(Q38315056)

2 September 2017

title

Polyamines are oncometabolites that regulate the LIN28/let-7 pathway in colorectal cancer cells (English)

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2 September 2017

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Edwin A Paz

1

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2 September 2017

Bonnie LaFleur

series ordinal

2

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2 September 2017

Eugene W Gerner

series ordinal

3

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2 September 2017

publication date

4 June 2013

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2 September 2017

published in

Molecular Carcinogenesis

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2 September 2017

volume

53 Suppl 1

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2 September 2017

page(s)

E96-106

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Targeting cancer metabolism: a therapeutic window opens

2 September 2017

cites work

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Posttranslational synthesis of hypusine: evolutionary progression and specificity of the hypusine modification

21 January 2018

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Polyamines and cancer: old molecules, new understanding

21 January 2018

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Disrupting polyamine homeostasis as a therapeutic strategy for neuroblastoma

21 January 2018

1 reference

Targeting ornithine decarboxylase impairs development of MYCN-amplified neuroblastoma

21 January 2018

1 reference

Difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas: a randomized placebo-controlled, double-blind trial

21 January 2018

1 reference

A randomized, double-blind, placebo-controlled phase 3 skin cancer prevention study of {alpha}-difluoromethylornithine in subjects with previous history of skin cancer

21 January 2018

1 reference

Cancer chemoprevention locks onto a new polyamine metabolic target

21 January 2018

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Formation of the First Peptide Bond: The Structure of EF-P Bound to the 70S Ribosome

21 January 2018

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Hypusine-containing protein eIF5A promotes translation elongation

21 January 2018

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eIF5A has a function in the elongation step of translation in yeast

21 January 2018

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eIF5A isoforms and cancer: two brothers for two functions?

21 January 2018

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The role of polyamines in supporting growth of mammalian cells is mediated through their requirement for translation initiation and elongation

21 January 2018

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Hypusine modification in eukaryotic initiation factor 5A in rodent cells selected for resistance to growth inhibition by ornithine decarboxylase-inhibiting drugs

21 January 2018

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Hypusine modification for growth is the major function of spermidine in Saccharomyces cerevisiae polyamine auxotrophs grown in limiting spermidine

21 January 2018

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An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer

21 January 2018

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A tumour suppressor network relying on the polyamine-hypusine axis

21 January 2018

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Regulation by c-Myc of ncRNA expression

21 January 2018

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Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?

21 January 2018

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RAS is regulated by the let-7 microRNA family

21 January 2018

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The tumor suppressor microRNA let-7 represses the HMGA2 oncogene

21 January 2018

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Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation

21 January 2018

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The let-7 family of microRNAs

21 January 2018

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Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation

21 January 2018

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The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans

21 January 2018

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TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation

21 January 2018

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Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms.

21 January 2018

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Lin28 promotes transformation and is associated with advanced human malignancies

21 January 2018

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The effect of difluoromethylornithine on decreasing prostate size and polyamines in men: results of a year-long phase IIb randomized placebo-controlled chemoprevention trial

21 January 2018

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Overexpression of HMGA2 promotes metastasis and impacts survival of colorectal cancers.

21 January 2018

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Roles of HMGA proteins in cancer

21 January 2018

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Silencing of microRNA families by seed-targeting tiny LNAs

21 January 2018

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Post-translational modification of the protein-synthesis initiation factor eIF-4D by spermidine in rat hepatoma cells

21 January 2018

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The early history of polyamine research

21 January 2018

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A single amino acid substitution in yeast eIF-5A results in mRNA stabilization

21 January 2018

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EF-P is essential for rapid synthesis of proteins containing consecutive proline residues

21 January 2018

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Translation elongation factor EF-P alleviates ribosome stalling at polyproline stretches.

21 January 2018

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The ornithine decarboxylase gene is a transcriptional target of c-Myc

21 January 2018

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AMD1 is essential for ESC self-renewal and is translationally down-regulated on differentiation to neural precursor cells

21 January 2018

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How does Lin28 let-7 control development and disease?

21 January 2018

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LIN28 binds messenger RNAs at GGAGA motifs and regulates splicing factor abundance

21 January 2018

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The Lin28/let-7 axis regulates glucose metabolism

21 January 2018

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Increased glucose oxidation and contents of insulin and ATP in polyamine-depleted rat insulinoma cells (RINm5F)

21 January 2018

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Tumour-suppressor microRNAs let-7 and mir-101 target the proto-oncogene MYCN and inhibit cell proliferation in MYCN-amplified neuroblastoma

21 January 2018

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LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/MC.22051

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2 September 2017

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