(Q38329400)

2 September 2017

1 reference

title

Critical roles of non-histone protein lysine methylation in human tumorigenesis (English)

1 reference

2 September 2017

Yusuke Nakamura

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25614009%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

language of work or name

English

0 references

publication date

1 February 2015

1 reference

2 September 2017

published in

Nature Reviews Cancer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25614009%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

volume

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25614009%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25614009%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

page(s)

110-124

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25614009%20AND%20SRC:MED&resulttype=core&format=json

ɛ-N-Methyl-lysine in Bacterial Flagellar Protein

31 May 2020

cites work

1 reference

THE OCCURRENCE OF EPSILON-N-METHYL LYSINE IN HISTONES

31 March 2020

1 reference

SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells

31 March 2020

1 reference

Regulation of chromatin structure by site-specific histone H3 methyltransferases

31 March 2020

1 reference

Set domain-containing protein, G9a, is a novel lysine-preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3

31 March 2020

1 reference

Histone trimethylation by Set1 is coordinated by the RRM, autoinhibitory, and catalytic domains

31 March 2020

1 reference

Distinct contributions of histone H3 lysine 9 and 27 methylation to locus-specific stability of polycomb complexes

31 March 2020

1 reference

Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain

31 March 2020

1 reference

Histone methylation: dynamic or static?

31 March 2020

1 reference

Histone demethylation mediated by the nuclear amine oxidase homolog LSD1

31 March 2020

1 reference

Histone demethylation by a family of JmjC domain-containing proteins

31 March 2020

1 reference

Enhanced SMYD3 expression is essential for the growth of breast cancer cells

31 March 2020

1 reference

pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4alpha tumor suppressor gene.

31 March 2020

1 reference

EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

31 March 2020

1 reference

Highly effective combination of LSD1 (KDM1A) antagonist and pan-histone deacetylase inhibitor against human AML cells

31 March 2020

1 reference

Validation of the histone methyltransferase EZH2 as a therapeutic target for various types of human cancer and as a prognostic marker

31 March 2020

1 reference

Over-expression of polycomb group protein EZH2 relates to decreased expression of p16 INK4a in cholangiocarcinogenesis in hepatolithiasis

31 March 2020

1 reference

Enhanced expression of EHMT2 is involved in the proliferation of cancer cells through negative regulation of SIAH1

31 March 2020

1 reference

The JmjC domain-containing histone demethylase KDM3A is a positive regulator of the G1/S transition in cancer cells via transcriptional regulation of the HOXA1 gene

31 March 2020

1 reference

The histone demethylase JMJD2B plays an essential role in human carcinogenesis through positive regulation of cyclin-dependent kinase 6.

31 March 2020

1 reference

RB1 methylation by SMYD2 enhances cell cycle progression through an increase of RB1 phosphorylation

31 March 2020

1 reference

Enhanced HSP70 lysine methylation promotes proliferation of cancer cells through activation of Aurora kinase B.

31 March 2020

1 reference

SMYD2-dependent HSP90 methylation promotes cancer cell proliferation by regulating the chaperone complex formation

31 March 2020

1 reference

The lysine 831 of vascular endothelial growth factor receptor 1 is a novel target of methylation by SMYD3.

31 March 2020

1 reference

The histone methyltransferase SMYD2 methylates PARP1 and promotes poly(ADP-ribosyl)ation activity in cancer cells

31 March 2020

1 reference

Chemical mechanisms of histone lysine and arginine modifications

31 March 2020

1 reference

Selenium-based S-adenosylmethionine analog reveals the mammalian seven-beta-strand methyltransferase METTL10 to be an EF1A1 lysine methyltransferase

31 March 2020

1 reference

Human LSD2/KDM1b/AOF1 regulates gene transcription by modulating intragenic H3K4me2 methylation.

31 March 2020

1 reference

The oncogenic polycomb histone methyltransferase EZH2 methylates lysine 120 on histone H2B and competes ubiquitination

31 March 2020

1 reference

Critical role of lysine 134 methylation on histone H2AX for γ-H2AX production and DNA repair.

31 March 2020

1 reference

SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer

31 March 2020

1 reference

Recognition of methylated histones: new twists and variations

31 March 2020

1 reference

The cation-π interaction at protein-protein interaction interfaces: developing and learning from synthetic mimics of proteins that bind methylated lysines

31 March 2020

1 reference

Identification of arginine- and lysine-methylation in the proteome of Saccharomyces cerevisiae and its functional implications

31 March 2020

1 reference

EZH2 generates a methyl degron that is recognized by the DCAF1/DDB1/CUL4 E3 ubiquitin ligase complex

31 March 2020

1 reference

Dissection of a nuclear localization signal

31 March 2020

1 reference

Regulation of p53 activity through lysine methylation

31 March 2020

1 reference

Lysine methylation of promoter-bound transcription factors and relevance to cancer

31 March 2020

1 reference

Regulation of NF-kappaB by NSD1/FBXL11-dependent reversible lysine methylation of p65.

31 March 2020

1 reference

Role of lysine methylation of NF-κB in differential gene regulation

31 March 2020

1 reference

Isolation of p53-target genes and their functional analysis

31 March 2020

1 reference

Repression of p53 activity by Smyd2-mediated methylation

31 March 2020

1 reference

p53 is regulated by the lysine demethylase LSD1

31 March 2020

1 reference

Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers

31 March 2020

1 reference

Modulation of p53 function by SET8-mediated methylation at lysine 382

31 March 2020

1 reference

The retinoblastoma tumor-suppressor gene, the exception that proves the rule

31 March 2020

1 reference

The retinoblastoma protein is phosphorylated during specific phases of the cell cycle

31 March 2020

1 reference

Methylation of the retinoblastoma tumor suppressor by SMYD2

31 March 2020

1 reference

Interplay between lysine methylation and Cdk phosphorylation in growth control by the retinoblastoma protein

31 March 2020

1 reference

Involvement of E2F transcription factor family in cancer

31 March 2020

1 reference

Emerging roles of E2Fs in cancer: an exit from cell cycle control

31 March 2020

1 reference

Lysine methylation regulates E2F1-induced cell death

31 March 2020

1 reference

Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications

31 March 2020

1 reference

Targeting the dynamic HSP90 complex in cancer

31 March 2020

1 reference

The HSP70 chaperone machinery: J proteins as drivers of functional specificity

31 March 2020

1 reference

The Hsp90 chaperone machinery

31 March 2020

1 reference

Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery

31 March 2020

1 reference

HSP90 and the chaperoning of cancer

31 March 2020

1 reference

VEGF receptor signalling - in control of vascular function

31 March 2020

1 reference

Expression and function of vascular endothelial growth factor receptor-1 on human colorectal cancer cells

31 March 2020

1 reference

Regulation of vascular endothelial growth factor receptor-1 expression by specificity proteins 1, 3, and 4 in pancreatic cancer cells

31 March 2020

1 reference

NF-kappaB signaling pathways in mammalian and insect innate immunity

31 March 2020

1 reference

Regulation of NF-kappaB activity through lysine monomethylation of p65.

31 March 2020

1 reference

Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling

31 March 2020

1 reference

Estrogen receptor alpha in human breast cancer: occurrence and significance

31 March 2020

1 reference

Regulation of estrogen receptor α by histone methyltransferase SMYD2-mediated protein methylation

31 March 2020

1 reference

The role of C/EBPbeta in mammary gland development and breast cancer

31 March 2020

1 reference

G9a-mediated lysine methylation alters the function of CCAAT/enhancer-binding protein-beta.

31 March 2020

1 reference

STAT3, a Poor Survival Predicator, Is Associated with Lymph Node Metastasis from Breast Cancer

31 March 2020

1 reference

Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes

31 March 2020

1 reference

Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells

31 March 2020

1 reference

Histone lysine methyltransferase SETD8 promotes carcinogenesis by deregulating PCNA expression

31 March 2020

1 reference

Targeting tyrosine phosphorylation of PCNA inhibits prostate cancer growth.

31 March 2020

1 reference

PARP inhibitors: its role in treatment of cancer

31 March 2020

1 reference

Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia

31 March 2020

1 reference

Exome sequencing identifies frequent mutation of MLL2 in non-small cell lung carcinoma from Chinese patients

31 March 2020

1 reference

Clinical and pathological impact of VHL, PBRM1, BAP1, SETD2, KDM6A, and JARID1c in clear cell renal cell carcinoma.

31 March 2020

1 reference

Identification of driver genes in hepatocellular carcinoma by exome sequencing

31 March 2020

1 reference

Aberrant patterns of H3K4 and H3K27 histone lysine methylation occur across subgroups in medulloblastoma.

31 March 2020

1 reference

Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A.

31 March 2020

1 reference

Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma

31 March 2020

1 reference

Somatic Mutations of the Mixed-Lineage Leukemia 3 (MLL3) Gene in Primary Breast Cancers

31 March 2020

1 reference

Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder

31 March 2020

1 reference

The mutational landscape of lethal castration-resistant prostate cancer

31 March 2020

1 reference

The mitochondrial and autosomal mutation landscapes of prostate cancer

31 March 2020

1 reference

The mutational landscape of adenoid cystic carcinoma

31 March 2020

1 reference

Mutational landscape and significance across 12 major cancer types

31 March 2020

1 reference

Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9.

31 March 2020

1 reference

Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase

31 March 2020

1 reference

Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294

31 March 2020

1 reference

Rational design of inhibitors that bind to inactive kinase conformations

31 March 2020

1 reference

A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells

31 March 2020

1 reference

Structural basis of substrate methylation and inhibition of SMYD2

31 March 2020

1 reference

A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells

31 March 2020

1 reference

Selective inhibition of EZH2 by EPZ-6438 leads to potent antitumor activity in EZH2-mutant non-Hodgkin lymphoma

31 March 2020

1 reference

Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes

31 March 2020

1 reference

Validation of a prognostic model and the impact of mutations in patients with lower-risk myelodysplastic syndromes

31 March 2020

1 reference

Loss of heterozygosity in 7q myeloid disorders: clinical associations and genomic pathogenesis

31 March 2020

1 reference

Concurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders

31 March 2020

1 reference

Nonclinical pharmacokinetics and metabolism of EPZ-5676, a novel DOT1L histone methyltransferase inhibitor

31 March 2020

1 reference

DOT1L inhibitor EPZ-5676 displays synergistic antiproliferative activity in combination with standard of care drugs and hypomethylating agents in MLL-rearranged leukemia cells

31 March 2020

1 reference

trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1.

31 March 2020

1 reference

Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia

31 March 2020

1 reference

Novel histone demethylase LSD1 inhibitors selectively target cancer cells with pluripotent stem cell properties

31 March 2020

1 reference

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

31 March 2020

1 reference

A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth

31 March 2020

1 reference

Nonhistone protein acetylation as cancer therapy targets

31 March 2020

1 reference

Overexpression of SMYD2 relates to tumor cell proliferation and malignant outcome of esophageal squamous cell carcinoma

31 March 2020

1 reference

The tale of two domains: proteomics and genomics analysis of SMYD2, a new histone methyltransferase

31 March 2020

1 reference

Identification and characterization of Smyd2: a split SET/MYND domain-containing histone H3 lysine 36-specific methyltransferase that interacts with the Sin3 histone deacetylase complex

31 March 2020

1 reference

Enhanced methyltransferase activity of SMYD3 by the cleavage of its N-terminal region in human cancer cells

31 March 2020

1 reference

Structural and Functional Profiling of the Human Histone Methyltransferase SMYD3

31 March 2020

1 reference

Effect of the downregulation of SMYD3 expression by RNAi on RIZ1 expression and proliferation of esophageal squamous cell carcinoma

31 March 2020

1 reference

31 March 2020

1 reference

Deregulated expression of selected histone methylases and demethylases in prostate carcinoma.

31 March 2020

1 reference

Knockdown of SMYD3 by RNA interference inhibits cervical carcinoma cell growth and invasion in vitro

31 March 2020

1 reference

Epigenetic regulation of miR-124 by hepatitis C virus core protein promotes migration and invasion of intrahepatic cholangiocarcinoma cells by targeting SMYD3.

31 March 2020

1 reference

Hepatitis C virus core upregulates the methylation status of the RASSF1A promoter through regulation of SMYD3 in hilar cholangiocarcinoma cells

31 March 2020

1 reference

NUP98-NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis.

31 March 2020

1 reference

Cryptic translocation t(5;11)(q35;p15.5) with involvement of the NSD1 and NUP98 genes without 5q deletion in childhood acute myeloid leukemia

31 March 2020

1 reference

NUP98/NSD1 characterizes a novel poor prognostic group in acute myeloid leukemia with a distinct HOX gene expression pattern

31 March 2020

1 reference

Histone lysine methyltransferase Wolf-Hirschhorn syndrome candidate 1 is involved in human carcinogenesis through regulation of the Wnt pathway

31 March 2020

1 reference

The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells.

31 March 2020

1 reference

The histone methyltransferase MMSET/WHSC1 activates TWIST1 to promote an epithelial-mesenchymal transition and invasive properties of prostate cancer

31 March 2020

1 reference

Multiple-myeloma-related WHSC1/MMSET isoform RE-IIBP is a histone methyltransferase with transcriptional repression activity

31 March 2020

1 reference

MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites

31 March 2020

1 reference

The histone methyltransferase Wolf-Hirschhorn syndrome candidate 1-like 1 (WHSC1L1) is involved in human carcinogenesis

31 March 2020

1 reference

The NSD3L histone methyltransferase regulates cell cycle and cell invasion in breast cancer cells

31 March 2020

1 reference

Characterization of a novel WHSC1-associated SET domain protein with H3K4 and H3K27 methyltransferase activity

31 March 2020

1 reference

hSETD1A regulates Wnt target genes and controls tumor growth of colorectal cancer cells

31 March 2020

1 reference

Set9, NF-κB, and microRNA-21 mediate berberine-induced apoptosis of human multiple myeloma cells

31 March 2020

1 reference

Regulation of Estrogen Receptor α by the SET7 Lysine Methyltransferase

31 March 2020

1 reference

Isolation and characterization of Suv39h2, a second histone H3 methyltransferase gene that displays testis-specific expression

31 March 2020

1 reference

The methyltransferase G9a regulates HoxA9-dependent transcription in AML.

31 March 2020

1 reference

Overexpression of G9a and MCM7 in oesophageal squamous cell carcinoma is associated with poor prognosis

31 March 2020

1 reference

Epigenetic regulator MLL2 shows altered expression in cancer cell lines and tumors from human breast and colon

31 March 2020

1 reference

Downregulation of MLL3 in esophageal squamous cell carcinoma is required for the growth and metastasis of cancer cells

31 March 2020

1 reference

Association of MLL3 expression with prognosis in gastric cancer

31 March 2020

1 reference

MLL3, a new human member of the TRX/MLL gene family, maps to 7q36, a chromosome region frequently deleted in myeloid leukaemia.

31 March 2020

1 reference

hDOT1L links histone methylation to leukemogenesis

31 March 2020

1 reference

DOT1L, the H3K79 methyltransferase, is required for MLL-AF9-mediated leukemogenesis

31 March 2020

1 reference

A role for DOT1L inMLL-rearranged leukemias

31 March 2020

1 reference

Role of the hypoxia-related gene, JMJD1A, in hepatocellular carcinoma: clinical impact on recurrence after hepatic resection

31 March 2020

1 reference

The expression of histone demethylase JMJD1A in renal cell carcinoma

31 March 2020

1 reference

Deregulation of the histone demethylase JMJD2A is involved in human carcinogenesis through regulation of the G(1)/S transition.

31 March 2020

1 reference

Oncogenic features of the JMJD2A histone demethylase in breast cancer.

31 March 2020

1 reference

JMJD2A predicts prognosis and regulates cell growth in human gastric cancer

31 March 2020

1 reference

Silencing of JMJD2B induces cell apoptosis via mitochondria-mediated and death receptor-mediated pathway activation in colorectal cancer.

31 March 2020

1 reference

Jumonji domain-containing protein 2B silencing induces DNA damage response via STAT3 pathway in colorectal cancer

31 March 2020

1 reference

JMJD2B promotes epithelial-mesenchymal transition by cooperating with β-catenin and enhances gastric cancer metastasis

31 March 2020

1 reference

Histone demethylase Jumonji D3 (JMJD3) as a tumor suppressor by regulating p53 protein nuclear stabilization

31 March 2020

1 reference

Concurrent alterations in TERT, KDM6A, and the BRCA pathway in bladder cancer.

31 March 2020

1 reference

Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia

31 March 2020

1 reference

Expression and significance of histone H3K27 demethylases in renal cell carcinoma

31 March 2020

1 reference

Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

31 March 2020

1 reference

Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway

31 March 2020

1 reference

JARID1B is a luminal lineage-driving oncogene in breast cancer

31 March 2020

1 reference

Jumonji/Arid1b (Jarid1b) protein modulates human esophageal cancer cell growth

31 March 2020

1 reference

Depletion of JARID1B induces cellular senescence in human colorectal cancer

31 March 2020

1 reference

JARID1B protein expression and prognostic implications in uveal melanoma

31 March 2020

1 reference

Demethylation of RB regulator MYPT1 by histone demethylase LSD1 promotes cell cycle progression in cancer cells.

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25614009

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25614009

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Expression and effects of JMJD2A histone demethylase in endometrial carcinoma

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25614009