(Q38529627)

3 September 2017

1 reference

title

The Role of TDP-43 in Alzheimer's Disease (English)

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3 September 2017

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Jin-Tai Yu

4

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Lan Tan

series ordinal

3

object named as

Lan Tan

1 reference

3 September 2017

Xiao-Long Chang

1

1 reference

3 September 2017

Meng-Shan Tan

series ordinal

2

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3 September 2017

publication date

17 June 2015

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3 September 2017

published in

Molecular Neurobiology

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3 September 2017

volume

53

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3 September 2017

issue

5

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3 September 2017

page(s)

3349-3359

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https://scigraph.springernature.com/pub.10.1007/s12035-015-9264-5

3 September 2017

exact match

0 references

cites work

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21 January 2018

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21 January 2018

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Functional complementation in Drosophila to predict the pathogenicity of TARDBP variants: evidence for a loss-of-function mechanism

21 January 2018

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Mutational analysis of TARDBP in neurodegenerative diseases

21 January 2018

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TARDBP mutation analysis in TDP-43 proteinopathies and deciphering the toxicity of mutant TDP-43

21 January 2018

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Peptidylprolyl isomerase A governs TARDBP function and assembly in heterogeneous nuclear ribonucleoprotein complexes

21 January 2018

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Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17

21 January 2018

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Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-015-9264-5

Poly-A binding protein-1 localization to a subset of TDP-43 inclusions in amyotrophic lateral sclerosis occurs more frequently in patients harboring an expansion in C9orf72

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-015-9264-5

Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viability

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-015-9264-5

Nuclear factor TDP-43 binds to the polymorphic TG repeats in CFTR intron 8 and causes skipping of exon 9: a functional link with disease penetrance

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-015-9264-5

The dual functions of the extreme N-terminus of TDP-43 in regulating its biological activity and inclusion formation

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-015-9264-5

The crystal structure of TDP-43 RRM1-DNA complex reveals the specific recognition for UG- and TG-rich nucleic acids

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-015-9264-5

Mutations in TDP-43 link glycine-rich domain functions to amyotrophic lateral sclerosis

21 January 2018

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Functional mapping of the interaction between TDP-43 and hnRNP A2 in vivo

21 January 2018

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Evolutionarily conserved heterogeneous nuclear ribonucleoprotein (hnRNP) A/B proteins functionally interact with human and Drosophila TAR DNA-binding protein 43 (TDP-43).

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21 January 2018

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Expression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 Proteinopathies

21 January 2018

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Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice

21 January 2018

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TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration

21 January 2018

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TDP-43-mediated neurodegeneration: towards a loss-of-function hypothesis?

21 January 2018

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TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease

21 January 2018

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Concomitant TAR-DNA-binding protein 43 pathology is present in Alzheimer disease and corticobasal degeneration but not in other tauopathies

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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TDP-43 is a key player in the clinical features associated with Alzheimer's disease

21 January 2018

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Abnormal TDP-43 immunoreactivity in AD modifies clinicopathologic and radiologic phenotype.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-015-9264-5

TDP-43 in Alzheimer's disease is not associated with clinical FTLD or Parkinsonism

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-015-9264-5

TAR DNA-binding protein 43 pathology in Alzheimer's disease with psychosis.

21 January 2018

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21 January 2018

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21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-015-9264-5

Plasma phosphorylated-TDP-43 protein levels correlate with brain pathology in frontotemporal lobar degeneration

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-015-9264-5

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21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-015-9264-5

TDP-43 interaction with the intracellular domain of amyloid precursor protein induces p53-associated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-015-9264-5

Beta amyloid protein deposition in the brain after severe head injury: implications for the pathogenesis of Alzheimer's disease

21 January 2018

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Mitochondrial Ca2+ overload underlies Abeta oligomers neurotoxicity providing an unexpected mechanism of neuroprotection by NSAIDs

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-015-9264-5

β-amyloid triggers ALS-associated TDP-43 pathology in AD models

21 January 2018

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Cytosolic proteins lose solubility as amyloid deposits in a transgenic mouse model of Alzheimer-type amyloidosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-015-9264-5

Full-length TDP-43 forms toxic amyloid oligomers that are present in frontotemporal lobar dementia-TDP patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-015-9264-5

Concurrence of TDP-43, tau and alpha-synuclein pathology in brains of Alzheimer's disease and dementia with Lewy bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-015-9264-5

No interaction between tau and TDP-43 pathologies in either frontotemporal lobar degeneration or motor neurone disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-015-9264-5

Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer's disease and tauopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-015-9264-5

The tau tubulin kinases TTBK1/2 promote accumulation of pathological TDP-43

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-015-9264-5

TDP-43: a new player on the AD field?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-015-9264-5

Neuroinflammation in Alzheimer's disease; A source of heterogeneity and target for personalized therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-015-9264-5

Progranulin and TDP-43: mechanistic links and future directions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-015-9264-5

Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-015-9264-5

Wild type TDP-43 induces neuro-inflammation and alters APP metabolism in lentiviral gene transfer models

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-015-9264-5

Identification of transactivation-responsive DNA-binding protein 43 (TARDBP43; TDP-43) as a novel factor for TNF-α expression upon lipopolysaccharide stimulation in human monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-015-9264-5

Microglial activation and TDP-43 pathology correlate with executive dysfunction in amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-015-9264-5

Is synaptic loss a unique hallmark of Alzheimer's disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-015-9264-5

Comparison of parallel high-throughput RNA sequencing between knockout of TDP-43 and its overexpression reveals primarily nonreciprocal and nonoverlapping gene expression changes in the central nervous system of Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-015-9264-5

Accumulation of C-terminal fragments of transactive response DNA-binding protein 43 leads to synaptic loss and cognitive deficits in human TDP-43 transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-015-9264-5

Identification of RNA bound to the TDP-43 ribonucleoprotein complex in the adult mouse brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-015-9264-5

Amyotrophic lateral sclerosis--a model of corticofugal axonal spread

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-015-9264-5

TDP-43 as a Modulator of Synaptic Plasticity in a Mouse Model of Spinal Motoneuron Degeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-015-9264-5

TDP-43 regulates Drosophila neuromuscular junctions growth by modulating Futsch/MAP1B levels and synaptic microtubules organization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-015-9264-5

Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-015-9264-5

Loss and gain of Drosophila TDP-43 impair synaptic efficacy and motor control leading to age-related neurodegeneration by loss-of-function phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-015-9264-5

Altering mitochondrial dysfunction as an approach to treating Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-015-9264-5

Mitochondrial bioenergetics and structural network organization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-015-9264-5

Mitochondrial biology in Alzheimer's disease pathogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-015-9264-5

ER-mitochondria associations are regulated by the VAPB-PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-015-9264-5

The molecular link between inefficient GluA2 Q/R site-RNA editing and TDP-43 pathology in motor neurons of sporadic amyotrophic lateral sclerosis patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-015-9264-5

Neurotoxic 43-kDa TAR DNA-binding protein (TDP-43) triggers mitochondrion-dependent programmed cell death in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-015-9264-5

Mitochondrial dysfunction in human TDP-43 transfected NSC34 cell lines and the protective effect of dimethoxy curcumin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-015-9264-5

Mitochondrial dysfunction and decrease in body weight of a transgenic knock-in mouse model for TDP-43.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-015-9264-5

Age-dependent changes in TDP-43 levels in a mouse model of Alzheimer disease are linked to Aβ oligomers accumulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-015-9264-5

Zinc induces depletion and aggregation of endogenous TDP-43.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-015-9264-5

Inhibition of gamma-secretase activity reduces Abeta production, reduces oxidative stress, increases mitochondrial activity and leads to reduced vulnerability to apoptosis: Implications for the treatment of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-015-9264-5

The ALS disease-associated mutant TDP-43 impairs mitochondrial dynamics and function in motor neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-015-9264-5

The ER mitochondria calcium cycle and ER stress response as therapeutic targets in amyotrophic lateral sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-015-9264-5

Methylene blue protects against TDP-43 and FUS neuronal toxicity in C. elegans and D. rerio

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-015-9264-5

Pharmacological reduction of ER stress protects against TDP-43 neuronal toxicity in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-015-9264-5

Calcium channel agonists protect against neuromuscular dysfunction in a genetic model of TDP-43 mutation in ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-015-9264-5

PPAR gamma activation is neuroprotective in a Drosophila model of ALS based on TDP-43.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-015-9264-5

Autophagy activation ameliorates neuronal pathogenesis of FTLD-U mice: a new light for treatment of TARDBP/TDP-43 proteinopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-015-9264-5

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-015-9264-5

Limited role of free TDP-43 as a diagnostic tool in neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-015-9264-5

TDP43-positive intraneuronal inclusions in a patient with motor neuron disease and Parkinson's disease

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26081142

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Alterations in subcellular localization of TDP-43 immunoreactivity in the anterior horns in sporadic amyotrophic lateral sclerosis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26081142

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Deaths: preliminary data for 2011.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26081142

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1007/S12035-015-9264-5

1 reference

Dimensions Publication ID

3 September 2017

1025848996

0 references

1 reference