(Q46975944)

English

Residues Tyr253 and Glu255 in strand 3 of beta-sheet C of antithrombin are key determinants of an exosite made accessible by heparin activation to promote rapid inhibition of factors Xa and IXa.

scientific article published on 3 March 2006

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

27 December 2017

http://europepmc.org/abstract/MED/16517611

Residues Tyr253 and Glu255 in strand 3 of beta-sheet C of antithrombin are key determinants of an exosite made accessible by heparin activation to promote rapid inhibition of factors Xa and IXa. (English)

1 reference

Europe PubMed Central

PubMed publication ID

27 December 2017

http://europepmc.org/abstract/MED/16517611

1 reference

based on heuristic

inferred from title

author name string

Gonzalo Izaguirre

1

1 reference

Europe PubMed Central

PubMed publication ID

27 December 2017

http://europepmc.org/abstract/MED/16517611

Steven T Olson

2

1 reference

Europe PubMed Central

PubMed publication ID

27 December 2017

http://europepmc.org/abstract/MED/16517611

language of work or name

0 references

publication date

3 March 2006

1 reference

Europe PubMed Central

PubMed publication ID

27 December 2017

http://europepmc.org/abstract/MED/16517611

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PubMed publication ID

27 December 2017

http://europepmc.org/abstract/MED/16517611

281

1 reference

Europe PubMed Central

PubMed publication ID

27 December 2017

http://europepmc.org/abstract/MED/16517611

19

1 reference

Europe PubMed Central

PubMed publication ID

27 December 2017

http://europepmc.org/abstract/MED/16517611

13424-13432

1 reference

Europe PubMed Central

PubMed publication ID

27 December 2017

http://europepmc.org/abstract/MED/16517611

Heparin and calcium ions dramatically enhance antithrombin reactivity with factor IXa by generating new interaction exosites.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600415200

21 January 2018

Serpin structure, mechanism, and function

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600415200

21 January 2018

Structure of a serpin-protease complex shows inhibition by deformation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600415200

21 January 2018

Formation of the covalent serpin-proteinase complex involves translocation of the proteinase by more than 70 A and full insertion of the reactive center loop into beta-sheet A.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600415200

21 January 2018

The pH dependence of serpin-proteinase complex dissociation reveals a mechanism of complex stabilization involving inactive and active conformational states of the proteinase which are perturbable by calcium

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600415200

21 January 2018

Characterization of specific receptors for vasopressin in the pituitary gland

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600415200

21 January 2018

Mechanism of heparin activation of antithrombin. Evidence for reactive center loop preinsertion with expulsion upon heparin binding

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600415200

21 January 2018

The anticoagulant activation of antithrombin by heparin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600415200

21 January 2018

Mechanism of heparin activation of antithrombin. Role of individual residues of the pentasaccharide activating sequence in the recognition of native and activated states of antithrombin.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600415200

21 January 2018

The antithrombin P1 residue is important for target proteinase specificity but not for heparin activation of the serpin. Characterization of P1 antithrombin variants with altered proteinase specificity but normal heparin activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600415200

21 January 2018

Heparin enhances the specificity of antithrombin for thrombin and factor Xa independent of the reactive center loop sequence. Evidence for an exosite determinant of factor Xa specificity in heparin-activated antithrombin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600415200

21 January 2018

Heparin activates antithrombin anticoagulant function by generating new interaction sites (exosites) for blood clotting proteinases.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600415200

21 January 2018

Calcium enhances heparin catalysis of the antithrombin-factor Xa reaction by a template mechanism. Evidence that calcium alleviates Gla domain antagonism of heparin binding to factor Xa.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600415200

21 January 2018

Localization of an Antithrombin Exosite That Promotes Rapid Inhibition of Factors Xa and IXa Dependent on Heparin Activation of the Serpin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600415200

21 January 2018

Insight into residues critical for antithrombin function from analysis of an expanded database of sequences that includes frog, turtle, and ostrich antithrombins.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600415200

21 January 2018

Lysine 114 of antithrombin is of crucial importance for the affinity and kinetics of heparin pentasaccharide binding

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600415200

21 January 2018

The Size and Shape of Human and Bovine Antithrombin III

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600415200

21 January 2018

Kinetic characterization of heparin-catalyzed and uncatalyzed inhibition of blood coagulation proteinases by antithrombin.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600415200

21 January 2018

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600415200

21 January 2018

Mechanisms of glycosaminoglycan activation of the serpins in hemostasis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600415200

21 January 2018

Allosteric activation of antithrombin critically depends upon hinge region extension

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600415200

21 January 2018

Biological implications of a 3 A structure of dimeric antithrombin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600415200

21 January 2018

The ternary complex of antithrombin-anhydrothrombin-heparin reveals the basis of inhibitor specificity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600415200

21 January 2018

Structure of the antithrombin-thrombin-heparin ternary complex reveals the antithrombotic mechanism of heparin.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600415200

21 January 2018

Elimination of P1 arginine 393 interaction with underlying glutamic acid 255 partially activates antithrombin III for thrombin inhibition but not factor Xa inhibition

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600415200

21 January 2018

Amino acid residues that affect interaction of tissue-type plasminogen activator with plasminogen activator inhibitor 1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600415200

21 January 2018

Role of basic residues of the autolysis loop in the catalytic function of factor Xa.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600415200

21 January 2018

Contribution of Basic Residues of the Autolysis Loop to the Substrate and Inhibitor Specificity of Factor IXa

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600415200

21 January 2018

Molecular determinants of the mechanism underlying acceleration of the interaction between antithrombin and factor Xa by heparin pentasaccharide

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600415200

21 January 2018

Mutagenesis studies toward understanding the mechanism of differential reactivity of factor Xa with the native and heparin-activated antithrombin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600415200

21 January 2018

Structure of human factor VIIa and its implications for the triggering of blood coagulation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600415200

21 January 2018

Cation-pi interactions in structural biology

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600415200

21 January 2018

Identifiers

10.1074/JBC.M600415200

1 reference

Europe PubMed Central

PubMed publication ID

27 December 2017

http://europepmc.org/abstract/MED/16517611

release_snjzwwbzivc4parz4xntcwgtoe

1 reference

https://api.fatcat.wiki/v0/release/snjzwwbzivc4parz4xntcwgtoe

24 November 2022

based on heuristic

mapped directly with Wikidata item

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

27 December 2017

http://europepmc.org/abstract/MED/16517611

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q46975944&oldid=1844284191"