(Q38436840)

3 September 2017

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title

Experimental and clinical aspects of melatonin and clock genes in diabetes (English)

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3 September 2017

Elmar Peschke

1

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PubMed ID

25904189

3 September 2017

Ina Bähr

series ordinal

2

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PubMed ID

25904189

3 September 2017

Eckhard Mühlbauer

series ordinal

3

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3 September 2017

6 June 2015

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Journal of Pineal Research

3 September 2017

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3 September 2017

59

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3 September 2017

1

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3 September 2017

1-23

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Effect of pinealectomy on plasma glucose, insulin and glucagon levels in the rat.

3 September 2017

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Melatonin suppresses hyperglycemia caused by intracerebroventricular injection of 2-deoxy-D-glucose in rats.

21 January 2018

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Melatonin rhythms in mice: role in autoimmune and lymphoproliferative diseases.

21 January 2018

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Role of the pineal gland and melatonin in the development of autoimmune diabetes in non-obese diabetic mice

21 January 2018

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Are Langerhan's islets influenced by the pineal body?

21 January 2018

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Effects of pinealectomy and of sham-pinealectomy on blood glucose levels in the alloxan-diabetic rat

21 January 2018

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Aging-dependent changes in the effect of daily melatonin supplementation on rat metabolic and behavioral responses

21 January 2018

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Influence of melatonin administration on glucose tolerance and insulin sensitivity of postmenopausal women

21 January 2018

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Alterations in components of the pineal melatonin synthetic pathway by acute insulin stress in the rat and Syrian hamster.

21 January 2018

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Experimentally-induced diabetes reduces nocturnal pineal melatonin content in the Syrian hamster.

21 January 2018

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Hormonal modulation of pineal melatonin synthesis in rats and Syrian hamsters: effects of streptozotocin-induced diabetes and insulin injections.

21 January 2018

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Adrenalectomy prevents changes in rat pineal melatonin content and N-acetyltransferase activity induced by acute insulin stress

21 January 2018

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Insulin release from isolated mouse islets in vitro: No effect of physiological levels of melatonin or arginine vasotocin

21 January 2018

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Lack of melatonin effects on insulin action in normal rats.

21 January 2018

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Effect of intravenous administration of melatonin on the efferent activity of the adrenal nerve.

21 January 2018

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Receptor (MT(1)) mediated influence of melatonin on cAMP concentration and insulin secretion of rat insulinoma cells INS-1.

21 January 2018

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Involvement of the cGMP pathway in mediating the insulin-inhibitory effect of melatonin in pancreatic beta-cells

21 January 2018

1 reference

Identification and functional characterization of melatonin Mel 1a receptors in pancreatic beta cells: potential role in incretin-mediated cell function by sensitization of cAMP signaling

21 January 2018

1 reference

Influence of melatonin and serotonin on glucose-stimulated insulin release from perifused rat pancreatic islets in vitro

21 January 2018

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Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus

21 January 2018

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Diurnal variations in insulin secretion and K+ permeability in isolated rat islets.

21 January 2018

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Daily rhythm of glucose-induced insulin secretion by isolated islets from intact and pinealectomized rat.

21 January 2018

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Disruption of circadian insulin secretion is associated with reduced glucose uptake in first-degree relatives of patients with type 2 diabetes.

21 January 2018

1 reference

Output pathways of the mammalian suprachiasmatic nucleus: coding circadian time by transmitter selection and specific targeting

21 January 2018

1 reference

Circadian control of the daily plasma glucose rhythm: an interplay of GABA and glutamate

21 January 2018

1 reference

Melatonin and type 2 diabetes - a possible link?

21 January 2018

1 reference

Clock Mutants of Drosophila melanogaster

21 January 2018

1 reference

Coordination of circadian timing in mammals

21 January 2018

1 reference

The mammalian circadian timing system: organization and coordination of central and peripheral clocks

21 January 2018

1 reference

Role of the CLOCK protein in the mammalian circadian mechanism

21 January 2018

1 reference

System-level identification of transcriptional circuits underlying mammalian circadian clocks

21 January 2018

1 reference

A noncanonical E-box enhancer drives mouse Period2 circadian oscillations in vivo

21 January 2018

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Identification of a new clock-related element EL-box involved in circadian regulation by BMAL1/CLOCK and HES1

21 January 2018

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Rhythmic CLOCK-BMAL1 binding to multiple E-box motifs drives circadian Dbp transcription and chromatin transitions

21 January 2018

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A novel E4BP4 element drives circadian expression of mPeriod2.

21 January 2018

1 reference

A Mutation of the Circadian System in Golden Hamsters

21 January 2018

1 reference

Positional syntenic cloning and functional characterization of the mammalian circadian mutation tau.

21 January 2018

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Circadian regulator CLOCK is a histone acetyltransferase

21 January 2018

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A serum shock induces circadian gene expression in mammalian tissue culture cells

21 January 2018

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Bioluminescence imaging of individual fibroblasts reveals persistent, independently phased circadian rhythms of clock gene expression

21 January 2018

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Circadian gene expression in cultured cells

21 January 2018

1 reference

PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues

21 January 2018

1 reference

Gene expression profiling reveals a regulatory role for ROR alpha and ROR gamma in phase I and phase II metabolism

21 January 2018

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Transcriptional profiling reveals a role for RORalpha in regulating gene expression in obesity-associated inflammation and hepatic steatosis

21 January 2018

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Homozygous staggerer (sg/sg) mice display improved insulin sensitivity and enhanced glucose uptake in skeletal muscle

21 January 2018

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Differential and day-time dependent expression of nuclear receptors RORα, RORβ, RORγ and RXRα in the rodent pancreas and islet

21 January 2018

1 reference

Melatonin feedback on clock genes: a theory involving the proteasome

21 January 2018

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Indication of circadian oscillations in the rat pancreas

21 January 2018

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Circadian regulation of islet genes involved in insulin production and secretion

21 January 2018

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Autonomous and self-sustained circadian oscillators displayed in human islet cells

21 January 2018

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An intrinsic circadian clock of the pancreas is required for normal insulin release and glucose homeostasis in mice

21 January 2018

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The daily rhythm in plasma glucagon concentrations in the rat is modulated by the biological clock and by feeding behavior

21 January 2018

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Diurnal rhythm in endogenous glucose production is a major contributor to fasting hyperglycaemia in type 2 diabetes. Suprachiasmatic deficit or limit cycle behaviour?

21 January 2018

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Entrainment of the circadian clock in the liver by feeding

21 January 2018

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Real-time recording of circadian liver gene expression in freely moving mice reveals the phase-setting behavior of hepatocyte clocks.

21 January 2018

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Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors

21 January 2018

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CLOCK-mediated acetylation of BMAL1 controls circadian function

21 January 2018

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Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1

21 January 2018

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SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging

21 January 2018

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BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis

21 January 2018

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Obesity and metabolic syndrome in circadian Clock mutant mice

21 January 2018

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Physiological significance of a peripheral tissue circadian clock

21 January 2018

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Loss of Bmal1 leads to uncoupling and impaired glucose-stimulated insulin secretion in β-cells

21 January 2018

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Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes

21 January 2018

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Disruption of circadian rhythms accelerates development of diabetes through pancreatic beta-cell loss and dysfunction

21 January 2018

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Clock gene expression in the liver of streptozotocin-induced and spontaneous type 1 diabetic rats

21 January 2018

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Regulation of core clock genes in human islets

21 January 2018

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NPAS2 and PER2 are linked to risk factors of the metabolic syndrome

21 January 2018

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Adverse metabolic and cardiovascular consequences of circadian misalignment

21 January 2018

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Modulation of glucose regulation and insulin secretion by circadian rhythmicity and sleep

21 January 2018

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The period length of fibroblast circadian gene expression varies widely among human individuals

21 January 2018

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Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses

21 January 2018

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Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor

21 January 2018

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Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion

21 January 2018

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Variants in MTNR1B influence fasting glucose levels

21 January 2018

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Distribution of melatonin receptors in murine pancreatic islets.

21 January 2018

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A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk

21 January 2018

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Function and expression of melatonin receptors on human pancreatic islets

21 January 2018

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Molecular dissection of two distinct actions of melatonin on the suprachiasmatic circadian clock.

21 January 2018

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Targeted disruption of the mouse Mel(1b) melatonin receptor

21 January 2018

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Melatonin inhibits insulin secretion and decreases PKA levels without interfering with glucose metabolism in rat pancreatic islets.

21 January 2018

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Slow-wave sleep and the risk of type 2 diabetes in humans

21 January 2018

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Exocytotic properties of human pancreatic beta-cells

21 January 2018

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Oscillatory control of insulin secretion

21 January 2018

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Regulation of insulin secretion in islets of Langerhans by Ca(2+)channels

21 January 2018

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Melatonin influences insulin secretion primarily via MT(1) receptors in rat insulinoma cells (INS-1) and mouse pancreatic islets

21 January 2018

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Modulation of the cGMP signaling pathway by melatonin in pancreatic beta-cells

21 January 2018

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Functional expression of MT2 (Mel1b) melatonin receptors in human PAZ6 adipocytes

21 January 2018

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Melatonin inhibits insulin secretion in rat insulinoma β-cells (INS-1) heterologously expressing the human melatonin receptor isoform MT2.

21 January 2018

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Phosphorylation of cyclic AMP-response element-binding protein (CREB) is influenced by melatonin treatment in pancreatic rat insulinoma β-cells (INS-1).

21 January 2018

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Transcripts of calcium/calmodulin-dependent kinases are changed after forskolin- or IBMX-induced insulin secretion due to melatonin treatment of rat insulinoma beta-cells (INS-1).

21 January 2018

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Calcium-signaling components in rat insulinoma β-cells (INS-1) and pancreatic islets are differentially influenced by melatonin

21 January 2018

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Influence of melatonin receptor signalling on parameters involved in blood glucose regulation

21 January 2018

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Characterization of a novel calcium response element in the glucagon gene

21 January 2018

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Regulation of human insulin gene transcription by the immunosuppressive drugs cyclosporin A and tacrolimus at concentrations that inhibit calcineurin activity and involving the transcription factor CREB.

21 January 2018

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The beta cell transcription factors and development of the pancreas

21 January 2018

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Circadian variations in serum glucagon and hepatic glycogen and cyclic amp concentrations

21 January 2018

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Twenty-four-hour variations of plasma pancreatic polypeptide, insulin and glucagon in normal human subjects.

21 January 2018

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Role of SCN in daily rhythms of plasma glucose, FFA, insulin and glucagon.

21 January 2018

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Effects of pinealectomy on glucagon responsiveness to hypoglycaemia induced by insulin injections in fed rats

21 January 2018

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Melatonin stimulates glucagon secretion in vitro and in vivo

21 January 2018

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Evidence of the receptor-mediated influence of melatonin on pancreatic glucagon secretion via the Gαq protein-coupled and PI3K signaling pathways

21 January 2018

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G protein-linked effector and second messenger systems involved in melatonin signal transduction

21 January 2018

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Melatonin and pancreatic islets: interrelationships between melatonin, insulin and glucagon

21 January 2018

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Long-term enteral administration of melatonin reduces plasma insulin and increases expression of pineal insulin receptors in both Wistar and type 2-diabetic Goto-Kakizaki rats

21 January 2018

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Diminished B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus

21 January 2018

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Hypoglycaemia: the limiting factor in the glycaemic management of Type I and Type II diabetes

21 January 2018

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Pancreatic alpha-cell dysfunction in diabetes

21 January 2018

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Physiology of the pancreatic alpha-cell and glucagon secretion: role in glucose homeostasis and diabetes.

21 January 2018

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Polymorphisms within the novel type 2 diabetes risk locus MTNR1B determine beta-cell function

21 January 2018

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Melatonin receptor 1A gene polymorphism associated with polycystic ovary syndrome.

21 January 2018

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The unique cytoarchitecture of human pancreatic islets has implications for islet cell function

21 January 2018

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Sleep loss alters basal metabolic hormone secretion and modulates the dynamic counterregulatory response to hypoglycemia.

21 January 2018

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Mild sleep restriction acutely reduces plasma glucagon levels in healthy men.

21 January 2018

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Association of sleep time with diabetes mellitus and impaired glucose tolerance

21 January 2018

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A single night of partial sleep deprivation induces insulin resistance in multiple metabolic pathways in healthy subjects

21 January 2018

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Sleep duration as a risk factor for the development of type 2 diabetes

21 January 2018

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Homologous and heterologous asynchronicity between identified alpha-, beta- and delta-cells within intact islets of Langerhans in the mouse

21 January 2018

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Somatostatin release, electrical activity, membrane currents and exocytosis in human pancreatic delta cells.

21 January 2018

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Somatostatin secreted by islet delta-cells fulfills multiple roles as a paracrine regulator of islet function

21 January 2018

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A role for islet somatostatin in mediating sympathetic regulation of glucagon secretion

21 January 2018

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Glucose generates coincident insulin and somatostatin pulses and antisynchronous glucagon pulses from human pancreatic islets

21 January 2018

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A stress response pathway in mice upregulates somatostatin level and transcription in pancreatic delta cells through Gs and β-arrestin 1.

21 January 2018

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Melatonin influences somatostatin secretion from human pancreatic δ-cells via MT1 and MT2 receptors

21 January 2018

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Pharmacological characterization of human recombinant melatonin mt(1) and MT(2) receptors

21 January 2018

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Expression and functional characterization of the mt1 melatonin receptor from rat brain in Xenopus oocytes: evidence for coupling to the phosphoinositol pathway

21 January 2018

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Modulation of melatonin receptors and G-protein function by microtubules.

21 January 2018

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Dual coupling of MT(1) and MT(2) melatonin receptors to cyclic AMP and phosphoinositide signal transduction cascades and their regulation following melatonin exposure.

21 January 2018

1 reference

Signal transduction of receptor-mediated antiproliferative action of melatonin on human prostate epithelial cells involves dual activation of Gα(s) and Gα(q) proteins.

21 January 2018

1 reference

In vivo activation of insulin receptor tyrosine kinase by melatonin in the rat hypothalamus.

21 January 2018

1 reference

Melatonin receptors are for the birds: molecular analysis of two receptor subtypes differentially expressed in chick brain

21 January 2018

1 reference

Generation of the melatonin endocrine message in mammals: a review of the complex regulation of melatonin synthesis by norepinephrine, peptides, and other pineal transmitters

21 January 2018

1 reference

Constitutive nitric oxide synthases in rat pancreatic islets: direct imaging of glucose-induced nitric oxide production in beta-cells

21 January 2018

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A neuronal isoform of nitric oxide synthase expressed in pancreatic beta-cells controls insulin secretion

21 January 2018

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Involvement of the cGMP signalling pathway in the regulation of viability in insulin-secreting BRIN-BD11 cells

21 January 2018

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Nitric oxide contributes to cytokine-induced apoptosis in pancreatic beta cells via potentiation of JNK activity and inhibition of Akt.

21 January 2018

1 reference

L-Arginine Stimulates Cyclic Guanosine 3′,5′- Monophosphate Formation in Rat Islets of Langerhans and RINm5F Insulinoma Cells: Evidence for LArgininerNitric Oxide Synthase*

21 January 2018

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Dual effect of nitric oxide on cytosolic Ca2+ concentration and insulin secretion in rat pancreatic beta-cells

21 January 2018

1 reference

Preferential formation of MT1/MT2 melatonin receptor heterodimers with distinct ligand interaction properties compared with MT2 homodimers

21 January 2018

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Are G protein-coupled receptor heterodimers of physiological relevance?--Focus on melatonin receptors

21 January 2018

1 reference

New evidence for a role of melatonin in glucose regulation

21 January 2018

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Melatonin effect on the cyclic GMP system in the golden hamster retina.

21 January 2018

1 reference

Inhibitory effect of melatonin on alpha1-adrenergic-induced vasoconstriction in mesenteric beds of spontaneously hypertensive rats

21 January 2018

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Melatonin stimulates inositol-1,4,5-trisphosphate and Ca2+ release from INS1 insulinoma cells

21 January 2018

1 reference

Chimeric Galphaq subunits can distinguish the long form of the Xenopus Mel1c melatonin receptor from the mammalian mt1 and MT2 melatonin receptors

21 January 2018

1 reference

Molecular determinants for the differential coupling of Galpha(16) to the melatonin MT1, MT2 and Xenopus Mel1c receptors

21 January 2018

1 reference

Melatonin receptors in pancreatic islets: good morning to a novel type 2 diabetes gene

21 January 2018

1 reference

Diabetic Goto Kakizaki rats as well as type 2 diabetic patients show a decreased diurnal serum melatonin level and an increased pancreatic melatonin-receptor status

21 January 2018

1 reference

Circadian Aspects of Postprandial Metabolism

21 January 2018

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The effects of nocturnal life on endocrine circadian patterns in healthy adults

21 January 2018

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Low testosterone levels and unimpaired melatonin secretion in young males with metabolic syndrome.

21 January 2018

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Pineal melatonin synthesis is decreased in type 2 diabetic Goto-Kakizaki rats

21 January 2018

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Parallel signaling pathways of melatonin in the pancreatic beta-cell

21 January 2018

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Adrenoceptor expression and diurnal rhythms of melatonin and its precursors in the pineal gland of type 2 diabetic goto-kakizaki rats

21 January 2018

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Catecholamines are the key for explaining the biological relevance of insulin-melatonin antagonisms in type 1 and type 2 diabetes.

21 January 2018

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Increased melatonin synthesis in pineal glands of rats in streptozotocin induced type 1 diabetes

21 January 2018

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Long-term melatonin administration reduces hyperinsulinemia and improves the altered fatty-acid compositions in type 2 diabetic rats via the restoration of Delta-5 desaturase activity

21 January 2018

1 reference

Metabolic effects of melatonin on oxidative stress and diabetes mellitus

21 January 2018

1 reference

Prolonged melatonin administration in 6-month-old Sprague-Dawley rats: metabolic alterations.

21 January 2018

1 reference

Effect of pinealectomy on plasma levels of insulin and leptin and on hepatic lipids in type 2 diabetic rats

21 January 2018

1 reference

The insulin-melatonin antagonism: studies in the LEW.1AR1-iddm rat (an animal model of human type 1 diabetes mellitus).

21 January 2018

1 reference

Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes

21 January 2018

1 reference

GLP-1 for type 2 diabetes

21 January 2018

1 reference

Localization and trafficking of alpha2-adrenergic receptor subtypes in cells and tissues

21 January 2018

1 reference

Arylalkylamine N-acetyltransferase: "the Timezyme".

21 January 2018

1 reference

Importance and relevance of melatonin to human biological rhythms

21 January 2018

1 reference

The circadian system: circuits-cells-clock genes.

21 January 2018

1 reference

Reducing oxidative/nitrosative stress: a newly-discovered genre for melatonin

21 January 2018

1 reference

Oxidative stress: the vulnerable beta-cell

21 January 2018

1 reference

Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B affect different aspects of pancreatic beta-cell function

21 January 2018

1 reference

Common genetic variation near melatonin receptor MTNR1B contributes to raised plasma glucose and increased risk of type 2 diabetes among Indian Asians and European Caucasians

21 January 2018

1 reference

No effect by the common gene variant rs10830963 of the melatonin receptor 1B on the association between sleep disturbances and type 2 diabetes: results from the Nord-Trøndelag Health Study.

21 January 2018

1 reference

MTNR1B G24E variant associates With BMI and fasting plasma glucose in the general population in studies of 22,142 Europeans

21 January 2018

1 reference

Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes

21 January 2018

1 reference

Alloxan: history and mechanism of action

21 January 2018

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Selective uptake of alloxan by pancreatic B-cells

21 January 2018

1 reference

Determinants of the selective toxicity of alloxan to the pancreatic B cell

21 January 2018

1 reference

'Classical' and 'new' diabetogens--comparison of their effects on isolated rat pancreatic islets in vitro

21 January 2018

1 reference

Melatonin, hydroxyl radical-mediated oxidative damage, and aging: a hypothesis

21 January 2018

1 reference

Melatonin in relation to cellular antioxidative defense mechanisms.

21 January 2018

1 reference

Evaluation of the antioxidant activity of melatonin in vitro

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1111/JPI.12240

1 reference

3 September 2017

1 reference

PubMed ID

25904189