(Q38496732)

3 September 2017

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title

DNA replication origin activation in space and time (English)

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3 September 2017

Michalis Fragkos

1

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3 September 2017

Olivier Ganier

series ordinal

2

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3 September 2017

Philippe Coulombe

series ordinal

3

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3 September 2017

Marcel Méchali

series ordinal

4

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3 September 2017

publication date

1 June 2015

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Nature Reviews Molecular Cell Biology

3 September 2017

published in

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3 September 2017

volume

16

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3 September 2017

issue

6

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3 September 2017

page(s)

360-374

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https://scigraph.springernature.com/pub.10.1038/nrm4002

3 September 2017

exact match

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cites work

Genomic instability in cancer

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Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells

31 March 2020

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A yeast chromosomal origin of DNA replication defined by multiple functional elements

31 March 2020

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31 March 2020

DNA replication origins.

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Genome-scale analysis of metazoan replication origins reveals their organization in specific but flexible sites defined by conserved features

31 March 2020

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Replication profile of Saccharomyces cerevisiae chromosome VI

31 March 2020

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Genome-wide characterization of fission yeast DNA replication origins

31 March 2020

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Eukaryotic DNA replication origins: many choices for appropriate answers

31 March 2020

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Regulated eukaryotic DNA replication origin firing with purified proteins

31 March 2020

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Eukaryotic chromosome DNA replication: where, when, and how?

31 March 2020

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Interdependent nuclear accumulation of budding yeast Cdt1 and Mcm2-7 during G1 phase.

31 March 2020

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Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing

31 March 2020

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Cdt1 forms a complex with the minichromosome maintenance protein (MCM) and activates its helicase activity.

31 March 2020

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XCDT1 is required for the assembly of pre-replicative complexes in Xenopus laevis

31 March 2020

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Cell cycle regulation of the licensing activity of Cdt1 in Xenopus laevis

31 March 2020

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Replication licensing and cancer--a fatal entanglement?

31 March 2020

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Regulating DNA replication in eukarya

31 March 2020

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Increase in DNA replication sites in cells held at the beginning of S phase

31 March 2020

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The units of DNA replication in Drosophila melanogaster chromosomes.

31 March 2020

1 reference

DNA Replication in the Chromosomes of Eukaryotes

31 March 2020

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Multiple functions for Mcm2-7 ATPase motifs during replication initiation

31 March 2020

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Eukaryotic origin-dependent DNA replication in vitro reveals sequential action of DDK and S-CDK kinases.

31 March 2020

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CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast

31 March 2020

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S-Cdk-dependent phosphorylation of Sld2 essential for chromosomal DNA replication in budding yeast

31 March 2020

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Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast.

31 March 2020

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Activation of the MCM2-7 helicase by association with Cdc45 and GINS proteins.

31 March 2020

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Prereplicative complexes assembled in vitro support origin-dependent and independent DNA replication

31 March 2020

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Treslin collaborates with TopBP1 in triggering the initiation of DNA replication

31 March 2020

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Regulation of DNA replication through Sld3-Dpb11 interaction is conserved from yeast to humans.

31 March 2020

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Direct regulation of Treslin by cyclin-dependent kinase is essential for the onset of DNA replication

31 March 2020

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Enigmatic roles of Mcm10 in DNA replication

31 March 2020

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Assembly of the Cdc45-Mcm2-7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins

31 March 2020

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Origin plasticity during budding yeast DNA replication in vitro.

31 March 2020

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Initiation of DNA replication at CpG islands in mammalian chromosomes

31 March 2020

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Genome-wide studies highlight indirect links between human replication origins and gene regulation.

31 March 2020

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Genome-wide mapping of Arabidopsis thaliana origins of DNA replication and their associated epigenetic marks

31 March 2020

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Unraveling cell type-specific and reprogrammable human replication origin signatures associated with G-quadruplex consensus motifs.

31 March 2020

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Chromatin structure and replication origins: determinants of chromosome replication and nuclear organization

31 March 2020

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New insights into replication origin characteristics in metazoans

31 March 2020

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G4 motifs affect origin positioning and efficiency in two vertebrate replicators

31 March 2020

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Genome-wide identification and characterization of replication origins by deep sequencing

31 March 2020

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Transcription factors and DNA replication origin selection

31 March 2020

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Replication timing of genes and middle repetitive sequences.

31 March 2020

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Genome-wide depletion of replication initiation events in highly transcribed regions

31 March 2020

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Transcription initiation activity sets replication origin efficiency in mammalian cells

31 March 2020

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Developmental changes in the Sciara II/9A initiation zone for DNA replication

31 March 2020

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CpG islands and the regulation of transcription

31 March 2020

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Specification of a DNA replication origin by a transcription complex.

31 March 2020

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Forkhead transcription factors establish origin timing and long-range clustering in S. cerevisiae

31 March 2020

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NCOA4 transcriptional coactivator inhibits activation of DNA replication origins

31 March 2020

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Drosophila ORC localizes to open chromatin and marks sites of cohesin complex loading

31 March 2020

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Diversity of eukaryotic DNA replication origins revealed by genome-wide analysis of chromatin structure

31 March 2020

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Conserved nucleosome positioning defines replication origins

31 March 2020

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Pre-replication complex proteins assemble at regions of low nucleosome occupancy within the Chinese hamster dihydrofolate reductase initiation zone

31 March 2020

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Chromatin architectures at fission yeast transcriptional promoters and replication origins

31 March 2020

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Concerted interaction between origin recognition complex (ORC), nucleosomes and replication origin DNA ensures stable ORC-origin binding.

31 March 2020

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Analysis of model replication origins in Drosophila reveals new aspects of the chromatin landscape and its relationship to origin activity and the prereplicative complex

31 March 2020

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High-resolution analysis of DNA synthesis start sites and nucleosome architecture at efficient mammalian replication origins.

31 March 2020

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Regulation of replication licensing by acetyltransferase Hbo1.

31 March 2020

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HBO1 histone acetylase activity is essential for DNA replication licensing and inhibited by Geminin

31 March 2020

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Replication factors MCM2 and ORC1 interact with the histone acetyltransferase HBO1

31 March 2020

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The histone H4 Lys 20 methyltransferase PR-Set7 regulates replication origins in mammalian cells.

31 March 2020

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The role of PR-Set7 in replication licensing depends on Suv4-20h

31 March 2020

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The BAH domain of ORC1 links H4K20me2 to DNA replication licensing and Meier–Gorlin syndrome

31 March 2020

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The spatiotemporal program of DNA replication is associated with specific combinations of chromatin marks in human cells

31 March 2020

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Histone H3 lysine 56 methylation regulates DNA replication through its interaction with PCNA

31 March 2020

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Methylation of histone H3 on lysine 79 associates with a group of replication origins and helps limit DNA replication once per cell cycle

31 March 2020

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Genome-wide analysis of histone H3.1 and H3.3 variants in Arabidopsis thaliana

31 March 2020

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Association of the origin recognition complex with heterochromatin and HP1 in higher eukaryotes

31 March 2020

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Human origin recognition complex is essential for HP1 binding to chromatin and heterochromatin organization.

31 March 2020

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No-nonsense functions for long noncoding RNAs

31 March 2020

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Tetrahymena ORC contains a ribosomal RNA fragment that participates in rDNA origin recognition.

31 March 2020

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RNA-dependent recruitment of the origin recognition complex

31 March 2020

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Role for G-quadruplex RNA binding by Epstein-Barr virus nuclear antigen 1 in DNA replication and metaphase chromosome attachment

31 March 2020

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Human origin recognition complex binds preferentially to G-quadruplex-preferable RNA and single-stranded DNA

31 March 2020

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Functional requirement of noncoding Y RNAs for human chromosomal DNA replication

31 March 2020

1 reference

The midblastula transition defines the onset of Y RNA-dependent DNA replication in Xenopus laevis

31 March 2020

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Disassembly of the nucleus in mitotic extracts: membrane vesicularization, lamin disassembly, and chromosome condensation are independent processes

31 March 2020

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Steps in the assembly of replication-competent nuclei in a cell-free system from Xenopus eggs

31 March 2020

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Chromotin binding, nuclear localization and phosphorylation of Xenopus cdc21 are cell-cycle dependent and associated with the control of initiation of DNA replication

31 March 2020

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Regulated chromosomal DNA replication in the absence of a nucleus

31 March 2020

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Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions

31 March 2020

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Relationship between DNA replication and the nuclear matrix.

31 March 2020

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On the mechanism of DNA replication in mammalian chromosomes

31 March 2020

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Single-cell Hi-C reveals cell-to-cell variability in chromosome structure

31 March 2020

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Initiation at closely spaced replication origins in a yeast chromosome

31 March 2020

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DNA replication origin interference increases the spacing between initiation events in human cells

31 March 2020

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Control of replication origin density and firing time in Xenopus egg extracts: role of a caffeine-sensitive, ATR-dependent checkpoint.

31 March 2020

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A relationship between replicon size and supercoiled loop domains in the eukaryotic genome.

31 March 2020

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Mitotic remodeling of the replicon and chromosome structure.

31 March 2020

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Replication fork movement sets chromatin loop size and origin choice in mammalian cells

31 March 2020

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Heterogeneity of eukaryotic replicons, replicon clusters, and replication foci

31 March 2020

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Analysis of replication factories in human cells by super-resolution light microscopy

31 March 2020

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Structure, function and dynamics of nuclear subcompartments

31 March 2020

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Recruitment of Xenopus Scc2 and cohesin to chromatin requires the pre-replication complex.

31 March 2020

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Cohesin organizes chromatin loops at DNA replication factories.

31 March 2020

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Replicon clusters are stable units of chromosome structure: evidence that nuclear organization contributes to the efficient activation and propagation of S phase in human cells

31 March 2020

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Dynamic properties of nuclear lamins: lamin B is associated with sites of DNA replication

31 March 2020

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Disruption of nuclear lamin organization blocks the elongation phase of DNA replication

31 March 2020

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DNA is a co-factor for its own replication in Xenopus egg extracts

31 March 2020

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DNA replication occurs at discrete sites in pseudonuclei assembled from purified DNA in vitro.

31 March 2020

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Time to be versatile: regulation of the replication timing program in budding yeast

31 March 2020

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Chromatin signatures of the Drosophila replication program

31 March 2020

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Genome-wide mapping of human DNA-replication origins: levels of transcription at ORC1 sites regulate origin selection and replication timing.

31 March 2020

1 reference

Cell-type-specific replication initiation programs set fragility of the FRA3B fragile site

31 March 2020

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Identification of early replicating fragile sites that contribute to genome instability

31 March 2020

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Sequencing newly replicated DNA reveals widespread plasticity in human replication timing

31 March 2020

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Evolutionarily conserved replication timing profiles predict long-range chromatin interactions and distinguish closely related cell types

31 March 2020

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Topological domains in mammalian genomes identified by analysis of chromatin interactions

31 March 2020

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Topologically associating domains are stable units of replication-timing regulation

31 March 2020

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Rif1 is a global regulator of timing of replication origin firing in fission yeast

31 March 2020

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Mouse Rif1 is a key regulator of the replication-timing programme in mammalian cells

31 March 2020

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Rif1 regulates the replication timing domains on the human genome

31 March 2020

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Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint

31 March 2020

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Mammalian Rif1 contributes to replication stress survival and homology-directed repair

31 March 2020

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Rif1 controls DNA replication by directing Protein Phosphatase 1 to reverse Cdc7-mediated phosphorylation of the MCM complex

31 March 2020

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Rif1 controls DNA replication timing in yeast through the PP1 phosphatase Glc7.

31 March 2020

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Protein phosphatase 1 recruitment by Rif1 regulates DNA replication origin firing by counteracting DDK activity

31 March 2020

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Heterochromatin protein 1 (HP1) modulates replication timing of the Drosophila genome

31 March 2020

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The heterochromatin protein Swi6/HP1 activates replication origins at the pericentromeric region and silent mating-type locus.

31 March 2020

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HP1a recruitment to promoters is independent of H3K9 methylation in Drosophila melanogaster

31 March 2020

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Early-replicating heterochromatin

31 March 2020

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Histone hypoacetylation is required to maintain late replication timing of constitutive heterochromatin.

31 March 2020

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Telomere-binding protein Taz1 controls global replication timing through its localization near late replication origins in fission yeast

31 March 2020

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Regulation of telomere length and function by a Myb-domain protein in fission yeast

31 March 2020

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Establishing the program of origin firing during S phase in fission Yeast.

31 March 2020

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Cdc45 limits replicon usage from a low density of preRCs in mammalian cells

31 March 2020

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The Hsk1(Cdc7) replication kinase regulates origin efficiency

31 March 2020

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Limiting replication initiation factors execute the temporal programme of origin firing in budding yeast.

31 March 2020

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A natural polymorphism in rDNA replication origins links origin activation with calorie restriction and lifespan

31 March 2020

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The histone deacetylases sir2 and rpd3 act on ribosomal DNA to control the replication program in budding yeast

31 March 2020

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Genetic variation in human DNA replication timing

31 March 2020

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Global reorganization of replication domains during embryonic stem cell differentiation

31 March 2020

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Genome-wide dynamics of replication timing revealed by in vitro models of mouse embryogenesis

31 March 2020

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Transition in specification of embryonic metazoan DNA replication origins

31 March 2020

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Specification of regions of DNA replication initiation during embryogenesis in the 65-kilobase DNApolalpha-dE2F locus of Drosophila melanogaster

31 March 2020

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Progressive activation of DNA replication initiation in large domains of the immunoglobulin heavy chain locus during B cell development.

31 March 2020

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Mechanisms of replication fork protection: a safeguard for genome stability

31 March 2020

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Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint

31 March 2020

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Controlling DNA replication origins in response to DNA damage - inhibit globally, activate locally

31 March 2020

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Dormant origins, the licensing checkpoint, and the response to replicative stresses

31 March 2020

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Checking on DNA damage in S phase

31 March 2020

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Regulating mammalian checkpoints through Cdc25 inactivation

31 March 2020

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Control of mitosis by changes in the subcellular location of cyclin-B1-Cdk1 and Cdc25C

31 March 2020

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The effect of the intra-S-phase checkpoint on origins of replication in human cells

31 March 2020

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Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint

31 March 2020

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Identification of a heteromeric complex that promotes DNA replication origin firing in human cells

31 March 2020

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Damage-induced phosphorylation of Sld3 is important to block late origin firing

31 March 2020

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Checkpoint-dependent inhibition of DNA replication initiation by Sld3 and Dbf4 phosphorylation

31 March 2020

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Dynamics of DNA replication in mammalian somatic cells: nucleotide pool modulates origin choice and interorigin spacing.

31 March 2020

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Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage

31 March 2020

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The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast

31 March 2020

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An essential gene, ESR1, is required for mitotic cell growth, DNA repair and meiotic recombination in Saccharomyces cerevisiae

31 March 2020

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Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systems

31 March 2020

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Chk1 regulates the density of active replication origins during the vertebrate S phase.

31 March 2020

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Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints

31 March 2020

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Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.

31 March 2020

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S phase progression in human cells is dictated by the genetic continuity of DNA foci

31 March 2020

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Chk1 inhibits replication factory activation but allows dormant origin firing in existing factories.

31 March 2020

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A p53-dependent checkpoint pathway prevents rereplication

31 March 2020

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Deregulated origin licensing leads to chromosomal breaks by rereplication of a gapped DNA template

31 March 2020

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Loss of Geminin induces rereplication in the presence of functional p53

31 March 2020

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Rereplication by depletion of geminin is seen regardless of p53 status and activates a G2/M checkpoint

31 March 2020

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Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin

31 March 2020

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Inhibition of eukaryotic DNA replication by geminin binding to Cdt1

31 March 2020

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Clb/Cdc28 kinases promote nuclear export of the replication initiator proteins Mcm2-7.

31 March 2020

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Ubiquitylation, phosphorylation and Orc2 modulate the subcellular location of Orc1 and prevent it from inducing apoptosis

31 March 2020

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Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization

31 March 2020

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A spontaneous Cdt1 mutation in 129 mouse strains reveals a regulatory domain restraining replication licensing

31 March 2020

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Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding

31 March 2020

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Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication

31 March 2020

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The SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation

31 March 2020

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Radiation-mediated proteolysis of CDT1 by CUL4–ROC1 and CSN complexes constitutes a new checkpoint

31 March 2020

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PCNA functions as a molecular platform to trigger Cdt1 destruction and prevent re-replication

31 March 2020

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Geminin, an inhibitor of DNA replication, is degraded during mitosis

31 March 2020

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Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1

31 March 2020

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Identification of novel human Cdt1-binding proteins by a proteomics approach: proteolytic regulation by APC/CCdh1

31 March 2020

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The ATR-mediated S phase checkpoint prevents rereplication in mammalian cells when licensing control is disrupted.

31 March 2020

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31 March 2020

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Integrative analysis of gene amplification in Drosophila follicle cells: parameters of origin activation and repression.

31 March 2020

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Chromatin regulates origin activity in Drosophila follicle cells

31 March 2020

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Oncogenic activity of Cdc6 through repression of the INK4/ARF locus

31 March 2020

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Cdt1 transgenic mice develop lymphoblastic lymphoma in the absence of p53.

31 March 2020

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Selective killing of cancer cells by suppression of geminin activity

31 March 2020

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Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress.

31 March 2020

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Programming DNA replication origins and chromosome organization

31 March 2020

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ATR disruption leads to chromosomal fragmentation and early embryonic lethality

31 March 2020

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12 December 2020

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

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12 December 2020

Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice

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12 December 2020

Xenopus lamin B3 has a direct role in the assembly of a replication competent nucleus: evidence from cell-free egg extracts

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12 December 2020

Xenopus cdc7 function is dependent on licensing but not on XORC, XCdc6, or CDK activity and is required for XCdc45 loading

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12 December 2020

Origins of DNA replication in metazoan chromosomes

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12 December 2020

Identifiers

DOI

10.1038/NRM4002

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Dimensions Publication ID

3 September 2017

1013555301

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