(Q38088948)

28 August 2017

title

Diabetic nephropathy: are there new and potentially promising therapies targeting oxygen biology? (English)

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28 August 2017

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Toshio Miyata

1

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28 August 2017

Norio Suzuki

series ordinal

2

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28 August 2017

Charles van Ypersele de Strihou

series ordinal

3

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28 August 2017

language of work or name

English

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publication date

13 March 2013

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28 August 2017

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28 August 2017

volume

84

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28 August 2017

issue

4

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28 August 2017

page(s)

693-702

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https://scigraph.springernature.com/pub.10.1038/ki.2013.74

28 August 2017

exact match

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cites work

Oxygen, the lead actor in the pathophysiologic drama: enactment of the trinity of normoxia, hypoxia, and hyperoxia in disease and therapy

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Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor

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Regulation of erythropoietin production

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Repression via the GATA box is essential for tissue-specific erythropoietin gene expression.

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The interstitial response to renal injury: Fibroblast–like cells show phenotypic changes and have reduced potential for erythropoietin gene expression

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Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice

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7 January 2021

Hyperglycemic pseudohypoxia and diabetic complications.

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7 January 2021

Increased oxidized form of human serum albumin in patients with diabetes mellitus

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7 January 2021

Polyol pathway activation and glutathione redox status in non-insulin-dependent diabetic patients

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7 January 2021

Age-dependent increase in ortho-tyrosine and methionine sulfoxide in human skin collagen is not accelerated in diabetes. Evidence against a generalized increase in oxidative stress in diabetes

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Immunohistochemical colocalization of glycoxidation products and lipid peroxidation products in diabetic renal glomerular lesions. Implication for glycoxidative stress in the pathogenesis of diabetic nephropathy

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Protein-bound acrolein: potential markers for oxidative stress

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A hydroxyl radical-like species oxidizes cynomolgus monkey artery wall proteins in early diabetic vascular disease

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7 January 2021

Oxidants in chronic kidney disease

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7 January 2021

Oxidative stress as a major culprit in kidney disease in diabetes

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7 January 2021

Angiotensin II induces superoxide anion production by mesangial cells

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7 January 2021

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

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7 January 2021

Transition metals redox: reviving an old plot for diabetic vascular disease

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7 January 2021

Nox4 NAD(P)H oxidase mediates hypertrophy and fibronectin expression in the diabetic kidney

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7 January 2021

AGE, RAGE, and ROS in diabetic nephropathy.

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Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

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7 January 2021

New era for drug discovery and development in renal disease

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Renal diffusion and BOLD MRI in experimental diabetic nephropathy. Blood oxygen level-dependent

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Hypoxia-inducible factors and tubular cell survival in isolated perfused kidneys

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Hypoxia in renal disease with proteinuria and/or glomerular hypertension

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7 January 2021

Chronic hypoxia and tubulointerstitial injury: a final common pathway to end-stage renal failure

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7 January 2021

Reduced nitric oxide in diabetic kidneys due to increased hepatic arginine metabolism: implications for renomedullary oxygen availability.

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7 January 2021

Pathogenesis of renal anemia

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7 January 2021

Erythropoietin and renoprotection

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https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Diabetic nephropathy: a disorder of oxygen metabolism?

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https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation

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7 January 2021

Diabetic nephropathy is associated with oxidative stress and decreased renal nitric oxide production

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7 January 2021

Endoplasmic reticulum stress: cell life and death decisions.

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7 January 2021

Proteinuria and hyperglycemia induce endoplasmic reticulum stress

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7 January 2021

Anemia of chronic renal failure: characterization in the mouse and correction with human recombinant erythropoietin

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Effects of erythropoietin-gene electrotransfer in rats with adenine-induced renal failure.

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Recent advances and clinical application of erythropoietin and erythropoiesis-stimulating agents.

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Cardio-renal-anemia syndrome: a link between erythropoietin, dimethylarginine and homocysteine

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7 January 2021

Erythroid-specific expression of the erythropoietin receptor rescued its null mutant mice from lethality

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7 January 2021

Use of gene-manipulated mice in the study of erythropoietin gene expression

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7 January 2021

Survival and proliferative roles of erythropoietin beyond the erythroid lineage

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7 January 2021

Targeting HIF-1 for cancer therapy

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7 January 2021

Cell biology. How cells endure low oxygen

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7 January 2021

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

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https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Oxygen sensing by HIF hydroxylases

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7 January 2021

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

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7 January 2021

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

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7 January 2021

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

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7 January 2021

Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

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https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

A nuclear localization signal of human aryl hydrocarbon receptor nuclear translocator/hypoxia-inducible factor 1beta is a novel bipartite type recognized by the two components of nuclear pore-targeting complex

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https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway

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7 January 2021

Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins

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https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

A gain-of-function mutation in the HIF2A gene in familial erythrocytosis

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https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Involvement of hypoxia-inducible transcription factors in polycystic kidney disease

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https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Protective role of hypoxia-inducible factor-2alpha against ischemic damage and oxidative stress in the kidney.

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https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease

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https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stress

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Presence of Cobalt in the Anti-Pernicious Anæmia Factor

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https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Erythropoietic effect of cobalt in patients with or without anemia

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https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing

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https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Cellular oxygen sensing: Importins and exportins are mediators of intracellular localisation of prolyl-4-hydroxylases PHD1 and PHD2.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Nuclear oxygen sensing: induction of endogenous prolyl-hydroxylase 2 activity by hypoxia and nitric oxide

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Role and regulation of prolyl hydroxylase domain proteins

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Nitric oxide modulates oxygen sensing by hypoxia-inducible factor 1-dependent induction of prolyl hydroxylase 2.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Non-hypoxic activation of the negative regulatory feedback loop of prolyl-hydroxylase oxygen sensors

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Regulatory mechanisms controlling gene expression mediated by the antioxidant response element

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https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation

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https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Role of NRF2 in protection against hyperoxic lung injury in mice

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https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

The transcription factor NRF2 protects against pulmonary fibrosis

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https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

A small-molecule-inducible Nrf2-mediated antioxidant response provides effective prophylaxis against cerebral ischemia in vivo.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Reoxygenation-specific activation of the antioxidant transcription factor Nrf2 mediates cytoprotective gene expression in ischemia-reperfusion injury

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Transcription factor Nrf2 is protective during ischemic and nephrotoxic acute kidney injury in mice

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation

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https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Hypoxia. 1. Intracellular sensors for oxygen and oxidative stress: novel therapeutic targets

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https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Nrf2 counteracts cholestatic liver injury via stimulation of hepatic defense systems

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https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Isolation and characterization of renal erythropoietin-producing cells from genetically produced anemia mice

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https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Identification of the renal erythropoietin-producing cells using transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Renal microenvironments and macrophage phenotypes determine progression or resolution of renal inflammation and fibrosis.

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https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Fibroblast expression of an IκB dominant-negative transgene attenuates renal fibrosis

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Selective inhibition of factor inhibiting hypoxia-inducible factor

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Inhibition of hypoxia inducible factor hydroxylases protects against renal ischemia-reperfusion injury

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

A novel class of prolyl hydroxylase inhibitors induces angiogenesis and exerts organ protection against ischemia

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Erythropoietin as a retinal angiogenic factor in proliferative diabetic retinopathy

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization

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https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Inhibition of prolyl hydroxylase domain proteins promotes therapeutic revascularization.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Hypoxia-inducible factor stabilizers and other small-molecule erythropoiesis-stimulating agents in current and preventive doping analysis

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

PHD2 mutation and congenital erythrocytosis with paraganglioma.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Selective inhibition of hypoxia-inducible factor (HIF) prolyl-hydroxylase 1 mediates neuroprotection against normoxic oxidative death via HIF- and CREB-independent pathways

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Hibernation, a model of neuroprotection

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https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Hypoxia tolerance in mammalian heterotherms.

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https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Inositol tripyrophosphate: a new membrane permeant allosteric effector of haemoglobin

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https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Control of Hemoglobin Function within the Red Cell

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https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Importance of oxygen-haemoglobin binding to oxygen transport in congestive heart failure

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https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Long-term physiological effects of enhanced O2 release by inositol hexaphosphate-loaded erythrocytes

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https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Enhanced exercise capacity in mice with severe heart failure treated with an allosteric effector of hemoglobin, myo-inositol trispyrophosphate

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https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Myo-InositolTrisPyroPhosphate treatment leads to HIF-1α suppression and eradication of early hepatoma tumors in rats.

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https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Anti-angiogenic properties of myo-inositol trispyrophosphate in ovo and growth reduction of implanted glioma

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https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

NXY-059 for the treatment of acute ischemic stroke

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https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Effects of NXY-059 in experimental stroke: an individual animal meta-analysis

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https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress

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https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Nrf2-deficient female mice develop lupus-like autoimmune nephritis

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https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Bardoxolone methyl and kidney function in CKD with type 2 diabetes

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https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Sulforaphane protects brains against hypoxic-ischemic injury through induction of Nrf2-dependent phase 2 enzyme

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https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Therapeutic potential of Nrf2 activators in streptozotocin-induced diabetic nephropathy

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https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism

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https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Specific contribution of the erythropoietin gene 3' enhancer to hepatic erythropoiesis after late embryonic stages

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https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Reactivation of hepatic EPO synthesis in mice after PHD loss

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https://api.crossref.org/works/10.1038%2FKI.2013.74

7 January 2021

Identifiers

DOI

10.1038/KI.2013.74

1 reference

Dimensions Publication ID

28 August 2017

1006143465

0 references

1 reference