(Q38303979)

1 September 2017

1 reference

title

Muscle wasting in disease: molecular mechanisms and promising therapies (English)

1 reference

1 September 2017

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25549588%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

James A Nathan

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25549588%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

author name string

Alfred L Goldberg

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25549588%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

publication date

1 January 2015

1 reference

Nature Reviews Drug Discovery

1 September 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25549588%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

volume

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25549588%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

page(s)

58-74

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25549588%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25549588%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/nrd4467

13 June 2020

exact match

0 references

cites work

The molecular basis of skeletal muscle atrophy

1 reference

Protein degradation by the ubiquitin-proteasome pathway in normal and disease states

31 March 2020

1 reference

Reversal of cancer cachexia and muscle wasting by ActRIIB antagonism leads to prolonged survival

31 March 2020

1 reference

Mechanisms of muscle wasting. The role of the ubiquitin-proteasome pathway

31 March 2020

1 reference

Muscle protein breakdown and the critical role of the ubiquitin-proteasome pathway in normal and disease states

31 March 2020

1 reference

Patterns of gene expression in atrophying skeletal muscles: response to food deprivation.

31 March 2020

1 reference

Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression

31 March 2020

1 reference

Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy

31 March 2020

1 reference

Rapid disuse and denervation atrophy involve transcriptional changes similar to those of muscle wasting during systemic diseases

31 March 2020

1 reference

FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells

31 March 2020

1 reference

FoxO3 controls autophagy in skeletal muscle in vivo

31 March 2020

1 reference

Identification of ubiquitin ligases required for skeletal muscle atrophy

31 March 2020

1 reference

During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation

31 March 2020

1 reference

Ubiquitylation by Trim32 causes coupled loss of desmin, Z-bands, and thin filaments in muscle atrophy

31 March 2020

1 reference

The E3 Ligase MuRF1 degrades myosin heavy chain protein in dexamethasone-treated skeletal muscle

31 March 2020

1 reference

The initiation factor eIF3-f is a major target for atrogin1/MAFbx function in skeletal muscle atrophy

31 March 2020

1 reference

Insulin-like growth factor-1 (IGF-1) inversely regulates atrophy-induced genes via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway

31 March 2020

1 reference

Cellular and molecular mechanisms of muscle atrophy

31 March 2020

1 reference

Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models

31 March 2020

1 reference

Skeletal muscle hypertrophy and atrophy signaling pathways

31 March 2020

1 reference

Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy

31 March 2020

1 reference

Smad2 and 3 transcription factors control muscle mass in adulthood.

31 March 2020

1 reference

Role of glucocorticoids in the molecular regulation of muscle wasting

31 March 2020

1 reference

IKKbeta/NF-kappaB activation causes severe muscle wasting in mice

31 March 2020

1 reference

Targeted ablation of IKK2 improves skeletal muscle strength, maintains mass, and promotes regeneration

31 March 2020

1 reference

Regulation of myostatin expression and myoblast differentiation by FoxO and SMAD transcription factors

31 March 2020

1 reference

Role and regulation of starvation-induced autophagy in the Drosophila fat body

31 March 2020

1 reference

Crosstalk between glucocorticoid receptor and nutritional sensor mTOR in skeletal muscle.

31 March 2020

1 reference

IGF-I stimulates muscle growth by suppressing protein breakdown and expression of atrophy-related ubiquitin ligases, atrogin-1 and MuRF1.

31 March 2020

1 reference

Conditional activation of akt in adult skeletal muscle induces rapid hypertrophy

31 March 2020

1 reference

Myostatin/activin pathway antagonism: molecular basis and therapeutic potential

31 March 2020

1 reference

Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size

31 March 2020

1 reference

JunB transcription factor maintains skeletal muscle mass and promotes hypertrophy

31 March 2020

1 reference

Regulation and function of JunB in cell proliferation

31 March 2020

1 reference

PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription

31 March 2020

1 reference

Peroxisome proliferator-activated receptor gamma coactivator 1alpha or 1beta overexpression inhibits muscle protein degradation, induction of ubiquitin ligases, and disuse atrophy

31 March 2020

1 reference

A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy

31 March 2020

1 reference

The role of exercise and PGC1alpha in inflammation and chronic disease

31 March 2020

1 reference

The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes

31 March 2020

1 reference

The cathepsin L gene is a direct target of FOXO1 in skeletal muscle.

31 March 2020

1 reference

The glucocorticoid receptor and FOXO1 synergistically activate the skeletal muscle atrophy-associated MuRF1 gene.

31 March 2020

1 reference

Sepsis increases the expression and activity of the transcription factor Forkhead Box O 1 (FOXO1) in skeletal muscle by a glucocorticoid-dependent mechanism

31 March 2020

1 reference

MST1, a key player, in enhancing fast skeletal muscle atrophy

31 March 2020

1 reference

An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans

31 March 2020

1 reference

The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor

31 March 2020

1 reference

SIRT1 protein, by blocking the activities of transcription factors FoxO1 and FoxO3, inhibits muscle atrophy and promotes muscle growth

31 March 2020

1 reference

Posttranslational modifications control FoxO3 activity during denervation

31 March 2020

1 reference

Inhibition of IkappaB kinase alpha (IKKα) or IKKbeta (IKKβ) plus forkhead box O (Foxo) abolishes skeletal muscle atrophy.

31 March 2020

1 reference

NF-kappaB-induced loss of MyoD messenger RNA: possible role in muscle decay and cachexia

31 March 2020

1 reference

Modulation of reactive oxygen species in skeletal muscle by myostatin is mediated through NF-κB

31 March 2020

1 reference

The E3 ubiquitin ligase TRAF6 intercedes in starvation-induced skeletal muscle atrophy through multiple mechanisms

31 March 2020

1 reference

Tumor necrosis factor-alpha and muscle wasting: a cellular perspective

31 March 2020

1 reference

Rel A/p65 is required for cytokine-induced myotube atrophy

31 March 2020

1 reference

31 March 2020

1 reference

The TWEAK-Fn14 system is a critical regulator of denervation-induced skeletal muscle atrophy in mice.

31 March 2020

1 reference

BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice

31 March 2020

1 reference

Sensitization of tumor cells toward chemotherapy: enhancing the efficacy of camptothecin with imidazolines.

31 March 2020

1 reference

Eicosapentaenoic acid (EPA, an omega-3 fatty acid from fish oils) for the treatment of cancer cachexia

31 March 2020

1 reference

The IKK NF-kappa B system: a treasure trove for drug development

31 March 2020

1 reference

Myostatin negatively regulates satellite cell activation and self-renewal

31 March 2020

1 reference

Muscle regeneration in the prolonged absence of myostatin

31 March 2020

1 reference

Myostatin decreases with aerobic exercise and associates with insulin resistance

31 March 2020

1 reference

Increased Smad signaling and reduced MRF expression in skeletal muscle from obese subjects

31 March 2020

1 reference

Mechanisms of glucocorticoid-induced myopathy

31 March 2020

1 reference

An antibody blocking activin type II receptors induces strong skeletal muscle hypertrophy and protects from atrophy

31 March 2020

1 reference

Regulation of myostatin activity and muscle growth

31 March 2020

1 reference

Mechanisms involved in the enhancement of mammalian target of rapamycin signalling and hypertrophy in skeletal muscle of myostatin-deficient mice

31 March 2020

1 reference

BMP signaling controls muscle mass

31 March 2020

1 reference

Myostatin knockout drives browning of white adipose tissue through activating the AMPK-PGC1α-Fndc5 pathway in muscle

31 March 2020

1 reference

Myosin accumulation and striated muscle myopathy result from the loss of muscle RING finger 1 and 3

31 March 2020

1 reference

Trim32 is a ubiquitin ligase mutated in limb girdle muscular dystrophy type 2H that binds to skeletal muscle myosin and ubiquitinates actin

31 March 2020

1 reference

Limb-girdle muscular dystrophy type 2H associated with mutation in TRIM32, a putative E3-ubiquitin-ligase gene

31 March 2020

1 reference

Deficiency of the E3 ubiquitin ligase TRIM32 in mice leads to a myopathy with a neurogenic component

31 March 2020

1 reference

Satellite cell senescence underlies myopathy in a mouse model of limb-girdle muscular dystrophy 2H.

31 March 2020

1 reference

Trim32 reduces PI3K-Akt-FoxO signaling in muscle atrophy by promoting plakoglobin-PI3K dissociation

31 March 2020

1 reference

Signaling in muscle atrophy and hypertrophy

31 March 2020

1 reference

AAA-ATPase p97/Cdc48p, a cytosolic chaperone required for endoplasmic reticulum-associated protein degradation

31 March 2020

1 reference

The p97/VCP ATPase is critical in muscle atrophy and the accelerated degradation of muscle proteins

31 March 2020

1 reference

Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways

31 March 2020

1 reference

Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death

31 March 2020

1 reference

Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein

31 March 2020

1 reference

Exome sequencing reveals VCP mutations as a cause of familial ALS

31 March 2020

1 reference

Development of proteasome inhibitors as research tools and cancer drugs

31 March 2020

1 reference

Prevention of muscle disuse atrophy by MG132 proteasome inhibitor

31 March 2020

1 reference

The proteasome inhibitor MG132 reduces immobilization-induced skeletal muscle atrophy in mice

31 March 2020

1 reference

Effect of proteasome inhibitors on endotoxin-induced diaphragm dysfunction

31 March 2020

1 reference

Cachexia: a new definition

31 March 2020

1 reference

Tumors secreting human TNF/cachectin induce cachexia in mice

31 March 2020

1 reference

Tumor necrosis factor-α regulates distinct molecular pathways and gene networks in cultured skeletal muscle cells

31 March 2020

1 reference

Tumor necrosis factor-alpha mediates changes in tissue protein turnover in a rat cancer cachexia model

31 March 2020

1 reference

Anti-TNF Treatment Reverts Increased Muscle Ubiquitin Gene Expression in Tumour-Bearing Rats

31 March 2020

1 reference

Tumor necrosis factor can induce fever in rats without activating protein breakdown in muscle or lipolysis in adipose tissue

31 March 2020

1 reference

The toxic effects of tumor necrosis factor in vivo and their prevention by cyclooxygenase inhibitors

31 March 2020

1 reference

A placebo-controlled double blind trial of etanercept for the cancer anorexia/weight loss syndrome: results from N00C1 from the North Central Cancer Treatment Group

31 March 2020

1 reference

A placebo-controlled, double-blind trial of infliximab for cancer-associated weight loss in elderly and/or poor performance non-small cell lung cancer patients (N01C9).

31 March 2020

1 reference

Cytokines in pancreatic carcinoma: correlation with phenotypic characteristics and prognosis

31 March 2020

1 reference

Interleukin 6 is associated with cachexia in patients with prostate cancer

31 March 2020

1 reference

The relationship between weight loss and interleukin 6 in non-small-cell lung cancer

31 March 2020

1 reference

Evidence for the involvement of interleukin 6 in experimental cancer cachexia

31 March 2020

1 reference

A humanized anti-IL-6 antibody (ALD518) in non-small cell lung cancer

31 March 2020

1 reference

Acute inhibition of myostatin-family proteins preserves skeletal muscle in mouse models of cancer cachexia

31 March 2020

1 reference

Myostatin blockage using actRIIB antagonism in mice bearing the Lewis lung carcinoma results in the improvement of muscle wasting and physical performance.

31 March 2020

1 reference

Antibody-directed myostatin inhibition enhances muscle mass and function in tumor-bearing mice

31 March 2020

1 reference

Critically ill polyneuropathy: electrophysiological studies and differentiation from Guillain-Barré syndrome

31 March 2020

1 reference

Risk factors for the development of polyneuropathy and myopathy in critically ill patients

31 March 2020

1 reference

Acute quadriplegic myopathy: an acquired "myosinopathy"

31 March 2020

1 reference

Myopathy in critically ill patients

31 March 2020

1 reference

Muscle fibre atrophy in critically ill patients is associated with the loss of myosin filaments and the presence of lysosomal enzymes and ubiquitin

31 March 2020

1 reference

Rapid disuse atrophy of diaphragm fibers in mechanically ventilated humans.

31 March 2020

1 reference

PPARβ/δ regulates glucocorticoid- and sepsis-induced FOXO1 activation and muscle wasting

31 March 2020

1 reference

The methyltransferase SMYD3 mediates the recruitment of transcriptional cofactors at the myostatin and c-Met genes and regulates skeletal muscle atrophy

31 March 2020

1 reference

Myostatin suppression of Akirin1 mediates glucocorticoid-induced satellite cell dysfunction.

31 March 2020

1 reference

Dexamethasone-induced skeletal muscle atrophy was associated with upregulation of myostatin promoter activity

31 March 2020

1 reference

Burn-induced increase in atrogin-1 and MuRF-1 in skeletal muscle is glucocorticoid independent but downregulated by IGF-I

31 March 2020

1 reference

Glucocorticoid antagonist RU38486 fails to block acid-induced muscle wasting in vivo or in vitro

31 March 2020

1 reference

Sepsis downregulates myostatin mRNA levels without altering myostatin protein levels in skeletal muscle

31 March 2020

1 reference

Origin of symptoms in patients with cachexia with special reference to weakness and shortness of breath

31 March 2020

1 reference

Review of muscle wasting associated with chronic kidney disease

31 March 2020

1 reference

Midthigh muscle cross-sectional area is a better predictor of mortality than body mass index in patients with chronic obstructive pulmonary disease

31 March 2020

1 reference

Quadriceps strength predicts mortality in patients with moderate to severe chronic obstructive pulmonary disease

31 March 2020

1 reference

Gene expression profiling in vastus lateralis muscle during an acute exacerbation of COPD.

31 March 2020

1 reference

Atrophy and hypertrophy signalling of the quadriceps and diaphragm in COPD

31 March 2020

1 reference

Atrophy and hypertrophy signalling in the diaphragm of patients with COPD

31 March 2020

1 reference

Mechanisms stimulating muscle wasting in chronic kidney disease: the roles of the ubiquitin-proteasome system and myostatin

31 March 2020

1 reference

Evaluation of signals activating ubiquitin-proteasome proteolysis in a model of muscle wasting

31 March 2020

1 reference

Activation of caspase-3 is an initial step triggering accelerated muscle proteolysis in catabolic conditions

31 March 2020

1 reference

Development of a diagnostic method for detecting increased muscle protein degradation in patients with catabolic conditions

31 March 2020

1 reference

Rates of ubiquitin conjugation increase when muscles atrophy, largely through activation of the N-end rule pathway

31 March 2020

1 reference

The N-end rule pathway catalyzes a major fraction of the protein degradation in skeletal muscle

31 March 2020

1 reference

Caspase-3 cleaves specific 19 S proteasome subunits in skeletal muscle stimulating proteasome activity

31 March 2020

1 reference

Absence of caspase-3 protects against denervation-induced skeletal muscle atrophy.

31 March 2020

1 reference

XIAP reduces muscle proteolysis induced by CKD.

31 March 2020

1 reference

Mechanisms of skeletal muscle aging: insights from Drosophila and mammalian models

31 March 2020

1 reference

Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010

31 March 2020

1 reference

Diaphragm Muscle Fiber Weakness in Pulmonary Hypertension

31 March 2020

1 reference

Peripheral muscle dysfunction in idiopathic pulmonary arterial hypertension

31 March 2020

1 reference

Effects of hypoxia on capillary density and fiber composition in rat skeletal muscle

31 March 2020

1 reference

Chronic hypobaric hypoxia mediated skeletal muscle atrophy: role of ubiquitin-proteasome pathway and calpains

31 March 2020

1 reference

Performing at extreme altitude: muscle cellular and subcellular adaptations

31 March 2020

1 reference

Maximal force and endurance to fatigue of respiratory and skeletal muscles in chronic hypoxemic patients: the effects of oxygen breathing.

31 March 2020

1 reference

Cardiac cachexia: a systematic overview

31 March 2020

1 reference

Myostatin, a transforming growth factor-? superfamily member, is expressed in heart muscle and is upregulated in cardiomyocytes after infarct

31 March 2020

1 reference

Genetic deletion of myostatin from the heart prevents skeletal muscle atrophy in heart failure

31 March 2020

1 reference

Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy

31 March 2020

1 reference

Consensus definition of sarcopenia, cachexia and pre-cachexia: joint document elaborated by Special Interest Groups (SIG) "cachexia-anorexia in chronic wasting diseases" and "nutrition in geriatrics"

31 March 2020

1 reference

Sarcopenia is predictive of nosocomial infection in care of the elderly.

31 March 2020

1 reference

Possible involvement of proteasome inhibition in aging: implications for oxidative stress.

31 March 2020

1 reference

Muscle wasting in aged, sarcopenic rats is associated with enhanced activity of the ubiquitin proteasome pathway

31 March 2020

1 reference

Skeletal muscle proteolysis in aging.

31 March 2020

1 reference

Contributions of the ubiquitin-proteasome pathway and apoptosis to human skeletal muscle wasting with age

31 March 2020

1 reference

Genomic and proteomic profiling reveals reduced mitochondrial function and disruption of the neuromuscular junction driving rat sarcopenia

31 March 2020

1 reference

Remodeling of the neuromuscular junction precedes sarcopenia related alterations in myofibers

31 March 2020

1 reference

Striking denervation of neuromuscular junctions without lumbar motoneuron loss in geriatric mouse muscle.

31 March 2020

1 reference

Clinical review 24: Androgens in the aging male

31 March 2020

1 reference

Hormonal changes in aging men: a therapeutic indication?

31 March 2020

1 reference

The influence of age on the 24-hour integrated concentration of growth hormone in normal individuals

31 March 2020

1 reference

Single and combined effects of growth hormone and testosterone administration on measures of body composition, physical performance, mood, sexual function, bone turnover, and muscle gene expression in healthy older men.

31 March 2020

1 reference

Effects of testosterone on muscle strength, physical function, body composition, and quality of life in intermediate-frail and frail elderly men: a randomized, double-blind, placebo-controlled study

31 March 2020

1 reference

Prolonged absence of myostatin reduces sarcopenia

31 March 2020

1 reference

Antagonism of myostatin enhances muscle regeneration during sarcopenia

31 March 2020

1 reference

Activin A serum levels and aging of the pituitary-gonadal axis: a cross-sectional study in middle-aged and elderly healthy subjects

31 March 2020

1 reference

Myostatin inhibition enhances the effects of exercise on performance and metabolic outcomes in aged mice

31 March 2020

1 reference

Antibody-directed myostatin inhibition in 21-mo-old mice reveals novel roles for myostatin signaling in skeletal muscle structure and function

31 March 2020

1 reference

Combined isometric, concentric, and eccentric resistance exercise prevents unloading-induced muscle atrophy in rats

31 March 2020

1 reference

Exercise training attenuates MuRF-1 expression in the skeletal muscle of patients with chronic heart failure independent of age: the randomized Leipzig Exercise Intervention in Chronic Heart Failure and Aging catabolism study

31 March 2020

1 reference

Hindlimb unloading-induced muscle atrophy and loss of function: protective effect of isometric exercise

31 March 2020

1 reference

Effect of resistance exercise contraction mode and protein supplementation on members of the STARS signalling pathway

31 March 2020

1 reference

Exercise training promotes SIRT1 activity in aged rats.

31 March 2020

1 reference

Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres

31 March 2020

1 reference

The transcriptional coactivator PGC-1beta drives the formation of oxidative type IIX fibers in skeletal muscle

31 March 2020

1 reference

PGC-1 beta-regulated mitochondrial biogenesis and function in myotubes is mediated by NRF-1 and ERR alpha

31 March 2020

1 reference

Striated muscle activator of Rho signalling (STARS) is a PGC-1α/oestrogen-related receptor-α target gene and is upregulated in human skeletal muscle after endurance exercise

31 March 2020

1 reference

Exercise and myocyte enhancer factor 2 regulation in human skeletal muscle

31 March 2020

1 reference

PGC-1alpha and exercise: important partners in combating insulin resistance

31 March 2020

1 reference

Retracted: Increased muscle PGC-1α expression protects from sarcopenia and metabolic disease during aging

31 March 2020

1 reference

Modulation of longevity and tissue homeostasis by the Drosophila PGC-1 homolog.

31 March 2020

1 reference

AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha

31 March 2020

1 reference

AMPK and PPARdelta agonists are exercise mimetics

31 March 2020

1 reference

AMPK activation stimulates myofibrillar protein degradation and expression of atrophy-related ubiquitin ligases by increasing FOXO transcription factors in C2C12 myotubes

31 March 2020

1 reference

AMP-activated protein kinase agonists increase mRNA content of the muscle-specific ubiquitin ligases MAFbx and MuRF1 in C2C12 cells

31 March 2020

1 reference

JunB-CBFbeta signaling is essential to maintain sarcomeric Z-disc structure and when defective leads to heart failure.

31 March 2020

1 reference

Recent progress in the biology and physiology of sirtuins

31 March 2020

1 reference

Sirtuins--novel therapeutic targets to treat age-associated diseases

31 March 2020

1 reference

Mammalian sirtuins: biological insights and disease relevance

31 March 2020

1 reference

SIRT1 controls the transcription of the peroxisome proliferator-activated receptor-gamma Co-activator-1alpha (PGC-1alpha) gene in skeletal muscle through the PGC-1alpha autoregulatory loop and interaction with MyoD.

31 March 2020

1 reference

Sirt1 increases skeletal muscle precursor cell proliferation

31 March 2020

1 reference

Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member

31 March 2020

1 reference

Follistatin gene delivery enhances muscle growth and strength in nonhuman primates

31 March 2020

1 reference

Functional improvement of dystrophic muscle by myostatin blockade.

31 March 2020

1 reference

Recombinant myostatin (GDF-8) propeptide enhances the repair and regeneration of both muscle and bone in a model of deep penetrant musculoskeletal injury

31 March 2020

1 reference

Identification of a novel pool of extracellular pro-myostatin in skeletal muscle.

31 March 2020

1 reference

Pharmacological inhibition of myostatin suppresses systemic inflammation and muscle atrophy in mice with chronic kidney disease

31 March 2020

1 reference

Inhibition of myostatin protects against diet-induced obesity by enhancing fatty acid oxidation and promoting a brown adipose phenotype in mice

31 March 2020

1 reference

The effects of a soluble activin type IIB receptor on obesity and insulin sensitivity

31 March 2020

1 reference

Myostatin inhibition induces muscle fibre hypertrophy prior to satellite cell activation

31 March 2020

1 reference

Follistatin induces muscle hypertrophy through satellite cell proliferation and inhibition of both myostatin and activin

31 March 2020

1 reference

Growth factor delivery methods in the management of sports injuries: the state of play

31 March 2020

1 reference

Pharmacodynamic hormonal effects of anamorelin, a novel oral ghrelin mimetic and growth hormone secretagogue in healthy volunteers

31 March 2020

1 reference

Acute peripheral tissue effects of ghrelin on interstitial levels of glucose, glycerol, and lactate: a microdialysis study in healthy human subjects

31 March 2020

1 reference

Role of beta-adrenoceptor signaling in skeletal muscle: implications for muscle wasting and disease

31 March 2020

1 reference

Skeletal muscle hypertrophy and anti-atrophy effects of clenbuterol are mediated by the beta2-adrenergic receptor

31 March 2020

1 reference

Rapamycin inhibits the growth and muscle-sparing effects of clenbuterol

31 March 2020

1 reference

Anticachectic effects of formoterol: a drug for potential treatment of muscle wasting.

31 March 2020

1 reference

Attenuation of age-related muscle wasting and weakness in rats after formoterol treatment: therapeutic implications for sarcopenia

31 March 2020

1 reference

cAMP signaling in skeletal muscle adaptation: hypertrophy, metabolism, and regeneration

31 March 2020

1 reference

Clenbuterol suppresses proteasomal and lysosomal proteolysis and atrophy-related genes in denervated rat soleus muscles independently of Akt.

31 March 2020

1 reference

Clenbuterol toxicity: a NSW poisons information centre experience.

31 March 2020

1 reference

Update on roflumilast, a phosphodiesterase 4 inhibitor for the treatment of chronic obstructive pulmonary disease

31 March 2020

1 reference

The preclinical pharmacology of roflumilast--a selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease

31 March 2020

1 reference

Phosphodiesterase-4 inhibitor therapy for lung diseases

31 March 2020

1 reference

Pentoxifylline improves insulin action limiting skeletal muscle catabolism after infection.

31 March 2020

1 reference

Pentoxifylline inhibits Ca2+-dependent and ATP proteasome-dependent proteolysis in skeletal muscle from acutely diabetic rats

31 March 2020

1 reference

Phosphodiesterase 4 inhibition reduces skeletal muscle atrophy

31 March 2020

1 reference

New phosphodiesterase inhibitors as therapeutics for the treatment of chronic lung disease

31 March 2020

1 reference

Phosphodiesterase-4 inhibitors in the treatment of inflammatory lung disease.

31 March 2020

1 reference

Mechanisms involved in 3',5'-cyclic adenosine monophosphate-mediated inhibition of the ubiquitin-proteasome system in skeletal muscle

31 March 2020

1 reference

Cyclic adenosine monophosphate-phosphodiesterase inhibitors reduce skeletal muscle protein catabolism in septic rats.

31 March 2020

1 reference

Testosterone-induced increase in muscle size in healthy young men is associated with muscle fiber hypertrophy

31 March 2020

1 reference

Effect of testosterone on muscle mass and muscle protein synthesis.

31 March 2020

1 reference

Testosterone-induced muscle hypertrophy is associated with an increase in satellite cell number in healthy, young men.

31 March 2020

1 reference

Dramatic rise in prostate-specific antigen after androgen replacement in a hypogonadal man with occult adenocarcinoma of the prostate.

31 March 2020

1 reference

Drug insight: Testosterone and selective androgen receptor modulators as anabolic therapies for chronic illness and aging

31 March 2020

1 reference

Selective androgen receptor modulators in preclinical and clinical development

31 March 2020

1 reference

Nonsteroidal selective androgen receptor modulator Ostarine in cancer cachexia.

31 March 2020

1 reference

Acute antibody-directed myostatin inhibition attenuates disuse muscle atrophy and weakness in mice

31 March 2020

1 reference

Ghrelin treatment of cachectic patients with chronic obstructive pulmonary disease: a multicenter, randomized, double-blind, placebo-controlled trial

31 March 2020

1 reference

Therapeutic potential of anamorelin, a novel, oral ghrelin mimetic, in patients with cancer-related cachexia: a multicenter, randomized, double-blind, crossover, pilot study

31 March 2020

1 reference

The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double-blind, placebo-controlled phase II trial.

31 March 2020

1 reference

Effects of enobosarm on muscle wasting and physical function in patients with cancer: a double-blind, randomised controlled phase 2 trial

31 March 2020

1 reference

The ACT-ONE trial, a multicentre, randomised, double-blind, placebo-controlled, dose-finding study of the anabolic/catabolic transforming agent, MT-102 in subjects with cachexia related to stage III and IV non-small cell lung cancer and colorectal c

31 March 2020

1 reference

The safety, pharmacokinetics, and effects of LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, in healthy young men

31 March 2020

1 reference

Stat3 activation links a C/EBPδ to myostatin pathway to stimulate loss of muscle mass

31 March 2020

1 reference

Skeletal muscle dysfunction in idiopathic pulmonary arterial hypertension.

31 March 2020

1 reference

12 December 2020

Relationship between serum levels of interleukin 6, various disease parameters and malnutrition in patients with esophageal squamous cell carcinoma

1 reference

12 December 2020

Serum myostatin-immunoreactive protein is increased in 60-92 year old women and men with muscle wasting

1 reference

12 December 2020

Endogenous glucocorticoids and impaired insulin signaling are both required to stimulate muscle wasting under pathophysiological conditions in mice

1 reference

12 December 2020

PI3 kinase regulation of skeletal muscle hypertrophy and atrophy

1 reference

12 December 2020

Phosphodiesterase-4 inhibition reduces proteolysis and atrogenes expression in rat skeletal muscles.

1 reference

12 December 2020

Sepsis and AMPK Activation by AICAR Differentially Regulate FoxO-1, -3 and -4 mRNA in Striated Muscle

1 reference

12 December 2020

Regulation of muscle growth by multiple ligands signaling through activin type II receptors

1 reference

12 December 2020

Activation of the ATP-ubiquitin-proteasome pathway in skeletal muscle of cachectic rats bearing a hepatoma

1 reference

12 December 2020

Disruption of either the Nfkb1 or the Bcl3 gene inhibits skeletal muscle atrophy

1 reference

12 December 2020

Acylated and unacylated ghrelin impair skeletal muscle atrophy in mice.

1 reference

12 December 2020

Cyclic nucleotides differentially regulate the synthesis of tumour necrosis factor-alpha and interleukin-1 beta by human mononuclear cells

1 reference

12 December 2020

Increased muscle proteasome activity correlates with disease severity in gastric cancer patients

1 reference

12 December 2020

Body mass, fat-free body mass, and prognosis in patients with chronic obstructive pulmonary disease from a random population sample: findings from the Copenhagen City Heart Study.

1 reference

12 December 2020

The expression of genes in the ubiquitin-proteasome proteolytic pathway is increased in skeletal muscle from patients with cancer

1 reference

12 December 2020

Myostatin, a transforming growth factor-beta superfamily member, is expressed in heart muscle and is upregulated in cardiomyocytes after infarct

1 reference

12 December 2020

Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: a key role for bioavailable estrogen.

1 reference

12 December 2020

Selective up-regulation of tumor necrosis factor receptor I in tumor-bearing rats with cancer-related cachexia.

1 reference

12 December 2020

Regulation of myostatin by glucocorticoids after thermal injury

1 reference

12 December 2020

Torbafylline (HWA 448) inhibits enhanced skeletal muscle ubiquitin-proteasome-dependent proteolysis in cancer and septic rats

1 reference

12 December 2020

Insulin-like growth factor-I and analogues increase growth in artificially-reared neonatal pigs

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRD4467

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25549588%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

13 June 2020

1007854399

0 references

Fatcat ID

release_ro7srhlzvjagvl7wcigrz466gm

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/ro7srhlzvjagvl7wcigrz466gm

24 November 2022

mapped directly with Wikidata item

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25549588%20AND%20SRC:MED&resulttype=core&format=json