(Q38539670)

3 September 2017

1 reference

title

MYC in pancreatic cancer: novel mechanistic insights and their translation into therapeutic strategies (English)

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3 September 2017

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E Hessmann

1

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3 September 2017

G Schneider

series ordinal

2

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3 September 2017

V Ellenrieder

series ordinal

3

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3 September 2017

J T Siveke

series ordinal

4

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3 September 2017

language of work or name

English

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publication date

29 June 2015

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3 September 2017

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3 September 2017

35

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3 September 2017

13

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3 September 2017

1609-1618

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https://scigraph.springernature.com/pub.10.1038/onc.2015.216

3 September 2017

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cites work

An overview of MYC and its interactome

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Therapeutic strategies to inhibit MYC

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Reflecting on 25 years with MYC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Pan-cancer patterns of somatic copy number alteration

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2015.216

Emerging landscape of oncogenic signatures across human cancers

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2015.216

MYC activation is a hallmark of cancer initiation and maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

21 January 2018

Neuroblastoma and MYCN

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https://api.crossref.org/works/10.1038%2FONC.2015.216

Role of MYC in Medulloblastoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Oncogenic mechanisms in Burkitt lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

MYC-induced cancer cell energy metabolism and therapeutic opportunities

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Immunology in the clinic review series; focus on cancer: multiple roles for the immune system in oncogene addiction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

MYC oncogenes and human neoplastic disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Pancreatic ductal adenocarcinoma and transcription factors: role of c-Myc

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Inhibition of Myc family proteins eradicates KRas-driven lung cancer in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Modelling Myc inhibition as a cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Wnt/beta-catenin signaling is required for development of the exocrine pancreas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Whole genomes redefine the mutational landscape of pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Roles for KRAS in pancreatic tumor development and progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Signatures of mutational processes in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Core signaling pathways in human pancreatic cancers revealed by global genomic analyses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

A multipotent progenitor domain guides pancreatic organogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Pancreas-specific deletion of beta-catenin reveals Wnt-dependent and Wnt-independent functions during development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Conditional inactivation of Myc impairs development of the exocrine pancreas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Stabilization of beta-catenin impacts pancreas growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Beta-catenin is essential for pancreatic acinar but not islet development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Identification of CDK4 as a target of c-MYC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Origin of pancreatic ductal adenocarcinoma from atypical flat lesions: a comparative study in transgenic mice and human tissues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Pancreatic ductal adenocarcinoma and acinar cells: a matter of differentiation and development?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Pancreatic tumor pathogenesis reflects the causative genetic lesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Dormant cancer cells contribute to residual disease in a model of reversible pancreatic cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Loss of Fbw7 reprograms adult pancreatic ductal cells into α, δ, and β cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Organoid models of human and mouse ductal pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Plasticity and dedifferentiation within the pancreas: development, homeostasis, and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Analysis of the tumor-initiating and metastatic capacity of PDX1-positive cells from the adult pancreas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Analysis of C-MYC function in normal cells via conditional gene-targeted mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

A modular and flexible ESC-based mouse model of pancreatic cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Myc-binding-site recognition in the human genome is determined by chromatin context

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Design and properties of a Myc derivative that efficiently homodimerizes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Omomyc expression in skin prevents Myc-induced papillomatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

In silico identification of transcriptional regulators associated with c-Myc.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

MYC and EGR1 synergize to trigger tumor cell death by controlling NOXA and BIM transcription upon treatment with the proteasome inhibitor bortezomib

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

The interaction of MYC with the trithorax protein ASH2L promotes gene transcription by regulating H3K27 modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Mutant K-Ras increases GSK-3β gene expression via an ETS-p300 transcriptional complex in pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Acetylation as a transcriptional control mechanism-HDACs and HATs in pancreatic ductal adenocarcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

c-Myc regulates transcriptional pause release

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Histone recognition and large-scale structural analysis of the human bromodomain family

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Conserved P-TEFb-interacting domain of BRD4 inhibits HIV transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Selective inhibition of BET bromodomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

BET bromodomain inhibition as a therapeutic strategy to target c-Myc

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Efficacy of BET bromodomain inhibition in Kras-mutant non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Discovery and characterization of super-enhancer-associated dependencies in diffuse large B cell lymphoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Predisposition to lymphomagenesis in pim-1 transgenic mice: cooperation with c-myc and N-myc in murine leukemia virus-induced tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

PIM1-dependent phosphorylation of histone H3 at serine 10 is required for MYC-dependent transcriptional activation and oncogenic transformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Inhibition of oncogenic Pim-3 kinase modulates transformed growth and chemosensitizes pancreatic cancer cells to gemcitabine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

The role of MIZ-1 in MYC-dependent tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

The interaction between Myc and Miz1 is required to antagonize TGFbeta-dependent autocrine signaling during lymphoma formation and maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Genome profiling of pancreatic adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Differential regulation of the c-myc oncogene promoter by the NF-kappa B rel family of transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Multiple Wnt/ß-catenin responsive enhancers align with the MYC promoter through long-range chromatin loops

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Mechanisms of TGF-beta signaling from cell membrane to the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Genetic alterations in pancreatic carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

LY2109761, a novel transforming growth factor beta receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Overexpression of c-myc in pancreatic cancer caused by ectopic activation of NFATc1 and the Ca2+/calcineurin signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Identification of a putative regulator of early T cell activation genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Sequential activation of NFAT and c-Myc transcription factors mediates the TGF-beta switch from a suppressor to a promoter of cancer cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

miRNA and mRNA cancer signatures determined by analysis of expression levels in large cohorts of patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

miRNA dysregulation in cancer: towards a mechanistic understanding

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

MicroRNAs as regulators and mediators of c-MYC function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

miR-494 acts as an anti-oncogene in gastric carcinoma by targeting c-myc

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

miR-34 cooperates with p53 in suppression of prostate cancer by joint regulation of stem cell compartment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

miR-34 miRNAs provide a barrier for somatic cell reprogramming

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

A positive feedback between p53 and miR-34 miRNAs mediates tumor suppression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

c-MYC and SIRT1 locked in a vicious cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

MicroRNAs as potential target gene in cancer gene therapy of gastrointestinal tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

miR-34a repression of SIRT1 regulates apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

A small piece in the cancer puzzle: microRNAs as tumor suppressors and oncogenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Control of cellular senescence by CPEB

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Antiproliferative protein Tob directly regulates c-myc proto-oncogene expression through cytoplasmic polyadenylation element-binding protein CPEB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Key contribution of CPEB4-mediated translational control to cancer progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

The ins and outs of MYC regulation by posttranslational mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

MYC expression and distribution in normal mature lymphoid cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Skp2 regulates Myc protein stability and activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

USP22 is a positive regulator of NFATc2 on promoting IL2 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Tumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Small molecule inhibitors of aurora-a induce proteasomal degradation of N-myc in childhood neuroblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Drugging MYCN through an allosteric transition in Aurora kinase A

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Suppression of Aurora-A oncogenic potential by c-Myc downregulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Microarray-based screening for molecular markers in medulloblastoma revealed STK15 as independent predictor for survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Characterization of gene expression in mucinous cystic neoplasms of the pancreas using oligonucleotide microarrays

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Functional characterization of BRCA1 sequence variants using a yeast small colony phenotype assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Therapeutic potential of a synthetic lethal interaction between the MYC proto-oncogene and inhibition of aurora-B kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Synthetic lethal screens as a means to understand and treat MYC-driven cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Deregulated MYC expression induces dependence upon AMPK-related kinase 5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

c-Myc proteolysis by the ubiquitin-proteasome pathway: stabilization of c-Myc in Burkitt's lymphoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

c-Myc phosphorylation is required for cellular response to oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Cyclin-dependent kinase inhibitor Dinaciclib (SCH727965) inhibits pancreatic cancer growth and progression in murine xenograft models

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Mechanism of transcriptional activation by the Myc oncoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Pancreatic cancer genomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Regulator of calcineurin 1 controls growth plasticity of adult pancreas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Disruption of a nuclear NFATc2 protein stabilization loop confers breast and pancreatic cancer growth suppression by zoledronic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Curcumin and gemcitabine in patients with advanced pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Dual inhibition of Janus and Src family kinases by novel indirubin derivative blocks constitutively-activated Stat3 signaling associated with apoptosis of human pancreatic cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

BET bromodomain inhibitors block growth of pancreatic cancer cells in three-dimensional collagen

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Pancreatic Inactivation of c-Myc Decreases Acinar Mass and Transdifferentiates Acinar Cells Into Adipocytes in Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Very high frequency of lymphoma induction by a chemical carcinogen in pim-1 transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Prognostic relevance of C-myc gene expression in giant-cell tumor of bone

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Therapeutic Effects of an Anti-Myc Drug on Mouse Pancreatic Cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Acinar-to-ductal metaplasia accompanies c-myc-induced exocrine pancreatic cancer progression in transgenic rodents

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

'Designer' tumors in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Genome recognition by MYC.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

N-myc downstream regulated gene 1 acts as a tumor suppressor in ovarian cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Synthesis and evaluation of a potent and selective cell-permeable p300 histone acetyltransferase inhibitor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

c-MYC activation in primary and metastatic ductal adenocarcinoma of the pancreas: incidence, mechanisms, and clinical significance

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

NFAT-induced histone acetylation relay switch promotes c-Myc-dependent growth in pancreatic cancer cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.216

Myc oncoproteins are phosphorylated by casein kinase II

31 March 2020

2 references

https://api.crossref.org/works/10.1038%2FONC.2015.216

31 March 2020

12 December 2020

The mitotic serine threonine kinase, Aurora-2, is a potential target for drug development in human pancreatic cancer

1 reference

12 December 2020

Phosphorylation sites mapping in the N-terminal domain of c-myc modulate its transforming potential.

1 reference

12 December 2020

Casein kinase II inhibition induces apoptosis in pancreatic cancer cells

1 reference

12 December 2020

Role of the Rel-family of transcription factors in the regulation of c-myc gene transcription and apoptosis of WEHI 231 murine B-cells

1 reference

12 December 2020

Tamoxifen functions as a molecular agonist inducing cell cycle-associated genes in breast cancer cells

1 reference

12 December 2020

Omomyc, a potential Myc dominant negative, enhances Myc-induced apoptosis.

1 reference

12 December 2020

Identifiers

DOI

10.1038/ONC.2015.216

1 reference

Dimensions Publication ID

3 September 2017

0 references

1 reference