(Q38258327)

1 September 2017

1 reference

title

Hypoxia-sensitive pathways in inflammation-driven fibrosis (English)

1 reference

1 September 2017

0 references

1 reference

Cormac T Taylor

3

0 references

author name string

Mario C Manresa

series ordinal

1

1 reference

PubMed ID

25298511

1 September 2017

Catherine Godson

series ordinal

2

1 reference

1 September 2017

8 October 2014

1 reference

American Journal of Physiology - Regulatory, Integrative and Comparative Physiology

1 September 2017

1 reference

1 September 2017

307

1 reference

1 September 2017

12

1 reference

1 September 2017

R1369-80

1 reference

Integrins and cadherins as therapeutic targets in fibrosis

1 September 2017

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Sequential expression of IGF-IB followed by active TGF-β1 induces synergistic pulmonary fibroproliferation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Progressive pulmonary fibrosis is mediated by TGF-beta isoform 1 but not TGF-beta3

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Inflammation meets cancer, with NF-κB as the matchmaker

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

TGF-β signaling in fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Hypoxic gene activation by lipopolysaccharide in macrophages: implication of hypoxia-inducible factor 1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

miR-210 promotes IPF fibroblast proliferation in response to hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Lipoxins attenuate renal fibrosis by inducing let-7c and suppressing TGFβR1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

NFκB and HIF display synergistic behaviour during hypoxic inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

NF-kappaB family of transcription factors: central regulators of innate and adaptive immune functions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Transmigrating neutrophils shape the mucosal microenvironment through localized oxygen depletion to influence resolution of inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Hypoxia-inducible factor (HIF) network: insights from mathematical models

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Emerging therapeutic interventions for idiopathic pulmonary fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Involvement of protein tyrosine kinase in Toll-like receptor 4-mediated NF-kappa B activation in human peripheral blood monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Integrin-mediated type II TGF-β receptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Impact of the increasing use of immunosuppressants in Crohn's disease on the need for intestinal surgery

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

HIF-1alpha is essential for myeloid cell-mediated inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Hydroxylases as therapeutic targets in inflammatory bowel disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

The hydroxylase inhibitor dimethyloxalylglycine is protective in a murine model of colitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Loss of endogenous bone morphogenetic protein-6 aggravates renal fibrosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Transforming growth factor beta signalling and matrix metalloproteinases in the mucosa overlying Crohn's disease strictures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Smad3 signaling critically regulates fibroblast phenotype and function in healing myocardial infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Slowing progression of chronic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Roles of Akt/PKB and IKK complex in constitutive induction of NF-kappaB in hepatocellular carcinomas of transforming growth factor alpha/c-myc transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

miR-29c is downregulated in renal interstitial fibrosis in humans and rats and restored by HIF-α activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Scar-free healing: from embryonic mechanisms to adult therapeutic intervention

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Themes in fibrosis and gastrointestinal inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

An intact canonical NF-κB pathway is required for inflammatory gene expression in response to hypoxia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Mice lacking Smad3 are protected against cutaneous injury induced by ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Regulation of angiogenesis by oxygen and metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Bacterial lipopolysaccharide induces HIF-1 activation in human monocytes via p44/42 MAPK and NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

TGF-β and NF-κB signal pathway cross-talk is mediated through TAK1 and SMAD7 in a subset of head and neck cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

TGF-beta coordinately activates TAK1/MEK/AKT/NFkB and SMAD pathways to promote osteoclast survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Hypoxia and Integrin-Mediated Epithelial Restitution during Mucosal Inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Increased short- and long-term risk of inflammatory bowel disease after salmonella or campylobacter gastroenteritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

The role of apoptosis in wound healing

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Effect of TGF-beta/Smad signaling pathway on lung myofibroblast differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Factors affecting wound healing

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Wound repair and regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

The hydroxylase inhibitor dimethyloxallyl glycine attenuates endotoxic shock via alternative activation of macrophages and IL-10 production by B1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

New therapies for diabetic kidney disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Hydroxylase inhibition abrogates TNF-alpha-induced intestinal epithelial damage by hypoxia-inducible factor-1-dependent repression of FADD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

The complexity of NF-κB signaling in inflammation and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Daikenchuto, a Kampo medicine, regulates intestinal fibrosis associated with decreasing expression of heat shock protein 47 and collagen content in a rat colitis model

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Endothelial HIF-2 mediates protection and recovery from ischemic kidney injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

A phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

SMADs: mediators and regulators of TGF-beta signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Diverse roles of TGF-β/Smads in renal fibrosis and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Anti-inflammatory lipid mediators and insights into the resolution of inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Turn me on: regulating HIF transcriptional activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

The in vivo fibrotic role of FIZZ1 in pulmonary fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

The evolving pharmacotherapy of pulmonary fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Lipoxins: resolutionary road

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

ATLa, an aspirin-triggered lipoxin A4 synthetic analog, prevents the inflammatory and fibrotic effects of bleomycin-induced pulmonary fibrosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Smad transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Oxygen sensors and angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Expression and regulation of tissue inhibitor of metalloproteinase-1 and matrix metalloproteinases by intestinal myofibroblasts in inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Transforming growth factor-beta type 1 receptor (ALK5) and Smad proteins mediate TIMP-1 and collagen synthesis in experimental intestinal fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Innate immunity: impact on the adaptive immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

HIF hydroxylation and cellular oxygen sensing

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Diabetic nephropathy: are there new and potentially promising therapies targeting oxygen biology?

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

The role of infection in the pathogenesis of idiopathic pulmonary fibrosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Reduced liver fibrosis in hypoxia-inducible factor-1alpha-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Exploring the full spectrum of macrophage activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Hypoxia regulates macrophage functions in inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Prolyl 4-hydroxylases, key enzymes in the synthesis of collagens and regulation of the response to hypoxia, and their roles as treatment targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

A dynamic model of the hypoxia-inducible factor 1α (HIF-1α) network

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

HDAC class I inhibitor, Mocetinostat, reverses cardiac fibrosis in heart failure and diminishes CD90+ cardiac myofibroblast activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Platelets, inflammation and tissue regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Inflammation and wound healing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Hypoxia. Regulation of NFkappaB signalling during inflammation: the role of hydroxylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Critical Role of Transforming Growth Factor Beta in Different Phases of Wound Healing

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Transforming growth factor-beta receptor type I-dependent fibrogenic gene program is mediated via activation of Smad1 and ERK1/2 pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Liver fibrosis: from the bench to clinical targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Treatment of inflammatory bowel disease (IBD)

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Wound healing and fibrosis in intestinal disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Biological therapies for inflammatory bowel diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Regulation of wound healing and fibrosis by hypoxia and hypoxia-inducible factor-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

TGF-β signaling in tissue fibrosis: redox controls, target genes and therapeutic opportunities

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Current directions in IBD therapy: what goals are feasible with biological modifiers?

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Regulation of IL-1β-induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Targeting the HIF pathway in inflammation and immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Oxygen in acute and chronic wound healing

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Pro-resolving lipid mediators are leads for resolution physiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Pirfenidone for diabetic nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Requirement of transforming growth factor beta-activated kinase 1 for transforming growth factor beta-induced alpha-smooth muscle actin expression and extracellular matrix contraction in fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Inhibition of the renin-angiotensin system and chronic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

IGF-I and TGF-beta1 have distinct effects on phenotype and proliferation of intestinal fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Activation of hypoxia-inducible factor attenuates renal injury in rat remnant kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Reply to Regarding the mechanism of action of a proposed peptide agonist of the bone morphogenetic protein receptor activin-like kinase 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Loss of prolyl hydroxylase-1 protects against colitis through reduced epithelial cell apoptosis and increased barrier function

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Oxygen in wound healing--more than a nutrient

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Mitochondria and cellular oxygen sensing in the HIF pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Hypoxia and gastrointestinal disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

The role of NF-kappaB in hypoxia-induced gene expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Tumor necrosis factor (TNF) alpha increases collagen accumulation and proliferation in intestinal myofibroblasts via TNF receptor 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Aetiology of inflammatory bowel disease (IBD): role of intestinal microbiota and gut-associated lymphoid tissue immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Noncanonical transforming growth factor beta signaling in scleroderma fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Smad2 and Smad3 play different roles in rat hepatic stellate cell function and alpha-smooth muscle actin organization

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

The wound healing process: an overview of the cellular and molecular mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Extracellular BMP-antagonist regulation in development and disease: tied up in knots

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Regarding the mechanism of action of a proposed peptide agonist of the bone morphogenetic protein receptor activin-like kinase 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Id1 is a critical mediator in TGF-beta-induced transdifferentiation of rat hepatic stellate cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

The treatment of idiopathic pulmonary fibrosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Macrophages: master regulators of inflammation and fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Unravelling the pathogenesis of inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Uterine sensitization-associated gene-1 (USAG-1), a novel BMP antagonist expressed in the kidney, accelerates tubular injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Type I transforming growth factor beta receptor binds to and activates phosphatidylinositol 3-kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Cellular and molecular basis for the regulation of inflammation by TGF-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Cellular and molecular mechanisms in the hypoxic tissue: role of HIF-1 and ROS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Activation of Wnt11 by transforming growth factor-β drives mesenchymal gene expression through non-canonical Wnt protein signaling in renal epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Matrix metalloproteinases contribute to kidney fibrosis in chronic kidney diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Role of von Hippel-Lindau protein in fibroblast proliferation and fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Renal Bone Morphogenetic Protein-7 Protects against Diabetic Nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Elevation of Expression of Smads 2, 3, and 4, Decorin and TGF-βin the Chronic Phase of Myocardial Infarct Scar Healing

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

Oxygen and the inflammatory cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00349.2014

10.1152/AJPREGU.00349.2014

21 January 2018

Identifiers

DOI

1 reference

1 September 2017

1 reference

PubMed ID

25298511