(Q38344667)

2 September 2017

title

Development of protein-based inhibitors of the proprotein of convertase SKI-1/S1P: processing of SREBP-2, ATF6, and a viral glycoprotein (English)

1 reference

2 September 2017

Nabil G Seidah

4

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Stuart T. Nichol

series ordinal

3

object named as

Stuart T Nichol

1 reference

2 September 2017

Philomena Pullikotil

1

1 reference

2 September 2017

Martin Vincent

series ordinal

2

1 reference

2 September 2017

language of work or name

English

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publication date

16 February 2004

1 reference

Journal of Biological Chemistry

2 September 2017

number of pages

10

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based on heuristic

inferred from page(s)

published in

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2 September 2017

volume

279

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2 September 2017

issue

17

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2 September 2017

page(s)

17338-17347

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Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides

2 September 2017

cites work

1 reference

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Furin: a mammalian subtilisin/Kex2p-like endoprotease involved in processing of a wide variety of precursor proteins

21 January 2018

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Proteolytic processing in the secretory pathway

21 January 2018

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Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization

21 January 2018

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Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells

21 January 2018

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Biosynthesis and cellular trafficking of the convertase SKI-1/S1P: ectodomain shedding requires SKI-1 activity

21 January 2018

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The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation

21 January 2018

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Functional characterization of Narc 1, a novel proteinase related to proteinase K

21 January 2018

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Proprotein convertases in tumor progression and malignancy: novel targets in cancer therapy

21 January 2018

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Processing of viral glycoproteins by the subtilisin-like endoprotease furin and its inhibition by specific peptidylchloroalkylketones

21 January 2018

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An internally quenched fluorogenic substrate of prohormone convertase 1 and furin leads to a potent prohormone convertase inhibitor

21 January 2018

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Polyarginines are potent furin inhibitors

21 January 2018

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Inhibition of proprotein convertases-1, -7 and furin by diterpines of Andrographis paniculata and their succinoyl esters

21 January 2018

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Inhibition of intracellular proteolytic processing of soluble proproteins by an engineered alpha 2-macroglobulin containing a furin recognition sequence in the bait region

21 January 2018

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Alpha1-antitrypsin Portland inhibits processing of precursors mediated by proprotein convertases primarily within the constitutive secretory pathway

21 January 2018

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alpha1-Antitrypsin Portland, a bioengineered serpin highly selective for furin: application as an antipathogenic agent

21 January 2018

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Inhibition of soluble recombinant furin by human proteinase inhibitor 8

21 January 2018

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Optimization of protease-inhibitor interactions by randomizing adventitious contacts

21 January 2018

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Development of selectivity of alpha1-antitrypsin variant by mutagenesis in its reactive site loop against proprotein convertase. A crucial role of the P4 arginine in PACE4 inhibition

21 January 2018

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Mechanism of Kex2p inhibition by its proregion.

21 January 2018

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Activation of the furin endoprotease is a multiple-step process: requirements for acidification and internal propeptide cleavage

21 January 2018

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The prosegments of furin and PC7 as potent inhibitors of proprotein convertases. In vitro and ex vivo assessment of their efficacy and selectivity

21 January 2018

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Proprotein convertase PC1/3-related peptides are potent slow tight-binding inhibitors of murine PC1/3 and Hfurin

21 January 2018

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Structure-function analysis of the prosegment of the proprotein convertase PC5A.

21 January 2018

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Inhibitory potency and specificity of subtilase-like pro-protein convertase (SPC) prodomains

21 January 2018

1 reference

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Biosynthesis and enzymatic characterization of human SKI-1/S1P and the processing of its inhibitory prosegment

21 January 2018

1 reference

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Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production

21 January 2018

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Autocatalytic processing of site-1 protease removes propeptide and permits cleavage of sterol regulatory element-binding proteins

21 January 2018

1 reference

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Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs

21 January 2018

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A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood

21 January 2018

1 reference

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ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs

21 January 2018

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Luman, the cellular counterpart of herpes simplex virus VP16, is processed by regulated intramembrane proteolysis

21 January 2018

1 reference

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The Lassa virus glycoprotein precursor GP-C is proteolytically processed by subtilase SKI-1/S1P.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313764200

A rapid fluorometric assay for the proteolytic activity of SKI-1/S1P based on the surface glycoprotein of the hemorrhagic fever Lassa virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313764200

Endoproteolytic processing of the lymphocytic choriomeningitis virus glycoprotein by the subtilase SKI-1/S1P.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313764200

Mechanisms for lymphocytic choriomeningitis virus glycoprotein cleavage, transport, and incorporation into virions

21 January 2018

1 reference

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Crimean-Congo hemorrhagic fever virus glycoprotein proteolytic processing by subtilase SKI-1.

21 January 2018

1 reference

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Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

21 January 2018

1 reference

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Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313764200

ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals

21 January 2018

1 reference

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Decreased lipid synthesis in livers of mice with disrupted Site-1 protease gene

21 January 2018

1 reference

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A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6.

21 January 2018

1 reference

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Isolation of cholesterol-requiring mutant Chinese hamster ovary cells with defects in cleavage of sterol regulatory element-binding proteins at site 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313764200

cDNA structure of the mouse and rat subtilisin/kexin-like PC5: a candidate proprotein convertase expressed in endocrine and nonendocrine cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313764200

The crystal structure of the proprotein processing proteinase furin explains its stringent specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313764200

Cleavage site for sterol-regulated protease localized to a leu-Ser bond in the lumenal loop of sterol regulatory element-binding protein-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313764200

The contribution of arginine residues within the P6-P1 region of alpha 1-antitrypsin to its reaction with furin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313764200

Fluorescent Peptidyl Substrates as an Aid in Studying the Substrate Specificity of Human Prohormone Convertase PC1 and Human Furin and Designing a Potent Irreversible Inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313764200

Synthesis of tight binding inhibitors and their action on the proprotein-processing enzyme furin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313764200

Engineered eglin c variants inhibit yeast and human proprotein processing proteases, Kex2 and furin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313764200

Folding pathway mediated by an intramolecular chaperone. The inhibitory and chaperone functions of the subtilisin propeptide are not obligatorily linked

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313764200

The serpin-proteinase complex revealed

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313764200

Structural insights into serpin-protease complexes reveal the inhibitory mechanism of serpins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313764200

Serpin-like properties of alpha1-antitrypsin Portland towards furin convertase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313764200

21 January 2018

Identifiers

DOI

10.1074/JBC.M313764200

1 reference

2 September 2017

1 reference