(Q38336527)

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Flavonoid interactions during digestion, absorption, distribution and metabolism: a sequential structure-activity/property relationship-based approach in the study of bioavailability and bioactivity

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Europe PubMed Central

PubMed publication ID

2 September 2017

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Europe PubMed Central

Flavonoid interactions during digestion, absorption, distribution and metabolism: a sequential structure-activity/property relationship-based approach in the study of bioavailability and bioactivity (English)

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Europe PubMed Central

PubMed publication ID

2 September 2017

bioavailability

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based on heuristic

inferred from title

Charlotte Grootaert

3

object named as

Charlotte Grootaert

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

2

object named as

Guy Smagghe

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

author name string

Gerard Bryan Gonzales

1

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

Moises Zotti

4

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

Katleen Raes

5

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

John Van Camp

6

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Europe PubMed Central

PubMed publication ID

2 September 2017

language of work or name

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publication date

30 January 2015

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Europe PubMed Central

PubMed publication ID

2 September 2017

Drug Metabolism Reviews

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Europe PubMed Central

PubMed publication ID

2 September 2017

47

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

2

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

175-190

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

Inhibition of angiotensin converting enzyme activity by flavanol-rich foods

1 reference

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21 January 2018

Flavonoid structure-activity studies identify 6-prenylchrysin and tectochrysin as potent and specific inhibitors of breast cancer resistance protein ABCG2.

1 reference

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21 January 2018

Angiotensin-converting enzyme inhibitory effects by plant phenolic compounds: a study of structure activity relationships

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21 January 2018

Modulation of the activity of ABC transporters (P-glycoprotein, MRP2, BCRP) by flavonoids and drug response.

1 reference

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21 January 2018

Absorption, Conjugation and Efflux of the Flavonoids, Kaempferol and Galangin, Using the Intestinal CACO-2/TC7 Cell Model

1 reference

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21 January 2018

A tunable Caco-2/HT29-MTX co-culture model mimicking variable permeabilities of the human intestine obtained by an original seeding procedure.

1 reference

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21 January 2018

Pancreatic lipase inhibitors from natural sources: unexplored potential

1 reference

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21 January 2018

Flavonoid binding to human serum albumin.

1 reference

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21 January 2018

Nature and consequences of non-covalent interactions between flavonoids and macronutrients in foods

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Recent advances in the discovery of flavonoids and analogs with high-affinity binding to P-glycoprotein responsible for cancer cell multidrug resistance.

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21 January 2018

Structures required of flavonoids for inhibiting digestive enzymes

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Flavonoids: a class of modulators with bifunctional interactions at vicinal ATP- and steroid-binding sites on mouse P-glycoprotein

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21 January 2018

Prenyl-flavonoids as potent inhibitors of the Pdr5p multidrug ABC transporter from Saccharomyces cerevisiae.

1 reference

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21 January 2018

Bioavailability of dietary flavonoids and phenolic compounds.

1 reference

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21 January 2018

Bioavailability of the polyphenols: status and controversies

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21 January 2018

Transport and metabolism of flavonoids from Chinese herbal remedy Xiaochaihu- tang across human intestinal Caco-2 cell monolayers

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21 January 2018

Plant Phenolics: Extraction, Analysis and Their Antioxidant and Anticancer Properties

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21 January 2018

Computational methods in developing quantitative structure-activity relationships (QSAR): a review

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21 January 2018

Structure-activity relationships of lanostane-type triterpenoids from Ganoderma lingzhi as α-glucosidase inhibitors

1 reference

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21 January 2018

Structure-activity relationships and quantitative structure-activity relationships for breast cancer resistance protein (ABCG2).

1 reference

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21 January 2018

Antimicrobial and anti-lipase activity of quercetin and its C2-C16 3-O-acyl-esters.

1 reference

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21 January 2018

Tea derived galloylated polyphenols cross-link purified gastrointestinal mucins

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21 January 2018

Ultra(high)-pressure liquid chromatography-electrospray ionization-time-of-flight-ion mobility-high definition mass spectrometry for the rapid identification and structural characterization of flavonoid glycosides from cauliflower waste.

1 reference

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21 January 2018

Phenolic compounds: evidence for inhibitory effects against obesity and their underlying molecular signaling mechanisms

1 reference

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21 January 2018

Mitochondrial dysfunction leads to deconjugation of quercetin glucuronides in inflammatory macrophages

1 reference

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21 January 2018

Effect of edible oils on quercetin, kaempferol and galangin transport and conjugation in the intestinal Caco-2/HT29-MTX co-culture model

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.1003649

21 January 2018

Bioavailability of phenolic compounds

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.1003649

21 January 2018

Flavonoids inhibit breast cancer resistance protein-mediated drug resistance: transporter specificity and structure-activity relationship.

1 reference

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21 January 2018

Alpha-amylase and alpha-glucosidase inhibition is differentially modulated by fucoidan obtained from Fucus vesiculosus and Ascophyllum nodosum

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.1003649

21 January 2018

Docking and 3D-QSAR (quantitative structure activity relationship) studies of flavones, the potent inhibitors of p-glycoprotein targeting the nucleotide binding domain

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.1003649

21 January 2018

Flavonoid glycosides are not transported by the human Na+/glucose transporter when expressed in Xenopus laevis oocytes, but effectively inhibit electrogenic glucose uptake

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.1003649

21 January 2018

Micro- and macrorheology of mucus

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.1003649

21 January 2018

Glucuronidation of bioflavonoids by human UGT1A10: structure-function relationships

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.1003649

21 January 2018

A strategy for the improvement of the bioavailability and antiosteoporosis activity of BCS IV flavonoid glycosides through the formulation of their lipophilic aglycone into nanocrystals

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.1003649

21 January 2018

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.1003649

21 January 2018

Absorption and metabolism of flavonoids in the caco-2 cell culture model and a perused rat intestinal model

1 reference

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21 January 2018

Flavonoids for Controlling Starch Digestion: Structural Requirements for Inhibiting Human α-Amylase

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The practice of structure activity relationships (SAR) in toxicology

1 reference

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SULT1A3-mediated regiospecific 7-O-sulfation of flavonoids in Caco-2 cells can be explained by the relevant molecular docking studies.

1 reference

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21 January 2018

Flavonoid-drug interactions: effects of flavonoids on ABC transporters

1 reference

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Inhibitory effects of oolong tea polyphenols on pancreatic lipase in vitro

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Influence of chocolate matrix composition on cocoa flavan-3-ol bioaccessibility in vitro and bioavailability in humans

1 reference

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Deglycosylation by small intestinal epithelial cell beta-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans

1 reference

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21 January 2018

Breast cancer resistance protein (BCRP/ABCG2): new inhibitors and QSAR studies by a 3D linear solvation energy approach.

1 reference

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21 January 2018

Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).

1 reference

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Quantitative structure-activity relationship methods: perspectives on drug discovery and toxicology

1 reference

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21 January 2018

Structure-activity relationships of flavonoids as inhibitors of breast cancer resistance protein (BCRP).

1 reference

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21 January 2018

Flavonoids as antioxidants

1 reference

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Structure of human salivary alpha-amylase at 1.6 A resolution: implications for its role in the oral cavity

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Oral bioavailability of quercetin from different quercetin glycosides in dogs

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Food effects on the absorption and pharmacokinetics of cocoa flavanols

1 reference

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Enhanced intestinal absorption of daidzein by borneol/menthol eutectic mixture and microemulsion

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A Quantitative Structure-Activity Relationship for the Modulation Effects of Flavonoids on P-Glycoprotein-Mediated Transport

1 reference

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21 January 2018

Inhibition of alpha-glucosidase and alpha-amylase by flavonoids

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.1003649

21 January 2018

Permeability characteristics and membrane affinity of flavonoids and alkyl gallates in Caco-2 cells and in phospholipid vesicles

1 reference

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21 January 2018

Systematic studies of sulfation and glucuronidation of 12 flavonoids in the mouse liver S9 fraction reveal both unique and shared positional preferences

1 reference

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21 January 2018

Conjugated quercetin glucuronides as bioactive metabolites and precursors of aglycone in vivo

1 reference

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21 January 2018

Flavonoid bioavailability and attempts for bioavailability enhancement

1 reference

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21 January 2018

Studies of intestinal permeability of 36 flavonoids using Caco-2 cell monolayer model

1 reference

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21 January 2018

ADMET in silico modelling: towards prediction paradise?

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.1003649

21 January 2018

Quantitative structure activity relationship studies on the flavonoid mediated inhibition of multidrug resistance proteins 1 and 2.

1 reference

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21 January 2018

Methylation of dietary flavones greatly improves their hepatic metabolic stability and intestinal absorption

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Prediction of human intestinal absorption of drug compounds from molecular structure.

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The modulation of pancreatic lipase activity by alginates

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Intestinal first-pass glucuronidation activities of selected dihydroxyflavones

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Regioselective sulfation and glucuronidation of phenolics: insights into the structural basis

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First-pass metabolism via UDP-glucuronosyltransferase: a barrier to oral bioavailability of phenolics

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Three-Dimensional Quantitative Structure-Activity Relationship Studies on UGT1A9-Mediated 3-O-Glucuronidation of Natural Flavonols Using a Pharmacophore-Based Comparative Molecular Field Analysis Model

1 reference

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21 January 2018

Accurate prediction of glucuronidation of structurally diverse phenolics by human UGT1A9 using combined experimental and in silico approaches

1 reference

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21 January 2018

Regioselective glucuronidation of flavonols by six human UGT1A isoforms

1 reference

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A review of dietary polyphenol-plasma protein interactions: characterization, influence on the bioactivity, and structure-affinity relationship.

1 reference

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21 January 2018

Advance in dietary polyphenols as α-glucosidases inhibitors: a review on structure-activity relationship aspect

1 reference

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A review on structure-activity relationship of dietary polyphenols inhibiting α-amylase

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Sulfation of selected mono-hydroxyflavones by sulfotransferases in vitro: a species and gender comparison

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Possible anti-obesity therapeutics from nature – A review

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Interaction of plant phenols with food macronutrients: characterisation and nutritional-physiological consequences

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21 January 2018

Structure activity relationships and quantitative structure activity relationships for the flavonoid-mediated inhibition of breast cancer resistance protein

1 reference

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21 January 2018

Probing the binding of the flavonoid, quercetin to human serum albumin by circular dichroism, electronic absorption spectroscopy and molecular modelling methods

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21 January 2018

Identifiers

10.3109/03602532.2014.1003649

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

ResearchGate publication ID

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