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Targeted treatment for sonic hedgehog-dependent medulloblastoma.
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scholarly article
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Europe PubMed Central
PMCID
4096181
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24951114%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
title
Targeted treatment for sonic hedgehog-dependent medulloblastoma
(English)
1 reference
stated in
Europe PubMed Central
PMCID
4096181
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24951114%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
main subject
medulloblastoma
0 references
author
Mark W. Kieran
series ordinal
1
object named as
Mark W Kieran
2 references
stated in
Europe PubMed Central
PMCID
4096181
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24951114%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
stated in
Europe PubMed Central
PMCID
4096181
retrieved
31 August 2017
publication date
20 June 2014
1 reference
stated in
Europe PubMed Central
PMCID
4096181
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24951114%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
published in
Neuro-Oncology
1 reference
stated in
Europe PubMed Central
PMCID
4096181
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24951114%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
volume
16
1 reference
stated in
Europe PubMed Central
PMCID
4096181
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24951114%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
issue
8
1 reference
stated in
Europe PubMed Central
PMCID
4096181
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24951114%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
page(s)
1037-1047
1 reference
stated in
Europe PubMed Central
PMCID
4096181
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24951114%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
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Oncogenic YAP promotes radioresistance and genomic instability in medulloblastoma through IGF2-mediated Akt activation
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6 September 2017
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6 September 2017
Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector
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6 September 2017
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6 September 2017
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6 September 2017
The miR-17/92 polycistron is up-regulated in sonic hedgehog-driven medulloblastomas and induced by N-myc in sonic hedgehog-treated cerebellar neural precursors
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6 September 2017
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6 September 2017
Insulin-like growth factor 2 is required for progression to advanced medulloblastoma in patched1 heterozygous mice
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6 September 2017
Hedgehog: functions and mechanisms
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6 September 2017
Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features
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6 September 2017
Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma
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6 September 2017
Cooperation between the Hic1 and Ptch1 tumor suppressors in medulloblastoma
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6 September 2017
Medulloblastoma: from molecular pathology to therapy
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6 September 2017
The origins of medulloblastoma subtypes
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6 September 2017
Disruption of the PACAP gene promotes medulloblastoma in ptc1 mutant mice.
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6 September 2017
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6 September 2017
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6 September 2017
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6 September 2017
Gli1, downregulated in colorectal cancers, inhibits proliferation of colon cancer cells involving Wnt signalling activation
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6 September 2017
Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation
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6 September 2017
Hedgehog signalling in cancer formation and maintenance
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6 September 2017
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6 September 2017
Pituitary adenylate cyclase-activating polypeptide and sonic hedgehog interact to control cerebellar granule precursor cell proliferation
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6 September 2017
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6 September 2017
Purkinje-cell-derived Sonic hedgehog regulates granule neuron precursor cell proliferation in the developing mouse cerebellum
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Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog
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6 September 2017
The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas
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6 September 2017
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6 September 2017
Effective targeting of Hedgehog signaling in a medulloblastoma model with PF-5274857, a potent and selective Smoothened antagonist that penetrates the blood-brain barrier
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6 September 2017
Sonic hedgehog regulates Bmi1 in human medulloblastoma brain tumor-initiating cells.
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6 September 2017
Sequential activation of Snail1 and N-Myc modulates sonic hedgehog-induced transformation of neural cells
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6 September 2017
GLI2 is a potential therapeutic target in pediatric medulloblastoma
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6 September 2017
Small molecule inhibition of GDC-0449 refractory smoothened mutants and downstream mechanisms of drug resistance
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14 September 2017
Double trouble: when sonic hedgehog signaling meets TSC inactivation
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14 September 2017
Insulin receptor substrate 1 is an effector of sonic hedgehog mitogenic signaling in cerebellar neural precursors
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14 September 2017
Blocking CXCR4-mediated cyclic AMP suppression inhibits brain tumor growth in vivo
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14 September 2017
Shh pathway activity is down-regulated in cultured medulloblastoma cells: implications for preclinical studies
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096181
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14 September 2017
Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096181
retrieved
14 September 2017
The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic hedgehog-induced medulloblastomas
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096181
retrieved
14 September 2017
Sonic hedgehog and insulin-like growth factor signaling synergize to induce medulloblastoma formation from nestin-expressing neural progenitors in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096181
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14 September 2017
A five-gene hedgehog signature developed as a patient preselection tool for hedgehog inhibitor therapy in medulloblastoma.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096181
retrieved
23 June 2018
A phase I, multicenter, open-label, first-in-human, dose-escalation study of the oral smoothened inhibitor Sonidegib (LDE225) in patients with advanced solid tumors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096181
retrieved
23 June 2018
High frequency of germline SUFU mutations in children with desmoplastic/nodular medulloblastoma younger than 3 years of age.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096181
retrieved
23 June 2018
CXCR4 activation defines a new subgroup of Sonic hedgehog-driven medulloblastoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096181
retrieved
23 June 2018
Divergent functions for eIF4E and S6 kinase by sonic hedgehog mitogenic signaling in the developing cerebellum
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096181
retrieved
23 June 2018
Mitogenic Sonic hedgehog signaling drives E2F1-dependent lipogenesis in progenitor cells and medulloblastoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096181
retrieved
23 June 2018
Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096181
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23 June 2018
Sox2 requirement in sonic hedgehog-associated medulloblastoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096181
retrieved
31 August 2018
Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096181
retrieved
31 August 2018
Discovery of pyrrolo[3,2-c]quinoline-4-one derivatives as novel hedgehog signaling inhibitors.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096181
retrieved
31 August 2018
Heterogeneity of familial medulloblastoma and contribution of germline PTCH1 and SUFU mutations to sporadic medulloblastoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096181
retrieved
31 August 2018
Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096181
retrieved
31 August 2018
Bmi1 directly represses p21Waf1/Cip1 in Shh-induced proliferation of cerebellar granule cell progenitors.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096181
retrieved
31 August 2018
Medulloblastoma: a disease with disorganized developmental signaling cascades.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096181
retrieved
31 August 2018
Transient inhibition of the Hedgehog pathway in young mice causes permanent defects in bone structure
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096181
retrieved
31 August 2018
Expression of Notch and Wnt pathway components and activation of Notch signaling in medulloblastomas from heterozygous patched mice.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096181
retrieved
31 August 2018
N-myc can substitute for insulin-like growth factor signaling in a mouse model of sonic hedgehog-induced medulloblastoma.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096181
retrieved
31 August 2018
Neurocognitive consequences of risk-adapted therapy for childhood medulloblastoma.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096181
retrieved
31 August 2018
Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096181
retrieved
31 August 2018
Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096181
retrieved
31 August 2018
Analysis of PTCH/SMO/SHH pathway genes in medulloblastoma.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096181
retrieved
31 August 2018
Medulloblastoma
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24951114
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1093/NEUONC/NOU109
1 reference
stated in
Europe PubMed Central
PMCID
4096181
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24951114%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
PMCID
4096181
1 reference
stated in
Europe PubMed Central
PMCID
4096181
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24951114%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
PubMed ID
24951114
1 reference
stated in
Europe PubMed Central
PMCID
4096181
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24951114%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
ResearchGate publication ID
263297114
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