(Q38343316)

2 September 2017

title

A mutation in human topoisomerase II alpha whose expression is lethal in DNA repair-deficient yeast cells (English)

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2 September 2017

2

Karin C Nitiss

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2 September 2017

9

John L Nitiss

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2 September 2017

Jerrylaine V Walker

1

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2 September 2017

Lars H Jensen

3

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2 September 2017

Christopher Mayne

4

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2 September 2017

Tao Hu

5

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2 September 2017

Peter B Jensen

6

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2 September 2017

Maxwell Sehested

7

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2 September 2017

Tao Hsieh

8

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2 September 2017

language of work or name

English

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publication date

22 March 2004

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Journal of Biological Chemistry

2 September 2017

published in

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2 September 2017

volume

279

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2 September 2017

issue

25

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2 September 2017

page(s)

25947-25954

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Moving one DNA double helix through another by a type II DNA topoisomerase: the story of a simple molecular machine

2 September 2017

cites work

1 reference

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DNA topoisomerase II as a target for cancer chemotherapy.

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DNA transport by a type II topoisomerase: direct evidence for a two-gate mechanism

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Cellular roles of dna topoisomerases: a molecular perspective

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Tumor cell death induced by topoisomerase-targeting drugs.

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Crystal structure of an N-terminal fragment of the DNA gyrase B protein.

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Structure and mechanism of DNA topoisomerase II

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Quaternary changes in topoisomerase II may direct orthogonal movement of two DNA strands

21 January 2018

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Crystal structure of the breakage-reunion domain of DNA gyrase

21 January 2018

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Structure and conformational changes of DNA topoisomerase II visualized by electron microscopy

21 January 2018

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Proteolysis patterns of epitopically labeled yeast DNA topoisomerase II suggest an allosteric transition in the enzyme induced by ATP binding

21 January 2018

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Antitopoisomerase drug action and resistance

21 January 2018

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Incomplete reversion of double stranded DNA cleavage mediated by Drosophila topoisomerase II: formation of single stranded DNA cleavage complex in the presence of an anti-tumor drug VM26

21 January 2018

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Atp-bound topoisomerase ii as a target for antitumor drugs

21 January 2018

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Mutations of human topoisomerase II alpha affecting multidrug resistance and sensitivity.

21 January 2018

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A mutation in yeast TOP2 homologous to a quinolone-resistant mutation in bacteria. Mutation of the amino acid homologous to Ser83 of Escherichia coli gyrA alters sensitivity to eukaryotic topoisomerase inhibitors

21 January 2018

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The bis(naphthalimide) DMP-840 causes cytotoxicity by its action against eukaryotic topoisomerase II.

21 January 2018

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Improved method for high efficiency transformation of intact yeast cells

21 January 2018

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Two differentially regulated mRNAs with different 5' ends encode secreted with intracellular forms of yeast invertase

21 January 2018

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Analysis of a core domain in Drosophila DNA topoisomerase II. Targeting of an antitumor agent ICRF-159.

21 January 2018

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A yeast type II topoisomerase selected for resistance to quinolones. Mutation of histidine 1012 to tyrosine confers resistance to nonintercalative drugs but hypersensitivity to ellipticine.

21 January 2018

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Effects of antineoplastic drugs on the post-strand-passage DNA cleavage/religation equilibrium of topoisomerase II.

21 January 2018

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Functional profiling of the Saccharomyces cerevisiae genome

21 January 2018

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Molecular analysis of yeast and human type II topoisomerases. Enzyme-DNA and drug interactions.

21 January 2018

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Substitutions of Asn-726 in the active site of yeast DNA topoisomerase I define novel mechanisms of stabilizing the covalent enzyme-DNA intermediate.

21 January 2018

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Interaction of human DNA topoisomerase II alpha with DNA: quantification by surface plasmon resonance

21 January 2018

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Pathways for repair of topoisomerase I covalent complexes in Saccharomyces cerevisiae

21 January 2018

1 reference

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Analysis of etoposide binding to subdomains of human DNA topoisomerase II alpha in the absence of DNA.

21 January 2018

1 reference

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CDC45 and DPB11 are required for processive DNA replication and resistance to DNA topoisomerase I-mediated DNA damage.

21 January 2018

1 reference

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Investigating the biological functions of DNA topoisomerases in eukaryotic cells

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M312314200

1 reference

2 September 2017

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