(Q38531516)

English

Characterization of the conformational alterations, reduced anticoagulant activity, and enhanced antiangiogenic activity of prelatent antithrombin

scientific article published on 28 March 2008

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

3 September 2017

Characterization of the conformational alterations, reduced anticoagulant activity, and enhanced antiangiogenic activity of prelatent antithrombin (English)

1 reference

Europe PubMed Central

PMC publication ID

3 September 2017

anticoagulation

1 reference

based on heuristic

inferred from title

angiogenesis inhibitor

1 reference

based on heuristic

inferred from title

author name string

Benjamin Richard

1

1 reference

Europe PubMed Central

PMC publication ID

3 September 2017

Richard Swanson

2

1 reference

Europe PubMed Central

PMC publication ID

3 September 2017

Sophia Schedin-Weiss

3

1 reference

Europe PubMed Central

PMC publication ID

3 September 2017

Ben Ramirez

4

1 reference

Europe PubMed Central

PMC publication ID

3 September 2017

Gonzalo Izaguirre

5

1 reference

Europe PubMed Central

PMC publication ID

3 September 2017

Peter G W Gettins

6

1 reference

Europe PubMed Central

PMC publication ID

3 September 2017

Steven T Olson

7

1 reference

Europe PubMed Central

PMC publication ID

3 September 2017

language of work or name

0 references

publication date

28 March 2008

1 reference

Europe PubMed Central

PMC publication ID

3 September 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PMC publication ID

3 September 2017

283

1 reference

Europe PubMed Central

PMC publication ID

3 September 2017

21

1 reference

Europe PubMed Central

PMC publication ID

3 September 2017

14417-14429

1 reference

Europe PubMed Central

PMC publication ID

3 September 2017

Antithrombin-S195A factor Xa-heparin structure reveals the allosteric mechanism of antithrombin activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386924

6 September 2017

Active site distortion is sufficient for proteinase inhibition by serpins: structure of the covalent complex of alpha1-proteinase inhibitor with porcine pancreatic elastase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386924

6 September 2017

Structure of the antithrombin-thrombin-heparin ternary complex reveals the antithrombotic mechanism of heparin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386924

6 September 2017

The ternary complex of antithrombin-anhydrothrombin-heparin reveals the basis of inhibitor specificity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386924

6 September 2017

Heparin activates antithrombin anticoagulant function by generating new interaction sites (exosites) for blood clotting proteinases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386924

6 September 2017

Kallistatin is a new inhibitor of angiogenesis and tumor growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386924

6 September 2017

Identification of critical molecular interactions mediating heparin activation of antithrombin: implications for the design of improved heparin anticoagulants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386924

6 September 2017

A novel anti-angiogenic form of antithrombin with retained proteinase binding ability and heparin affinity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386924

6 September 2017

Structure of a serpin-protease complex shows inhibition by deformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386924

6 September 2017

Formation of the antithrombin heterodimer in vivo and the onset of thrombosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386924

6 September 2017

Antiangiogenic activity of the cleaved conformation of the serpin antithrombin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386924

6 September 2017

Pigment epithelium-derived factor: a potent inhibitor of angiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386924

6 September 2017

Implications for function and therapy of a 2.9 A structure of binary-complexed antithrombin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386924

6 September 2017

The anticoagulant activation of antithrombin by heparin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386924

6 September 2017

Preparative induction and characterization of L-antithrombin: a structural homologue of latent plasminogen activator inhibitor-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386924

6 September 2017

The oligosaccharide side chain on Asn-135 of alpha-antithrombin, absent in beta-antithrombin, decreases the heparin affinity of the inhibitor by affecting the heparin-induced conformational change

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386924

6 September 2017

The 2.6 A structure of antithrombin indicates a conformational change at the heparin binding site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386924

6 September 2017

Mechanism of acceleration of antithrombin-proteinase reactions by low affinity heparin. Role of the antithrombin binding pentasaccharide in heparin rate enhancement

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386924

6 September 2017

Evidence for a 3-O-sulfated D-glucosamine residue in the antithrombin-binding sequence of heparin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386924

6 September 2017

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386924

6 September 2017

Contribution of monosaccharide residues in heparin binding to antithrombin III.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386924

6 September 2017

Antithrombin III and its interaction with heparin. Comparison of the human, bovine, and porcine proteins by 1H NMR spectroscopy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386924

6 September 2017

Predominant contribution of surface approximation to the mechanism of heparin acceleration of the antithrombin-thrombin reaction. Elucidation from salt concentration effects.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386924

6 September 2017

Role of the antithrombin-binding pentasaccharide in heparin acceleration of antithrombin-proteinase reactions. Resolution of the antithrombin conformational change contribution to heparin rate enhancement

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386924

6 September 2017

Generation of multiple angiogenesis inhibitors by human pancreatic cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386924

14 September 2017

The Size and Shape of Human and Bovine Antithrombin III

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386924

27 September 2017

The heparin-binding site of antithrombin is crucial for antiangiogenic activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386924

23 June 2018

Mechanism of heparin activation of antithrombin. Evidence for reactive center loop preinsertion with expulsion upon heparin binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386924

23 June 2018

Kinetic characterization of heparin-catalyzed and uncatalyzed inhibition of blood coagulation proteinases by antithrombin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386924

23 June 2018

Engineering plasminogen activator inhibitor 1 mutants with increased functional stability.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386924

23 June 2018

Binding of high affinity heparin to antithrombin III. Stopped flow kinetic studies of the binding interaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386924

23 June 2018

Characterization of the kinetic pathway for liberation of fibrinopeptides during assembly of fibrin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386924

23 June 2018

Denaturation behavior of antithrombin in guanidinium chloride. Irreversibility of unfolding caused by aggregation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386924

23 June 2018

Residues Tyr253 and Glu255 in strand 3 of beta-sheet C of antithrombin are key determinants of an exosite made accessible by heparin activation to promote rapid inhibition of factors Xa and IXa.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386924

31 August 2018

Localization of an Antithrombin Exosite That Promotes Rapid Inhibition of Factors Xa and IXa Dependent on Heparin Activation of the Serpin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386924

31 August 2018

Antiangiogenic effects of latent antithrombin through perturbed cell-matrix interactions and apoptosis of endothelial cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386924

31 August 2018

Calcium enhances heparin catalysis of the antithrombin-factor Xa reaction by a template mechanism. Evidence that calcium alleviates Gla domain antagonism of heparin binding to factor Xa.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386924

31 August 2018

Characterization of specific receptors for vasopressin in the pituitary gland

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710327200

21 January 2018

Regulation of Hemostasis by Heparin-Binding Serpins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710327200

21 January 2018

Activation of prothrombin with (taipan snake) venom

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710327200

21 January 2018

Maspin is an angiogenesis inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/18375953

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Separation of latent, prelatent, and native forms of human antithrombin by heparin affinity high-performance liquid chromatography

1 reference

https://pubmed.ncbi.nlm.nih.gov/18375953

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thermal denaturation of antithrombin III. Stabilization by heparin and lyotropic anions

1 reference

https://pubmed.ncbi.nlm.nih.gov/18375953

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure-activity relationship in heparin: a synthetic pentasaccharide with high affinity for antithrombin III and eliciting high anti-factor Xa activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/18375953

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heparin promotes the inactivation of antithrombin by neutrophil elastase

1 reference

https://pubmed.ncbi.nlm.nih.gov/18375953

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conversion of antithrombin from an inhibitor of thrombin to a substrate with reduced heparin affinity and enhanced conformational stability by binding of a tetradecapeptide corresponding to the P1 to P14 region of the putative reactive bond loop of

1 reference

https://pubmed.ncbi.nlm.nih.gov/18375953

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for a pre-latent form of the serpin plasminogen activator inhibitor-1 with a detached beta-strand 1C

1 reference

https://pubmed.ncbi.nlm.nih.gov/18375953

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism by which exosites promote the inhibition of blood coagulation proteases by heparin-activated antithrombin

1 reference

https://pubmed.ncbi.nlm.nih.gov/18375953

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M710327200

1 reference

Europe PubMed Central

PMC publication ID

3 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

3 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

3 September 2017

ResearchGate publication ID

0 references

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