A GIP receptor agonist exhibits beta-cell anti-apoptotic actions in rat models of diabetes resulting in improved beta-cell function and glycemic control

1 reference

12 December 2020

Polymorphisms within novel risk loci for type 2 diabetes determine beta-cell function

1 reference

12 December 2020

TCF7L2 variants are associated with increased proinsulin/insulin ratios but not obesity traits in the Framingham Heart Study

1 reference

12 December 2020

Association of type 2 diabetes candidate polymorphisms in KCNQ1 with incretin and insulin secretion

1 reference

12 December 2020

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

1 reference

12 December 2020

KCNQ1-dependent transport in renal and gastrointestinal epithelia

1 reference

12 December 2020

Association of TCF7L2 gene polymorphisms with reduced acute insulin response in Hispanic Americans

1 reference

12 December 2020

RETRACTED: Transcription factor 7-like 2 regulates beta-cell survival and function in human pancreatic islets

1 reference

12 December 2020

Endoplasmic reticulum stress signaling in disease

1 reference

12 December 2020

Polymorphisms within the novel type 2 diabetes risk locus MTNR1B determine beta-cell function

1 reference

12 December 2020

Genetic variation in KCNQ1 associates with fasting glucose and beta-cell function: a study of 3,734 subjects comprising three ethnicities living in Singapore

1 reference

12 December 2020

Variants in MTNR1B influence fasting glucose levels

1 reference

12 December 2020

Novel meta-analysis-derived type 2 diabetes risk loci do not determine prediabetic phenotypes

1 reference

12 December 2020

Discovery of amino acid variants in the human glucose-dependent insulinotropic polypeptide (GIP) receptor: the impact on the pancreatic beta cell responses and functional expression studies in Chinese hamster fibroblast cells

1 reference

12 December 2020

Association testing of novel type 2 diabetes risk alleles in the JAZF1, CDC123/CAMK1D, TSPAN8, THADA, ADAMTS9, and NOTCH2 loci with insulin release, insulin sensitivity, and obesity in a population-based sample of 4,516 glucose-tolerant middle-aged D

1 reference

12 December 2020

Impact of polymorphisms in WFS1 on prediabetic phenotypes in a population-based sample of middle-aged people with normal and abnormal glucose regulation

1 reference

12 December 2020

A variant in CDKAL1 influences insulin response and risk of type 2 diabetes

1 reference

12 December 2020

Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus.

1 reference

12 December 2020

Global prevalence of diabetes: estimates for the year 2000 and projections for 2030

1 reference

12 December 2020

The incretin system and its role in type 2 diabetes mellitus

1 reference

12 December 2020

TCF7L2 controls insulin gene expression and insulin secretion in mature pancreatic beta-cells

1 reference

12 December 2020

The WNT signalling pathway and diabetes mellitus

1 reference

12 December 2020

Expression and localization of Wolfram syndrome 1 gene in the developing rat pancreas

1 reference

12 December 2020

Glucose intolerance and reduced proliferation of pancreatic beta-cells in transgenic pigs with impaired glucose-dependent insulinotropic polypeptide function

1 reference

12 December 2020

Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis

1 reference

12 December 2020

Identification of two missense mutations in the GIP receptor gene: a functional study and association analysis with NIDDM: no evidence of association with Japanese NIDDM subjects

1 reference

12 December 2020

Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes

1 reference

12 December 2020

Neonatal growth and regeneration of beta-cells are regulated by the Wnt/beta-catenin signaling in normal and diabetic rats.

1 reference

12 December 2020

DIETARY, EVOLUTIONARY, AND MODERNIZING INFLUENCES ON THE PREVALENCE OF TYPE 2 DIABETES

1 reference

12 December 2020

Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies.

1 reference

12 December 2020

Identification of determinants of glucose-dependent insulinotropic polypeptide receptor that interact with N-terminal biologically active region of the natural ligand.

1 reference

12 December 2020

Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage

1 reference

12 December 2020

Two variants on chromosome 17 confer prostate cancer risk and the one in TCF2 protects against type 2 diabetes

1 reference

12 December 2020

A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants

1 reference

12 December 2020

Physiologic and pharmacologic modulation of glucose-dependent insulinotropic polypeptide (GIP) receptor expression in beta-cells by peroxisome proliferator-activated receptor (PPAR)-gamma signaling: possible mechanism for the GIP resistance in type

1 reference

12 December 2020

SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations

1 reference

12 December 2020

Disruption of the WFS1 gene in mice causes progressive beta-cell loss and impaired stimulus-secretion coupling in insulin secretion

1 reference

12 December 2020

Mechanisms underlying proglucagon gene expression

1 reference

12 December 2020

TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action.

1 reference

12 December 2020

A genome-wide association study identifies novel risk loci for type 2 diabetes

1 reference

12 December 2020

Effects of the type 2 diabetes-associated PPARG P12A polymorphism on progression to diabetes and response to troglitazone

1 reference

12 December 2020

WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic beta-cells

1 reference

12 December 2020

TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells

1 reference

12 December 2020

Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function

1 reference

12 December 2020

Association analyses of GIP and GIPR polymorphisms with traits of the metabolic syndrome

1 reference

12 December 2020

Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic beta cell proliferation

1 reference

12 December 2020

Testing of diabetes-associated WFS1 polymorphisms in the Diabetes Prevention Program

1 reference

12 December 2020

Extension of type 2 diabetes genome-wide association scan results in the diabetes prevention program

1 reference

12 December 2020

Sequence variation in PPARG may underlie differential response to troglitazone

1 reference

12 December 2020

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

1 reference

12 December 2020

Changes in insulin sensitivity in response to troglitazone do not differ between subjects with and without the common, functional Pro12Ala peroxisome proliferator-activated receptor-gamma2 gene variant: results from the Troglitazone in Prevention of

1 reference

12 December 2020

Analysis of the relationship between the Pro12Ala variant in the PPAR-gamma2 gene and the response rate to therapy with pioglitazone in patients with type 2 diabetes

1 reference

12 December 2020

A variant in the KCNQ1 gene predicts future type 2 diabetes and mediates impaired insulin secretion

1 reference

12 December 2020

Impact of TCF7L2 rs7903146 on insulin secretion and action in young and elderly Danish twins

1 reference

12 December 2020

Variation in TCF7L2 influences therapeutic response to sulfonylureas: a GoDARTs study

1 reference

12 December 2020

The type 2 diabetes associated minor allele of rs2237895 KCNQ1 associates with reduced insulin release following an oral glucose load

1 reference

12 December 2020

Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion.

1 reference

12 December 2020

Effects of I(Ks) channel inhibitors in insulin-secreting INS-1 cells

1 reference

12 December 2020

TCF7L2 polymorphisms modulate proinsulin levels and beta-cell function in a British Europid population

1 reference

12 December 2020

KCNJ11 Lys23Glu and TCF7L2 rs290487(C/T) polymorphisms affect therapeutic efficacy of repaglinide in Chinese patients with type 2 diabetes

1 reference

12 December 2020

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

1 reference

12 December 2020

Common variants in WFS1 confer risk of type 2 diabetes

1 reference

12 December 2020

Effects of Pro12Ala polymorphism of peroxisome proliferator-activated receptor gamma2 gene on rosiglitazone response in type 2 diabetes

1 reference

12 December 2020

Variants of CDKAL1 and IGF2BP2 affect first-phase insulin secretion during hyperglycaemic clamps

1 reference

12 December 2020

Quantitative trait analysis of type 2 diabetes susceptibility loci identified from whole genome association studies in the Insulin Resistance Atherosclerosis Family Study

1 reference

12 December 2020

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

1 reference

12 December 2020

Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals

1 reference

12 December 2020

10.1007/S00125-010-1876-8

Identifiers

DOI

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23 August 2017

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