(Q38556467)

4 September 2017

1 reference

title

Cytosolic sensing of aberrant DNA: arming STING on the endoplasmic reticulum (English)

1 reference

4 September 2017

endoplasmic reticulum

0 references

1 reference

Qiang Wang

1

1 reference

4 September 2017

Xing Liu

series ordinal

2

1 reference

4 September 2017

Qin Zhou

series ordinal

3

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4 September 2017

Chen Wang

series ordinal

4

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4 September 2017

language of work or name

English

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publication date

28 July 2015

1 reference

Expert Opinion on Therapeutic Targets

4 September 2017

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4 September 2017

19

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4 September 2017

10

1 reference

4 September 2017

1397-1409

1 reference

Pathogen recognition and innate immunity

4 September 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

The roles of TLRs, RLRs and NLRs in pathogen recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Dynamic regulation of innate immunity by ubiquitin and ubiquitin-like proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

RNA recognition and signal transduction by RIG-I-like receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Immune signaling by RIG-I-like receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

21 January 2018

Immune sensing of DNA

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Innate immune sensing of DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Pattern recognition receptors and control of adaptive immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Endogenous circulating DNA in systemic lupus erythematosus. Occurrence as multimeric complexes bound to histone

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Role of DNA/RNA sensors and contribution to autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

DNA vaccines: an historical perspective and view to the future

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

A Toll-like receptor recognizes bacterial DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

DNA vaccines: immunology, application, and optimization*

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Vaccination with plasmid DNA activates dendritic cells via Toll-like receptor 9 (TLR9) but functions in TLR9-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

TLR9-/- and TLR9+/+ mice display similar immune responses to a DNA vaccine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Recognition of cytosolic DNA activates an IRF3-dependent innate immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Innate immunity: cytoplasmic DNA sensing by the AIM2 inflammasome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

STING-dependent cytosolic DNA sensing pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

IFI16 is an innate immune sensor for intracellular DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

IFI16: At the interphase between innate DNA sensing and genome regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

DAI (DLM-1/ZBP1) as a genetic adjuvant for DNA vaccines that promotes effective antitumor CTL immunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Bruton's tyrosine kinase phosphorylates DDX41 and activates its binding of dsDNA and STING to initiate type 1 interferon response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

The prokaryote messenger c-di-GMP triggers stalk cell differentiation in Dictyostelium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

c-di-GMP (3'-5'-cyclic diguanylic acid) inhibits Staphylococcus aureus cell-cell interactions and biofilm formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Roles of cyclic diguanylate in the regulation of bacterial pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

c-di-AMP secreted by intracellular Listeria monocytogenes activates a host type I interferon response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

The potential of 3',5'-cyclic diguanylic acid (c-di-GMP) as an effective vaccine adjuvant

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Bis-(3',5')-cyclic dimeric adenosine monophosphate: strong Th1/Th2/Th17 promoting mucosal adjuvant

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Cyclic di-nucleotides: new era for small molecules as adjuvants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Cyclic GMP-AMP displays mucosal adjuvant activity in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN production

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Mitochondrial DNA stress primes the antiviral innate immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

DNA damage primes the type I interferon system via the cytosolic DNA sensor STING to promote anti-microbial innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

STING manifests self DNA-dependent inflammatory disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Self-DNA, STING-dependent signaling and the origins of autoinflammatory disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

DNase II: genes, enzymes and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

DNA degradation in development and programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Requirement of DNase II for definitive erythropoiesis in the mouse fetal liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Dnase2a deficiency uncovers lysosomal clearance of damaged nuclear DNA via autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Gene-targeted mice lacking the Trex1 (DNase III) 3'-->5' DNA exonuclease develop inflammatory myocarditis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Trex1 prevents cell-intrinsic initiation of autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Mutation of DNASE1 in people with systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Features of systemic lupus erythematosus in Dnase1-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Host restriction factor SAMHD1 limits human T cell leukemia virus type 1 infection of monocytes via STING-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

The E3 ubiquitin ligase AMFR and INSIG1 bridge the activation of TBK1 kinase by modifying the adaptor STING.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

TRIM32 protein modulates type I interferon induction and cellular antiviral response by targeting MITA/STING protein for K63-linked ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

The E3 ubiquitin ligase RNF5 targets virus-induced signaling adaptor for ubiquitination and degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

RNF26 temporally regulates virus-triggered type I interferon induction by two distinct mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Cyclic dinucleotides trigger ULK1 (ATG1) phosphorylation of STING to prevent sustained innate immune signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

The ER-associated protein ZDHHC1 is a positive regulator of DNA virus-triggered, MITA/STING-dependent innate immune signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

A role for DNA-dependent activator of interferon regulatory factor in the recognition of herpes simplex virus type 1 by glial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

DENV inhibits type I IFN production in infected cells by cleaving human STING

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

The mechanism of double-stranded DNA sensing through the cGAS-STING pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Sensing and responding to cytosolic viruses invasions: An orchestra of kaleidoscopic ubiquitinations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Hepatitis C virus NS4B protein targets STING and abrogates RIG-I-mediated type I interferon-dependent innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Hepatitis C virus NS4B blocks the interaction of STING and TBK1 to evade host innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Dengue virus targets the adaptor protein MITA to subvert host innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Coronavirus papain-like proteases negatively regulate antiviral innate immune response through disruption of STING-mediated signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Innate signaling in the inflammatory immune disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Cytosolic sensing of viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Antiviral defense: RIG-Ing the immune system to STING.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Activation of STAT6 by STING is critical for antiviral innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Species-specific detection of the antiviral small-molecule compound CMA by STING

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Disrupting tumour blood vessels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Clinical aspects of a phase I trial of 5,6-dimethylxanthenone-4-acetic acid (DMXAA), a novel antivascular agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

The chemotherapeutic agent DMXAA potently and specifically activates the TBK1-IRF-3 signaling axis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

5,6-Dimethylxanthenone-4-acetic acid (DMXAA) activates stimulator of interferon gene (STING)-dependent innate immune pathways and is regulated by mitochondrial membrane potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Binding-pocket and lid-region substitutions render human STING sensitive to the species-specific drug DMXAA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2015.1067303

10.1517/14728222.2015.1067303

21 January 2018

Identifiers

DOI

1 reference

4 September 2017

1 reference