(Q37654732)

21 August 2017

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title

Diabetic nephropathy: a disorder of oxygen metabolism? (English)

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21 August 2017

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Toshio Miyata

1

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21 August 2017

Charles van Ypersele de Strihou

series ordinal

2

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21 August 2017

language of work or name

English

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publication date

15 December 2009

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Nature Reviews Nephrology

21 August 2017

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21 August 2017

6

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21 August 2017

2

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21 August 2017

83-95

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https://scigraph.springernature.com/pub.10.1038/nrneph.2009.211

21 August 2017

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31 March 2020

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31 March 2020

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HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

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A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth

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Oxygen, the lead actor in the pathophysiologic drama: enactment of the trinity of normoxia, hypoxia, and hyperoxia in disease and therapy

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31 March 2020

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Renal diffusion and BOLD MRI in experimental diabetic nephropathy. Blood oxygen level-dependent

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Reduced nitric oxide in diabetic kidneys due to increased hepatic arginine metabolism: implications for renomedullary oxygen availability.

31 March 2020

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Pathogenesis of renal anemia

31 March 2020

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Erythropoietin and renoprotection

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Nitric oxide, oxidative stress, and progression of chronic renal failure

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Diabetic nephropathy is associated with oxidative stress and decreased renal nitric oxide production

31 March 2020

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Nitric oxide and kidney oxygenation.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

From molecular footprints of disease to new therapeutic interventions in diabetic nephropathy: a detective story

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Implication of an increased oxidative stress in the formation of advanced glycation end products in patients with end-stage renal failure

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Advanced oxidation protein products as a novel marker of oxidative stress in uremia

31 March 2020

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Diabetes, oxidative stress, nitric oxide and mitochondria function.

31 March 2020

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Endoplasmic reticulum stress: cell life and death decisions.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Proteinuria and hyperglycemia induce endoplasmic reticulum stress

31 March 2020

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Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes

31 March 2020

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31 March 2020

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The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Microalbuminuria reduction with valsartan in patients with type 2 diabetes mellitus: a blood pressure-independent effect

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Aliskiren combined with losartan in type 2 diabetes and nephropathy

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Endogenous angiotensin concentrations in specific intrarenal fluid compartments of the rat.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Evidence of tubular hypoxia in the early phase in the remnant kidney model

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Angiotensin II type 2 receptors and nitric oxide sustain oxygenation in the clipped kidney of early Goldblatt hypertensive rats

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Oxidative stress and nitric oxide synthase in rat diabetic nephropathy: effects of ACEI and ARB.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Disruption of the Ang II type 1 receptor promotes longevity in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Angiotensin II receptor antagonists and angiotensin-converting enzyme inhibitors lower in vitro the formation of advanced glycation end products: biochemical mechanisms

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Anti-Hypertensive Agents Inhibit In Vivo the Formation of Advanced Glycation End Products and Improve Renal Damage in a Type 2 Diabetic Nephropathy Rat Model

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Candesartan suppresses chronic renal inflammation by a novel antioxidant action independent of AT1R blockade

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

ACE-inhibitor suppresses the apoptosis induced by endoplasmic reticulum stress in renal tubular in experimental diabetic rats

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

A novel Sartan derivative with very low angiotensin II type 1 receptor affinity protects the kidney in type 2 diabetic rats.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

A sartan derivative with a very low angiotensin II receptor affinity ameliorates ischemic cerebral damage.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Sustained effect of intensive treatment of type 1 diabetes mellitus on development and progression of diabetic nephropathy: the Epidemiology of Diabetes Interventions and Complications (EDIC) study

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Insulin resistance, hyperinsulinemia, and renal injury: mechanisms and implications

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Altered Gene Expression Related to Glomerulogenesis and Podocyte Structure in Early Diabetic Nephropathy of db/db Mice and Its Restoration by Pioglitazone

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Thiazolidinediones provide better renoprotection than insulin in an obese, hypertensive type II diabetic rat model

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Pioglitazone mitigates renal glomerular vascular changes in high-fat, high-calorie-induced type 2 diabetes mellitus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Inhibition of TGF-beta expression: a novel role for thiazolidinediones to implement renoprotection in diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Minireview: the role of oxidative stress in relation to caloric restriction and longevity.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Oral glycotoxins determine the effects of calorie restriction on oxidant stress, age-related diseases, and lifespan

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Emerging role of adipose tissue hypoxia in obesity and insulin resistance

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Energy restriction in obese subjects impact differently two mitochondrial function markers.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

In a type 2 diabetic nephropathy rat model, the improvement of obesity by a low calorie diet reduces oxidative/carbonyl stress and prevents diabetic nephropathy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Translation of basic science into clinical medicine: novel targets for diabetic nephropathy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Targeting HIF-1 for cancer therapy

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Cell biology. How cells endure low oxygen.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Oxygen sensing by HIF hydroxylases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

A nuclear localization signal of human aryl hydrocarbon receptor nuclear translocator/hypoxia-inducible factor 1beta is a novel bipartite type recognized by the two components of nuclear pore-targeting complex

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

A gain-of-function mutation in the HIF2A gene in familial erythrocytosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Involvement of hypoxia-inducible transcription factors in polycystic kidney disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Protective role of hypoxia-inducible factor-2alpha against ischemic damage and oxidative stress in the kidney.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Evidence for sustained renal hypoxia and transient hypoxia adaptation in experimental rhabdomyolysis-induced acute kidney injury

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Inhibition of hypoxia inducible factor hydroxylases protects against renal ischemia-reperfusion injury

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stress

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Induction of renoprotective gene expression by cobalt ameliorates ischemic injury of the kidney in rats

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Induction of protective genes by cobalt ameliorates tubulointerstitial injury in the progressive Thy1 nephritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Cobalt promotes angiogenesis via hypoxia-inducible factor and protects tubulointerstitium in the remnant kidney model.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Hypoxia-inducible factor modulates tubular cell survival in cisplatin nephrotoxicity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Cobalt ameliorates renal injury in an obese, hypertensive type 2 diabetes rat model

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Presence of Cobalt in the Anti-Pernicious Anæmia Factor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Erythropoietic effect of cobalt in patients with or without anemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Use of cobaltous chloride in anaemia of maintenance hemodialysis patients

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Selective inhibition of factor inhibiting hypoxia-inducible factor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

A novel class of prolyl hydroxylase inhibitors induces angiogenesis and exerts organ protection against ischemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Preconditional activation of hypoxia-inducible factors ameliorates ischemic acute renal failure

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Erythropoietin as a retinal angiogenic factor in proliferative diabetic retinopathy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Cellular oxygen sensing: Importins and exportins are mediators of intracellular localisation of prolyl-4-hydroxylases PHD1 and PHD2.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Nuclear oxygen sensing: induction of endogenous prolyl-hydroxylase 2 activity by hypoxia and nitric oxide

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Role and regulation of prolyl hydroxylase domain proteins

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Non-hypoxic activation of the negative regulatory feedback loop of prolyl-hydroxylase oxygen sensors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Nitric oxide modulates oxygen sensing by hypoxia-inducible factor 1-dependent induction of prolyl hydroxylase 2.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

HIF-prolyl hydroxylases in the rat kidney: physiologic expression patterns and regulation in acute kidney injury

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Inhibition of prolyl hydroxylase domain proteins promotes therapeutic revascularization.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Hypoxia signalling in cancer and approaches to enforce tumour regression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

The von Hippel-Lindau tumor suppressor protein and Egl-9-Type proline hydroxylases regulate the large subunit of RNA polymerase II in response to oxidative stress

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Neuron-specific inactivation of the hypoxia inducible factor 1 alpha increases brain injury in a mouse model of transient focal cerebral ischemia.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Oxygen-dependent ATF-4 stability is mediated by the PHD3 oxygen sensor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Prolyl hydroxylase inhibition attenuates post-ischemic cardiac injury via induction of endoplasmic reticulum stress genes.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Hypoxia tolerance in mammalian heterotherms.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Selective inhibition of hypoxia-inducible factor (HIF) prolyl-hydroxylase 1 mediates neuroprotection against normoxic oxidative death via HIF- and CREB-independent pathways

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

PHD2 mutation and congenital erythrocytosis with paraganglioma.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Ang-1 gene therapy inhibits hypoxia-inducible factor-1alpha (HIF-1alpha)-prolyl-4-hydroxylase-2, stabilizes HIF-1alpha expression, and normalizes immature vasculature in db/db mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Hypoxia/reoxygenation induces CTGF and PAI-1 in cultured human retinal pigment epithelium cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Hypoxia interferes with connective tissue growth factor (CTGF) gene expression in human proximal tubular cell lines.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

The role of plasminogen activator inhibitor 1 in renal and cardiovascular diseases.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Inhibition of plasminogen activator inhibitor-1: its mechanism and effectiveness on coagulation and fibrosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2009.211

Advanced glycation and lipoxidation end products: role of reactive carbonyl compounds generated during carbohydrate and lipid metabolism.

31 March 2020

1 reference

12 December 2020

Progressive renal disease: the chronic hypoxia hypothesis

1 reference

12 December 2020

Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins.

1 reference

12 December 2020

Vitamin C metabolites and microangiopathy in diabetes mellitus

1 reference

12 December 2020

Oxygen consumption and oxidant stress in surviving nephrons

1 reference

12 December 2020

Immunohistochemical evidence for an increased oxidative stress and carbonyl modification of proteins in diabetic glomerular lesions

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRNEPH.2009.211

1 reference

Dimensions Publication ID

21 August 2017

0 references

1 reference