(Q46070008)

19 December 2017

title

A common genetic variant in WFS1 determines impaired glucagon-like peptide-1-induced insulin secretion (English)

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19 December 2017

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3

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19 December 2017

Norbert Stefan

5

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19 December 2017

Andreas Fritsche

8

A Fritsche

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19 December 2017

Fausto Machicao

4

F Machicao

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19 December 2017

Hans-Ulrich Häring

7

H U Häring

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19 December 2017

Karsten Müssig

2

K Müssig

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19 December 2017

author name string

S A Schäfer

1

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19 December 2017

B Gallwitz

6

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19 December 2017

publication date

28 March 2009

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19 December 2017

published in

Diabetologia

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19 December 2017

volume

52

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19 December 2017

issue

6

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19 December 2017

page(s)

1075-1082

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19 December 2017

https://scigraph.springernature.com/pub.10.1007/s00125-009-1344-5

exact match

0 references

cites work

Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

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12 December 2020

Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance

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12 December 2020

A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations: results from the EUGENE2 study

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12 December 2020

WFS1 (Wolfram syndrome 1) gene product: predominant subcellular localization to endoplasmic reticulum in cultured cells and neuronal expression in rat brain

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12 December 2020

Prehepatic insulin production in man: kinetic analysis using peripheral connecting peptide behavior.

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12 December 2020

The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes

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12 December 2020

Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

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12 December 2020

Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp.

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12 December 2020

Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms.

1 reference

12 December 2020

WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic beta-cells

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12 December 2020

TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program

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12 December 2020

Polymorphisms within novel risk loci for type 2 diabetes determine beta-cell function

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12 December 2020

Replication of the association between variants in WFS1 and risk of type 2 diabetes in European populations

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12 December 2020

RETRACTED: Transcription factor 7-like 2 regulates beta-cell survival and function in human pancreatic islets

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12 December 2020

Endoplasmic reticulum stress signaling in disease

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12 December 2020

Association Studies of Genetic Variation in the WFS1 Gene and Type 2 Diabetes in U.K. Populations

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12 December 2020

Impact of polymorphisms in WFS1 on prediabetic phenotypes in a population-based sample of middle-aged people with normal and abnormal glucose regulation

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12 December 2020

The incretin system and its role in type 2 diabetes mellitus

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12 December 2020

The WNT signalling pathway and diabetes mellitus

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12 December 2020

Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis

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12 December 2020

A novel hyperglycaemic clamp for characterization of islet function in humans: assessment of three different secretagogues, maximal insulin response and reproducibility.

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12 December 2020

Polymorphisms in the gene encoding adiponectin receptor 1 are associated with insulin resistance and high liver fat.

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12 December 2020

Importance of obtaining independent measures of insulin secretion and insulin sensitivity during the same test: results with the Botnia clamp

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12 December 2020

GLP-1 receptor activation improves beta cell function and survival following induction of endoplasmic reticulum stress

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12 December 2020

Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies.

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12 December 2020

A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants

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12 December 2020

Disruption of the WFS1 gene in mice causes progressive beta-cell loss and impaired stimulus-secretion coupling in insulin secretion

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12 December 2020

A genome-wide association study identifies novel risk loci for type 2 diabetes

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12 December 2020

WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic beta-cells

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12 December 2020

Control of glycaemia: from molecules to men. Minkowski Lecture 2003.

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12 December 2020

Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function

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12 December 2020

Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study

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12 December 2020

Estimation of insulin secretion rates from C-peptide levels. Comparison of individual and standard kinetic parameters for C-peptide clearance

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12 December 2020

Wolfram (DIDMOAD) syndrome.

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12 December 2020

Testing of diabetes-associated WFS1 polymorphisms in the Diabetes Prevention Program

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12 December 2020

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

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12 December 2020

Genetic factors and insulin secretion: gene variants in the IGF genes

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12 December 2020

Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion.

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12 December 2020

Common variants in WFS1 confer risk of type 2 diabetes

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12 December 2020

Quantitative trait analysis of type 2 diabetes susceptibility loci identified from whole genome association studies in the Insulin Resistance Atherosclerosis Family Study

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12 December 2020

The common SLC30A8 Arg325Trp variant is associated with reduced first-phase insulin release in 846 non-diabetic offspring of type 2 diabetes patients--the EUGENE2 study

1 reference

12 December 2020

Characterisation of beta-cell dysfunction of impaired glucose tolerance: evidence for impairment of incretin-induced insulin secretion.

1 reference

12 December 2020

10.1007/S00125-009-1344-5

Identifiers

DOI

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19 December 2017

PubMed ID

19330314

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19 December 2017