(Q38263091)

1 September 2017

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title

The Hippo pathway in chemotherapeutic drug resistance (English)

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1 September 2017

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Yulei Zhao

1

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PubMed ID

25348697

1 September 2017

Xiaolong Yang

series ordinal

2

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PubMed ID

25348697

1 September 2017

language of work or name

English

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publication date

27 October 2014

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International Journal of Cancer

1 September 2017

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1 September 2017

137

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1 September 2017

12

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1 September 2017

2767-2773

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A history of cancer chemotherapy

1 September 2017

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Timeline: Chemotherapy and the war on cancer.

21 January 2018

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Molecular mechanisms of drug resistance

21 January 2018

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The hippo signaling pathway in development and cancer

21 January 2018

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The Hippo pathway: regulators and regulations

21 January 2018

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WW domain-mediated interaction with Wbp2 is important for the oncogenic property of TAZ

21 January 2018

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Hippo signaling: growth control and beyond

21 January 2018

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The Hippo pathway and human cancer.

21 January 2018

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The Salvador-Warts-Hippo pathway - an emerging tumour-suppressor network

21 January 2018

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Stem cell regulation by the Hippo pathway.

21 January 2018

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The Hippo-YAP pathway: new connections between regulation of organ size and cancer

21 January 2018

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The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal

21 January 2018

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Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control

21 January 2018

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The hippo tumor pathway promotes TAZ degradation by phosphorylating a phosphodegron and recruiting the SCF{beta}-TrCP E3 ligase.

21 January 2018

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TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway

21 January 2018

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A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP)

21 January 2018

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The Hippo pathway regulates the bantam microRNA to control cell proliferation and apoptosis in Drosophila

21 January 2018

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The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain

21 January 2018

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TAZ induces growth factor-independent proliferation through activation of EGFR ligand amphiregulin

21 January 2018

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Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon

21 January 2018

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Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction

21 January 2018

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Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene

21 January 2018

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Elucidation of a universal size-control mechanism in Drosophila and mammals

21 January 2018

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A role for TAZ in migration, invasion, and tumorigenesis of breast cancer cells

21 January 2018

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Yes-associated protein promotes tumour development in luminal epithelial derived breast cancer

21 January 2018

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An integrative analysis of the tumorigenic role of TAZ in human non-small cell lung cancer.

21 January 2018

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Expression and clinical significance of YAP, TAZ, and AREG in hepatocellular carcinoma

21 January 2018

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Overexpression of YAP and TAZ is an independent predictor of prognosis in colorectal cancer and related to the proliferation and metastasis of colon cancer cells

21 January 2018

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TAZ expression as a prognostic indicator in colorectal cancer

21 January 2018

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Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers

21 January 2018

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Hypermethylation of the large tumor suppressor genes in Japanese lung cancer

21 January 2018

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The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1

21 January 2018

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Prognostic significance of mammalian sterile20-like kinase 1 in colorectal cancer.

21 January 2018

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Down-regulation of mammalian sterile 20-like kinase 1 by heat shock protein 70 mediates cisplatin resistance in prostate cancer cells

21 January 2018

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LATS tumor suppressor: a new governor of cellular homeostasis

21 January 2018

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Identification of LATS transcriptional targets in HeLa cells using whole human genome oligonucleotide microarray.

21 January 2018

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Itch E3 ubiquitin ligase regulates large tumor suppressor 1 stability [corrected]

21 January 2018

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Itch inhibition regulates chemosensitivity in vitro

21 January 2018

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Kpm/Lats2 is linked to chemosensitivity of leukemic cells through the stabilization of p73.

21 January 2018

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Low LATS2 mRNA level can predict favorable response to epirubicin plus cyclophosphamide, but not to docetaxel, in breast cancers.

21 January 2018

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TEAD mediates YAP-dependent gene induction and growth control

21 January 2018

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YAP promotes ovarian cancer cell tumorigenesis and is indicative of a poor prognosis for ovarian cancer patients

21 January 2018

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The Hippo pathway transcriptional co-activator, YAP, is an ovarian cancer oncogene.

21 January 2018

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Colon cancer cells escape 5FU chemotherapy-induced cell death by entering stemness and quiescence associated with the c-Yes/YAP axis.

21 January 2018

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Tumor suppressor LATS1 is a negative regulator of oncogene YAP

21 January 2018

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YAP-induced resistance of cancer cells to antitubulin drugs is modulated by a Hippo-independent pathway.

21 January 2018

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Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP

21 January 2018

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Functional complexes between YAP2 and ZO-2 are PDZ domain-dependent, and regulate YAP2 nuclear localization and signalling

21 January 2018

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Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein

21 January 2018

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Yap1 acts downstream of α-catenin to control epidermal proliferation

21 January 2018

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Nuclear localization and pro-apoptotic signaling of YAP2 require intact PDZ-binding motif.

21 January 2018

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YAP modifies cancer cell sensitivity to EGFR and survivin inhibitors and is negatively regulated by the non-receptor type protein tyrosine phosphatase 14.

21 January 2018

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YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway

21 January 2018

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SIRT1 regulates YAP2-mediated cell proliferation and chemoresistance in hepatocellular carcinoma

21 January 2018

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Hippo pathway-independent restriction of TAZ and YAP by angiomotin

21 January 2018

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The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway.

21 January 2018

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TAZ interacts with zonula occludens-1 and -2 proteins in a PDZ-1 dependent manner

21 January 2018

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The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells

21 January 2018

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A novel CYR61-triggered 'CYR61-alphavbeta3 integrin loop' regulates breast cancer cell survival and chemosensitivity through activation of ERK1/ERK2 MAPK signaling pathway.

21 January 2018

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Upstream regulation of the hippo size control pathway

21 January 2018

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The role of RASSF1A methylation in cancer

21 January 2018

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Control of microtubule stability by the RASSF1A tumor suppressor

21 January 2018

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Regulation of mitosis and taxane response by Daxx and Rassf1.

21 January 2018

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RASSF1A and the Taxol Response in Ovarian Cancer

21 January 2018

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A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor.

21 January 2018

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Inhibition of the hyaluronan-CD44 interaction by merlin contributes to the tumor-suppressor activity of merlin

21 January 2018

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The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis

21 January 2018

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Kibra is a regulator of the Salvador/Warts/Hippo signaling network

21 January 2018

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Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded

21 January 2018

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The WW domain protein Kibra acts upstream of Hippo in Drosophila.

21 January 2018

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The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals

21 January 2018

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Merlin is a potent inhibitor of glioma growth

21 January 2018

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CD44 attenuates activation of the hippo signaling pathway and is a prime therapeutic target for glioblastoma

21 January 2018

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The FERM-domain protein Expanded regulates Hippo pathway activity via direct interactions with the transcriptional activator Yorkie

21 January 2018

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Human homolog of Drosophila expanded, hEx, functions as a putative tumor suppressor in human cancer cell lines independently of the Hippo pathway

21 January 2018

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EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer

21 January 2018

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Mechanisms of chemoresistance in cancer stem cells

21 January 2018

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Stem cell pathways contribute to clinical chemoresistance in ovarian cancer

21 January 2018

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Hippo coactivator YAP1 upregulates SOX9 and endows esophageal cancer cells with stem-like properties

21 January 2018

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The Hippo pathway regulates Wnt/beta-catenin signaling

21 January 2018

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Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size

21 January 2018

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The Hippo superhighway: signaling crossroads converging on the Hippo/Yap pathway in stem cells and development

21 January 2018

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TAZ-mediated crosstalk between Wnt and Hippo signaling.

21 January 2018

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Integrating developmental signals: a Hippo in the (path)way

21 January 2018

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Src controls tumorigenesis via JNK-dependent regulation of the Hippo pathway in Drosophila

21 January 2018

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TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm

21 January 2018

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Mutual repression by bantam miRNA and Capicua links the EGFR/MAPK and Hippo pathways in growth control.

21 January 2018

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Regulation of Hippo signaling by EGFR-MAPK signaling through Ajuba family proteins.

21 January 2018

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Regulation of Hippo pathway by mitogenic growth factors via phosphoinositide 3-kinase and phosphoinositide-dependent kinase-1

21 January 2018

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Taming the Hippo: Raf-1 controls apoptosis by suppressing MST2/Hippo

21 January 2018

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Inhibition of Src tyrosine kinase reverts chemoresistance toward 5-fluorouracil in human pancreatic carcinoma cells: an involvement of epidermal growth factor receptor signaling

21 January 2018

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ErbB2-mediated Src and signal transducer and activator of transcription 3 activation leads to transcriptional up-regulation of p21Cip1 and chemoresistance in breast cancer cells

21 January 2018

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Roles of the PI-3K and MEK pathways in Ras-mediated chemoresistance in breast cancer cells.

21 January 2018

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Phosphoinositide 3-kinase/Akt pathway plays an important role in chemoresistance of gastric cancer cells against etoposide and doxorubicin induced cell death

21 January 2018

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Akt involvement in paclitaxel chemoresistance of human ovarian cancer cells

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/IJC.29293

1 reference

1 September 2017

1 reference

PubMed ID

25348697