(Q38272580)

1 September 2017

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title

NEDD4-2 (NEDD4L): the ubiquitin ligase for multiple membrane proteins (English)

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1 September 2017

part of the series

Gene Wiki Review Series

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3

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1 September 2017

Pranay Goel

1

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1 September 2017

Jantina A Manning

series ordinal

2

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1 September 2017

language of work or name

English

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publication date

26 November 2014

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1 September 2017

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1 September 2017

volume

557

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1 September 2017

issue

1

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1 September 2017

page(s)

1-10

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All three WW domains of murine Nedd4 are involved in the regulation of epithelial sodium channels by intracellular Na+

1 September 2017

cites work

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12 December 2020

Nedd4-like proteins: an emerging family of ubiquitin-protein ligases implicated in diverse cellular functions

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12 December 2020

DEG/ENaC channels: a touchy superfamily that watches its salt

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12 December 2020

Apical membrane targeting of Nedd4 is mediated by an association of its C2 domain with annexin XIIIb

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12 December 2020

A novel mouse Nedd4 protein suppresses the activity of the epithelial Na+ channel

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12 December 2020

The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel

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12 December 2020

Protein regulation by monoubiquitin

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12 December 2020

Serum and glucocorticoid-regulated kinase modulates Nedd4-2-mediated inhibition of the epithelial Na+ channel

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12 December 2020

N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein

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12 December 2020

NEDD4L on human chromosome 18q21 has multiple forms of transcripts and is a homologue of the mouse Nedd4-2 gene.

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12 December 2020

Mutations in the surfactant protein C gene associated with interstitial lung disease

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12 December 2020

The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction

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12 December 2020

Regulation of the epithelial sodium channel by N4WBP5A, a novel Nedd4/Nedd4-2-interacting protein

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12 December 2020

The role of individual Nedd4-2 (KIAA0439) WW domains in binding and regulating epithelial sodium channels

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12 December 2020

Common variant of human NEDD4L activates a cryptic splice site to form a frameshifted transcript

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12 December 2020

Regulation of the glutamate transporter EAAT1 by the ubiquitin ligase Nedd4-2 and the serum and glucocorticoid-inducible kinase isoforms SGK1/3 and protein kinase B.

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12 December 2020

The ubiquitin-conjugation system

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12 December 2020

Identification of a set of genes with developmentally down-regulated expression in the mouse brain

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12 December 2020

Androgens differentially regulate the expression of NEDD4L transcripts in LNCaP human prostate cancer cells

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12 December 2020

Relative contribution of Nedd4 and Nedd4-2 to ENaC regulation in epithelia determined by RNA interference

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12 December 2020

Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.

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12 December 2020

Regulation of glucose transporter SGLT1 by ubiquitin ligase Nedd4-2 and kinases SGK1, SGK3, and PKB.

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12 December 2020

Cardiac voltage-gated sodium channel Nav1.5 is regulated by Nedd4-2 mediated ubiquitination

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12 December 2020

N4WBP5A (Ndfip2), a Nedd4-interacting protein, localizes to multivesicular bodies and the Golgi, and has a potential role in protein trafficking

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12 December 2020

cAMP and serum and glucocorticoid-inducible kinase (SGK) regulate the epithelial Na(+) channel through convergent phosphorylation of Nedd4-2.

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12 December 2020

Nedd4-2 functionally interacts with ClC-5: involvement in constitutive albumin endocytosis in proximal tubule cells

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12 December 2020

NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor

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12 December 2020

Regulation of CLC-Ka/barttin by the ubiquitin ligase Nedd4-2 and the serum- and glucocorticoid-dependent kinases

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12 December 2020

Molecular determinants of voltage-gated sodium channel regulation by the Nedd4/Nedd4-like proteins

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12 December 2020

HECT ubiquitin ligases link viral and cellular PPXY motifs to the vacuolar protein-sorting pathway

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12 December 2020

14-3-3 proteins modulate the expression of epithelial Na+ channels by phosphorylation-dependent interaction with Nedd4-2 ubiquitin ligase.

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12 December 2020

Nedd4-2 isoforms differentially associate with ENaC and regulate its activity.

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12 December 2020

Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligases

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12 December 2020

Occludin: structure, function and regulation

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12 December 2020

Epithelial Na+ channel subunit stoichiometry

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12 December 2020

Acute rejection after rat renal transplantation leads to downregulation of NA+ and water channels in the collecting duct.

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12 December 2020

Tsg101 and Alix interact with murine leukemia virus Gag and cooperate with Nedd4 ubiquitin ligases during budding

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12 December 2020

14-3-3 proteins: a number of functions for a numbered protein

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12 December 2020

Serum- and glucocorticoid-regulated kinase 1 regulates ubiquitin ligase neural precursor cell-expressed, developmentally down-regulated protein 4-2 by inducing interaction with 14-3-3.

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12 December 2020

Association of NEDD4L ubiquitin ligase with essential hypertension

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12 December 2020

The ubiquitin-protein ligases Nedd4 and Nedd4-2 show similar ubiquitin-conjugating enzyme specificities

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12 December 2020

Post-translational regulation of EAAT2 function by co-expressed ubiquitin ligase Nedd4-2 is impacted by SGK kinases.

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12 December 2020

Regulation of functional diversity within the Nedd4 family by accessory and adaptor proteins

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12 December 2020

14-3-3 Mediates phosphorylation-dependent inhibition of the interaction between the ubiquitin E3 ligase Nedd4-2 and epithelial Na+ channels.

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12 December 2020

24-h ambulatory blood pressure is linked to chromosome 18q21-22 and genetic variation of NEDD4L associates with cross-sectional and longitudinal blood pressure in Swedes

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12 December 2020

RNA interference screen reveals an essential role of Nedd4-2 in dopamine transporter ubiquitination and endocytosis

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12 December 2020

Regulation of amino acid transporter ATA2 by ubiquitin ligase Nedd4-2

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12 December 2020

(Patho)physiological significance of the serum- and glucocorticoid-inducible kinase isoforms

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12 December 2020

The KCNQ1 potassium channel is down-regulated by ubiquitylating enzymes of the Nedd4/Nedd4-like family

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12 December 2020

Regulation of the voltage-gated K(+) channels KCNQ2/3 and KCNQ3/5 by ubiquitination. Novel role for Nedd4-2

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12 December 2020

Akt mediates the effect of insulin on epithelial sodium channels by inhibiting Nedd4-2

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12 December 2020

Sézary syndrome is a unique cutaneous T-cell lymphoma as identified by an expanded gene signature including diagnostic marker molecules CDO1 and DNM3.

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12 December 2020

Gp78 cooperates with RMA1 in endoplasmic reticulum-associated degradation of CFTRDeltaF508.

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12 December 2020

Expression, transcription, and possible antagonistic interaction of the human Nedd4L gene variant: implications for essential hypertension

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12 December 2020

Two polymorphisms in NEDD4L gene and essential hypertension in Chinese Hans - a population-based case-control study

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12 December 2020

NEDD4L overexpression rescues the release and infectivity of human immunodeficiency virus type 1 constructs lacking PTAP and YPXL late domains

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12 December 2020

Nedd4-2 isoforms ubiquitinate individual epithelial sodium channel subunits and reduce surface expression and function of the epithelial sodium channel

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12 December 2020

Regulation of the voltage-gated K(+) channels KCNQ2/3 and KCNQ3/5 by serum- and glucocorticoid-regulated kinase-1.

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12 December 2020

Regulation of Nedd4-2 self-ubiquitination and stability by a PY motif located within its HECT-domain

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12 December 2020

Salt-sensitive hypertension and cardiac hypertrophy in mice deficient in the ubiquitin ligase Nedd4-2

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12 December 2020

The ubiquitin-protein ligase Nedd4-2 differentially interacts with and regulates members of the Tweety family of chloride ion channels

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12 December 2020

Mechanisms of ENaC regulation and clinical implications

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12 December 2020

Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2

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12 December 2020

Nedd4 family-interacting protein 1 (Ndfip1) is required for the exosomal secretion of Nedd4 family proteins

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12 December 2020

Arrestin-like proteins mediate ubiquitination and endocytosis of the yeast metal transporter Smf1.

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12 December 2020

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12 December 2020

Nedd4L expression is downregulated in prostate cancer compared to benign prostatic hyperplasia

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12 December 2020

The ESCRT pathway and HIV-1 budding

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12 December 2020

Down-regulation of active ACK1 is mediated by association with the E3 ubiquitin ligase Nedd4-2.

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12 December 2020

The nucleocapsid region of HIV-1 Gag cooperates with the PTAP and LYPXnL late domains to recruit the cellular machinery necessary for viral budding

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12 December 2020

The activity of the epithelial sodium channels is regulated by caveolin-1 via a Nedd4-2-dependent mechanism

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12 December 2020

Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins

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12 December 2020

Anterograde transport of surfactant protein C proprotein to distal processing compartments requires PPDY-mediated association with Nedd4 ubiquitin ligases

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12 December 2020

Nedd4-2-mediated ubiquitination facilitates processing of surfactant protein-C

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12 December 2020

Physiological functions of the HECT family of ubiquitin ligases

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12 December 2020

Nedd4 and Nedd4-2: closely related ubiquitin-protein ligases with distinct physiological functions

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12 December 2020

Rescue of DeltaF508-CFTR by the SGK1/Nedd4-2 signaling pathway

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12 December 2020

A functional variant of NEDD4L is associated with hypertension, antihypertensive response, and orthostatic hypotension.

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12 December 2020

Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons

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12 December 2020

Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling

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12 December 2020

Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays

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12 December 2020

Human Nedd4L rs4149601 G allele generates evolutionary new isoform I with C2 domain

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12 December 2020

Lysine 63-linked polyubiquitination of the dopamine transporter requires WW3 and WW4 domains of Nedd4-2 and UBE2D ubiquitin-conjugating enzymes

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12 December 2020

E3 ligase Nedd4 promotes axon branching by downregulating PTEN

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12 December 2020

Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development

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12 December 2020

Role of ClC-5 in renal endocytosis is unique among ClC exchangers and does not require PY-motif-dependent ubiquitylation

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12 December 2020

Nedd4-2 interacts with occludin to inhibit tight junction formation and enhance paracellular conductance in collecting duct epithelia

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12 December 2020

The ESCRT-associated protein Alix recruits the ubiquitin ligase Nedd4-1 to facilitate HIV-1 release through the LYPXnL L domain motif

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12 December 2020

c-Cbl facilitates endocytosis and lysosomal degradation of cystic fibrosis transmembrane conductance regulator in human airway epithelial cells

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12 December 2020

Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2

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12 December 2020

AMP-activated protein kinase inhibits KCNQ1 channels through regulation of the ubiquitin ligase Nedd4-2 in renal epithelial cells

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12 December 2020

Nedd4L modulates the transcription of metalloproteinase-1 and -13 genes to increase the invasive activity of gallbladder cancer

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12 December 2020

A functional variant of the NEDD4L gene is associated with beneficial treatment response with β-blockers and diuretics in hypertensive patients

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12 December 2020

Transcription alterations of members of the ubiquitin-proteasome network in prostate carcinoma.

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12 December 2020

Protein kinase C-dependent ubiquitination and clathrin-mediated endocytosis of the cationic amino acid transporter CAT-1.

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12 December 2020

Deletion of the ubiquitin ligase Nedd4L in lung epithelia causes cystic fibrosis-like disease

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12 December 2020

Ubiquitination of TrkA by Nedd4-2 regulates receptor lysosomal targeting and mediates receptor signaling

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12 December 2020

Stimulation of Ca2+-channel Orai1/STIM1 by serum- and glucocorticoid-inducible kinase 1 (SGK1).

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12 December 2020

Nedd4-2-dependent ubiquitylation and regulation of the cardiac potassium channel hERG1

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12 December 2020

Ubiquitin-specific protease 2-45 (Usp2-45) binds to epithelial Na+ channel (ENaC)-ubiquitylating enzyme Nedd4-2.

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12 December 2020

Respiratory distress and perinatal lethality in Nedd4-2-deficient mice

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12 December 2020

Nedd4-2 modulates renal Na+-Cl- cotransporter via the aldosterone-SGK1-Nedd4-2 pathway

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12 December 2020

Decreased expression of Nedd4L correlates with poor prognosis in gastric cancer patient

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12 December 2020

Dlg3 trafficking and apical tight junction formation is regulated by nedd4 and nedd4-2 e3 ubiquitin ligases

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12 December 2020

Deubiquitylating enzyme USP2 counteracts Nedd4-2-mediated downregulation of KCNQ1 potassium channels

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12 December 2020

Down-regulation of Nedd4L is associated with the aggressive progression and worse prognosis of malignant glioma

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12 December 2020

Epithelial Na(+) channel regulation by cytoplasmic and extracellular factors

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12 December 2020

The iron-regulated metastasis suppressor NDRG1 targets NEDD4L, PTEN, and SMAD4 and inhibits the PI3K and Ras signaling pathways

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12 December 2020

The CFTR and ENaC debate: how important is ENaC in CF lung disease?

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12 December 2020

Regulation of Orai1/STIM1 by the kinases SGK1 and AMPK.

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12 December 2020

Cell surface expression of human ether-a-go-go-related gene (hERG) channels is regulated by caveolin-3 protein via the ubiquitin ligase Nedd4-2

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12 December 2020

Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation

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12 December 2020

Nedd4-2 does not regulate wt-CFTR in human airway epithelial cells

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12 December 2020

Neuronal expression of the ubiquitin ligase Nedd4-2 in rat dorsal root ganglia: modulation in the spared nerve injury model of neuropathic pain.

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12 December 2020

Linear ubiquitination: a newly discovered regulator of cell signalling

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12 December 2020

Renal tubular NEDD4-2 deficiency causes NCC-mediated salt-dependent hypertension

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12 December 2020

HECT domain-containing E3 ubiquitin ligase NEDD4L negatively regulates Wnt signaling by targeting dishevelled for proteasomal degradation

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12 December 2020

Mammalian HECT ubiquitin-protein ligases: biological and pathophysiological aspects

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12 December 2020

Mice carrying ubiquitin-specific protease 2 (Usp2) gene inactivation maintain normal sodium balance and blood pressure.

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12 December 2020

Structure of a ubiquitin-loaded HECT ligase reveals the molecular basis for catalytic priming

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12 December 2020

Dysregulation of voltage-gated sodium channels by ubiquitin ligase NEDD4-2 in neuropathic pain.

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12 December 2020

Regulation of the human ether-a-go-go-related gene (hERG) channel by Rab4 protein through neural precursor cell-expressed developmentally down-regulated protein 4-2 (Nedd4-2).

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12 December 2020

Identification of the NEDD4L gene as a prognostic marker by integrated microarray analysis of copy number and gene expression profiling in non-small cell lung cancer

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12 December 2020

MicroRNAs cooperatively inhibit a network of tumor suppressor genes to promote pancreatic tumor growth and progression

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12 December 2020

Nedd4-2 (NEDD4L) controls intracellular Na(+)-mediated activity of voltage-gated sodium channels in primary cortical neurons

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12 December 2020

Genetic variation in NEDD4L, an epithelial sodium channel regulator, is associated with cardiovascular disease and cardiovascular death

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12 December 2020

Genetic risk variants for dyslexia on chromosome 18 in a German cohort.

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12 December 2020

Nedd4-2 regulates surface expression and may affect N-glycosylation of hyperpolarization-activated cyclic nucleotide-gated (HCN)-1 channels

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12 December 2020

Pathobiological properties of the ubiquitin ligase Nedd4L in melanoma

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12 December 2020

Characteristics and regulatory mechanisms of the amiloride-blockable Na+ channel

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12 December 2020

Muscarinic receptor activation increases hERG channel expression through phosphorylation of ubiquitin ligase Nedd4-2.

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12 December 2020

In vivo regulation of NGF-mediated functions by Nedd4-2 ubiquitination of TrkA

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12 December 2020

NEDD4L regulates convergent extension movements in Xenopus embryos via Disheveled-mediated non-canonical Wnt signaling

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12 December 2020

WNK3 abrogates the NEDD4-2-mediated inhibition of the renal Na+-Cl- cotransporter

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12 December 2020

Ubiquitin E3 ligase Nedd4-1 acts as a downstream target of PI3K/PTEN-mTORC1 signaling to promote neurite growth.

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12 December 2020

Ubiquitin adenylate: structure and role in ubiquitin activation

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12 December 2020

A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase

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12 December 2020

WWP, a new amino acid motif present in single or multiple copies in various proteins including dystrophin and the SH3-binding Yes-associated protein YAP65

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12 December 2020

The rsp5-domain is shared by proteins of diverse functions

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12 December 2020

Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits

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12 December 2020

WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome

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12 December 2020

cDNA cloning, expression analysis, and mapping of the mouse Nedd4 gene.

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12 December 2020

Mutations in the chloride channel gene, CLCNKB, cause Bartter's syndrome type III

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12 December 2020

Nedd4 mediates control of an epithelial Na+ channel in salivary duct cells by cytosolic Na+

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12 December 2020

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12 December 2020

The ubiquitin-proteasome pathway: on protein death and cell life

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12 December 2020

Ubiquitin and the control of protein fate in the secretory and endocytic pathways

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12 December 2020

Role of CFTR in airway disease

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12 December 2020

10.1016/J.GENE.2014.11.051

Identifiers

DOI

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1 September 2017

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