(Q38270913)

1 September 2017

1 reference

title

Two-pore domain potassium channels: potential therapeutic targets for the treatment of pain (English)

1 reference

1 September 2017

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25420526%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Emma L. Veale

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25420526%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

1

Alistair Mathie

1 reference

1 September 2017

Emma L Veale

2

1 reference

1 September 2017

26 November 2014

1 reference

1 September 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25420526%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

volume

467

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25420526%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

issue

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25420526%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

page(s)

931-943

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25420526%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1007/s00424-014-1655-3

9 June 2020

exact match

0 references

cites work

TREK2 expressed selectively in IB4-binding C-fiber nociceptors hyperpolarizes their membrane potentials and limits spontaneous pain.

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

TREK-1, a K+ channel involved in polymodal pain perception

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Functional analysis of missense variants in the TRESK (KCNK18) K channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

A high-throughput functional screen identifies small molecule regulators of temperature- and mechano-sensitive K2P channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Metabolic and thermal stimuli control K(2P)2.1 (TREK-1) through modular sensory and gating domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Multiple modalities converge on a common gate to control K2P channel function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Cellular and Molecular Mechanisms of Pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Pungent agents from Szechuan peppers excite sensory neurons by inhibiting two-pore potassium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Emerging roles for two-pore-domain potassium channels and their potential therapeutic impact

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Domain-swapped chain connectivity and gated membrane access in a Fab-mediated crystal of the human TRAAK K+ channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Crystal structure of the human K2P TRAAK, a lipid- and mechano-sensitive K+ ion channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Identification of novel small molecule modulators of K2P18.1 two-pore potassium channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

mGlu4 potentiation of K(2P)2.1 is dependant on C-terminal dephosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Mechanisms underlying excitatory effects of group I metabotropic glutamate receptors via inhibition of 2P domain K+ channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Gating the pore of potassium leak channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Pain-associated signals, acidosis and lysophosphatidic acid, modulate the neuronal K(2P)2.1 channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Targeting of calcineurin to an NFAT-like docking site is required for the calcium-dependent activation of the background K+ channel, TRESK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

The LQLP calcineurin docking site is a major determinant of the calcium-dependent activation of human TRESK background K+ channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

The two-pore domain K+ channel, TRESK, is activated by the cytoplasmic calcium signal through calcineurin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Phosphorylation-dependent binding of 14-3-3 proteins controls TRESK regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Caffeic acid esters activate TREK-1 potassium channels and inhibit depolarization-dependent secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

The mechano-gated K(2P) channel TREK-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Activation of TREK-1 by morphine results in analgesia without adverse side effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

TRESK two-pore-domain K+ channels constitute a significant component of background potassium currents in murine dorsal root ganglion neurones.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Potassium channels in peripheral pain pathways: expression, function and therapeutic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

TREK-1 isoforms generated by alternative translation initiation display different susceptibility to the antidepressant fluoxetine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Molecular background of leak K+ currents: two-pore domain potassium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

SuperPain--a resource on pain-relieving compounds targeting ion channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Two-pore-domain K+ channels are a novel target for the anesthetic gases xenon, nitrous oxide, and cyclopropane

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Flufenamic acid as an ion channel modulator

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Over-expression of TRESK K(+) channels reduces the excitability of trigeminal ganglion nociceptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Nonmigraine-associated TRESK K+ channel variant C110R does not increase the excitability of trigeminal ganglion neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

TREK-1, a K+ channel involved in neuroprotection and general anesthesia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

The neuronal background K2P channels: focus on TREK1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

An intracellular proton sensor commands lipid- and mechano-gating of the K(+) channel TREK-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Roles of TRESK, a novel two-pore domain K+ channel, in pain pathway and general anesthesia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Thermosensitivity of the two-pore domain K+ channels TREK-2 and TRAAK

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

TREK-2 (K2P10.1) and TRESK (K2P18.1) are major background K+ channels in dorsal root ganglion neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Inhibition of the human two-pore domain potassium channel, TREK-1, by fluoxetine and its metabolite norfluoxetine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Chemoselective regulation of TREK2 channel: activation by sulfonate chalcones and inhibition by sulfonamide chalcones

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Identification of blocker binding site in mouse TRESK by molecular modeling and mutational studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

TREK-1 regulation by nitric oxide and cGMP-dependent protein kinase. An essential role in smooth muscle inhibitory neurotransmission

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Colitis decreases mechanosensitive K2P channel expression and function in mouse colon sensory neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Polyunsaturated fatty acids are potent neuroprotectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Imiquimod enhances excitability of dorsal root ganglion neurons by inhibiting background (K(2P)) and voltage-gated (K(v)1.1 and K(v)1.2) potassium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Physiological basis of tingling paresthesia evoked by hydroxy-alpha-sanshool

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Biophysical, pharmacological, and functional characteristics of cloned and native mammalian two-pore domain K+ channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Functional analysis of a migraine-associated TRESK K+ channel mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

External Ba2+ block of the two-pore domain potassium channel TREK-1 defines conformational transition in its selectivity filter

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Analysis of 3 common polymorphisms in the KCNK18 gene in an Australian Migraine case-control cohort.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

TREK-1 is a heat-activated background K(+) channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Lysophospholipids open the two-pore domain mechano-gated K(+) channels TREK-1 and TRAAK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Leak K⁺ channel mRNAs in dorsal root ganglia: relation to inflammation and spontaneous pain behaviour

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Neuronal two-pore-domain potassium channels and their regulation by G protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Ion channels as novel therapeutic targets in the treatment of pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Gating of two pore domain potassium channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and periphery

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Crystal structure of the human two-pore domain potassium channel K2P1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Ion channel profile of TRPM8 cold receptors reveals a role of TASK-3 potassium channels in thermosensation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Sequential phosphorylation mediates receptor- and kinase-induced inhibition of TREK-1 background potassium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Molecular regulations governing TREK and TRAAK channel functions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

The mechano-activated K+ channels TRAAK and TREK-1 control both warm and cold perception

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Inhalational anesthetics activate two-pore-domain background K+ channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

A mammalian two pore domain mechano-gated S-like K+ channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

The pore structure and gating mechanism of K2P channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

A Role for K2P Channels in the Operation of Somatosensory Nociceptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Expression of background potassium channels in rat DRG is cell-specific and down-regulated in a neuropathic pain model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

PKC-dependent activation of human K(2P) 18.1 K(+) channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

State-independent intracellular access of quaternary ammonium blockers to the pore of TREK-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Synthesis and structure-activity relationship study of substituted caffeate esters as antinociceptive agents modulating the TREK-1 channel.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Extracellular acidification exerts opposite actions on TREK1 and TREK2 potassium channels via a single conserved histidine residue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Optical control of endogenous proteins with a photoswitchable conditional subunit reveals a role for TREK1 in GABA(B) signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

AKAP150, a switch to convert mechano-, pH- and arachidonic acid-sensitive TREK K(+) channels into open leak channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

A Novel Two-pore Domain K+ Channel, TRESK, Is Localized in the Spinal Cord

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Activation of lumbar spinal wide-dynamic range neurons by a sanshool derivative

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Pharmacoinformatics elucidation of potential drug targets against migraine to target ion channel protein KCNK18

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Fenamates and diltiazem modulate lipid-sensitive mechano-gated 2P domain K(+) channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

BL-1249 [(5,6,7,8-tetrahydro-naphthalen-1-yl)-[2-(1H-tetrazol-5-yl)-phenyl]-amine]: a putative potassium channel opener with bladder-relaxant properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Alternative translation initiation in rat brain yields K2P2.1 potassium channels permeable to sodium

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Opening paths to novel analgesics: the role of potassium channels in chronic pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Mammalian somatosensory mechanotransduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

TRESK channel contribution to nociceptive sensory neurons excitability: modulation by nerve injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Dominant negative effects of a non-conducting TREK1 splice variant expressed in brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Regulating excitability of peripheral afferents: emerging ion channel targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Nociceptors--noxious stimulus detectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Cloxyquin (5-chloroquinolin-8-ol) is an activator of the two-pore domain potassium channel TRESK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Immunohistochemical colocalization of TREK-1, TREK-2 and TRAAK with TRP channels in the trigeminal ganglion cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Thrilling moment of an inhibitory channel.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Regional expression of the anesthetic-activated potassium channel TRESK in the rat nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Intrathecal TRESK gene recombinant adenovirus attenuates spared nerve injury-induced neuropathic pain in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1655-3

Therapeutic potential of neuronal two-pore domain potassium-channel modulators

21 January 2018

1 reference

12 December 2020

The neuroprotective agent riluzole activates the two P domain K(+) channels TREK-1 and TRAAK

1 reference

12 December 2020

TRESK gene recombinant adenovirus vector inhibits capsaicin-mediated substance P release from cultured rat dorsal root ganglion neurons

1 reference

12 December 2020

Cloning, functional expression and brain localization of a novel unconventional outward rectifier K+ channel

1 reference

12 December 2020

Control of somatic membrane potential in nociceptive neurons and its implications for peripheral nociceptive transmission.

1 reference

12 December 2020

KCNK2: reversible conversion of a hippocampal potassium leak into a voltage-dependent channel

1 reference

12 December 2020

A disulphide-linked heterodimer of TWIK-1 and TREK-1 mediates passive conductance in astrocytes

1 reference

12 December 2020

Influence of the N terminus on the biophysical properties and pharmacology of TREK1 potassium channels

1 reference

12 December 2020

Deletion of the background potassium channel TREK-1 results in a depression-resistant phenotype

1 reference

12 December 2020

Cns distribution of members of the two-pore-domain (KCNK) potassium channel family.

1 reference

12 December 2020

Baicalein and wogonin are activators of rat TREK-2 two-pore domain K+ channel

1 reference

12 December 2020

Role of the TREK2 potassium channel in cold and warm thermosensation and in pain perception

1 reference

12 December 2020