(Q38261874)

1 September 2017

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title

Regulation of ribosomal gene expression in cancer (English)

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1 September 2017

Le Xuan Truong Nguyen

1

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1 September 2017

Aparna Raval

2

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1 September 2017

Jacqueline S Garcia

3

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1 September 2017

Beverly S Mitchell

4

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1 September 2017

1 June 2015

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Journal of Cellular Physiology

1 September 2017

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1 September 2017

230

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1 September 2017

6

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1 September 2017

1181-1188

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Old drug, new target: ellipticines selectively inhibit RNA polymerase I transcription

1 September 2017

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c-Myc associates with ribosomal DNA and activates RNA polymerase I transcription.

21 January 2018

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p14ARF links the tumour suppressors RB and p53.

21 January 2018

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The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors

21 January 2018

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Phosphorylation by casein kinase 2 facilitates rRNA gene transcription by promoting dissociation of TIF-IA from elongating RNA polymerase I.

21 January 2018

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Poly(ADP-Ribose) polymerase 1 (PARP-1) regulates ribosomal biogenesis in Drosophila nucleoli

21 January 2018

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N-myc enhances the expression of a large set of genes functioning in ribosome biogenesis and protein synthesis

21 January 2018

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Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors.

21 January 2018

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CSB is a component of RNA pol I transcription

21 January 2018

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Chemotherapeutic drugs inhibit ribosome biogenesis at various levels

21 January 2018

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Dysregulation of the basal RNA polymerase transcription apparatus in cancer

21 January 2018

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Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53

21 January 2018

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DNA damage-induced inhibition of rRNA synthesis by DNA-PK and PARP-1.

21 January 2018

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Activity of RNA polymerase I transcription factor UBF blocked by Rb gene product

21 January 2018

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Rrn3 phosphorylation is a regulatory checkpoint for ribosome biogenesis

21 January 2018

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AKT promotes rRNA synthesis and cooperates with c-MYC to stimulate ribosome biogenesis in cancer

21 January 2018

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Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses

21 January 2018

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H3K9 histone methyltransferase G9a promotes lung cancer invasion and metastasis by silencing the cell adhesion molecule Ep-CAM.

21 January 2018

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Specific activation of the p53 pathway by low dose actinomycin D: a new route to p53 based cyclotherapy.

21 January 2018

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Overlapping functions of the pRb family in the regulation of rRNA synthesis

21 January 2018

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Tor Pathway Regulates Rrn3p-dependent Recruitment of Yeast RNA Polymerase I to the Promoter but Does Not Participate in Alteration of the Number of Active Genes

21 January 2018

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Mechanism of RNA polymerase I transcription

21 January 2018

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Ribosomal gene clusters are uniquely proportioned between open and closed chromatin structures in both tomato leaf cells and exponentially growing suspension cultures

21 January 2018

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A model for the topology of active ribosomal RNA genes

21 January 2018

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What the nucleolus says to a tumour pathologist.

21 January 2018

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Human papillomavirus 16 oncoprotein E7 stimulates UBF1-mediated rDNA gene transcription, inhibiting a p53-independent activity of p14ARF

21 January 2018

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Targeting RNA polymerase I with an oral small molecule CX-5461 inhibits ribosomal RNA synthesis and solid tumor growth.

21 January 2018

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The RNA polymerase I transcription machinery: an emerging target for the treatment of cancer

21 January 2018

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Anticancer activity of CX-3543: a direct inhibitor of rRNA biogenesis

21 January 2018

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Gfi1 coordinates epigenetic repression of p21Cip/WAF1 by recruitment of histone lysine methyltransferase G9a and histone deacetylase 1

21 January 2018

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Epigenetic disruption of ribosomal RNA genes and nucleolar architecture in DNA methyltransferase 1 (Dnmt1) deficient cells

21 January 2018

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Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies.

21 January 2018

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Processing of the external transcribed spacer of murine rRNA and site of action of actinomydn D

21 January 2018

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Mutant p53: one name, many proteins

21 January 2018

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Role of human ribosomal RNA (rRNA) promoter methylation and of methyl-CpG-binding protein MBD2 in the suppression of rRNA gene expression

21 January 2018

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c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I

21 January 2018

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Drosophila TIF-IA is required for ribosome synthesis and cell growth and is regulated by the TOR pathway

21 January 2018

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Life on a planet of its own: regulation of RNA polymerase I transcription in the nucleolus

21 January 2018

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Inheritance of silent rDNA chromatin is mediated by PARP1 via noncoding RNA.

21 January 2018

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RNA polymerase I: a multifunctional molecular machine.

21 January 2018

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Rb and p130 regulate RNA polymerase I transcription: Rb disrupts the interaction between UBF and SL-1

21 January 2018

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RNA polymerase I transcription in confluent cells: Rb downregulates rDNA transcription during confluence-induced cell cycle arrest

21 January 2018

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mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF.

21 January 2018

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The nucleolus: an emerging target for cancer therapy

21 January 2018

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Mitotic silencing of human rRNA synthesis: inactivation of the promoter selectivity factor SL1 by cdc2/cyclin B-mediated phosphorylation

21 January 2018

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Loss of Dnmt3b function upregulates the tumor modifier Ment and accelerates mouse lymphomagenesis

21 January 2018

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AMP-activated protein kinase adapts rRNA synthesis to cellular energy supply

21 January 2018

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G9a and Glp methylate lysine 373 in the tumor suppressor p53

21 January 2018

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Upstream binding factor up-regulated in hepatocellular carcinoma is related to the survival and cisplatin-sensitivity of cancer cells

21 January 2018

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Abundance of ribosomal RNA gene copies maintains genome integrity

21 January 2018

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Phosphatidylinositol 3-kinase and mTOR signaling pathways regulate RNA polymerase I transcription in response to IGF-1 and nutrients.

21 January 2018

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Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast

21 January 2018

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Aberrant DNA methylation is a dominant mechanism in MDS progression to AML.

21 January 2018

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Loss of Bloom syndrome protein destabilizes human gene cluster architecture

21 January 2018

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UHRF1 binds G9a and participates in p21 transcriptional regulation in mammalian cells

21 January 2018

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Induction of ribosomal genes and hepatocyte hypertrophy by adenovirus-mediated expression of c-Myc in vivo

21 January 2018

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Heterochromatin formation promotes longevity and represses ribosomal RNA synthesis

21 January 2018

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A concerted DNA methylation/histone methylation switch regulates rRNA gene dosage control and nucleolar dominance

21 January 2018

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21 January 2018

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NoRC-dependent nucleosome positioning silences rRNA genes

21 January 2018

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Nutrient regulates Tor1 nuclear localization and association with rDNA promoter.

21 January 2018

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Activation of p53 by SIRT1 inhibition enhances elimination of CML leukemia stem cells in combination with imatinib

21 January 2018

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CK2-mediated stimulation of Pol I transcription by stabilization of UBF-SL1 interaction

21 January 2018

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Nucleolar adaptation in human cancer

21 January 2018

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Targeting the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin module for acute myelogenous leukemia therapy: from bench to bedside

21 January 2018

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The structure of NoRC-associated RNA is crucial for targeting the chromatin remodelling complex NoRC to the nucleolus

21 January 2018

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Intergenic transcripts regulate the epigenetic state of rRNA genes

21 January 2018

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mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability

21 January 2018

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Reflecting on 25 years with MYC.

21 January 2018

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hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters

21 January 2018

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Nucleolus, ribosomes, and cancer

21 January 2018

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Epigenetic therapy in myelodysplastic syndromes

21 January 2018

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mTOR function in skeletal muscle hypertrophy: increased ribosomal RNA via cell cycle regulators

21 January 2018

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The chromatin remodeling complex NoRC and TTF-I cooperate in the regulation of the mammalian rRNA genes in vivo

21 January 2018

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Akt activation enhances ribosomal RNA synthesis through casein kinase II and TIF-IA

21 January 2018

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Effect of CAL-101, a PI3Kδ inhibitor, on ribosomal rna synthesis and cell proliferation in acute myeloid leukemia cells

21 January 2018

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UBF binding in vivo is not restricted to regulatory sequences within the vertebrate ribosomal DNA repeat

21 January 2018

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Cancer cells express aberrant DNMT3B transcripts encoding truncated proteins

21 January 2018

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Casein kinase 2 associates with initiation-competent RNA polymerase I and has multiple roles in ribosomal DNA transcription

21 January 2018

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What's up and down with histone deacetylation and transcription?

21 January 2018

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A targeting modality for destruction of RNA polymerase I that possesses anticancer activity.

21 January 2018

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H3K9 methylation and RNA interference regulate nucleolar organization and repeated DNA stability

21 January 2018

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The PI3K/PKB signaling module as key regulator of hematopoiesis: implications for therapeutic strategies in leukemia.

21 January 2018

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MAD1 and c-MYC regulate UBF and rDNA transcription during granulocyte differentiation

21 January 2018

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Reduced rRNA expression and increased rDNA promoter methylation in CD34+ cells of patients with myelodysplastic syndromes

21 January 2018

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Does the ribosome translate cancer?

21 January 2018

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The Akt of translational control

21 January 2018

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The RNA polymerase I transcription machinery

21 January 2018

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The role of UBF in regulating the structure and dynamics of transcriptionally active rDNA chromatin

21 January 2018

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UBF levels determine the number of active ribosomal RNA genes in mammals

21 January 2018

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Molecular mechanisms mediating methylation-dependent silencing of ribosomal gene transcription

21 January 2018

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Epigenetic mechanism of rRNA gene silencing: temporal order of NoRC-mediated histone modification, chromatin remodeling, and DNA methylation

21 January 2018

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The nucleolar remodeling complex NoRC mediates heterochromatin formation and silencing of ribosomal gene transcription

21 January 2018

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A role for c-Myc in the regulation of ribosomal RNA processing

21 January 2018

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Interaction of noncoding RNA with the rDNA promoter mediates recruitment of DNMT3b and silencing of rRNA genes

21 January 2018

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DNMT3B7, a truncated DNMT3B isoform expressed in human tumors, disrupts embryonic development and accelerates lymphomagenesis.

21 January 2018

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G9a, a multipotent regulator of gene expression

21 January 2018

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c-Myc induces changes in higher order rDNA structure on stimulation of quiescent cells

21 January 2018

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Growth factor signaling regulates elongation of RNA polymerase I transcription in mammals via UBF phosphorylation and r-chromatin remodeling

21 January 2018

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The splice variants of UBF differentially regulate RNA polymerase I transcription elongation in response to ERK phosphorylation

21 January 2018

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An immediate response of ribosomal transcription to growth factor stimulation in mammals is mediated by ERK phosphorylation of UBF

21 January 2018

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NoRC--a novel member of mammalian ISWI-containing chromatin remodeling machines

21 January 2018

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Function of the SIRT1 protein deacetylase in cancer

21 January 2018

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Poly(ADP-ribose) polymerase-1 plays a role in suppressing mammary tumourigenesis in mice.

21 January 2018

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Nucleolar size and activity are related to pRb and p53 status in human breast cancer.

21 January 2018

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Cockayne syndrome group B (CSB) protein: at the crossroads of transcriptional networks.

21 January 2018

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Phosphorylation of UBF at serine 388 is required for interaction with RNA polymerase I and activation of rDNA transcription

21 January 2018

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Mechanism of repression of RNA polymerase I transcription by the retinoblastoma protein

21 January 2018

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Phosphorylation by G1-specific cdk-cyclin complexes activates the nucleolar transcription factor UBF.

21 January 2018

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Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice

21 January 2018

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RNA polymerases I and III, growth control and cancer

21 January 2018

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A high-content chemical screen identifies ellipticine as a modulator of p53 nuclear localization

21 January 2018

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Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter

21 January 2018

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Activation of RNA polymerase I transcription by cockayne syndrome group B protein and histone methyltransferase G9a

21 January 2018

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Integrative genomic analysis of human ribosomal DNA.

21 January 2018

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Repression of RNA polymerase I transcription by the tumor suppressor p53

21 January 2018

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ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth.

21 January 2018

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Reversible acetylation of the chromatin remodelling complex NoRC is required for non-coding RNA-dependent silencing

21 January 2018

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MYC as a regulator of ribosome biogenesis and protein synthesis

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JCP.24854

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1 September 2017

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